Observation of nonlinear edge states in an interacting atomic trimer array.

Exploring the interplay between topology and nonlinearity leads to an emerging field of nonlinear topological physics, which extends the study of fascinating properties of topological states to a regime where interactions between the particles cannot be neglected. For ultracold atomic systems, although many exotic topological states have been recently observed, the nonlinear effect remains elusive. Here, based on the laser-driven couplings of discrete atomic momentum states, we synthesize a topological trimer array, where the atomic interactions give rise to tunable nonlinearities.

Efficacy of Taiji imagery therapy in stroke patients: A systematic review and meta-analysis.

Background: To explore the efficacy of Taiji imagery therapy (TIT), a combination of Taiji and imagery therapy, in treating stroke patients.

Methods: Suitable studies for the meta-analysis were retrieved from 8 research databases: China National Knowledge Infrastructure, SinoMed, China Wanfang, Chongqing VIP Information, Web of Science, PubMed, Cochrane Library, and EMBASE (date of retrieval: October 26, 2024). Articles were searched manually and independently by 2 researchers.

Systematic Analysis of Lysine Succinylation in Streptococcus mutans.

Lysine succinylation (Ksuc) is a novel post-translational modification (PTM), which regulates biological functions in bacteria. Streptococcus mutans has been identified as a predominant cariogenic pathogen responsible for the initiation and progression of dental caries. However, lysine succinylation in S.

Prediction of high-performing spleen-targeted lipid nanoparticles using a deep learning model for robust anticancer immunotherapy.

Messenger RNA (mRNA) therapeutics hold significant potential across a wide range of medical applications. LNPs are the most clinically advanced mRNA delivery vehicles, but challenges such as off-target effects and liver accumulation limit their broader clinical use. While high-throughput screening is effective for identifying more efficient and selective ionizable lipids, the substantial experimental validation required limits its practical application.

Implants for fixation of intertrochanteric femoral fracture: a systematic review and network meta-analysis of randomized controlled trials.

Background: A variety of implant devices have been used for treatment of intertrochanteric femoral fractures (IFF), but the optimal has long been disputed. We aim to summarize the latest evidence for the effectiveness and safety of implants for IFF.

Methods: This systematic review and network meta-analysis included searches of PubMed, Embase, the Cochrane Library, and Web of Science from January 1, 2000 to August 31, 2024, for randomized controlled trials of implants in older adult patients with intertrochanteric femoral fracture.

A Dynamic Multi-Scale Hypergraph Learning Framework Driven by Features and Structures for ceRNA-Disease Association Prediction.

Competitive endogenous RNA (ceRNA) networks are pivotal for uncovering disease molecular mechanisms. Graph representation learning is a cornerstone for modeling biological regulatory networks and predicting disease-related biomarkers. However, current methods face challenges: traditional graph neural network (GNN) rely on low-order graph structures, which struggle to capture highorder molecular interactions, resulting in topological information loss; shallow GNN fail to model long-range dependencies, while deep architectures suffer from oversmoothing, limiting complex regulatory expression; static embeddings overlook dynamic molecular interactions, reducing biomarker accuracy.

Cross-neutralization effect of the third dose of inactivated COVID-19 vaccine against the SARS-CoV-2 variants.

Background: The ongoing emergence of SARS-CoV-2 variants has raised concerns about the breadth of the immune response provided by existing vaccines.

Research Design And Methods: In this study, participants aged 18-75 years with no prior COVID-19 infection or vaccination history were enrolled to receive the CoronaVac vaccine. The interval between the first and second vaccine doses was 28 days, while the third dose was given 6 months after the second.

Impact of maternal iron and zinc intake on low birth weight risk: a nested case-control study.

Background: The association between maternal iron/zinc intake and the risk of low birth weight (LBW) in infants is still unclear. This study aimed to investigate the effects of iron and zinc daily intake preconception and during pregnancy on the risk of delivering LBW babies and to assess whether there is an interaction between iron and zinc intake on the risk of LBW.

Methods: A nested case-control study was performed, including 565 cases and 7,510 controls in Lanzhou City, China.

Crosstalk Between Lysine Lactylation and Acetylation Regulates Lactate Dehydrogenase in Streptococcus mutans.

