Development of a prediction tool for kidney function decline in children with chronic kidney disease.

Background: A paucity of literature exists on the development of predictive tools for the decline of kidney function in pediatric chronic kidney disease (CKD). The objective of this study is to develop and internally validate a tool for the short-term prediction of a kidney function decline in pediatric patients with CKD.

Methods: A total of 539 patients participating in the KNOW-PedCKD (KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease) were evaluated for 48 variables related to sociodemographic characteristics, laboratory data, and treatment use.

Idiopathic epiretinal membrane area changes in eyes with good vision and the association with visual function.

Purpose: To evaluate idiopathic epiretinal membrane (iERM) area changes and the association with visual function in patients with good vision, using confocal scanning laser ophthalmoscopy (cSLO).

Methods: The medical records of patients with iERM with best-corrected visual acuity (BCVA) ≥ 20/25 and a follow-up period ≥ 2 years were reviewed retrospectively. BCVA, metamorphopsia, fundus images using cSLO, and optical coherence tomography images were obtained at baseline and every 6 months.

Lamina Cribrosa Steepness Index to Measure the Morphology of the Lamina Cribrosa in Myopic Eyes With Optic Disc Distortion.

Purpose: To propose a new parameter for evaluating lamina cribrosa (LC) morphology in myopic eyes with optic nerve head (ONH) distortion.

Methods: This study included 169 eyes with normal-tension glaucoma (NTG) and myopic ONH distortion from the Myopic NTG Treatment Study. The LC curvature index (LCCI) and the LC steepness index (LCSI) were assessed in optical coherence tomography B-scan images obtained using an enhanced-depth imaging technique.

Early Intrableb Features on Anterior Segment Swept-Source Optical Coherence Tomography Predict Surgical Success After Trabeculectomy in Uveitic and Neovascular Glaucoma.

: This study aimed to evaluate prognostic factors of early filtering blebs using anterior segment swept-source optical coherence tomography (AS SS-OCT) in patients with uveitic and neovascular glaucoma. : This retrospective cohort study included 22 eyes from 22 patients who underwent trabeculectomy (11 eyes each with uveitic or neovascular glaucoma). Intrableb characteristics were assessed using AS SS-OCT at 1 month, postoperatively.

A Combined Index of Steady-State Pattern Electroretinogram and Optical Coherence Tomography Improved the Detection of Early Glaucoma.

Introduction: The aims of the study were to evaluate the structure-function relationship between steady-state pattern electroretinogram (ssPERG), optical coherence tomography (OCT), and visual field (VF) tests and to investigate indicators that enhance the detection of preperimetric and early-stage primary open-angle glaucoma (POAG).

Methods: In this retrospective cohort study, patients with POAG and normal subjects who underwent ssPERG, OCT, and VF tests were included. We defined the ratio of the amplitudes from 0.

Distinctive Intrableb Structures of Functioning Blebs following Trabeculectomy according to Amniotic Membrane Transplantation.

Introduction: Intrableb structures are hallmark features of the filtering bleb. This study aimed to compare the characteristics of functioning blebs using anterior segment optical coherence tomography (AS-OCT) according to amniotic membrane transplantation (AMT).

Methods: Forty eyes from 40 patients diagnosed with primary open-angle glaucoma who underwent trabeculectomy, either with AMT (20 eyes) or without AMT (control group, 20 eyes), were included.

Comparative Analysis of Intense Pulsed Light Therapy in Patients with Meibomian Gland Dysfunction, with and Without Glaucoma Medication.

: This study assessed the efficacy of intense pulsed light (IPL) therapy for treating meibomian gland dysfunction (MGD), a key contributor to evaporative dry eye disease (DED), by comparing outcomes in patients with idiopathic MGD versus those with MGD induced by glaucoma medications. : In a retrospective analysis of 45 patients, divided into groups based on glaucoma medication use (20 patients) and non-use (25 patients), all underwent four IPL sessions combined with meibomian gland expression (MGX) at 3-week intervals. Key metrics evaluated included Ocular Surface Disease Index (OSDI) scores, tear breakup time (TBUT), Schirmer I test scores, and meibography scores, pre- and post-treatment.

Fuzzy clustering of 24-2 visual field patterns can detect glaucoma progression.

Purpose: To represent 24-2 visual field (VF) losses of individual patients using a hybrid approach of archetypal analysis (AA) and fuzzy c-means (FCM) clustering.

Methods: In this multicenter retrospective study, we classified characteristic patterns of 24-2 VF using AA and decomposed them with FCM clustering. We predicted the change in mean deviation (MD) through supervised machine learning from decomposition coefficient change.

Bidirectional gated recurrent unit network model can generate future visual field with variable number of input elements.

