Factors influencing ethical decision-making in nursing: A mixed-methods systematic review.

BackgroundEthical decision-making in nursing significantly impacts population health, yet systematic analyses of factors influencing this process remain scarce.AimThe aim is to systematically evaluate factors influencing ethical decision-making in clinical care and provide a reference for follow-up nursing ethics education, medical institution management, and policy research in this field.Research DesignThis study was conducted using a mixed-methods systematic review design.

1+1>2: Synergistic Integration and Biomedical Applications of Nanozyme@Hydrogel Platforms.

Nanozyme-based therapies have shown substantial promise in antibacterial, anti-inflammatory, and anticancer applications. The success of nanozymes in these areas largely depends on strategies such as chemical modification, ligand coupling, or carrier encapsulation, which enhance their in vivo stability and catalytic activity. Hydrogels, characterized by their soft, water-swollen three-dimensional (3D) networks, possess unique features such as biodegradability, tunable physicochemical properties, and injectability.

Corrigendum to "Advances in sciatic nerve regeneration: A review of contemporary techniques" [Regen Ther, Volume 29C, (June 2025), 563-574].

[This corrects the article DOI: 10.1016/j.reth.

An enhanced bioluminescent probe for in vivo imaging of drug-induced apoptosis via acetylcholinesterase targeting.

Acetylcholinesterase has emerged as a compelling biomarker for optical imaging of tissue apoptosis. Existing AChE-targeted imaging approaches rely heavily on fluorescent probes, whose performance is often hindered by autofluorescence, light scattering, phototoxicity, photobleaching, and limited in vivo accuracy. Bioluminescence imaging, an intrinsic light-emitting modality that requires no external excitation, overcomes these limitations while offering superior sensitivity and applicability in living systems.

Vertically Aligned Mesoporous Arrays Catalyzing Long-Chain Polysulfide Conversion to Unlock High-Energy Magnesium-Sulfur Batteries.

Rechargeable magnesium-sulfur (Mg-S) batteries are attractive for next-generation energy storage systems owing to their safety and superior volumetric energy density. Nevertheless, the underlying origins of the severe shuttle effect in Mg-S batteries remain unclear, significantly limiting improvements in their electrochemical performance. Herein, insufficient MgS conversion kinetics is identified as the primary cause of the shuttle effect in Mg-S batteries.

Leukemia Burden Impacts the Efficacy and Toxicity of Blinatumomab in Pediatric B-Cell Acute Lymphoblastic Leukemia.

Background: Blinatumomab has been approved for the treatment of pediatric B-cell acute lymphoblastic leukemia (B-ALL). This study aimed to investigate the association between leukemia burden and the efficacy of blinatumomab in real-world applications.

Methods: A real-world study was conducted by enrolling patients aged 0-18 years who were diagnosed with CD19-positive B-ALL and treated with blinatumomab between January 2021 and May 2023 from 14 centers in China.

T-cell immunity in the experimental autoimmune vasculitis rat model.

ANCA-vasculitis (AAV) is a small-vessel vasculitis characterized by the presence of autoantibodies against proteinase-3 (PR3) or myeloperoxidase (MPO). The dynamics of the T-cell response within tissues is studied best in animal models. It was the aim to analyze the lesional T-cell dynamics in the experimental autoimmune vasculitis model.

TRIM31 triggers colorectal carcinogenesis and progression by maintaining YBX1 protein stability through ubiquitination modification.

Colorectal cancer (CRC) is one of the most common gastrointestinal tumors, and one of the leading causes of cancer-related deaths worldwide. However, the molecular mechanisms underlying CRC development and progression have not been fully elucidated until now. Emerging studies have shown that post-translational modifications of proteins, especially ubiquitination modifications, play an important role in tumorigenesis and progression.

Large-scale protein interactome reveals lineage-specific genes driving plant-parasitic nematode adaptive innovations.

Mounting evidence suggests that lineage-specific genes drive phenotype diversity. Plant-parasitic nematodes (PPNs), among the most destructive plant pathogens, have evolved innovated traits required for plant parasitism, yet the genetic basis remains unclear. Here, we identify PPN lineage-specific genes (PPNLSGs) and analyze the large-scale protein interactome of their encoded proteins (PPNLSPs).

