A Novel Method for Localizing PD Source in Power Transformer: Considering NLOS Propagation of Electromagnetic Waves.

A novel partial discharge (PD) source localization method was proposed based on the traditional time difference in arrival (TDOA) method. Specifically, the non-line-of-sight (NLOS) propagation phenomenon of the ultra-high-frequency (UHF) signal was considered, and the NLOS propagation error was approximately replaced by a constant, thereby limiting the effect of NLOS propagation. Moreover, the strategy of utilizing more than four sensors was adopted to reduce the possible effect of overcorrection on NLOS propagation.

Stellarin I: A Bioactive Cyclic Nonapeptide with Potent Anti-renal Fibrosis Activity from the Root of Stellaria yunnanensis Franch.

An undescribed cyclic nonapeptide (1) was isolated from the crude root extract of the medicinal plant Stellaria yunnanensis Franch. Comprehensive spectral analysis was performed utilizing high-resolution mass spectrometry, one- and two-dimensional nuclear magnetic resonance spectroscopy, and experimental and calculated circular dichroism spectroscopy to elucidate the structure of the cyclic nonapeptide (1), which was identified as cyclo-(Tyr-Ala-Thr-Leu-Thr-Ala-Phe-Ala-Thr). Anti-renal fibrosis activity evaluation of compounds 1-3 showed that they have potential for anti-renal fibrosis by reducing the expression of fibrotic protein collagen I in NRK-49F cells induced by TGF-β1.

Associations between serum neuropeptide Y levels and anxiety, depression, and quality of life in Chinese patients with primary glaucoma.

Background: Patients with glaucoma demonstrate significantly elevated prevalence rates of anxiety and depression compared to healthy controls, although these psychiatric comorbidities remain frequently underrecognised in clinical practice. This study evaluated serum neuropeptide Y (NPY) concentrations in patients with primary glaucoma to investigate potential associations with anxiety, depression, and quality of life (QOL).

Methods: The study cohort comprised 45 healthy controls and 89 patients with primary glaucoma, including 55 patients with primary open-angle glaucoma (POAG) and 34 patients with primary angle-closure glaucoma (PACG).

Multi-omics analysis revealed the addiction to glutamine and susceptibility to de novo lipogenesis of endometrial neoplasm.

The endometrium is a proliferative tissue controlled by the menstrual cycle. Endometrial hyperplasia (EH) is a type of neoplastic disease that may develop into endometrial hyperplasia with atypia (EHA) or endometrial adenocarcinoma (EA). We performed a multi-omics analysis of a collection of endometrial tissues with four different proliferative statuses from two independent cohorts of patients.

Omalizumab controls surface phenotypes of dendritic cells and monocytes in asthma.

Background: Omalizumab can provide clinical benefits to a fraction of moderate-to-severe asthma patients. However, the mechanisms of action of omalizumab have not been fully understood.

Objective: This study investigated whether omalizumab could affect the frequency and surface phenotypes of blood circulating dendritic cell (DC) and monocyte subsets, which could be associated with the mechanisms of action of omalizumab.

Emergency Management of Extensive Spinal Epidural Hematoma Causing Medullary Compression After Single-Level Anterior Cervical Discectomy and Fusion (ACDF): A Novel Segmental Decompression and Catheter Irrigation Strategy.

Here, we present a retrospective analysis of a 48-year-old male patient who developed a rare complication of extensive spinal epidural hematoma (SEH) with spinal cord and medullary compression following single-level anterior cervical discectomy and fusion (ACDF), manifesting as acute dyspnea, coma, and quadriplegia. The emergency treatment entailed anterior segmental decompression under general anesthesia, removal of internal fixation devices, and targeted catheter irrigation to evacuate the hematoma spanning from C1 to C7. Postoperatively, the patient demonstrated remarkable neurological recovery, with the American Spinal Injury Association (ASIA) impairment grade improving from preoperative grade A (complete paralysis) to grade E (normal function), and was discharged after uneventful rehabilitation.

Prognostic and clinicopathological value of soluble programmed cell death ligand-1 (sPD-L1) in patients with colorectal cancer: a meta-analysis.

Background: The effect of soluble programmed cell death 1 ligand 1 (sPD-L1) on the prognosis of colorectal cancer (CRC) has been extensively explored; however, the results remain controversial. Therefore, we performed a meta-analysis to determine its exact function in predicting CRC prognosis.

Methods: We retrieved relevant data from the Web of Science, PubMed, Embase, and Cochrane Library databases from their inception to February 24, 2025.

miR-690 ameliorates hepatic steatosis by targeting NF-KappaB P65 and regulating 15-LOX to induce autophagy in db/db mice.

