Publications by authors named "Qin-Yu Cai"

Background: This study compares the prevalence of placenta accreta in singleton and twin pregnancies and examines its impact on adverse perinatal outcomes, exploring whether twin gestation increases the risk of poor outcomes in placenta accreta cases.

Methods: A multivariate logistic regression analysis assessed the link between twin pregnancy and placenta accreta, comparing associated adverse perinatal outcomes in twin vs. singleton pregnancies.

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Recent studies on maternal exposure to air pollution and preterm birth (PTB) have yielded inconsistent results, with varying critical windows of exposure. This study aims to explore the association between air pollution and the risk of preterm birth in different subtypes of twin pregnancies, while identifying the sensitive time windows. In this retrospective study, we analyzed 3623 twin-pregnant women, categorized by timing and clinical condition of preterm birth.

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Air pollution may raise hypertension risk, but its effects on gestational hypertension and preeclampsia in twin pregnancies are unclear. This retrospective study of 3670 twin pregnancies divided participants into three groups: gestational hypertension, preeclampsia, and no hypertension. The preeclampsia group was further split into mild and severe preeclampsia.

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Obstructive sleep apnea (OSA) has long been recognized as a significant risk factor for hypertension, and in recent years, its association with hypertensive disorders of pregnancy (HDP) has gained increasing attention, especially in the unique population of pregnant women. However, this relationship remains underappreciated in clinical practice. While early studies have suggested a link between OSA and adverse pregnancy outcomes, the mechanisms connecting OSA to HDP are not fully understood.

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Background: The study investigates the link between indoor air pollution from non-clean fuels and kidney function decline, particularly in middle-aged and elderly individuals in China.

Method: This prospective cohort study included 4,207 participants, with kidney function assessed through eGFR (using serum creatinine and cystatin C). Logistic regression models were used to examine the link between household solid fuel use and the risk of rapid kidney decline and CKD.

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Background: This study aims to evaluate the association between the frailty index trajectory in older adults from a longitudinal cohort and rapid decline in kidney function as well as the incidence of chronic kidney disease (CKD).

Method: This study included 4,207 participants aged 45 and above from the China Health and Retirement Longitudinal Study (CHARLS), who underwent baseline assessments in 2011-2012 and were followed up in 2013 and 2015. The study selected 31 items to construct the frailty index (FI), with the FI value positively correlated with the degree of frailty in individuals.

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Extreme temperature events have become more frequent due to industrialization, urbanization, and climate change, leading to health risks. Women with twin pregnancies are particularly vulnerable, yet research on how these temperatures affect gestational diabetes mellitus (GDM) remains limited. This study investigates the impact of extreme temperatures on GDM incidence in twin pregnancies, focusing on identifying critical periods of susceptibility.

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Background: Accelerated industrialization globally has intensified air pollution, but the susceptibility periods for extreme air pollution in twin pregnancies remain undefined.

Methods: This study investigated the association between extreme air pollution exposure and preterm birth risk in twin pregnancies. Data on 3623 twin pregnancies in Chongqing from 2017 to 2022 and air pollution readings from 12 monitoring stations were analyzed using distributed lag non-linear quasi-Poisson regression models.

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Background: Corticosteroids are widely used in obstetric clinical practice for cases with signs of preterm labor to promote fetal lung maturity and reduce neonatal morbidity and mortality. Although short-term use is considered safe, there is ongoing debate regarding the dosage, therapeutic window, neonatal benefits, and maternal-fetal side effects, especially in high-risk pregnancies such as twins, where the impact remains unclear.

Methods: This retrospective study included 1,997 twin pregnancies, divided into two groups: those who received antenatal corticosteroid therapy (ACS) and those who did not.

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Background: The COVID-19 pandemic has significantly impacted healthcare systems worldwide, including obstetric care. However, the long-term effects on twin pregnancies remain unclear. This study investigates the impact of COVID-19 on the clinical characteristics and antibiotic prescribing patterns in hospitalized twin pregnancies.

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Background: Globally, common gynecological disorders such as Polycystic Ovary Syndrome (PCOS), endometriosis, uterine fibroids (non-malignant gynecological diseases), as well as cervical cancer, uterine cancer, and ovarian cancer (gynecological cancers), profoundly impact women's physical and mental health. The burden of these diseases exhibits significant geographical disparities across different countries and regions, making a comprehensive and precise assessment of the global burden of gynecological diseases particularly crucial. Such an assessment will facilitate the development of region-specific prevention and treatment strategies, contributing to a more effective response to these health challenges.