Post-translational modifications (PTMs) provide essential fine-tuning of protein functions in response to environmental changes. Among the PTMs, lysine acetylation (Kac) and the recently identified lysine lactylation (Kla) play crucial roles in metabolic regulation considering that lactate and acetyl-CoA (Ac-CoA) are generated from pyruvate as the outlet of glycolysis. However, their crosstalk and regulatory mechanisms remain largely unknown, particularly in prokaryotes.

Respiratory pathogens in infants and young children with acute respiratory illness: a prospective cohort study, China, 2023-2024.

Background: Infants are vulnerable to acute respiratory infections (ARIs), which result in pediatric morbidity and even fatalities. A surge of ARIs among infants and young children was reported in China in 2023, garnering global attention. We aimed to investigate the frequency and types of respiratory pathogens associated with the risk of acute respiratory illnesses in infants and young children during this period.

Beyond Competitive Binding: New Biochemical Insights Challenge Endocrine Disrupting Chemical Screening Paradigms.

Endocrine-disrupting chemicals (EDCs) pose significant health risks at environmentally relevant levels. Global screening efforts have predominantly relied on competitive binding assays. Here, using biochemical assays and computational simulations, we identified a crucial but largely overlooked noncompetitive binding mode between EDCs and the androgen receptor (AR).

Development of a highly efficient -coumaric acid-responsive biosensor in .

Developing biosensors to monitor and regulate intracellular biosynthesis pathways can significantly enhance natural product yields in microbial cell factories. This study created a novel biosensor in to respond to -coumaric acid, a critical precursor in the biosynthesis of polyphenols and flavonoids. This biosensor was constructed by expressing the BsPadR repressor from and engineering hybrid promoters.

A wearable and wireless electrochemical device based on Cu-BTC MOF for pyocyanin detection and wound healing.

The prevalent and serious antimicrobial resistance in Pseudomonas aeruginosa (PA) infections has emerged as a critical public health challenge worldwide. Pyocyanin (PYO), an important virulence component produced by PA, is considered as an ideal indicator for identifying infections linked to this pathogen. This study evaluated ten metal-organic frameworks (MOFs) as signal amplifiers for the sensitive detection of PYO.

Strong Evidence of Organophosphite Antioxidant Transformation as an Important Source of High-Risk Novel Organophosphate Esters in River Water.

Organophosphate esters (OPEs) are widely detected in various environmental media, but the indirect source from the transformation of organophosphite antioxidants (OPAs) is usually neglected. This study identified 12 novel OPEs (NOPEs) in water from the upper reaches of the Yellow River, China. The total concentrations of dissolved OPEs in water ranged from 51 to 1575 ng/L, while the suspended particulate matter associated with the OPEs were 84-8009 ng/g dw, both dominated by four suspected transformation products of the OPAs.

Biological characterization and genomic analysis of the newly discovered mycobacteriophage WST1.

The rising prevalence of multidrug-resistant mycobacteria necessitates novel therapeutic strategies. Phages targeting clinically relevant mycobacteria remain scarce, lytic phages represent promising alternatives. In this study, we isolated mycobacterium phage WST1 from wastewater, exhibiting strict lytic specificity for Mycobacterium smegmatis.

Silibinin attenuates 3-nitropropionic acid-induced ovarian toxicity by alleviating oxidative stress and granulosa cell apoptosis.

3-Nitropropionic acid (3-NP), a mycotoxin present in various plants and fungi, poses significant reproductive health risks to animals and humans through food chains contamination. This study aimed to explore the protective effects and mechanisms of silibinin, a bioactive flavonoid derived from the herbal plant Silybum marianum, against 3-NP-induced reproductive toxicity. Our findings demonstrated that silibinin treatment significantly alleviated 3-NP-induced ovarian follicular atresia and preserved ovarian histoarchitecture.

A closed-loop bioelectronic patch for intelligent blood pressure management.

Cardiovascular diseases remain a leading cause of mortality due to passive and delayed drug interventions. This study introduces an intelligent blood pressure management system (BPMS) for real-time monitoring and adaptive intervention through a closed-loop framework integrating sensors, control circuits, and microneedle electrodes. A hierarchical microneedle architecture, featuring gold nanoparticle (Au NP) electrocatalysts and copper-nitrogen-doped carbon nanoribbon (Cu-NC NB) nanozymes, selectively catalyzes the in situ generation of nitric oxide (NO) for vasodilation.

