[A prospective controlled study on degenerative lumbar spondylolisthesis treated with three steps and nine methods combined with physiotherapy].

Objective: To explore the clinical efficacy and safety of the "Three-Step Nine-Method Lumbar Correction" combined with physical therapy in the treatment of patients with degenerative lumbar spondylolisthesis(DLS).

Methods: From January 2021 to December 2021, 72 patients diagnosed with DLS were enrolled and divided into the Three-Step Nine-Method Lumbar Correction group and the pelvic traction group, with 36 cases in each group. In the Three-Step Nine-Method Lumbar Correction group, there were 15 males and 21 females;aged 54 to 66 years old, with an average of (59.

Ion-Mediated Self-Healing Strategy Enabling Efficient and Stable ETL-Free Perovskite Solar Cells.

Perovskite solar cells without electron transport layers (ETL-free PSCs) have garnered increasing attention in recent years due to their simplified fabrication process and low production costs. However, non-radiative recombination of charge carriers and band energy mismatch at the interface significantly limit device performance. Here, we propose an ion-mediated self-healing strategy introducing an indium sulfate (ln(SO)) functional layer at the buried interface of the perovskite.

Structure and function of the human apoptotic scramblase Xkr4.

Phosphatidylserine externalization on the surface of dying cells is a key signal for their recognition and clearance by macrophages and is mediated by members of the X-Kell related (Xkr) protein family. Defective Xkr-mediated scrambling impairs clearance, leading to inflammation. It was proposed that activation of the Xkr4 apoptotic scramblase requires caspase cleavage, followed by dimerization and ligand binding.

Pulmonary infection caused by : a case study.

Although pulmonary infections caused by () are still relatively rare in clinical practice, they are increasingly familiar and valued by clinicians. The clinical symptoms and imaging of pulmonary infection with are not typical, thus diagnosis needs to be confirmed by clinical etiology. is one of the main fungal species causing allergic bronchopulmonary mycosis.

The efficacy and safety of adjuvant immunotherapy after neoadjuvant immunotherapy combined with chemotherapy in locally advanced resectable esophageal squamous cell carcinoma: a real-world study.

Background: The promising therapeutic outcomes of neoadjuvant immunotherapy with chemotherapy (NAIC) in the treatment of resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) have been confirmed by several clinical trials. However, the potential benefits of adjuvant therapy for LA-ESCC patients remain unclear.

Materials And Methods: We analyzed the LA-ESCC patients underwent NAIC and adjuvant immunotherapy between January 2020 and September 2023.

TMNRED, A Chinese Language EEG Dataset for Fuzzy Semantic Target Identification in Natural Reading Environments.

Semantic understanding is central to advanced cognitive functions, and the mechanisms by which the brain processes language information are still being explored. Existing EEG datasets often lack natural reading data specific to Chinese, limiting research on Chinese semantic decoding and natural language processing. This study aims to construct a Chinese natural reading EEG dataset, TMNRED, for semantic target identification in natural reading environments.

Magnetically Driven Hydrogel Microrobots for Targeted Antibiotic Delivery.

Precise targeted delivery of antibiotics to infected sites is crucial for enhancing therapeutic efficacy and minimizing side effects. In this work, we present magnetic hydrogel-based microrobots for active antibiotic delivery to achieve targeted bacterial elimination. These microrobots comprise a poly(acrylic acid-co-acrylamide) hydrogel microspheres encapsulating FeO nanoparticle chains.

Multiple active site additive-mediated suppression of Sn oxidation and regulation of crystallization for high-performance Sn-Pb mixed perovskite solar cells.

The oxidation of Sn and fast crystallization jointly limit the photovoltaic performances and stability of tin (Sn)-lead (Pb) mixed perovskite solar cells, but the mitigation of a single issue only obtains restricted enhancement of device performance. Herein, we introduce -hydroxythiophene-2-carboximidamide (NHC) as a multiple active site additive, the rich functional groups of which can interact with perovskite to form strong Lewis acid-base coordination and abundant hydrogen bonds, simultaneously suppressing Sn oxidation and regulating crystallization rate. The NHC-treated Sn-Pb mixed perovskite exhibited lower defect density, reduced non-radiative recombination, and improved carrier transport dynamics.

Competitive-Coordination-Induced Crystallization Regulation for Efficient and Stable Sn-Pb Perovskite Solar Cells.

The unbalanced crystallization rate between Sn- and Pb-based perovskites leads to their heterogeneous distribution and inferior quality of Sn-Pb perovskite films. The promising strategy of selective molecular interaction would balance the crystallization rate. However, the deeper selectivity mechanism needs to be considered, particularly in terms of the entire coordination reaction in the perovskite precursor solution.

Dual-threshold sample selection with latent tendency difference for label-noise-robust pneumoconiosis staging.

BackgroundThe precise pneumoconiosis staging suffers from progressive pair label noise (PPLN) in chest X-ray datasets, because adjacent stages are confused due to unidentifialble and diffuse opacities in the lung fields. As deep neural networks are employed to aid the disease staging, the performance is degraded under such label noise.ObjectiveThis study improves the effectiveness of pneumoconiosis staging by mitigating the impact of PPLN through network architecture refinement and sample selection mechanism adjustment.

The complete chloroplast genome of M.G.Gilbert, Y.Tang & Dorr 2007 and its phylogenetic analysis.

