Identifying the Oxidase-like Behavior of N-Doped Carbon Nanozymes via Postsynthetic Modification for Colorimetric Sensing.

N-doped carbon nanomaterials (NCMs) have attracted significant interest as metal-free nanozymes for sensing due to their exceptional stability and biocompatibility. However, the controversial active sites and catalytic pathways severely hinder the application of NCM-based nanozymes. Here, postsynthetic modification methods have been developed to study the catalytic mechanism, including selective deactivation, chemical grafting, and surface doping.

Geographical association of heavy metal exposure and semen quality: A national multi-center study.

Background: Assessing the adverse effects of geographical heavy metal mixture exposure on human semen quality is challenging. Our study aims to quantify the impact of these heavy metals on semen quality under both individual and combined exposures.

Methods: We recruited 32,072 reproductive-age men from ten human sperm banks across 31 provinces in China during the period from 2019 to 2022.

A qualitative study on the post-discharge self-management experiences and needs of patients with secondary lymphedema.

Guided by the Chronic Illness Trajectory Framework, this study aimed to explore the post-discharge self-management experiences of patients with secondary lymphedema following lymphovenous anastomosis surgery, providing evidence for developing targeted interventions. A descriptive phenomenological design was employed. Through purposive sampling, 16 participants who underwent lymphovenous anastomosis surgery were recruited in February 2025.

From Flue Gas to Syngas: Composite Electrode Based on Ionic Liquid and Microporous Polymer for MEA-Based CO Electrolysis.

The electrochemical CO reduction reaction (ECOR) offers a promising pathway to convert CO into value-added products. While catalyst advances remain crucial, gas-diffusion electrodes (GDEs) architecture is equally vital in CO electrolyzer design. Most ECOR studies use pure CO feeds, whereas industrial sources like flue gas contain ∼15% CO, requiring costly purification.

Toward Smart SiC Self-Powered Deep Ultraviolet Photodetectors.

The reasonable construction of a heterojunction is promising for wide bandgap semiconductors in smart self-powered deep ultraviolet (DUV) photodetection. In this work, PbI nanosheet (NS) is prepared directly on the wide bandgap semiconductor of a SiC wafer for the success construction of a type-II heterojunction by a simple drop-casting method. Benefiting from the built-in electric field at the heterojunction interface, the as-fabricated SiC type-II heterojunction photodetector exhibits enhanced DUV photoresponse compared to the SiC wafer and PbI NS photodetectors.

Global trends and future predictions of gastrointestinal ulcers in youth.

Background: By analyzing past disease trends and comparing two time series statistical models, we can predict the global burden of gastrointestinal ulcers in specific populations of adolescents and young adults aged 10-24. This prediction can provide important references for optimizing prevention and control strategies in healthcare systems.

Methods: We collected data on prevalence, incidence, disability-adjusted life years (DALYs), and mortality for specific age groups between 10 and 24 years from 1990 to 2019.

3D Covalent Organic Network Membranes With Regionally Ordered Nanochannels for Efficient Molecular Sieving.

Polymeric composite membranes hold significant promise for molecular sieving in organic solvents, yet struggle with the precise fractionation of small molecules, a critical need in the chemical and pharmaceutical industries. Here an innovative covalent organic network (CON) membrane featuring 3D interpenetrated ultra-microporous channels for effective fractionation of small-molecule solutes is presented. Rational utilization of unique tetrahedral amine (TAM) as aqueous-phase building blocks to crosslink with acyl chlorides yields CON polyamide thin films with finely tuned ordered porosity.

The Critical Role of Enhanced OXPHOS and Mitochondrial Hyperpolarization in Simulated Microgravity-Induced Oocyte Maturation Arrest.

Meiosis is essential for sexual reproduction, yet the impact of microgravity on oocyte maturation remains unclear, raising concerns for reproductive success in space environments. Here, it is examined the effects of simulated microgravity (SMG) on mouse oocytes and found that SMG impaired mitochondrial function, evidenced by elevated oxidative phosphorylation and mitochondrial membrane hyperpolarization, resulting in meiotic arrest. This response is distinct from that induced by other stressors or seen in somatic cells under microgravity, highlighting the unique sensitivity of oocytes.

