Publications by authors named "Youn-Hee Lim"

Black carbon (BC), a major component of fine particulate matter (PM), has been implicated in adverse neurodevelopmental outcomes, including autism spectrum disorders (ASD). While PM has been associated with increased ASD risk, the specific role of BC remains uncertain. This study aimed to assess prenatal exposure to BC and risk for ASD development in a low exposure setting, using a large, high-quality register database, with disease diagnosis made by a single team.

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Background: Testicular germ cell cancer (TGCC) originates during fetal life. Fetal exposure to environmental chemicals may contribute to its development, but epidemiological data are lacking. We investigated per- and polyfluoroalkyl substances (PFAS), which can act as endocrine disruptors during fetal development, and TGCC risk in adulthood.

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: Urban green space has been increasingly recognized as a determinant of maternal and child health. This study investigated the association between prenatal exposure to different types of green space and the risk of congenital anomalies in South Korea. : We analyzed data from the National Health Insurance Service (N = 142,422).

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Alzheimer's disease (AD) is a debilitating neurodegenerative disease that predominantly affects older individuals. Although several studies have been conducted on the relationship between air pollution and AD, inconsistencies remain. This study explored the relationship between long-term exposure to air pollution and AD incidence among older adults in Korea using a large-scale retrospective cohort derived from the Korean National Health Information Database (NHID), a nationwide database covering the Korean population that enables temporal tracking of exposure and outcomes over a 10-year follow-up period, unlike cross-sectional studies.

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Background: Global Burden of Disease (GBD) studies have proposed integrated exposure-response models primarily based on North American and European data, which may not be directly applicable to the Asia-Pacific region. Through a systematic review and meta-analysis, we aimed to explore the association between long-term exposure to ambient particulate matter (PM) and mortality in the Asia-Pacific states.

Methods: We searched 3 databases (PubMed [n = 8,326], Embase [n = 4,709], and Cochrane Library [n = 357]) between 1st January 1990 and 31st July 2023.

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Background: Increasing evidence associates air pollution with dementia, but some pollutants and susceptible groups are understudied.

Methods: We followed all Danish residents aged ≥60 years as of 1-1-2000, without prior dementia, until 12-31-2018 for dementia incidence identified via hospital contact or prescription. We assessed annual mean levels of fine particulate matter (PM), nitrogen dioxide (NO), and black carbon (BC) in 2010 utilizing European-wide hybrid land-use regression models, at baseline (2000) residential addresses.

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Background: Global warming has raised the earth's temperature approximately 1°C compared to the pre-industrial level. Particulate matter is one pathway through which climate change affects health. This study aimed to estimate the attribution of PM on mortality associated with increased temperatures in seven major Korean cities.

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Objectives: This study aimed to evaluate the association between long-term exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM2.5) and cause-specific mortality among older adults in Korea, providing insights into the evolving public health burden in an aging society.

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Introduction: Short-term exposure to ultrafine particles (UFP; <100 nm) may trigger respiratory hospitalizations, potentially even more so among children than adults, but available evidence is limited. We examined the association between short-term UFP exposure and respiratory infection hospital admissions in children in Copenhagen, Denmark.

Methods: Daily concentrations of UFP were monitored at an urban background station during 2002-2018.

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Background: Patient-based cohorts were frequently used to investigate air pollution-related coronavirus disease 2019 (COVID-19) evidence, which can be subject to collider bias. However, this bias has not been explored. We aimed to quantify and adjust the collider bias by limiting study population to patients with COVID-19 when estimating the association between long-term exposure to air pollution (LTAP) and COVID-19 mortality.

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Airports are major sources of ultrafine particles (UFP), raising health concerns among people living in immediate proximity. However, little is known about UFP concentrations in residential areas around airports. In this study, we mapped UFP exposure concentrations in a residential area nearby Copenhagen International Airport (CPH).

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Background: Ultrafine particles (UFP; <0.1 µm in diameter) are not regulated or commonly monitored but may be harmful to human health, particularly for children. In this study, we aimed to examine the association between short-term exposure to UFP and asthma hospital admissions in children.

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Long-term exposure to air pollution has been linked with acute lower respiratory infections (ALRIs) in children, but the evidence in adults is still mixed and sparse. We aimed to examine the association between long-term exposure to air pollution and incident ALRIs in adults. We followed all Danish residents aged ≥30 years ( = 3,083,227) for the first-ever hospital contact (inpatient, outpatient, or emergency) for ALRIs (and pneumonia or influenza separately) from 2000 to 2018.

