The Clinical Impact of Intravascular Imaging-Guided Percutaneous Coronary Intervention in Acute Myocardial Infarction Patients with High Thrombus Burden.

Despite the established clinical efficacy following intravascular imaging (IVI)-guided percutaneous coronary intervention (PCI) than angiography-guided PCI, evidence regarding prognostic benefits of IVI-guided PCI in acute myocardial infarction (AMI) patients with high thrombus burden remains limited. Using the nationwide registries of KAMIR-NIH and KAMIR-V, we evaluated the prognostic impact of IVI-guided PCI in AMI patients with high thrombus burden. A total of 4,074 patients with AMI and TIMI thrombus grades 4 or 5 who underwent aspiration thrombectomy were selected, of whom 892 patients (21.

Non-invasive PCO monitoring during polysomnography: transcutaneous versus end-tidal measurement.

Purpose: The objectives of this study were to monitor transcutaneous and end-tidal partial pressures of CO simultaneously during polysomnography, determine the advantages and disadvantages of each method, and identify relevant factors that can affect the results.

Methods: This cross-sectional study enrolled 55 adults who underwent polysomnography at the Ajou University Hospital Sleep Center between February 2021 and September 2022. They were volunteers who spontaneously breathed room air.

Epstein-Barr Virus Corneal Endotheliitis and Uveitis in a Patient With Extranodal Natural Killer/T-Cell Lymphoma.

Purpose: To report a case of Epstein-Barr virus (EBV) corneal endotheliitis and uveitis in a patient diagnosed with extranodal natural killer/T-cell lymphoma (ENKTL).

Methods: This is a case report performed at a tertiary care center in the Republic of Korea.

Results: A 64-year-old man presented with decreased vision in his right eye that had persisted for 4 days.

Long-term Outcomes of Hypertension and Antihypertensive Drugs in Healthy Young Adults: A Nationwide Population-Based Prospective Cohort Study in Korea.

Objectives: To investigate the effect of hypertension (HTN) and antihypertensive medications on the incidence of cardiovascular disease in healthy young adults (approximately 20 to 45 years).

Patients And Methods: In total, 4,590,597 young Korean adults without comorbidities who underwent regular health examinations were included in this study. They were stratified into 4 groups according to their blood pressure (BP) (optimal BP, normal BP, high normal BP, and HTN).

Advanced power structure for enhanced optical performance of AMOLED displays at low luminance levels.

To improve the image quality of active-matrix organic light-emitting diode (AMOLED) displays at low luminance levels, a novel power structure is proposed. Its effectiveness was validated by fabricating a 13-inch AMOLED panel with a tandem OLED and evaluating its optical performance. Compared to the conventional structure, the proposed structure reduced panel luminance deviation by 12% and color deviation by 41%, while also achieving a 41% reduction in hysteresis-induced color shift.

Antioxidant activities of solvent fractions against urban particulate matter-induced oxidation.

Urban particulate matter (PM) significantly contributes to air pollution. was extracted using ethanol (SHE) and subsequently partitioned with n-hexane, chloroform, ethyl acetate, and water. Antioxidant activities of fractions, including DPPH and ABTS radical, hydrogen peroxide, hydroxyl radical scavenging activities, and metal chelating effects, were evaluated against oxidative damage induced by PM.

Postoperative Full Thickness Macular Hole Formation after Vitrectomy for the Removal of Epiretinal Membrane.

Purpose: To evaluate the incidence, clinical features, risk factors, and outcomes of full-thickness macular hole (FTMH) formation after pars plana vitrectomy (PPV) for the removal of epiretinal membrane (ERM).

Methods: This retrospective study reviewed the medical charts of the 309 eyes of the 306 patients with PPV for ERM removal from 2012 to 2024 using clinical data warehouse search. Patients were categorized into two groups; one group with development of macular hole (MH) ('MH' group) and the other group without MH development ('no MH' group) after ERM surgery.

Predicting the Need for Cardiopulmonary Resuscitation in Preterm Infants in the Delivery Room Using Machine Learning Models: Analysis of a Korean Neonatal Network Database.

Background: This study aimed to develop a specialized model for predicting the stages of neonatal resuscitation for preterm infants using prospectively collected data on very-low-birth-weight infants in South Korea.

Methods: A prospective cohort study was conducted using the Korean Neonatal Network database, including neonates weighing < 1,500 g. Overall, 9,684 infants were included, and external validation was performed using data of 71 infants collected from Jeonbuk National University Hospital.

Purchase of both proximal and distal fragments by the calcar screw is critical when using a locking plate in the treatment of proximal humeral fractures : the role of the calcar screw as a medial bridging screw.

