Unusual Ferromagnetic Band Evolution and High Curie Temperature in Monolayer 1T-CrTe on Bilayer Graphene.

2D van der Waals ferromagnets hold immense promise for spintronic applications due to their controllability and versatility. Despite their significance, the realization and in-depth characterization of ferromagnetic materials in atomically thin single layers, close to the true 2D limit, has been scarce. Here, a successful synthesis of monolayer (ML) 1T-CrTe is reported on a bilayer graphene (BLG) substrate via molecular beam epitaxy.

Current status of the use of validated home blood pressure monitoring devices among Korean patients with hypertension.

The implementation of Home Blood Pressure Monitoring (HBPM) has improved the diagnosis and treatment of hypertension. Current clinical guidelines advocate the use of validated HBPM devices. However, few studies have examined the current use of validated HBPM devices.

The Factors Influencing Quality of Life Among Patients With Hepatobiliary and Pancreatic Cancers.

Background: Maintaining a good quality of life improves treatment outcomes and overall survival rate among patients with hepatobiliary and pancreatic cancers. However, known factors influencing the quality of life are fragmented and require a comprehensive investigation of influencing factors to improve the quality of life among patients with hepatobiliary and pancreatic cancers during treatment periods.

Objective: We aimed to comprehensively identify the factors influencing the quality of life among patients with hepatobiliary or pancreatic cancer during illness and treatment periods.

Idiopathic epiretinal membrane area changes in eyes with good vision and the association with visual function.

Purpose: To evaluate idiopathic epiretinal membrane (iERM) area changes and the association with visual function in patients with good vision, using confocal scanning laser ophthalmoscopy (cSLO).

Methods: The medical records of patients with iERM with best-corrected visual acuity (BCVA) ≥ 20/25 and a follow-up period ≥ 2 years were reviewed retrospectively. BCVA, metamorphopsia, fundus images using cSLO, and optical coherence tomography images were obtained at baseline and every 6 months.

PET-leveraged ALDH probe toward cancer stem cells.

Developing novel aldehyde dehydrogenase (ALDH) probes is essential for enhancing the localization and visualization of cancer stem cells (CSCs) by improving specificity and signal-to-noise ratios. This study introduces four new ALDH fluorescent probes (AldeCou1-4), designed using a coumarin-linker-benzaldehyde scaffold. Among them, AldeCou-1 exhibits a significant Stokes shift of 125 nm (/ = 380/505 nm), which enhances the signal-to-noise ratio and minimizes inner-filter effects.

Protopine Exerts Anti-Leukemic Effects by Promoting ROS-mediated Inhibition of Survival Signals in Acute Myeloid Leukemia Cells.

Background/aim: The inhibition of differentiation in myeloid progenitor cells is a hallmark of acute myeloid leukemia (AML). The chemotherapy regimen for AML patients, the so-called 7+3 protocol and the survival rate, have remained unchanged for decades, leaving AML one of the most lethal diseases among adults. Differentiation therapy represents a promising approach that aims to induce the maturation of leukemic progenitor cells into non-proliferative, terminally differentiated cells, thereby directly targeting the underlying pathogenesis of the disease.

Red ginseng extract enhances mitochondrial function and alleviates immunosenescence in T cells.

Background: Mitochondrial function is essential for immune cell regulation, and its decline is linked to aging and chronic diseases. Impaired activity contributes to inflammation and reduced immunity. This study explores Red ginseng extract (RGE)'s potential in enhancing mitochondrial function and immune cell viability, offering benefits in mitigating immunosenescence.

Data from the Effects of Congruent and Incongruent Perceptual Cues on Middle Schoolers' Mathematical Performance, Learning, and Retention Study.

This paper presents datasets for a research project that investigated the individual and combined effects of two perceptual cues-spacing and color-under varying conditions of congruence with the order of operations. The datasets contain 1,100 6th-grade students' data collected through a randomized controlled trial conducted in 2024 in a U.S.

Modulation of retinal inflammation delays degeneration in a mouse model of geographic atrophy.

Geographic atrophy, the advanced form of age-related macular degeneration (AMD), is associated with increased oxidative stress and chronic inflammation. Pro-inflammatory genes, like TNF-α and IL-1β, are under the regulation of the transcription factor p65/RelA. We have previously shown that adeno-associated virus (AAV) delivery of the RelA inhibitory gene M013 blocks retinal inflammation in uveitis models.