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Background: Bisphenol A (BPA) is widely used in the manufacturing of plastics. BPA can pass the placental barrier and influence fetal development. Due to its estrogenic and anti-androgenic properties, BPA may contribute sex-specific differences in developmental effects.

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Introduction: Ambient air pollution and road traffic noise are stroke risk factors, but evidence on their potential joint effects remains limited. This study investigated the independent and joint associations of air pollution and road traffic noise on stroke incidence using both multiplicative and additive scales.

Methods: We followed stroke incidence in ten cohorts in Sweden, Denmark, and Finland.

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In this work, a new n-type small molecule consisting of a fused thiophene backbone and barbituric acid as the electron-withdrawing group is reported. For green-selective organic photodiodes, when combined with p-type subphthalocyanine, the external quantum efficiency reached 64% at -3 V, owing to suitable absorption properties, efficient charge separation and relatively good transport.

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Introduction: Exposure to environmental chemicals during fetal development may increase the risk of testicular germ cell cancer (TGCC), but few studies have tested the hypothesis. We focused on organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), previously investigated in relation to other male reproductive health outcomes.

Methods: We conducted a nested case-control study of 332 mother-son pairs, comprising 65 TGCC cases and 267 controls, identified from a Danish Pregnancy Screening Registry with biobanked serum samples collected from pregnant women in 1985-1995, when exposure to the studied chemicals was relatively high.

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Article Synopsis
  • The study investigates the link between residential greenspace and the impact of COVID-19 on health, focusing on Danish adults 50 and older during the pandemic.* -
  • Researchers found that increased greenspace was associated with lower rates of COVID-19 infection, hospitalization, and mortality, especially among vulnerable groups like the elderly and those with chronic illnesses.* -
  • Health impact assessments suggested that enhancing local greenspace could have potentially prevented 8-14% of COVID-19 cases in the population studied, indicating benefits of greening initiatives.*
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Ultrafine particles (UFP), commonly expressed as particle number concentrations (PNC), have been associated with harm to human health yet are currently not regulated or routinely monitored in many places. This has limited the potential for studies of health effects of long-term exposure to UFP. The present study aims to understand the spatial and temporal variation in façade-level UFP exposures in Copenhagen, Denmark.

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Article Synopsis
  • * Using advanced statistical models, researchers analyzed data over a significant follow-up period, revealing that lung cancer incidence was positively linked to fine particulate matter (PM), nitrogen dioxide (NO₂), and black carbon (BC), while showing a negative association with ozone (O) which flipped after adjusting for NO.
  • * The results indicated that the increased risk of lung cancer incidence was nearly as strong as that for mortality, with both associations remaining significant even at lower pollution levels, suggesting that air quality should be a crucial public health consideration.
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  • This study investigated the relationship between transportation noise and atrial fibrillation (AF) using data from 11 Nordic cohorts, totaling over 161,000 participants.
  • Researchers found that higher road traffic noise exposure is linked to an increased risk of developing AF, particularly in women and overweight individuals.
  • Aircraft noise also showed a potential association with AF risk, while railway noise did not appear to be related; overall, road and aircraft noise combined raised the risk significantly.
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Objectives: The global prevalence of non-alcoholic fatty liver disease (NAFLD) in adolescents has increased. In addition to childhood obesity, environmental risk factors, such as heavy metals that are known to be involved in hepatotoxicity, play role in NAFLD occurrence. However, their association with NAFLD remains unclear.

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  • A study examined how early life exposure to fine particulate matter (PM) and nitrogen dioxide (NO) affects thyroid function in children, focusing on their levels of thyrotropin, triiodothyronine, and free thyroxine.
  • Results indicated that increases in PM exposure during the first trimester were linked to lower thyrotropin levels in children at ages 4 and 6.
  • Conversely, childhood PM exposure was positively associated with higher thyrotropin levels at ages 4 and 6 and negatively related to free thyroxine levels at age 8, suggesting the importance of timing in understanding these effects.
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  • The study investigates how exposure to endocrine-disrupting chemicals (EDCs) during pregnancy and childhood affects early breast development (thelarche) in girls, specifically before age 8.
  • Researchers analyzed data from 211 girls, focusing on chemicals like cadmium, lead, mercury, bisphenol-A (BPA), and others from prenatal samples and assessed breast development through Tanner staging.
  • Results revealed that higher prenatal exposure to cadmium increased the likelihood of early thelarche, while prenatal exposure to BPA appeared to lower this risk; however, no significant associations were found with chemical exposures at age 8.
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