The objective of this study was to explore the effects and underlying mechanisms of miR-690 on hepatic steatosis in db/db mice. Our findings revealed that miR-690 was downregulated in the liver of db/db mice and high-glucose (HG)-treated NCTC1469 cells. In vivo, miR-690 overexpression alleviated hyperglycemia, hyperlipidemia, and hyperinsulinemia, improved liver function, and mitigated steatosis and pathological damage.

Ultrafast microwave construction of stabilized RuCo alloys for overall water splitting.

Ruthenium-based catalysts are considered efficient and cost-effective potential alkaline electrolysis water catalysts that exhibit both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) activities. Therefore, it is crucial to develop straightforward and low-energy synthesis methods for ruthenium-based alloy catalysts. In this study, we present a microwave synthesis approach for rapidly fabricating RuCo alloy supported on copper foam.

A catalyst for education? A study on the impact of artificial intelligence assisted learning in painting courses on college students' continuous learning intention.

This study examines artificial intelligence in college students' painting education and their potential impact on students' continuous learning intention. In this study, two surveys were conducted. The first survey included 793 valid samples, and the second survey contained 210 valid samples.

[Effects of Major Urban Meteorological Factors on Near-surface Ozone on the Northern Slope of the Tianshan Mountains from 2018 to 2022].

The analysis of the ozone trend after removing the influence of meteorological factors is extremely important to evaluate the implementation effect of air pollution prevention and control policies. The effects of meteorological factors on near-surface ozone concentrations in four cities （Shihezi, Changji, Wujiaqu, and Urumqi） with serious air pollution in the economic zone of the northern slope of the Tianshan Mountains in the past five years （2018-2022） were investigated using a combination of the KZ filtering method and multiple linear stepwise regression. The results showed that the seasonal component of O-8h contributed the most （≥69.

Hollow carbon nanoreactors integrating NiFe-LDH nanodots with adjacent La single atoms for efficient oxygen electrocatalytic reactions.

Optimizing both mass transport and electronic structure of the active component is of interest to obtain electrocatalysts with superior oxygen evolution reaction (OER) performance. Here, we miniaturized the classical NiFe-layered double hydroxides (NiFe-LDHs) and integrated them into S/N co-doped hollow hierarchical porous carbon (SNHPC) loaded with rare earth La single atoms (La SAs) to obtain nanoreactors. The unique carbon framework induced uniform deposition of LDH nanodots and ensured adequate exposure during electrocatalysis.

Prognostic and clinicopathological impact of systemic inflammation response index (SIRI) on patients with esophageal cancer: a meta-analysis.

Background: Although the systemic inflammation response index (SIRI) is often associated with prognostic significance in esophageal cancer (EC) patients, the results continue to be conflicting. We focused on identifying SIRI's precise role in forecasting EC prognosis through performing this meta-analysis.

Methods: This work searched PubMed, Web of Science, Embase, Cochrane Library, and CNKI till November 16, 2024, and determined pooled hazard ratios (HRs) and 95% confidence intervals (CIs) for evaluating EC prognosis forecasting efficiency of SIRI.

Uncommon pulmonary manifestation of hepatitis B virus: a case report of secondary organizing pneumonia.

Background: Hepatitis B virus (HBV) primarily affects the liver, but increasingly, it is recognized for its potential extrahepatic manifestations. This case highlights the importance of considering viral infections in the differential diagnosis of pulmonary nodules.

Case Presentation: A 63-year-old man presented with a new mixed ground-glass nodule in the left lower lobe during a routine check-up.

Metabolomic and transcriptomic analyses provide insights into the role of MiMYB114 and MiMYC2 in the MeJA-induced regulatory network for mango pericarp coloration.

The color of mango fruit peel is a critical factor influencing consumer preference and market value. MeJA can enhance mango pericarp coloration, but its effects on different pigments accumulation and the underlying molecular mechanisms remain unclear. In this study, exogenous treatment of 4 mmol/L MeJA enhances the red and yellow pigments in the pericarp of mango cultivar 'Guifei'.

High-Entropy Rare Earth Oxides Anchoring Tunable Cu Nanochimneys for Self-Tandem C-C Coupling Catalysis.

Copper (Cu)-based materials are promising for carbon-carbon bond (C─C) coupling catalysis, but they are limited to poor structural stability, high activation energy, and low selectivity toward C products. Here a customized synthetic protocol is defined for the fabrication of 2D ultrathin high-entropy rare earth (RE) oxides (HE-REOs) with rich lattice distortions and oxygen vacancies, which act as robust supports for anchoring Cu serial domains with tunable oxidation states. The rationally integrated HE-REOs-Cu heterostructures feature largely exposed synergistic multi-site driving rapid *CO spillover, and multiple stabilized Cu chimneys promoting cascade *CO coupling, together with intrinsic electron activation channels enabling RE 4f electron delocalization to lower the energy barrier.