Purpose: This study aimed to predict future visual field tests using a bidirectional gated recurrent unit (Bi-GRU) and assess its performance based on the number of input visual field tests and the prediction time interval.

Materials And Methods: This study included patients who underwent visual field tests at least four times at five university hospitals between June 2004 and April 2022. All data were accessed in October 2022 for research purposes.

One-Year Outcomes of Ab Externo XEN45 Gel Stent Implantation with an Open Conjunctiva Approach in Patients with Open-Angle Glaucoma.

Purpose: This study aimed to evaluate the 1-year surgical outcomes of XEN45 gel stent implantation with an open conjunctiva approach in patients with open-angle glaucoma (OAG).

Methods: This retrospective cohort study included 19 eyes of 19 patients who underwent XEN45 gel stent implantation with an open conjunctival approach. Surgical success was defined by intraocular pressure (IOP) ≤18 mmHg and one of the following: IOP reduction ≥30% or reduction of two glaucoma medications with final IOP if baseline IOP ≤18 mmHg.

Visual field prediction using a deep bidirectional gated recurrent unit network model.

Although deep learning architecture has been used to process sequential data, only a few studies have explored the usefulness of deep learning algorithms to detect glaucoma progression. Here, we proposed a bidirectional gated recurrent unit (Bi-GRU) algorithm to predict visual field loss. In total, 5413 eyes from 3321 patients were included in the training set, whereas 1272 eyes from 1272 patients were included in the test set.

Comparison of the Intrableb Characteristics of Anterior Segment Optical Coherence Tomography Imaging in Trabeculectomy according to Amniotic Membrane Transplantation.

Introduction: The purpose of this study was to compare the characteristics of filtering bleb with anterior segment optical coherence tomography (AS-OCT) according to amniotic membrane transplantation (AMT).

Methods: One hundred and sixteen eyes of 103 glaucoma patients who underwent trabeculectomy with (AMT group; 85 eyes) or without AMT (control group; 31 eyes) were included. Intrableb parameters were evaluated with AS-OCT.

Bleb analysis using anterior segment optical coherence tomography after trabeculectomy with amniotic membrane transplantation.

Introduction: Little has been known about the intrableb structures associated with bleb function after trabeculectomy with amniotic membrane transplantation (AMT). The aim of this study is to analyze the characteristics of intrableb structures using anterior segment optical coherence tomography (AS-OCT) after trabeculectomy with AMT.

Methods: A total of 68 eyes of 68 patients with primary open-angle glaucoma who underwent trabeculectomy with AMT were included.

Comparison of Retinal Structural and Neurovascular Changes between Patients with and without Amyloid Pathology.

To evaluate whether an impaired anterior visual pathway (retinal structures with microvasculature) is associated with underlying beta-amyloid (Aβ) pathologies in patients with Alzheimer's disease dementia (ADD) and mild cognitive impairment (MCI), we compared retinal structural and vascular factors in each subgroup with positive or negative amyloid biomarkers. Twenty-seven patients with dementia, thirty-five with MCI, and nine with cognitively unimpaired (CU) controls were consecutively recruited. All participants were divided into positive Aβ (A+) or negative Aβ (A-) pathology based on amyloid positron emission tomography or cerebrospinal fluid Aβ.

The Effect of Amniotic Membrane Transplantation on Trabeculectomy in Patients with Pseudoexfoliation Glaucoma.

Purpose: The aim is to evaluate the effect of amniotic membrane transplantation (AMT) on trabeculectomy with mitomycin C in patients with pseudoexfoliation glaucoma (PXG).

Methods: This retrospective cohort study included 85 eyes of PXG who underwent trabeculectomy with or without AMT (52/33 eyes in the AMT/control group). Surgical success was defined by these criteria: (1) intraocular pressure (IOP) ≤18 mmHg and IOP reduction ≥20% and (2) IOP ≤15 mmHg and IOP reduction ≥25%.

Clinical and genetic analysis of Ser341Pro variant in a Korean family with primary open angle glaucoma.

Aim: To report the first discovery of Ser341Pro () variant in Korea and analyze its clinical characteristics and genetic significance.

Methods: Ten family members from three generations participated in this study and received the thorough ophthalmologic examination. Focused exome sequencing on a proband was performed to confirm the target mutations ( c.

Hybrid dimensionality reduction method based on support vector machine and independent component analysis.

This paper presents a new hybrid dimensionality reduction method to seek projection through optimization of both structural risk (supervised criterion) and data independence (unsupervised criterion). Classification accuracy is used as a metric to evaluate the performance of the method. By minimizing the structural risk, projection originated from the decision boundaries directly improves the classification performance from a supervised perspective.