Exposure to diethyl phthalates impairs ovarian reserve and oocyte maturation in female mice.

Diethyl phthalates (DEP) are commonly used as a plasticizer and have been found to cause male reproductive defects and metabolic disease in mammals as a potential environmental endocrine disruptor. However, the effects and underlying mechanisms of DEP exposure on female follicle development and oocyte maturation were still unclear. In this study, we found that mice exposed to DEP had significantly reduced primordial follicles.

Disease burden of seasonal influenza in China from 2010 to 2019: A systematic review and meta-analysis based on multiple indicators.

Through systematic review and meta-analysis, the average annual disease burden of seasonal influenza in China from 2010 to 2019 was estimated, and the differences between the northern and the southern regions were compared. A systematic review was conducted to collect articles from 2010 to 2019 on the disease burden of seasonal influenza in China. Study quality was assessed using the cross-sectional appraisal tool from the Agency for Healthcare Research and Quality.

An intelligent agent for sentence completion test: creation and application in depression assessment.

During large-scale psychological screening, traditional self-report questionnaires face challenges like response deception or social desirability bias, while the Sentence Completion Test (SCT) as a projective technique shows potential but is limited by manual scoring and high costs. Leveraging advancements in Large Language Models (LLMs), this study integrates SCT's theoretical framework with LLM capabilities to develop a specialized set of SCT items for depression assessment in Chinese university students, using a self-built intelligent agent across three progressive empirical studies. Results show the agent demonstrates good reliability (Cronbach's  = 0.

promotes malignancy of HBV-related hepatocellular carcinoma by regulating IGF2BP3-mediated nuclear-cytoplasmic shuttling.

Hepatitis B virus (HBV) X protein (HBx) plays a critical role in the progression of HBV-related hepatocellular carcinoma (HCC). Long non-coding RNAs (lncRNAs) regulate various biological processes and contribute to HCC development, with their therapeutic potential in disease progression recently gaining significant attention. However, the involvement of lncRNAs in HBx-related hepatocarcinogenesis and the underlying regulatory mechanisms remain unclear.

Electro-Mechanical Mapping of the Small Intestine and the Influence of High-Energy Pacing.

Purpose: Compromised electrical and mechanical activity in the gastrointestinal tract is associated with several motility disorders. Conventional treatment fails in a significant proportion of the patient population, and pacing is a promising alternative therapy. However, the correlation between slow waves and contractions during pacing remains unexplored.

Tuina Alleviates Neuropathic Pain in CCI Rats by Regulating the TRPV4-CaMKII Signaling Pathway in Dorsal Root Ganglion.

Peripheral sensitization mediated by the Transient Receptor Potential Vanilloid 4-Calcium/calmodulin-dependent protein kinase II (TRPV4-CaMKII) signaling pathway plays a fundamental role in the generation and maintenance of neuropathic pain (NP). Tuina, a safe and effective therapy in traditional Chinese medicine, shows analgesic effects; however, the underlying mechanisms remain unclear. We aimed to investigate whether Tuina alleviates pain by modulating the TRPV4-CaMKII/CREB/NLRP3 signaling pathway.

Chinese massage therapy (Tuina) inhibits motor neuron apoptosis in rats with sciatic nerve injury by regulating the cPLA2 and RhoA/ROCK2 signaling pathways.

Objective: To investigate whether Tuina therapy alleviated inflammation and motor neuron apoptosis in sciatic nerve injury (SNI) rats by regulating cytosolic phospholipase A2 (cPLA2) and Ras homolog family member A/Rho-associated coiled-coil comprising protein kinase 2 (RhoA/ROCK2) signaling cascades.

Methods: Four experimental cohorts were established utilizing 36 male Sprague-Dawley rats: control, sham, SNI, and TUI. We implemented a sciatic nerve injury (SNI) model.

Influence of isoflurane and propofol on gastric slow wave patterns and pacing efficacy in pigs.