The E3 ubiquitin ligase TRIM31 enhances the progression of esophageal cancer through the ubiquitination of BBOX1.

Esophageal cancer, a prevalent malignant neoplasm affecting the digestive system, is characterized by a poor prognosis and high rates of mortality and morbidity. The tripartite motif containing 31 (TRIM31) gene has been implicated in a variety of human cancers. However, little is known about its phenotypic expression and mechanistic role in esophageal cancer progression.

Fe-Co dual-sites p-d orbital hybridization: Electronic restructuring for accelerated oxygen evolution kinetics.

The sluggish anodic oxygen evolution reaction (OER) kinetics remains a critical bottleneck for sustainable hydrogen production via water electrolysis. Guided by Density Functional Theory (DFT) calculations, we engineered Fe-CoS/NiS dual-site catalysts where Co and Fe centers synergistically optimize p-d orbital hybridization to enhance OER kinetics. Operando analyses reveal Co as primary active sites facilitating rate-limiting OOH* → O desorption with Gibbs free energy (ΔG) reduced by 0.

Study on the mechanism of family resilience on loneliness in older adults with stroke.

Objective: This study examines loneliness in stroke patients who were ≥60 years of age, identifying key factors such as family resilience, social support, family function, and psychological capital.

Methods: We sampled 234 stroke patients who were ≥60 years of age. These patients were diagnosed with stroke (ischemic stroke, hemorrhagic stroke) by the hospital and their condition is stable in the recovery period.

Semiparametric regression analysis of panel binary data with a dependent failure time.

In health and clinical research, panel binary data from recurrent events arise when subjects are surveyed to report occurrence statuses of recurrent events over fixed observation windows. In practice, such data can be cut short by a dependent failure event such as death. For the analysis of panel binary data, tools from generalized linear models overlook the recurrence nature of panel binary data, and other relevant literature does not accommodate the failure time.

Demethylated miR-184 regulates EPB41L5 and downregulates Notch signaling to inhibit metastasis in colorectal cancer.

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with metastasis being a major contributor to poor prognosis. MicroRNA-184 (miR-184) has been implicated in the progression of various cancers, but its role in CRC metastasis remains poorly defined. This study investigated the effects of miR-184 promoter demethylation on EPB41L5 expression and Notch signaling in CRC.

Engineering Flow-Through Hollow Fiber Gas-Diffusion Electrodes for Unlocking High-Rate Gas-Phase Electrochemical Conversion.

Designing advanced electrodes with efficient contact with gas, electrolytes, and catalysts presents significant opportunities to enhance the accessibility of concentrated gas molecules to the catalytic sites while mitigating undesirable side reactions such as the hydrogen evolution reaction (HER), which advances the gas-phase electrochemical reduction toward industrial-scale applications. Traditional planar electrodes face challenges, including limited gas solubility and restricted mass transport. Although commercial flow-by gas-diffusion electrodes can reduce mass transfer resistance by enabling direct diffusion of gas molecules to active sites, the reliance on diffusive gas flow becomes insufficient to meet the rapid consumption demands of gas reactants at high current density.

Multi-omics analysis reveals the attenuation effect of C-phycocyanin on aging-induced subfertility in female mice.

Excessive inflammatory responses within the ovary are one of the main causes of subfertility in elderly women. Eliminating these responses can reverse fertility in aged individuals. Here, we demonstrate that administering 300 mg kg day C-phycocyanin (PC) to 36-week-old female mice for 45 days can reduce age-related fertility decline, resulting in an increase in litter size from 7.

Associations between urinary antibiotics exposure and semen parameters among adult men: A biomonitoring-based cross-sectional study.

Exposure to multiple antibiotics is inevitable among adult men. Nevertheless, biomonitoring-based epidemiological studies on urinary antibiotics exposure and semen quality are lacking. The current cross-sectional study aimed to examine the associations between urinary multiple antibiotic exposure and semen parameters in reproductive-age men.

Specific Detection of RHDV GI.1 and GI.2 by RT-LAMP-CRISPR/Cas12a Platform.

Rabbit hemorrhagic disease is a highly contagious and acute fatal disease caused by rabbit hemorrhagic disease virus (RHDV). The first outbreak of RHDV2 in 2020 has posed a serious threat to the rabbit breeding industry in China. An effective and specific detection strategy for RHDV GI.