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Background: The Cardiometabolic Index (CMI) is a new measure that combines fat distribution and lipid profiles. However, its relationship with rapid decline in renal function and the chronic kidney disease (CKD), especially in individuals with varying glucose metabolism, is still unclear.

Method: This study included 3,485 participants aged 45 and above from the China Longitudinal Study on Health and Retirement (CHARLS), with baseline assessments in 2011-2012 and follow-ups in 2015 and 2018.

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Background: This investigation assesses the perinatal risks associated with different clinical subtypes of intrahepatic cholestasis of pregnancy (ICP) based on clinical symptomatology, with the goal of informing optimal delivery timing for each specific ICP subtype.

Study Design: The retrospective study encompassed 2,057 singleton pregnancies with ICP, categorized into the single-symptomatic (ICP-S) and the multisymptomatic (ICP-M) groups. The ICP-M group was further subdivided based on symptom combinations: elevated TBA with elevated transaminases (ICP-M), elevated TBA with pruritus (ICP-M), and combined elevations with pruritus (ICP-M).

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Background: The impact of gestational diabetes mellitus (GDM) complicated with preeclampsia (PE) on perinatal outcomes in twin pregnancies, particularly across different GDM subtypes, remains unclear.

Methods: This case-control study included 1,263 twin pregnancies with GDM and categorized participants as follows: (i) GDM without PE and GDM with PE groups, and (ii) GDM subgroups based on oral glucose tolerance test (OGTT) values at different time points, including GDM-IFH, GDM-IPH, and GDM-CH. Initially, the study investigated risk factors for PE occurrence in women with GDM.

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Article Synopsis
  • - This study investigates how traditional oral glucose tolerance test (OGTT) results may not effectively prevent negative outcomes in twin pregnancies, focusing on different glucose level patterns (high, medium, low).
  • - Analyzing 2,644 twin pregnancies, the researchers identified three glucose patterns, revealing that those with high glucose (HG) levels faced significantly higher risks for issues like stillbirth and neonatal complications compared to those with low glucose levels (LG).
  • - The findings suggest that pregnant women with the HG pattern should receive more careful monitoring and targeted interventions due to their increased risk of adverse outcomes for their newborns.
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Article Synopsis
  • The placenta has a layer called syncytiotrophoblast (SCT) that acts as a barrier between the mother and baby, and problems with it can lead to issues like preeclampsia.
  • A gene called P57 is important for the cells in the placenta to change and combine into SCT, and if it's not working right, it can cause health problems for both mom and baby.
  • Researchers discovered that a protein named STK40 interacts with P57 and can affect the fusion of placenta cells—too much STK40 might lead to conditions like preeclampsia.
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Objective: To investigate the influence of inappropriate gestational weight gain (GWG) on pregnancy outcomes in twin pregnant women with in vitro fertilization (IVF) treatment.

Methods: This retrospective cohort study included 2992 twin pregnant women and categorized the participants as follows: (i) they were classified into spontaneous conception (SC) or IVF groups based on whether they received IVF treatment, and (ii) they were categorized into inadequate, optimal, or excessive GWG groups according to the International Organization for Migration Twin Pregnancy Guidelines. Initially, the study investigated the separate effects of IVF treatment and different levels of GWG on the outcomes of twin pregnancies.

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Coronavirus disease-2019 (COVID-19) has caused continuous effects on the global public, especially for susceptible and vulnerable populations like pregnant women. COVID-19-related studies and publications have shown blowout development, making it challenging to identify development trends and hot areas by using traditional review methods for such massive data. Aimed to perform a bibliometric analysis to explore the status and hotspots of COVID-19 in obstetrics.

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Purpose: This study aimed to systematically evaluate the quality of content and information in videos related to gestational diabetes mellitus on Chinese social media platforms.

Methods: The videos on various platforms, TikTok, Bilibili, and Weibo, were searched with the keyword "gestational diabetes mellitus" in Chinese, and the first 50 videos with a comprehensive ranking on each platform were included for subsequent analysis. Characteristic information of video was collected, such as their duration, number of days online, number of likes, comments, and number of shares.

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