Gut motility is partly driven by underlying rhythmic electrical activity called slow waves. The origin and propagation of these electrical events are studied extensively in anesthetized animal models. However, the effects of anesthesia on slow waves remain unclear.

Scenario-dependent O driver identification and formation responses to VOCs/NO emission reduction pathways from integrated and sectoral sources in the Beijing-Tianjin-Hebei region, China.

Persistent surface ozone (O) in China's Beijing-Tianjin-Hebei region, driven by complex meteorology-precursor interactions, has become a critical air quality crisis. A longstanding challenge in O pollution mitigation is identifying drivers of O formation and its response to precursor emissions. Using explainable ensemble machine learning, scenario-based modeling and empirical kinetic modeling approach, we quantified O formation drivers and evaluated scenario-dependent responses to integrated/sectoral precursor emission reductions across multiple dynamic scenarios.

Flourishing chemosynthetic life at the greatest depths of hadal trenches.

Hadal trenches, some of the Earth's least explored and understood environments, have long been proposed to harbour chemosynthesis-based communities. Despite increasing attention, actual documentation of such communities has been exceptionally rare. Here we report the discovery of the deepest and the most extensive chemosynthesis-based communities known to exist on Earth during an expedition to the Kuril-Kamchatka Trench and the western Aleutian Trench using the manned submersible Fendouzhe.

Efficacy and safety of first-line treatments for metastatic castration-resistant prostate cancer based on phase II and III randomized controlled trials: A PROSTA-MAP systematic review and network meta-analysis.

Background: The landscape of metastatic castration-resistant prostate cancer (mCRPC) treatment has evolved greatly; however, limited data are available regarding its relative efficacy and safety. We conducted a systematic review and network meta-analysis to analyze and compare the effectiveness and safety of first-line therapies for mCRPC, particularly doublet therapy and monotherapy.

Methods: The PubMed, Embase, and Cochrane Library databases were searched from their inception until June 6, 2023.

Immunomodulatory effects of photothermal therapy in breast cancer: advances and challenges.

Breast cancer (BC) is the leading cause of cancer death in women, partly because of the significant toxicity and low specificity associated with chemotherapy drugs. Photothermal therapy (PTT) provides a new paradigm for the precise treatment of BC through local thermal ablation and immune regulation. PTT utilizes the heat generated by laser irradiation to kill tumor cells.

Source discrimination of colchicine based on carbon stable isotope analysis.

Colchicine, a highly toxic alkaloid, has been frequently employed as a poisoning agent in criminal cases. Toxicant source tracing represents a critical research direction in forensic science, where the discrimination of colchicine origins holds particular significance for chemical fingerprint identification in poisoning incidents. The stable isotopic signature of colchicine serves as a crucial indicator for source comparison and traceability.

Ventricular Arrhythmias and Myocardial Infarction: Electrophysiological and Neuroimmune Mechanisms.

Ventricular arrhythmias (VAs) after myocardial infarction (MI) are still one of the most important causes of cardiovascular death, though patients receive timely vascular recanalization and drug treatment. And it requires further exploring the mechanism and new therapeutics of VAs induced by MI. Here, we review the electrophysiological and neuroimmune mechanisms of VAs induced by MI.

Dissecting the METTL3/STC2 axis in colorectal cancer: implications for drug resistance and metastasis.

In recent years, the role of epigenetic modifications, especially N6-methyladenosine (m6A) modifications, in the occurrence and development of cancer has received increasing attention. This study aims to elucidate the role of m6A modification in colorectal cancer (CRC), focusing on the effect of METTL3 on STC2 expression and its effects on cell proliferation, drug resistance and metastasis. Using MeRIP-seq, mRNA-seq, EdU staining, CCK-8 (Cell Counting Kit-8) assay, Transwell assay, Western blot and flow cytometry, this study confirmed that RNA methylation was predominantly located in the CDS region and that STC2 was overexpressed in advanced cancer and 5-FU (5-Fluorouracil)-resistant cell lines.

