Harmine suppresses pancreatic cancer through DYRK1A-mediated hyper-activated RAS/MAPK inhibition.

KRAS is the most frequent RAS mutation in pancreatic cancer (PC). Recently, small molecule inhibitors like MRTX1133, which target KRAS , have shown efficacy in inhibiting PC growth. However, the development of intrinsic and acquired resistance to these inhibitors has been observed, necessitating the identification of novel therapeutic targets.

Deciphering the mechanism of baicalein in cervical cancer via bioinformatics, machine learning and computational simulations: PIM1 and CDK2 are key target proteins.

Cervical cancer is one of the leading causes of death among women worldwide. Current treatments are limited by chemoresistance and chemotherapeutic agents' adverse effects, prompting the search for better therapeutic alternatives. Baicalein, a natural compound with potent antitumor activity and low toxicity, has drawn significant attention.

Burden of diabetes mellitus in Weifang: Changing trends in prevalence and deaths from 2010 to 2021.

Objective: The objective of this study is to analyze the death characteristics and burden of disease (BOD) in diabetes mellitus (DM) patients in Weifang from 2010 to 2021. The findings will serve as a foundational data source and theoretical framework for public health administrative departments in the formulation of DM-related policies.

Methods: The annual percent change (APC) and average annual percent change (AAPC) of the disability-adjusted life years (DALY), years of life lost (YLL), and years lived with disability (YLD) in DM residents from 2010 to 2021 were analyzed using the Joinpoint software to reflect the changing trend of the BOD in DM patients.

Stigmast-4-en-3-one from Euonymus alatus (Thunb.) Siebold. improves diabetic retinopathy and angiogenesis mediated by glucocorticoids receptor.

Ethnopharmacological Relevance: Euonymus alatus (Thunb.) Siebold. (EA), a traditional Chinese medicine, is widely used in the treatment of diabetes.

Synthesis, anti-aging and mechanism of magnolol derivatives.

Magnolol (M), a hydroquinone containing an allyl side chain, is one of the major active components of for antioxidation and anti-aging. To enhance the antioxidant activity of magnolol, the different sites of magnolol were structurally modified in this experiment, and a total of 12 magnolol derivatives were obtained. Based on the preliminary exploration of the anti-aging effect of magnolol derivatives in a () model.

RAS-targeted cancer therapy: Advances in drugging specific mutations.

Rat sarcoma (RAS), as a frequently mutated oncogene, has been studied as an attractive target for treating RAS-driven cancers for over four decades. However, it is until the recent success of kirsten-RAS (KRAS) inhibitor that RAS gets rid of the title "undruggable". It is worth noting that the therapeutic effect of KRAS inhibitors on different RAS allelic mutations or even different cancers with KRAS varies significantly.

Function and inhibition of DYRK1A: Emerging roles of treating multiple human diseases.

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is an evolutionarily conserved protein kinase and the most studied member of the Dual-specificity tyrosine-regulated kinase (DYRK) family. It has been shown that it participates in the development of plenty of diseases, and both the low or high expression of DYRK1A protein could lead to disorder. Thus, DYRK1A is recognized as a key target for the therapy for these diseases, and the studies on natural or synthetic DYRK1A inhibitors have become more and more popular.

Financial compensation for natural forest logging ban: Standard calculation based on willingness to accept.

To alleviate the deteriorating environment and protect biodiversity, China has implemented a natural forest protection system, demonstrating the importance of sustainable forest management for ecological conservation and socio-economic development, including the complete cessation of commercial logging of natural forests. Financial compensation is adopted to increase farmers' enthusiasm within the commercial Logging Ban of Natural Forests framework. This study used the contingent valuation method and the Heckman two-stage model to explore farmers' willingness to participate in the Logging Ban of Natural Forests and the willingness to accept by survey data on 486 farming households.