Integrating AI into OLED material design: a comprehensive review of computational frameworks, challenges, and opportunities.

Artificial intelligence (AI) is profoundly reshaping the discovery and design of organic light-emitting diode (OLED) materials, shifting conventional intuition-driven development into an integrated, data-driven paradigm. The increasing demand for high-performance OLED emitters with ultra-narrow emission spectrum and enhanced operational stability has highlighted the urgent need for a dedicated, multi-scale computational framework tailored to OLED-specific challenges. This review proposes a systematic AI-driven framework that combines quantum chemistry calculations, property prediction models, and generative algorithms to enable high-throughput screening and inverse design workflows for organic luminescent materials.

Advancements and Perspectives in the Bioprosthetic Heart Valve: A Comprehensive Review on Biomaterial Processing and Emerging Polymeric Materials.

Heart valve disease contributes to cardiovascular disease-associated death. Bioprosthetic heart valves have emerged as a preferred option for heart valve replacement due to their superior hemodynamic performance and reduced need for lifelong anticoagulation. However, their long-term durability is compromised by calcification, immunogenicity, and structural degeneration, primarily due to glutaraldehyde fixation and residual xenogeneic antigens.

Multi-Omics approaches in gene therapy for vascular diseases: bridging genomics, transcriptomics, and epigenetics.

Vascular diseases such as atherosclerosis, aneurysms, and peripheral arterial disease remain leading causes of morbidity and mortality, with current treatments primarily managing symptoms rather than addressing underlying molecular drivers. Gene therapy offers a promising avenue for targeted intervention, and recent advances in multi-omics approaches-including genomics, transcriptomics, and epigenetics-are enhancing the precision and efficacy of these therapies. High-throughput sequencing and integrative omics analyses have facilitated the identification of causal genes, non-coding RNAs, and epigenetic regulators involved in vascular pathology.

A novel protein encoded by circUBE2G1 suppresses glycolysis in gastric cancer through binding to ENO1.

Gastric cancer (GC), a malignant neoplasm originating in the stomach epithelium, is characterized by substantial global incidence and mortality rates, posing a substantial threat to public health systems worldwide. The present study was designed to identify and validate a previously unannotated protein encoded by circular RNA (circRNA), with the principal objective of elucidating its functional significance and mechanistic basis in gastric carcinogenesis.CircUBE2G1 (hsa_circ_003239) was identified as a translationally active circRNA exhibiting significant downregulation in gastric cancer.

[Mechanism and Effect of Digital Economy Development on Ecological Resilience].

On the basis of importance that China attaches to the construction of ecological civilization and green development， this study analyzes the impact of digital economy development on ecological resilience by using the panel data of 286 cities at the prefecture level and above in China from 2011 to 2022. The results showed that the development of the digital economy could significantly improve the ecological resilience， and this result still held after a series of robustness tests. Furthermore， the enhancement effect of digital economy development on ecological resilience had a non-linear feature of marginal increase.

QTL detection and candidate gene identification for prostrate growth habit in interspecific crosses of wild chrysanthemum ( × ).

The prostrate growth habit is an important ornamental trait in ground-cover chrysanthemum, offering high aesthetic value, strong lodging resistance, and excellent landscape greening capability. However, the genetic basis underlying this trait in chrysanthemum remains largely unclear. In this study, we utilized the prostrate-type (tetraploid), the erect-type (tetraploid), and their 199 F hybrid progenies to construct a high-density genetic linkage map through genotyping-by-sequencing.

Revisiting Acyclovir Dosing for Adult Viral Encephalitis Using a Full Bayesian LeiCNS PBPK Modeling Approach.

Background And Objective: Acyclovir is a primary treatment for central nervous system (CNS) infections caused by herpes simplex virus (HSV) and varicella-zoster virus (VZV). However, patient outcomes remain suboptimal, despite acyclovir treatment. Given the lack of alternative therapies, there is a pressing clinical need to revisit acyclovir dosing for viral encephalitis.

The E3 ubiquitin ligase TRIM31 enhances the progression of esophageal cancer through the ubiquitination of BBOX1.

