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Background And Objective: Traumatic dental injuries (TDIs) in children pose a significant public health challenge, with a global prevalence of 20-30%. These injuries predominantly affect preschool-aged children (1-3 years) due to underdeveloped motor coordination, while school-aged children face risks from sports and accidents. Maxillary central incisors are most commonly involved, often leading to complications such as pulp necrosis, root resorption, and malocclusion, which impair long-term oral function and aesthetics. Socioeconomic disparities exacerbate outcomes, with higher prevalence and severity in low-resource settings. This narrative review synthesizes current evidence on the classification, risk factors, diagnostic advancements, and management strategies for pediatric TDI, focusing on emerging technologies and biologically driven therapies.
Methods: A comprehensive literature search was conducted across MEDLINE/PubMed, Scopus, and Web of Science, prioritizing studies from the past decade (2015-2025). Key topics included epidemiology, International Association of Dental Traumatology (IADT) classification, pulp vitality assessment (e.g., laser Doppler flowmetry, pulse oximetry), regenerative endodontics, and preventive interventions.
Key Content And Findings: The IADT guidelines provide a standardized framework for TDI classification and management. Modern diagnostic tools improve accuracy in detecting pulp vitality and root fractures. Bioceramic materials and stem cell-based therapies show promise in preserving pulp vitality and promoting periodontal healing. Preventive strategies, including educational programs and mouthguard policies, demonstrate efficacy in reducing TDI incidence.
Conclusions: Pediatric TDI require multidisciplinary management combining accurate diagnosis, biologically driven treatments, and preventive measures. Future research should prioritize longitudinal outcome studies and the integration of artificial intelligence in trauma assessment.
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http://dx.doi.org/10.21037/tp-2025-243 | DOI Listing |
J Mol Histol
September 2025
Faculty of Dentistry, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca, Mexico.
Unlabelled: Galectin-1 is a protein from the lectin family that is capable of recognizing β-galactosides, and it is involved in modulating the inflammatory response and tissue homeostasis. However, the presence and distribution of galectin-1 in pulp tissue, as well as its role in pulp inflammation, are poorly understood. Although galectin-1 has been reported to be present in healthy and necrotic pulp tissue at the proteomic level, the modifications and implications of these changes in galectin in tissues with irreversible pulpitis and infiltrating macrophages that could help clarify the inflammatory phenomenon have not yet been described.
View Article and Find Full Text PDFHua Xi Kou Qiang Yi Xue Za Zhi
August 2025
Key Laboratory of Shaanxi Province for Craniofacial Precison Medicine Research, Hospital of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.
Objectives: This study aimed to evaluate the clinical application value of in-situ crown reattachment technique combined with pulpotomy in the treatment of complicated crown-root fractures in young permanent anterior teeth.
Methods: A prospective study was conducted on 50 children with complicated crown-root fractures in young permanent anterior teeth, who were treated at the Pediatric Dentistry Department, Hospital of Stomatology, Xi'an Jiaotong University from June 2023 to June 2024. All patients underwent in-situ crown reattachment technique combined with pulpotomy.
Int Endod J
September 2025
Department of Endodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, P. R. China.
Aim: This study explores how lipid metabolic reprogramming contributes to the pathogenesis of pulpitis and identifies key molecular targets involved in regulating inflammation, with the goal of developing metabolic interventions to preserve dental pulp vitality.
Methodology: Primary human dental pulp cells (HDPCs) were stimulated with lipopolysaccharide (LPS) and subjected to integrated transcriptomic and metabolomic profiling to map inflammation-associated metabolic shifts. Functional validation included linolenic acid (LA) supplementation (alone or combined with a Fatty Acid Synthase (FASN) inhibitor, TVB-2640), Nuclear receptor subfamily 4 group A member 1 (NR4A1) knockdown, cytokine/NF-κB assessment (ELISA, Western blot), and lipid droplet/FASN visualisation (immunofluorescence).
Cureus
July 2025
Department of Conservative Dentistry and Endodontics, DY Patil School of Dentistry, Navi Mumbai, IND.
The present systematic review and meta-analysis aimed to evaluate and compare the clinical efficacy of Mineral Trioxide Aggregate (MTA) and Biodentine (BD) as direct pulp capping materials in cariously exposed mature permanent teeth, focusing on outcomes such as pulp vitality preservation, dentin bridge formation, and complication rates, including tooth discoloration. A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, and other dental databases following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The review protocol was registered in PROSPERO (CRD42023463513).
View Article and Find Full Text PDFCureus
July 2025
Department of Conservative Dentistry and Endodontics, Kalinga Institute of Dental Sciences, Bhubaneswar, IND.
Regenerative endodontics utilizes stem cell biology and bioactive materials to restore pulp vitality. Human dental pulp stem cells (hDPSCs), with their self-renewal and odontogenic differentiation potential, are central to regenerative endodontics. Hydraulic calcium silicate-based cements (HCSCs), such as mineral trioxide aggregate (MTA) and Biodentine (Septodont, Saint-Maur-des-Fossés, France), are widely used in vital pulp therapies to promote pulp vitality recovery.
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