Long-term clinical outcomes according to first responsive dose of acetylcholine in patients with coronary artery spasm.

Background: Coronary artery spasm (CAS) has become a focus of recent prognostic studies. However, research evaluating prognosis based on the initial dose of acetylcholine (ACH) at which patients first respond is lacking. This study aims to investigate long-term clinical outcomes according to the first responsive dose of ACH in patients with CAS.

How pet food selection attributes influence customer satisfaction and loyalty: evidence from South Korea.

Background: This study examined the impact of pet food selection attributes, including price, quality, reliability, and convenience, on customer satisfaction and loyalty in South Korea's evolving pet food market. The pet industry in South Korea is expanding rapidly, driven by changes in demographics like the rise of single-person households and aging populations. It is essential to understand consumer preferences in pet food attributes.

A Novel You Only Listen Once (YOLO) Deep Learning Model for Automatic Prominent Bowel Sounds Detection: Feasibility Study in Healthy Subjects.

Accurate diagnosis of gastrointestinal (GI) diseases typically requires invasive procedures or imaging studies that pose the risk of various post-procedural complications or involve radiation exposure. Bowel sounds (BSs), though typically described during a GI-focused physical exam, are highly inaccurate and variable, with low clinical value in diagnosis. Interpretation of the acoustic characteristics of BSs, i.

Differential Effects of Green Space Typologies on Congenital Anomalies: Data from the Korean National Health Insurance Service (2008-2013).

: Urban green space has been increasingly recognized as a determinant of maternal and child health. This study investigated the association between prenatal exposure to different types of green space and the risk of congenital anomalies in South Korea. : We analyzed data from the National Health Insurance Service (N = 142,422).

Spatial Omics Profiling of Treatment-Naïve Lung Adenocarcinoma with Brain Metastasis as the Initial Presentation.

Background/objectives: Brain metastasis (BM) is a common and often early manifestation in lung adenocarcinoma (LUAD), yet its tumor microenvironment remains poorly defined at the time of initial diagnosis. This study aims to characterize early immune microenvironmental alterations in synchronous BM using spatial proteomic profiling.

Methods: We performed digital spatial proteomic profiling using the NanoString GeoMx platform on formalin-fixed paraffin-embedded tissues from five treatment-naïve LUAD patients in whom BM was the initial presenting lesion.

Randomized, phase II trial to evaluate the efficacy and safety of atezolizumab plus capecitabine adjuvant therapy compared to capecitabine monotherapy for triple receptor-negative breast cancer with residual invasive cancer after neoadjuvant chemotherapy (MIRINAE trial, KCSG-BR18-21).

Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis, especially in patients with residual disease post-neoadjuvant chemotherapy. This phase II MIRINAE trial (KCSG-BR18-21) evaluates the efficacy and safety of atezolizumab combined with capecitabine versus capecitabine monotherapy as adjuvant treatment in TNBC patients with residual invasive cancer. The primary endpoint is the 5-year invasive disease-free survival (IDFS) rate.

Probiotic potential of ginseng derived Lacticaseibacillus rhamnosus strains with hypocholesterolemic, antioxidant and antibacterial activities.

Cardiovascular diseases remain one of the leading causes of mortality among adults worldwide, with elevated blood lipid levels serving as a key modifiable risk factor. This study aimed to investigate the probiotic potential of lactic acid bacteria (LAB) isolated from ginseng sprouts (Panax ginseng Meyer) cultivated under smart-farming conditions, with a particular emphasis on their cholesterol-lowering properties. Out of 485 isolates, five strains of Lacticaseibacillus rhamnosus were selected based on superior in vitro performance and identified through 16 S rRNA sequencing and phylogenetic analysis.

Hearing changes and trajectories during the menopausal transition and their association with metabolic factors.

Background: Hearing loss is an emerging public health concern, with women typically experiencing deterioration during menopause; however, longitudinal studies across this transition are limited. This study examined hearing changes across the menopausal transition in order to identify distinct patterns of hearing decline from 11 years before to 9 years after the final menstrual period, with the goal of informing strategies for early detection and intervention.

Materials And Methods: We followed 4448 women aged 42-52 years who underwent regular health exams at the Kangbuk Samsung Hospital Total Healthcare Centers (2014-2018) through 2023.

Fluid Shear-Controlled Pro/Anti-Inflammatory Osteomodulatory Construct for Drug-Free Immune Activation Through Cationic Ion Channel Activation.