Behavioral and transcriptomic responses of wild least horseshoe bats to artificial light.

Artificial light has altered nighttime environments, jeopardizing the fitness of organisms. While many nocturnal animals avoid artificial light, the molecular mechanisms behind this phenomenon remain elusive. This study aimed to explore the behavioral and transcriptomic responses of least horseshoe bats () to artificial light.

Corrigendum: Efficacy and safety of PD-1/PD-L1 inhibitors as first-line treatment for esophageal squamous cell carcinoma: a systematic review and meta-analysis.

[This corrects the article DOI: 10.3389/fimmu.2025.

Fabrication of zirconium/chitosan functionalized magnetic carbon nanotubes for enhanced adsorption of alizarin red.

In this study, a composite adsorbent (Zr-CMCNTs) based on modification of magnetic carbon nanotubes (MCNTs) with chitosan (CS) and zirconium oxychloride octahydrate (ZrOCl·8HO) was synthesized and showed excellent adsorption ability for alizarin red (AR) in aqueous solution. The maximum adsorption capacity of Zr-CMCNTs for AR could reach 889 mg·g at 313 K (pH = 3.4).

Tuina promotes nerve myelin regeneration in SNI rats through Piezo1/YAP/TAZ pathway.

Purpose: The changes in the mechanical environment of local nerves after peripheral nerve injury (PNI) can cause a series of mechanical electrochemical signal reactions that affect the process of nerve regeneration and functional recovery. Piezo1/YAP/TAZ is an important transduction pathway that affects myelin regeneration. Our previous studies showed that Tuina could treat PNI in a variety of ways, including promoting nerve repair.

Mechanisms and potential roles of active ingredients of traditional Chinese medicine in the treatment of chronic obstructive pulmonary disease.

Objectives: Chronic obstructive pulmonary disease (COPD) is a respiratory condition with high rates of morbidity and mortality. Recent studies have shown that the increasing research on Traditional Chinese Medicine (TCM) also plays an important role in COPD. The purpose of this review is to categorize TCM and its active ingredients and to summarize their pharmacological effects.

PM pollution characteristics, drivers, and regional transport during different pollution levels in Linyi, China: An integrated PMF-ML-SHAP framework and transport models.

Despite significant progress in air quality improvement, heavy fine particulate matter (PM) pollution events persist in China. The pollution characteristics of PM vary during different pollution levels, highlighting the necessity for a deeper understanding of its underlying driving factors and regional transport. This study systematically investigated the compositional characteristics, drivers, and regional transport of PM in Linyi by integrating multi-data fusion analysis, positive matrix factorization-machine learning-shapley additive explanation (PMF-ML-SHAP), and concentration weighted trajectory model.

Performance enhancement and mechanism of tetracycline removal by visible light-driven photo bio-electro-fenton system with CoFe-LDH/g-CN cathode.

Bio-electro-Fenton (BEF) technology has shown significant advantages in the treatment of antibiotic wastewater. However, the strict pH application range (2-3) still limits the practical application of BEF. To overcome the limitation of pH on traditional BEF, CoFe-LDH/g-CN composite catalyst was synthesized by hydrothermal method and applied to the BEF cathode to construct a photo-BEF (PBEF) system.

Effectiveness and safety of Tuina massage therapy for paediatric fever: a systematic review and meta-analysis of randomised controlled trials.

Objective: To systematically analyse the efficacy and safety of Tuina massage therapy for paediatric fever.

Methods And Results: A search was conducted across PubMed, Embase, Cochrane Central Register of Controlled Trials and China National Knowledge Infrastructure databases, and it retrieved relevant randomised controlled trials (RCTs) up to November 2023. Fifteen trials (1,661 pediatric patients) were included, focusing on Tuina massage and tepid water massage.