Built-In Electric Field Augments Hypersalinity Resistance of Heterostructured Metal Oxides for Efficient Fenton-like Catalysis.

Fenton-like oxidation processes for saline wastewater treatment are plagued by high energy/chemical consumption, mainly due to severe interferences by the high-concentration inorganic salt. Such salt inhibition can be partially alleviated by shifting to nonradical catalytic processes, but the surface-accumulated salt ions in heterogeneous catalytic systems still cause electrostatic and steric hindrance to restrict the interfacial reactant transfer. Herein, we fabricated a heterostructured CuO/ZnFeO catalyst that provides a built-in electric field (BIEF) to strengthen the reactant-catalyst interaction and weaken the salt interferences.

The Role of PIWI-Interacting RNA in Urologic Carcinoma and Its Clinical Implications.

Piwi-interacting RNA (piRNA) represents a class of small non-coding RNA molecules, typically ranging in length from 18 to 35 nucleotides. These molecules are critically involved in the preservation of genomic integrity and the regulation of protein translation processes. Recently, emerging scholarly research indicates that piRNA exhibits tissue-specific expression profiles within a variety of human malignancies, where they intricately regulate key signaling pathways at both the transcriptional and post-transcriptional levels.

Candesartan Mitigates Perioperative Neurocognitive Disorders by Modulating Hypertension-Linked Neuroinflammatory Factor.

Perioperative neurocognitive disorders (PND) are linked to neuroinflammation, a key factor in hypertension, but their causal relationship is underexplored. This study aims to investigate whether hypertension is a risk factor for PND, identify related neuroinflammatory targets, and determine if the angiotensin receptor blockers (ARBs) candesartan can improve cognitive function in PND mouse models by modulating these targets. This study identified hypertension as a risk factor for cognitive dysfunction (OR = 1.

The PlMYB73-PlMYB70-PlMYB108 complex regulates to promote geraniol biosynthesis in .

Geraniol contributes significantly to the floral scent of herbaceous peony () and is abundant in fragrant cultivars. However, the regulatory mechanism of geraniol biosynthesis in herbaceous peony remains unclear. In this study, we identified a transcriptional regulatory complex (PlMYB73-PlMYB70-PlMYB108) that cooperatively regulated geraniol biosynthesis in herbaceous peony.

Genotyping by target sequencing (GBTS)-based genetic mapping uncovers synergistic interactions for stripe rust resistance in wheat cultivar Flanders.

YrFLA.1, YrFLA.2 and YrFLA.

A novel pansharpening method based on side window filter and new injection gain matrices.

The acquisition of remote sensing images with both high spatial resolution and high spectral resolution is constrained by limitations in spectral imaging technology. Pan-sharpening is utilized to generate high-resolution multispectral images that correspond to the resolution of panchromatic (PAN) images through the fusion of multispectral (MS) and PAN images. Traditional methods frequently encounter challenges associated with the loss of image details.

Baicalein of inhibits biofilm formation to restore the antibiotics susceptibility.

is resistant to traditional anti-TB medications and most currently available antibiotics, its strong biofilm formation may contribute to the resistance and make the situation even worse. In this study, extract significantly inhibited the planktonic growth as well as the biofilm formation of . Baicalein, the principal active element in extract, inhibited the biofilm formation instead of the planktonic growth and reduced extracellular matrix lipids in biofilm.

Imidazole Hexafluorophosphate Ionic Liquid as a Greener Corrosion Inhibitor for Carbon Steel in Hydrochloric Acid and Sulfuric Acid Solutions.

The inhibitory effect of 1-hexadecyl-2,3-dimethylimidazole hexafluorophosphate ([CDMIM][PF]) on carbon steel was investigated in both 1 M hydrochloric acid (HCl) and 1 M sulfuric acid (HSO) solutions. The thermodynamic and kinetic corrosion parameters were calculated through weight loss and electrochemical measurements. The results showed that the addition of 0.