Development of the Screen for Child Anxiety Related Emotional Disorders (SCARED) optimal short scale for Chinese children and adolescents: based on FasterRisk machine learning modeling.

Background: Although the Screen for Child Anxiety Related Emotional Disorders (SCARED) is a widely used tool for assessing anxiety, its 41-item format makes it a time-intensive method for identifying children and adolescents at high risk of anxiety. This study aims to develop an optimized version of the SCARED for Chinese children and adolescents using a novel machine learning approach, Fast and Accurate Interpretable Risk Scores (FasterRisk), to improve the efficiency of prediction and intervention.

Method: The full version of the SCARED scale and sociodemographic information were given to 8,315 children and adolescents aged 4-9 years in Henan Province, China.

The Correlation Between Plasma Vitamin D and Blood Parameters in Prenatal Women.

: Fat-soluble 25-hydroxyvitamin D (25-OHD) may be endogenously synthesized or obtained from dietary sources. Notably, it is crucial in calcium homeostasis, gene regulation, and immune system modulation, being even more relevant during prenatal stages, as the embryo utilizes vitamin D obtained from maternal plasma. Moreover, 25-OHD has been recently demonstrated to affect hematological parameters.

Photoactive Nanoplatforms with Immunomodulation Effect for Antibacterial Therapy.

The accelerating increase in bacterial resistance to conventional antibiotics is a significant obstacle to the effective management of infectious diseases. Phototherapy is considered as a promising antibacterial strategy because of its non-invasiveness and broad antibacterial spectrum without induction of drug resistance. Unfortunately, single-mode phototherapy may cause thermal damage to surrounding tissue and reactive oxygen species (ROS) have a short half-life, which reduces their therapeutic efficacy.

Perovskite Tandems: the Next Big Leap in Photovoltaic Technology.

The global demand for clean energy is driving the need for next-generation solar technologies with higher power conversion efficiencies. Multijunction solar cells, which stack absorbers with cascaded bandgaps, offer a compelling path forward by more efficiently utilizing the solar spectrum. Among these, metal halide perovskites stand out for their bandgap tunability, enabling efficient tandem solar cells (TSCs) when paired with a range of semiconductors-including perovskite/perovskite, perovskite/silicon, perovskite/organic, and perovskite/CIGS.

Transcriptional corepressor OsTPR1 regulates tillering and lateral root development in rice.

TOPLESS (TPL) and TOPLESS-Related (TPR) corepressors are key regulatory proteins that interact with a variety of transcription factors to form specific complexes, thereby modulating a wide range of signaling pathways and metabolic processes. This study explored the function of the rice TPR gene OsTPR1. Transgenic rice lines overexpressing OsTPR1 (OsTPR1-Ox) exhibited reduced lateral root density, whereas OsTPR1 RNA interference lines (OsTPR1-Ri) showed increased lateral root density.

Immunomodulatory effects of photothermal therapy in breast cancer: advances and challenges.

Breast cancer (BC) is the leading cause of cancer death in women, partly because of the significant toxicity and low specificity associated with chemotherapy drugs. Photothermal therapy (PTT) provides a new paradigm for the precise treatment of BC through local thermal ablation and immune regulation. PTT utilizes the heat generated by laser irradiation to kill tumor cells.

Fall risk perception toolkit based on "digital human" for community-dwelling older patients with stroke: development and validation.

Background: This study aims to develop a fall risk perception toolkit based on "digital human" (FRP-digital human), test its usability among community-dwelling older patients with stroke, and verify its implementation effect.

Methods: The toolkit underwent three phases: development, usability test, and effectiveness verification. A mixed method usability test was conducted with 20 participants who met the criteria.

A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance.

Platelets are a class of blood cells exfoliated from bone marrow megakaryocytes and important participants in the blood. Aggregation is a prominent part of the platelets involved in the hemostasis process, regulated by multiple signaling pathways. Abnormal platelet aggregation could lead to thrombosis or hemorrhagic disorders, which is closely related to the abnormal expression of receptors inside and outside platelet cells and the mis-transmission of signaling factors.

Scrotal wall metastasis of gastric adenocarcinoma: a rare case report and literature review.