Assessment of the hepatoprotective effects of Bicyclol's forced degradation products using a zebrafish model.

Bicyclol (BIC), a synthetic hepatoprotective agent widely prescribed in China, lacks comprehensive safety and activity profiles for its degradation products (DPs). Here, we systematically investigated BIC's forced degradation behavior using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). Three hydrolytic degradation products (DP1-DP3) were isolated via HPLC and structurally characterized, revealing methylenedioxy group hydrolysis as the primary degradation pathway.

Omalizumab is ineffective in regulating proasthmatic serum cytokine and chemokine levels in nonresponders with high BMI.

Background: Omalizumab provides clinical benefits to a fraction of patients with asthma. It remains unclear why some patients do not respond to omalizumab therapy.

Objective: We sought to investigate whether omalizumab could alter serum cytokine and chemokine levels that could be associated with asthma pathogenesis.

Low-profile metamaterial with ultra-wide band ratio based on active frequency selective surfaces.

This paper presents a low-profile metamaterial with ultra-wide band ratio (BR) based on active frequency selective surfaces (AFSSs) to overcome the limited tuning range and suboptimal profile of current designs. The proposed design consists of a periodic pattern printed on the top of a thin substrate and a bias network on the bottom, with varactor diodes symmetrically integrated into the top metal layer. Based on the equivalent circuit model, the mechanism of wideband tuning is analyzed theoretically.

Constructing government attention through policy synergy in China's haze governance.

Against the backdrop of widespread concern over the haze problem, China is committed to seeking effective governance strategies. This study aims to explore the ways in which actors seek to attract the attention of the government in order to promote policy synergy. The study employs a mixed-methods approach, collecting data from government websites and reports (2008-2023).

Association between atherogenic index of plasma and future cardiovascular disease risk in middle-aged and elderly individuals with cardiovascular-kidney-metabolic syndrome stage 0-3.

Background: Cardiovascular disease (CVD) is strongly correlated with plasma atherogenic index (AIP); however, there is limited literature exploring the association between trajectories of change in AIP and the risk of CVD. This study aimed to investigate whether changes in AIP are associated with CVD in individuals with cardiovascular-kidney-metabolic (CKM) syndrome stage 0-3.

Methods: Data were sourced from the China Health and Retirement Longitudinal Study (CHARLS), aimed to compile high-quality microdata on individuals and households aged 45 and older in China.

Should teaching strategies emphasize emotion or competence? Enhancing audience acceptance of children with autism through online music performances - evidence from China.

This study investigates the experiences and perceptions of audiences watching online music performances by children with autism, focusing on how the emotions and competence displayed by the children during the performances affect the audience's sense of immersion and acceptance. We conducted an online survey with 949 respondents, t-tests was used to compare the differences before and after the respondents watching the performance, and structural equation modeling was used to analyzed the path relationships among variables. The results showed that audience acceptance was significantly higher after watching the music performances (t = -6.

TAOK1 promotes filament formation in HR repair through phosphorylating USP7.

Poly-ADP-ribose polymerase (PARP) inhibitors are vital therapeutic agents that exploit synthetic lethality, particularly effective in tumors with homologous recombination (HR) defects. However, broadening their clinical utility remains a significant challenge. In this study, we conducted a high-throughput kinase inhibitor screen to identify potential targets exhibiting synthetical lethality with PARP inhibitors.

How to improve users' purchase intention of agricultural products through live streaming systems?

With the development and improvement of technology, live streaming systems have emerged in people's daily lives, providing new channels for agricultural product sales. This study aims to understand how to scientifically design live streaming systems for agricultural product sales based on user perceptions and preferences. We conducted an online survey, and Study 1 obtained 569 valid samples.

Spatial variations of PM-bound parent, nitrated, and oxygenated PAHs at urban and suburban sites in the Ili River Valley: Characteristics, sources, and health risks.

Polycyclic Aromatic Hydrocarbons (PAHs), along with their derivatives nitro-PAHs and oxy-PAHs, are globally recognized toxic pollutants. This research conducted daily PM sampling in winter 2021 at three urban (YNCE, SWP, and NG) and three suburban sites (HC, CTV, and YNE) in the Ili River Valley (IRV). For the first time in the IRV, a comprehensive study on 39 PAHs and derivatives was carried out.