Aims: Inferior positioning of the calcar screw is important in the purchase of medial screws when treating proximal humeral fractures with a locking plate. However, the impact of the overall trajectory of the calcar screw has not been investigated. The aim of this study was to investigate whether the failure of a calcar screw to purchase both proximal and distal fragments would contribute to an increased risk of failure of fixation in these patients.

Exploring the Protective Effects of Taxifolin in Cardiovascular Health: A Comprehensive Review.

Taxifolin is a natural flavonoid found in a variety of plants, including Siberian larch () and milk thistle (), that has attracted attention for its multifaceted pharmacological properties, including cardioprotective effects. Through its antioxidant and anti-inflammatory activities, taxifolin has shown significant therapeutic potential in cardiovascular diseases such as atherosclerosis, myocardial ischemia, and diabetic cardiomyopathy. This review highlights the cardioprotective effects of taxifolin in preclinical models of atherosclerosis, ischemia/reperfusion injury, and diabetic cardiomyopathy.

Biomarker-Driven Optimization of Saponin Therapy in MASLD: From Mouse Models to Human Liver Organoids.

(1) Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by liver damage similar to alcoholic fatty liver disease, including triglyceride infiltration of hepatocytes, regardless of alcohol consumption. It leads to progressive liver damage, such as loss of liver function, cirrhosis, and liver cancer, and the response rate of drugs under clinical research is less than 50%. There is an urgent need for biomarkers to evaluate the efficacy of these drugs.

Clinical Relevance of Fractional Flow Reserve-Guided Percutaneous Coronary Interevention According to Left Ventricular Ejection Fraction in Patients With Acute Myocardial Infarction and Multivessel Disease.

Background: Fractional flow reserve (FFR)-guided or angiography-guided complete revascularization has not been evaluated in patients with acute myocardial infarction (AMI) with multivessel disease and reduced left ventricular ejection fraction (LVEF). This study sought to evaluate the impact of FFR-guided percutaneous coronary intervention (PCI) for patients with AMI with multivessel disease according to left ventricular systolic function.

Methods: We performed a prespecified analysis of the FRAME-AMI (Fractional Flow Reserve Versus Angiography-Guided Strategy in Acute Myocardial Infarction With Multivessel Disease) trial, which randomly allocated 562 patients to undergo either FFR-guided PCI (FFR ≤0.

study of visible light-activated photocatalytic conversion reaction enhancement of biomass using a magnetic heterostructure.

Although cadmium sulfide (CdS) is a promising visible light-active photocatalyst, it is highly toxic. Therefore, in addition to improving the photocatalytic properties of CdS, enhancing its recoverability would allow for more environmentally friendly photocatalytic reactions. In this study, ferrimagnetic FeO nanoparticles (NPs) were added to CdS to form a heterostructure, and photocatalytic CdS NPs were efficiently recovered.

Exploring the efficacy and safety of dual antiplatelet therapy in patients with embolic stroke of undetermined source according to stroke risk stratification: Propensity-score matched analysis.

Introduction: Dual antiplatelet therapy (DAPT) is widely used for embolic stroke of undetermined source (ESUS) despite limited evidence regarding its efficacy and safety. This study compared DAPT and single antiplatelet therapy (SAPT) in patients with ESUS during hospitalization (first 7 days) and up to 30 days post-stroke, identifying subgroups that benefit most from DAPT.

Methods: We retrospectively analyzed data from 4,505 patients with ESUS enrolled in a multicenter registry from 2014 to 2019.

Comparison Between the Human-Sourced Ellipsoid Method and Kidney Volumetry Using Artificial Intelligence in Polycystic Kidney Disease.

The Mayo imaging classification (MIC) for polycystic kidney disease (PKD) is a crucial basis for clinical treatment decisions; however, the volumetric assessment for its evaluation remains tedious and inaccurate. While the ellipsoid method for measuring the total kidney volume (TKV) in patients with PKD provides a practical TKV estimation using computed tomography (CT), its inconsistency and inaccuracy are limitations, highlighting the need for improved, accessible techniques in real-world clinics. We compared manual ellipsoid and artificial intelligence (AI)-based kidney volumetry methods using a convolutional neural network-based segmentation model (3D Dynamic U-Net) for measuring the TKV by assessing 32 patients with PKD in a single tertiary hospital.

Association of carotid artery stenosis with cerebral artery signal intensity gradient on time-of-flight magnetic resonance angiography.

Purpose: Extracranial internal carotid artery (ICA) stenosis is a known cause of large artery ischemic stroke. However, its association with cerebral arterial hemodynamics has been relatively underexplored. This study investigates the relationship between extracranial ICA stenosis and signal intensity gradient (SIG) in major cerebral arteries.

Two specific interactions of GATE16 with TRPML3 and RAB33B regulate autophagy.

