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Introduction: The aim of this study was to investigate the relationship between obesity and the accelerated decline in Total Sleep Time (TST) and its potential impact on the self-reported diagnoses of diabetes.
Methods: Our study addresses this gap by analyzing trends in a longitudinal cohort study conducted in China, using data from the China Health and Nutrition Survey (CHNS). Employing a joint model, inter-individual variability and intra-individual variability in TST, and its impact on self-reported diagnoses of diabetes were considered.
Results: Our findings reveal that self-reported diagnoses of diabetes prevalence in China rose from 1.10% in 2004 to 3.06% in 2015, accompanied by a decrease in average TST from 8.12 to 7.80. With age, TST decreased by 0.01 per year. Among coffee or tea consumers, it decreased by 0.03, while alcohol users saw a decrease of 0.07. The obese group experienced a decrease of 0.05, the overweight group 0.03, and the normal weight group 0.01. Each 1-hour decrease in TST was associated with a substantial 3.61-fold increase in self-reported diagnoses of diabetes risk (95% CI: 2.92-4.44). Specifically, individuals with a higher baseline TST tend to experience smaller changes over time, whereas those with a lower baseline TST tend to experience larger changes.
Discussion: For the obese, TST decreases at an accelerated rate which contributes to the risk of self-reported diagnoses of diabetes. The findings underscore the role of sleep loss in diabetes risk, with implications for public policy. Future research and interventions should emphasise the impact of sleep management, particularly on obesity and metabolic health, to develop more effective prevention and treatment strategies.
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http://dx.doi.org/10.3389/fendo.2025.1473892 | DOI Listing |
Clinics (Sao Paulo)
September 2025
Department of Physiological Sciences, Universidade Federal do Espírito Santo, Vitória, ES, Brazil.
Background: Endometriosis diagnosis is challenging due to non-specific symptoms that overlap with other gynaecological conditions. This study proposes a non-invasive Machine Learning (ML) ‒ based urine test using Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy for rapid, high-throughput screening.
Methods: A total of 302 symptomatic patients presenting with pelvic pain and MRI referral indications were recruited.
Talanta
September 2025
College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Qingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and Treatment, Instrument
Rational optimization of the pore size and topology of porous nanocarriers is crucial for improving the loading amount of luminophore and enhancing electrochemiluminescence (ECL) performance. In this study, an equimolar linear ligand replacement strategy was employed to synthesize novel mesoporous metal-organic frameworks (MOFs) for encapsulating Ru(bpy) (Ru@Zr MOFs) under room temperature without an acid modulator. Ingenious ligand substitution allows precise control of pore size, enabling encapsulation at the single-molecule level within mesoporous cages.
View Article and Find Full Text PDFWomens Health (Lond)
September 2025
Worldwide Medical and Safety, Pfizer Inc, New York, NY, USA.
Background: Endometriosis symptoms have multifaceted manifestations, and there are few approved nonsurgical treatment options. Gonadotropin-releasing hormone (GnRH) agonists/antagonists for endometriosis vary on efficacy, safety profile, and out-of-pocket (OOP) cost, among other features.
Objectives: This study quantified the importance that women with endometriosis in the United States (US) placed on pain and non-pain features that differ among these medications.
Nicotine Tob Res
August 2025
Section of Pulmonary and Critical Care, Department of Medicine, Dartmouth-Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH, 03766, USA.
Introduction: This study examined the main and interactive effects of sex, cigarette smoking status, cigarette pack-years, and second-hand smoke exposure on COPD prevalence and incidence.
Methods: COPD prevalence was estimated for US adults aged 40+ years from Wave 1 of the Population Assessment of Tobacco and Health Study (n = 12 296). Incidence analyses included adults from the initial sample without a COPD diagnosis (n = 6611).
BMJ Open Gastroenterol
September 2025
Center for Innovations in Quality, Effectiveness, and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX, USA
Objective: Approximately 30% of the 700 000 US Gulf War Veterans (GWVs) report symptoms collectively termed Gulf War Illness (GWI), a multisymptom illness of uncertain pathophysiology. Prior studies in GWI focus on overlap with irritable bowel syndrome. This study examines the associations between upper gastrointestinal (UGI) symptoms, GWI and specialty GI care.
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