Metastasis of gastric adenocarcinoma typically involves the liver, peritoneum, and lymph nodes, whereas scrotal wall metastasis is extremely rare, with very few cases reported in the literature. We report a case of a 60-year-old male patient who presented with right-sided scrotal swelling. The patient had previously undergone total gastrectomy and multiple chemotherapy sessions for gastric adenocarcinoma.

Design, Synthesis, and Activity Evaluation of Novel Nucleosides as ADAR1 Inhibitor for the Treatment of Prostate Cancer.

Prostate cancer (PCa) is a common malignant tumor in men, characterized by high incidence and mortality. Despite endocrine therapy being the primary treatment, drug resistance necessitates the exploration of new therapeutic agents. Nucleoside analogs, with their unique chemical structures and broad biological effects, have become essential in modern medicine.

Industry-Compatible Fully Laminated Perovskite-CIGS Tandem Solar Cells with Co-Evaporated Perovskite.

Perovskite-CIGS thin-film tandem solar cells could potentially share vacuum-based production equipment between sub-cells, reducing CapEx and supply chain dependence while enabling flexible, lightweight designs for versatile photovoltaic applications. However, scalable vacuum-based fabrication techniques for perovskite-CIGS tandems remain limited and challenging. Here, a highly efficient and stable bilayer methylammonium lead iodide perovskite fabricated using a scalable co-evaporation technique is presented.

Effectiveness of remote gamification pulmonary rehabilitation intervention based on the health action process approach theory in older adults with chronic obstructive pulmonary disease: a pilot randomized controlled trial.

Background: Remote pulmonary rehabilitation (PR) is widely used in the management of chronic obstructive pulmonary disease (COPD), but there is a problem of adherence. Health Action Process Theory (HAPA) is an effective behavior change theory, and combining it with gamification is expected to further improve PR adherence. This study explored the improvement effect of remote gamification PR intervention based on HAPA theory on rehabilitation adherence, clinical symptoms, quality of life and psychological outcome indicators of COPD patients, and compared it with self-efficacy theory and HAPA theory based remote PR.

Regulating wide-bandgap perovskite face-on stacking in hybrid-deposited perovskite/organic tandem solar cells.

Vacuum-assisted hybrid deposition for wide-bandgap (WBG) perovskites has been widely recognized for its advantages, including convenience for scaling up and conformal growth, while avoiding toxic solvents. However, the growth of WBG perovskites (>1.8 eV), which is critical for advancing the performance of thin-film-based tandem solar cells, remains insufficiently controlled under hybrid deposition.

Efficient near-infrared harvesting in perovskite-organic tandem solar cells.

The broad bandgap tunability of both perovskites and organic semiconductors enables the development of perovskite-organic tandem solar cells with promising theoretical efficiency. However, the certified efficiencies of reported perovskite-organic tandem solar cells remain lower than those of single-junction perovskite solar cells, primarily because of insufficient near-infrared photocurrent in narrow-bandgap organic subcells. Here we design and synthesize an asymmetric non-fullerene acceptor (NFA), P2EH-1V, featuring a unilateral conjugated π-bridge to reduce the optical bandgap to 1.

Engineering bonding sites enables uniform and robust self-assembled monolayer for stable perovskite solar cells.

The efficiency of perovskite solar cells has recently been dramatically improved by a self-assembled monolayer (SAM), but forming uniform, dense and especially stable SAM remains a challenge. The hydroxyl groups on indium tin oxide (ITO) serve as the bonding sites for the SAM molecule, directly determining the distribution and anchoring stability of SAM. We developed a solution-based strategy to fully hydroxylate the ITO in as fast as 15 s.

ASO Therapy Targeting STAU2 to Inhibit Pancreatic Ductal Adenocarcinoma Progression and Metastasis by Regulating the PALLD-Mediated EMT Signaling Pathway.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy marked by high morbidity, recurrence, and metastasis, with limited treatment options and poor prognosis. The challenge of early diagnosis and the inefficacy of current therapeutic strategies underscore the urgent need for novel biomarkers and therapeutic targets. RNA-binding proteins (RBPs) are emerging as critical regulators of post-transcriptional processes and are implicated in cancer progression.