Esophageal cancer, a prevalent malignant neoplasm affecting the digestive system, is characterized by a poor prognosis and high rates of mortality and morbidity. The tripartite motif containing 31 (TRIM31) gene has been implicated in a variety of human cancers. However, little is known about its phenotypic expression and mechanistic role in esophageal cancer progression.

[Analysis of Risk Factors for Mortality of Children with Severe Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation].

Objective: To analyze the factors associated with mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with severe aplastic anemia (SAA).

Methods: The clinical data of 90 children with SAA who received allo-HSCT in the Department of Hematology, Wuhan Children's Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology from August 2016 to July 2023 were collected. The clinical features and causes of death were analyzed retrospectively.

[Prognostic significance of molecular minimal residual disease before and after allogeneic hematopoietic stem cell transplantation in children with acute myeloid leukemia].

Objectives: To investigate the prognostic value of molecular minimal residual disease (Mol-MRD) monitored before and after allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric acute myeloid leukemia (AML).

Methods: Clinical data of 71 pediatric AML patients who underwent HSCT between August 2016 and December 2023 were analyzed. Mol-MRD levels were dynamically monitored in MRD-positive patients, and survival outcomes were evaluated.

Effects of feeding on microbial community structure and pathogen abundance in marine aquaculture ponds.

Microbial communities in aquaculture ponds play a vital role in regulating water quality, driving nutrient cycling, and maintaining ecological balance. In 2023, we conducted a study to evaluate how feeding affects microbial communities by comparing the microbial composition and water quality in both fed and unfed aquaculture ponds. Metagenomic sequencing indicated that feeding significantly elevated the relative abundance of bacteria within the microbial community.

SSB cooperates with METTL16-mediated mA RNA methylation to promote chemoresistance in colorectal cancer cells.

mA RNA methylation is the most prevalent internal modification in mammalian mRNAs and is involved in many biological processes. METTL16 is a recently identified RNA mA methyltransferase. However, how METTL16 activity is regulated remains poorly understood.

A retrospective comparison of hyperbaric oxygen and core decompression for mild to moderate avascular necrosis of the femoral head.

JOURNAL/mgres/04.03/01612956-202603000-00001/figure1/v/2025-06-28T140100Z/r/image-tiff Avascular necrosis of the femoral head is a condition resulting from disrupted blood supply, leading to ischemia and bone tissue necrosis. Core decompression (CD) restores the blood supply through pressure relief, whereas hyperbaric oxygen (HBO) enhances tissue oxygenation and promotes bone repair.

Cesium Accumulation Patterns and Stress Response in Hydroponic Radish ( L.): A Physiological-Transcriptomic Study.

The present study systematically investigated the cesium (Cs) enrichment characteristics and physiological responses to Cs exposure in radish ( L.) seedlings under hydroponic conditions through integrated physiological, biochemical, and transcriptome analyses. The results showed that the Cs content in radish roots, stems, and cotyledons increased progressively with rising Cs concentrations (0.

GPC2-Targeted CAR T Cells Engineered with NFAT-Inducible Membrane-Tethered IL15/IL21 Exhibit Enhanced Activity against Neuroblastoma.

Neuroblastoma is a highly aggressive childhood solid tumor with poor outcomes. Chimeric antigen receptor (CAR) T cells have shown limited efficacy in neuroblastoma, with the best outcomes reported in patients with a low tumor burden, highlighting the need for further CAR optimization. One approach to addressing the high tumor burden involves engineering CAR T cells to release or express transgenic cytokines.

Efficient near-infrared harvesting in perovskite-organic tandem solar cells.

The broad bandgap tunability of both perovskites and organic semiconductors enables the development of perovskite-organic tandem solar cells with promising theoretical efficiency. However, the certified efficiencies of reported perovskite-organic tandem solar cells remain lower than those of single-junction perovskite solar cells, primarily because of insufficient near-infrared photocurrent in narrow-bandgap organic subcells. Here we design and synthesize an asymmetric non-fullerene acceptor (NFA), P2EH-1V, featuring a unilateral conjugated π-bridge to reduce the optical bandgap to 1.