, a wild medicinal and edible Malvaceae species, lacked genomic data until now. In this study, we presented its first complete chloroplast genome (158,793 bp), featuring a quadripartite structure: 87,215 bp LSC, 20,766 bp SSC, and two 25,406 bp IRs. The genome contains 129 genes (85 protein-coding, 36 tRNA, 8 rRNA) with 37.

A novel complex of pectin-crosslinked β-cyclodextrin: Effectively reducing cholesterol content in hotpot beef tallow.

The high cholesterol content of beef tallow is one of the potential risks affecting the nutritional value and safety of beef tallow hotpot. In this study, a novel pectin-crosslinked β-cyclodextrin (β-CD) complex was successfully prepared by the cross-linking method to reduce the cholesterol content in beef tallow. When 3% (by mass of beef tallow) of the pectin-crosslinked β-CD complex was added, the removal rate of cholesterol in beef tallow reached 73.

Halogen-bond-mediated inhibition of ion migration for stable Sn-Pb perovskite solar cells.

The incorporation of perfluorooctane iodides into Sn-Pb perovskite solar cells significantly mitigates performance losses caused by ion migration and the internal field shielding effect, while simultaneously enhancing both device efficiency and stability.

Mimicking the Reactivity of LPMOs with a Mononuclear Cu Complex.

Lytic polysaccharide monooxygenases (LPMOs) are Cu-dependent metalloenzymes that catalyze the hydroxylation of strong C-H bonds in polysaccharides using O or HO as oxidants (monooxygenase/peroxygenase). In the absence of C-H substrate, LPMOs reduce O to HO (oxidase) and HO to HO (peroxidase) using proton/electron donors. This rich oxidative reactivity is promoted by a mononuclear Cu center in which some of the amino acid residues surrounding the metal might can accept and donate protons and/or electrons during O and HO reduction.

Efficacy of Percutaneous Vertebroplasty Using Cross-Puncture in the Treatment of Genant Grade 0-1 Osteoporotic Vertebral Compression Fractures.

Background: Percutaneous vertebroplasty (PVP) is a common surgical method for osteoporotic vertebral compression fractures (OVCFs). The puncture method and location of the puncture needle can directly affect bone cement distribution in the vertebra. This retrospective study aimed to compare the clinical efficacy and safety of PVP using the cross-puncture and bilateral conventional puncture for the treatment of Genant grade 0-1 OVCFs.

A Universal Method for Fingerprinting Multiplexed Bacteria: Evolving Pruned Sensor Arrays via Machine Learning-Driven Combinatorial Group-Specificity Strategy.

Array-based sensing technology holds immense potential for discerning the intricacies of biological systems. Nevertheless, developing a universal strategy for simultaneous identification of diverse types of multianalytes and meeting the diagnostic needs of a range of multiclassified clinical diseases poses substantial challenges. Herein, we introduce a combination method for constructing sensor arrays by assembling two types of group-specific elements.

Atractylenolide-I Attenuates MPTP/MPP‑Mediated Oxidative Stress in Parkinson's Disease Through SIRT1/PGC‑1α/Nrf2 Axis.

Parkinson's disease (PD) is typically marked by motor dysfunction accompanied by loss of dopaminergic (DA) neurons and aggravated oxidative stress in the substantia nigra pars compacta (SNpc). Atractylenolide-I (ATR-I) is a potent antioxidant sesquiterpene with neuroprotective properties. However, whether ATR-I plays a neuroprotective role against oxidative stress in PD remains unclear.

Chromatin Buffers Torsional Stress During Transcription.

Transcription through chromatin under torsion represents a fundamental problem in biology. Pol II must overcome nucleosome obstacles and, because of the DNA helical structure, must also rotate relative to the DNA, generating torsional stress. However, there is a limited understanding of how Pol II transcribes through nucleosomes while supercoiling DNA.

Torsion is a Dynamic Regulator of DNA Replication Stalling and Reactivation.

The inherent helical structure of DNA dictates that a replisome must rotate relative to DNA during replication, presenting inevitable topological challenges to replication. However, little is known about how the replisome progresses against torsional stress. Here, we developed a label-free, high-resolution, real-time assay to monitor replisome movement under torsion.

Enhanced Electric Field Minimizing Quasi-Fermi Level Splitting Deficit for High-Performance Tin-Lead Perovskite Solar Cells.

The quasi-Fermi level splitting (QFLS) deficit caused by the non-radiative recombination at the interface of perovskite/electron transport layer (ETL) can lead to severe open-circuit voltage (V) loss and thus decreases the efficiency of perovskite solar cells (PSCs), however, has received limited attention in inverted tin-lead PSCs. Herein, the strategy of constructing an extra-electric field is presented by introducing ferroelectric polymer dipoles (FPD)-β-poly(1,1-difluoroethylene)-to suppress the QFLS deficit. The directional polarization of FPD can enhance the built-in electric field (BEF) and thus promote the charge transfer at the perovskite/ETL interface, which effectively suppresses non-radiative recombination.

Magnetic-chemotactic hybrid microrobots with precise remote targeting capability.

Micro/nanorobots (MNRs) hold great promise for various applications due to their capability to execute complex tasks in hard-to-reach micro/nano cavities. However, the developed magnetic MNRs, as marionettes of external magnetic fields, lack built-in intelligence for self-targeting, while chemotactic MNRs suffer from limited self-targeting range. Here, we demonstrate magnetic-chemotactic ZnO/Fe-Ag Janus microrobots (JMRs) capable of rapid, remote self-targeting for bacterial elimination.