Hypersensitive Multiparametric MRA for Mild Traumatic Brain Injury: Simultaneous Imaging of Hemorrhagic Foci, Vascular Integrity, and Collaterals.

Diagnosing mild traumatic brain injury (mTBI) remains a significant clinical challenge as many injuries are either invisible or difficult to detect with conventional medical imaging techniques. Here, an advanced multiparametric magnetic resonance angiography (MRA) strategy using biocompatible NaGdF nanoparticles is proposed for precise mTBI diagnosis. The NaGdF nanoparticles demonstrate excellent imaging performance due to their optimal hydrodynamic diameters and surface Gd ions.

Simultaneous Visualization of Anatomical Structure and Molecular Pathology Variation in Vascular Inflammation with Informationized Serum Albumin.

Vascular inflammation is a common dangerous factor in the pathogenesis of many prevalent diseases, such as sepsis, thrombosis, myocardial infarction, cerebral encephalitis, and stroke. Herein, a serum albumin-based nanoprobe has been developed for diagnosing vascular inflammation. As a paradigm of serum albumin, BSA is dually informationized by the TAFe complex and HA molecules, known as BSA-TAFe@HA nanoprobes.

Corrigendum: Autonomy support in telehealth: an evolutionary concept analysis.

[This corrects the article DOI: 10.3389/fpubh.2025.

Discovery of a Novel and Potent Transcription Inhibitor Targeting Promoter G-Quadruplex for the Treatment of NSCLC.

c-Met is a promising molecular target in oncological treatment, and related targeted therapy drugs have achieved inspiring results in clinical practice. However, the clinical emergence of acquired resistance to c-Met inhibitors in recent years presents a significant therapeutic challenge. In this study, we identified a novel transcriptional inhibitor, , which efficiently binds to the G-quadruplex in the promoter and suppresses the expression of c-Met.

Identification of novel drug targets through integrative PWAS of brain and plasma proteins with Ulcerative Colitis GWAS.

Previous genome-wide association studies (GWAS) have identified various risk variants for ulcerative colitis (UC), but there is a lack of evidence showing how these variants contribute to the development of UC. We employed an integrated pipeline to effectively translate genetic associations in order to identify pathogenic genes for UC.By combining GWAS data for UC with proteomic data from the human brain and plasma, we conducted a protein-wide association study (PWAS) and utilized protein-protein interaction (PPI) network analysis to screen for potential key proteins.

Arctiin, a lignan compound, enhances adipose tissue browning and energy expenditure by activating the adenosine A receptor.

Background: The activation of brown adipose tissue (BAT) or the browning of white adipose tissue (WAT) represents a promising therapeutic strategy for obesity. Arctiin (ARC), a lignan compound known for its anti-inflammatory, anti-tumor, and hypoglycemic properties, has not been fully elucidated regarding its effects and mechanisms on obesity.

Methods: In the present study, we established both high-fat diet-induced obese mouse models and mature adipocyte cultures to comprehensively investigate the therapeutic effects of ARC on obesity.

Effects of dezocine with ropivacaine on epidural analgesia during labor: a randomized controlled trial.

Background: Adding μ-opioid receptor agonists to local anesthetics are usually used for labor analgesia, while they are associated with pruritus. Kappa opioid agonists (dezocine) are widely used for pain management. Recently, they have emerged as a novel type of potent antipruritic agents.

Co-Doped ErFeO for Dual-Band Laser Absorption with High-Temperature Stability.

The development of multi-band laser suppression materials has been driven by the limitations of single-band laser suppression materials. Inorganic ceramic materials, compared with organic laser suppression materials, photonic crystals, and metamaterials, offer significant advantages in fabrication methods and environmental stability. In this study, Co ions, with relatively higher electronegativity, were introduced to substitute some Fe ion sites in ErFeO.

Machine Learning-Driven Insights for Phase-Stable FA Cs Pb(I Br ) Perovskites in Tandem Solar Cells.

The inherent chemical tunability of perovskite materials has spurred extensive research into composition engineering within the perovskite community. However, identifying the optimal composition across a broad range of variations still remains a significant challenge. Conventional trial-and-error methods are prohibitively expensive and environmentally taxing for comprehensive screening.