Effective bone regeneration requires the integration of immune and mechanical signals, which current biomaterials often fail to achieve. To address this, an immunomodulatory scaffold is developed combining 3D printing and electrospinning, designed to mimic the bone and periosteum. The scaffold features an outer electrospun nanofiber mat and an inner 3D-printed core, creating a biomimetic structure that facilitates the polarization of macrophages into pro-inflammatory (M1) and anti-inflammatory (M2) states under physiological fluid shear stress (FSS).

Spin Frustration and Unconventional Surface Spin Canting State in Van der Waals Ferromagnet/Antiferromagnet Heterostructures.

Atomically flat surfaces of van der Waals (vdW) materials pave an avenue for addressing a long-standing fundamental issue of how a compensated antiferromagnet (AFM) surface frustrates a ferromagnetic (FM) overlayer in FM/AFM heterostructures. We investigate FeGeTe/NiPS vdW heterostructures by characterizing AFM and FM spins separately. We find that in-plane zig-zag AFM NiPS develops three equivalent AFM domains, which are robust against external magnetic field and magnetic coupling with FeGeTe.

Identification of Simultaneous Occurrence of Amphibian Chytrid Fungi and Ranavirus in South Korea.

Emerging infectious diseases such as chytridiomycosis and ranavirosis, caused by () and ranavirus (RV), respectively, are major contributors to global amphibian declines. Despite their significance, comprehensive data on the spatial epidemiology of these pathogens in South Korea remain limited. This study aimed to assess the nationwide co-occurrence and prevalence of and RV across four anuran species in five administrative regions.

Effectiveness and Clinical Outcomes of PGT-M Using Karyomapping for Successful Pregnancy and Birth in Various Types of Charcot-Marie-Tooth Disease.

Charcot-Marie-Tooth disease (CMT) is a genetically and clinically heterogeneous group of progressive peripheral neuropathies. Preimplantation genetic testing for monogenic disorders (PGT-M), a well-established assisted reproductive technology used to detect specific genetic mutations in embryos before implantation, has been used in common CMT subtypes (e.g.

Leveraging Multi-Level Biomarkers Using Machine Learning: Identifying Physiological and Skin Microbial Dynamics in Bd-Resistant Amphibians.

Amphibians worldwide are declining due to various anthropogenic and environmental stressors. One of the most important threats is large-scale epidemics of chytridiomycosis, which is caused by Batrachochytrium dendrobatidis (Bd). Unlike in other continents, amphibian species in South Korea, such as Pelophylax nigromaculatus, are resistant to Bd, making it difficult to discern its detailed effects.

Prevalence of germline pathogenic variants in unselected Korean patients with HER2-negative metastatic breast cancer: a nationwide prospective study (KCSG BR19-10).

Background: Assessment of germline (g) status is recommended for all patients with HER2-negative metastatic breast cancer (MBC) to identify candidates for poly(ADP-ribose) polymerase (PARP) inhibitor therapy, which is not always possible in clinical practice due to limited testing resources. In this study, we investigate the cross-sectional prevalence of g pathogenic variant (PV) carriers in unselected Korean patients with HER2-negative MBC.

Methods: Patients diagnosed with HER2-negative metastatic BC receiving palliative systemic treatment were eligible for inclusion in the study.

Immunomodulatory Effect of Phosvitin Phosphopeptides on Forced Swimming-Induced Immune Dysfunction in BALB/c Mice.

The dysfunction of the immune system can make the host susceptible to various diseases, and the consumption of immunomodulating agents can be an effective way to control immune responses. Phosphopeptides derived from egg yolk phosvitin exert various beneficial effects. This study investigated the immunomodulatory effect of egg yolk-derived phosvitin phosphopeptides (PPPs) on forced swimming-induced immune dysfunction in BALB/c mice.

Targeting CD155 in lung adenocarcinoma: A5 nanobody-based therapeutics for precision treatment and enhanced drug delivery.

This study presents a novel approach targeting CD155, an overexpressed protein in lung adenocarcinoma (LUAD), using nanobodies with exceptional precision and efficacy. The significant upregulation of CD155 in LUAD, associated with poor patient outcomes, highlights its potential as a therapeutic target. An anti-CD155 nanobody (A5 Nb) is developed that binds to CD155-positive lung cancer cells with high affinity (A5 Nb K = 0.