Ovarian Endometriosis Accelerates Premature Ovarian Failure and Contributes to Osteoporosis and Cognitive Decline in Aging Mice.

Ovarian endometriosis (OEM) is a chronic inflammatory condition that impairs ovarian function. While its effects on ovarian reserve are well established, the long-term consequences of OEM on ovarian dysfunction, premature ovarian failure (POF), and systemic health, particularly in the context of accelerated aging, remain insufficiently studied. In this study, we employed an OEM mouse model and bulk RNA sequencing to investigate the underlying mechanisms.

Short-term changes in myocardial perfusion of the predominant donor vessel after percutaneous coronary intervention for chronic total occlusion.

Background: It remains unclear how rapidly the collateral circulation regresses after percutaneous coronary intervention (PCI) of chronic total occlusion (CTO). This study aimed to investigate the short-term changes of myocardial perfusion in the predominant donor vessel after successful CTO PCI.

Methods: A total of 68 patients who underwent single-photon emission computerized tomography (SPECT) assessment before and within 24-72 hours after successful CTO PCI were retrospectively included into this study.

In Situ Growth of Hierarchical Silver Sub-Nanosheets on Zinc Nanosheets-Based Hollow Fiber Gas-Diffusion Electrodes for Electrochemical CO Reduction to CO.

Electrochemical reduction of CO (CORR) is an effective strategy to mitigate carbon emission effects and store renewable electricity in value-added feedstocks, but it still suffers low production rate and current density. A nanostructured catalyst offers opportunities to enhance CORR activity by contributing numerous active sites and promoting charge transfer. Herein, a Cu hollow fiber gas diffusion electrode (HFGDE) with silver sub-nanosheets on a zinc nanosheet structure to produce CO is reported.

The transhiatal tunnel valvuloplasty technique following laparoscopic proximal gastrectomy: the single-center experience in a retrospective cohort.

Background: The debate over the optimal reconstruction technique following proximal gastrectomy continues. Transhiatal tunnel valvuloplasty (ThTV) is a novel esophagogastrostomy method. This study aimed to evaluate the feasibility and safety of ThTV.

Revealing impact of yeast-lactic acid bacteria cooperation in liquefaction pretreatment on enhancing anaerobic digestion performance of food waste.

Anaerobic digestion (AD) is a promising technology for food waste (FW) treatment and renewable energy recovery, yet hindered by its inefficiencies. This study proposed a cross-kingdom collaborative liquefaction pretreatment (LPT) using Bacillus (lactic acid bacteria, LAB) and yeast to enhance FW biodegradability and improve subsequent AD performance. LPT increased the soluble chemical oxygen demand (SCOD) by 113 %, with ethanol (11,903.

Smart Breath Sentinel: A NO Gas Sensor with ppt-Level Detection Lower Limit and High Signal-to-Noise Ratio Based on In(OH)-α-FeO-ZnO for an Application on Intelligent Upgrade of Ordinary Masks.

Nitrogen dioxide (NO), the main component of pollutants in atmospheric environments, causes and exacerbates respiratory diseases, especially during outdoor sports even at the 100 ppb level. Currently, environmental gas detection still faces challenges such as high detection limits, low SNR, and low sensitivity. A NO sensor based on In(OH)-α-FeO-ZnO was prepared using a hydrothermal method, featuring an ultralow detection limit of 82 ppt, an exceptionally high SNR of 574,000, and an ultrahigh sensitivity of 252.

Enteral nutrition therapy for elderly patients with common-type COVID-19, a retrospective study based on medical records.

Background: The objective was to investigate the implications of enteral nutrition for elderly patients with common-type coronavirus disease 2019 (COVID-19).

Methods: Data were retrospectively extracted from medical records. Enteral nutritional supplementation was recommended for patients with a nutritional risk score >3.

3D Printable Supramolecular Viologen-Cationic Polyurethane Ionotronics for Multimodal Sensing and Displays.

Ionic polyurethanes with excellent properties have garnered significant attention in flexible wearables. However, it is still challenging to achieve ionic polyurethane ionotronics with both excellent mechanical properties and functionalization. Here, a series of hydroxypropyl viologen (HDPV) cationic-based supramolecular polyurethane with tunable strength (7.