ATG8s are essential for autophagy as they recruit various machinery to autophagic structures. We previously reported that the intracellular Ca channel TRPML3 specifically interacts with the mammalian ATG8 homolog GATE16, but not LC3B to increase autophagy. However, the underlying mechanism and the role of this specific interaction remain unclear.

Cytotoxic Profiling of Korea Chemical Bank Diversity Library.

Cytotoxicity profiling of screening libraries is a critical component in early-stage drug discovery to identify compounds with undesirable toxic effects. Here, we report the cytotoxicity profiling of the Korea Chemical Bank (KCB) diversity library, comprising 7040 compounds curated via virtual screening, clustering, and druggability assessment. A subset of 5181 compounds was randomly selected and screened using the WST-1 assay in five mammalian cell lines (HEK293, HFL1, HepG2, NIH3T3, and CHOK1) at concentrations of 30 µM and 10 µM, following 24 h and 48 h incubation periods.

Reliability and Inter-Device Agreement Between a Portable Handheld Ultrasound Scanner and a Conventional Ultrasound System for Assessing the Thickness of the Rectus Femoris and Vastus Intermedius.

: Ultrasound (U/S) can be used to evaluate skeletal muscle characteristics in clinical and sports settings. Handheld U/S devices have recently emerged as a cheaper and portable alternative to conventional U/S systems. However, further research is warranted on their reliability.

Comparison of Telehealth and Onsite Supervised Maintenance Exercise Programs for Adults With Chronic Lung Disease: Protocol for a Pilot Randomized Feasibility Trial.

Background: Chronic lung diseases (CLDs) such as chronic obstructive pulmonary disease, interstitial lung disease, and chronic asthma contribute significantly to the global burden of disease. Pulmonary rehabilitation (PR) is an effective intervention for improving the exercise capacity, increasing the quality of life, and reducing hospitalizations in individuals with CLD. However, benefits from PR quickly decline following discharge from traditional programs.

Menopause Is Not Associated with Asthma or Severe Asthma.

The effect of menopause on asthma outcomes is confounded by age, obesity, and female sex hormone use. A better understanding of this complex relationship between aging, inflammation, and hormone use is needed to guide future personalized approaches in asthma care.

Pan-reactome analysis of Streptomyces strains reveals association and disconnection between primary and secondary metabolism.

Secondary metabolites have crucial medicinal and industrial applications, but their alignment with primary metabolism remains unclear. As secondary metabolism depends on primary metabolism for precursor supply, we present a pan-reactome analysis of 242 Streptomyces strains to investigate their association and disconnection. This analysis includes phylogenetic grouping of the strains using genome data, and uniform manifold approximation and projection (UMAP) analysis of their genome-scale metabolic models (GEMs) and biosynthetic gene cluster (BGC) data, which represent biochemical reactions in primary and secondary metabolism.

Neutralizing activity against Omicron subvariants BA.1, BA.2, and BA.4/5 following the third SARS-CoV-2 vaccination in cancer patients undergoing chemotherapy.

Objectives: Despite the availability of bivalent vaccines targeting both the ancestral SARS-CoV-2 strain and Omicron subvariants, vaccination rates remain low in South Korea. This study aims to evaluate the neutralizing activity against Omicron subvariants following the third SARS-CoV-2 vaccination in patients undergoing chemotherapy, as well as to assess the need for additional vaccinations.

Methods: Between April and November 2022, the authors assessed the neutralizing activity of the third SARS-CoV-2 vaccine dose in 63 patients undergoing chemotherapy using an ELISA-based surrogate Virus Neutralization Test (sVNT).

Simultaneous generation of color-coded arteriography, venography, and dynamic angiography: methodology and clinical applications in stroke.

Cerebrovascular accident is a leading cause of death and disability. Early detection of cerebrovascular diseases is crucial for timely treatment. This study introduces a novel method for the simultaneous generation of color-coded arteriography, venography, and dynamic angiography derived from dynamic contrast-enhanced magnetic resonance angiography and computed tomography perfusion.

Impact of CAR T cell therapy on thymus size in children and young adults with acute lymphoblastic leukemia.

Chimeric Antigen Receptor (CAR) T-cell therapy has demonstrated efficacy in children and young adult patients with acute lymphoblastic leukemia (ALL). The purpose of our study was to investigate thymus size changes after CAR T-cell therapy, explore the associated clinical conditions, and assess survival differences of patients who underwent CAR T-cell therapy, we conducted a single-center retrospective study of children and young adult patients who underwent CAR T-cell therapy for ALL between April 2015 and October 2023.We measured the volume of the thymus on pre- and post-CAR T-cell chest CT scans of 20 patients (median [IQR] age, 18[11] years; 11 females).