Macrophage hitchhiking for smart nanomedicine: Bridging immune navigation and targeted therapy.

The intrinsic abilities of macrophages, including innate homing, robust phagocytic capacity, and phenotypic plasticity, make them ideal candidates for targeted drug delivery. By utilizing macrophages as carriers, nanoparticles can be precisely transported to specific physiological sites, enhancing therapeutic efficacy and minimizing off-target effects. This strategy, known as the "macrophages hitchhiking", leverages the natural capabilities of macrophages to traverse biological barriers.

Bibliometric Analysis of Nanomaterials for Spinal Cord Injury Repair.

This bibliometric analysis, conducted on 735 publications from the Web of Science Core Collection database up to April 16, 2025, sheds light on the evolving landscape of nanomaterials in spinal cord injury (SCI) repair. Utilizing tools such as Bibliometrix, VOSviewer, and CiteSpace, the study reveals a significant and exponential growth in literature within this field since 2020, marked by an impressive average annual increase of 13.16%.

Tough, Antibacterial, and Antithrombogenic Hydrogel Coatings for Blood-Contacting Silicone Medical Devices.

Silicone medical devices are widely used as various medical devices due to their excellent advantages when compared with petroleum-derived polymers. Thrombosis and bacterial infections are two vital challenges of blood-contacting silicone devices. The traditional strategies used for contact antibacterial silicone typically facilitate thrombosis due to electrostatic interactions.

An amorphous Li-V-O-F cathode with tetrahedral coordination and O-O formal redox at low voltage.

The ever-increasing demand for lithium-ion batteries has necessitated the development of high-performance cathode materials. However, previous studies have predominantly focused on crystal cathodes comprising the octahedral coordination of metal atoms and a well-ordered layered topology. This omits other cathode materials with other structures or coordination that could potentially surpass conventional counterparts in terms of performance.

The Critical Role of Enhanced OXPHOS and Mitochondrial Hyperpolarization in Simulated Microgravity-Induced Oocyte Maturation Arrest.

Meiosis is essential for sexual reproduction, yet the impact of microgravity on oocyte maturation remains unclear, raising concerns for reproductive success in space environments. Here, it is examined the effects of simulated microgravity (SMG) on mouse oocytes and found that SMG impaired mitochondrial function, evidenced by elevated oxidative phosphorylation and mitochondrial membrane hyperpolarization, resulting in meiotic arrest. This response is distinct from that induced by other stressors or seen in somatic cells under microgravity, highlighting the unique sensitivity of oocytes.

Charged Water Enables the Determination of Inherited Metabolic Diseases by Mass Spectrometry.

Inherited metabolic diseases (IMDs) have drawn considerable attention due to their disruption of normal metabolic pathways. However, conventional extraction techniques are predominantly offline and time-consuming, making them inadequate for the rapid screening required in clinical settings. We developed a novel method involving the extraction of dried sample spots, which are subsequently mixed with charged water (HO) before infusion electrospray ionization-mass spectrometry analysis.

One-Step Strategy to Synthesize Sulfonic Acid-Functionalized Silica Chromatographic Stationary Phases for Separation of Rare-Earth Elements.

Separation and analysis of rare-earth elements (REEs) with impurities are challenging processes. Ion-exchange chromatography has emerged as a valuable technology for rare-earth separation, and developing a simple and efficient preparation method for stationary ion-exchange chromatography remains a hot topic. In this study, a sulfonic acid-modified silica stationary phase was synthesized through a facile one-step strategy, where 1,3-propanesultone reacted with the silanol group.

An improved SMOTE algorithm for enhanced imbalanced data classification by expanding sample generation space.

Class imbalance in datasets often degrades the performance of classification models. Although the Synthetic Minority Over-sampling Technique (SMOTE) and its variants alleviate this issue by generating synthetic samples, they frequently overlook local density and distribution characteristics. Consequently, developing methods that incorporate local spatial information to synthesize samples that better preserve the original data distribution is critical for improving model robustness in class-imbalanced scenarios.

Staphylococcus aureus Promotes Cutaneous Lesions in Patients With Epidermolysis Bullosa.

Epidermolysis bullosa (EB) is a group of rare, heterogeneous congenital conditions characterised by epidermal fragility, resulting in blister formation and lesions. Patients with EB are prone to developing cutaneous wounds. However, the composition of the EB skin microbiome in Chinese individuals remains poorly understood.

Local Visible-Photocatalytic Production of Hydrogen and Warm Heat for Combination Treatment of Pressure Ulcer.

Pressure ulcer (PU) is hardly cured due to repeated pressures-induced serious ischemia-reperfusion injury (IRI), poor microcirculation, and chronical inflammation. Hydrogen molecule (H) is proved as an emerging anti-inflammatory and anti-IRI agent with high biological safety, while local warm heating is well identified and able to improve tissue microcirculation for promoting wound repair. This work proposes a new strategy of visible-photocatalytic hydrogen/warm heat production for combination treatment of PU, and develops palladium nanodots-deposited hydrogen-doped titanium dioxide nanorod (HTON-Pd) as a novel multifunctional photocatalyst, achieving controllable and sustainable visible-photocatalytic production of H and heat.

Safety and efficacy of systemic chemotherapy plus PD-1 inhibitor in combination with intravenous or intraperitoneal bevacizumab in gastric cancer with peritoneal metastasis.

Background: For gastric cancer patients, peritoneal metastasis poses a life-threatening risk due to the high incidence of treatment failure and disease recurrence. Conducting additional research aimed at identifying more efficacious strategies is imperative for enhancing treatment outcomes. This study examined the efficacy and safety of systemic chemotherapy plus a PD-1 inhibitor combination with intravenous or intraperitoneal bevacizumab for gastric cancer with peritoneal metastasis.

Flexible phosphonium and sulfonate pair-to-pair self-assembled ionic organic single crystals for iodine capture.

In this work, four flexible chain phosphonium-based ionic organic single crystals (IOCs) are first facilely prepared by pair-to-pair ionic self-assembly of phosphonium salts and sulfonic acids (salts) under mild conditions. Their structures, morphology, stability, and surface areas are characterized in detail. Featuring a wealth of sulfonate and phenyl groups as powerful active sites for iodine adsorption, these materials exhibit considerable capture capacities.

Enhancing Magnon-Magnon Coupling Strength to 0.6 GHz in Dion-Jacobson Cu(II)-Hybrid Perovskites by Tuning the Topology of Ligands.

Copper(II) hybrid organic-inorganic perovskites (HOIPs) offer a unique platform to explore magnetic interactions responsible for ferro- or antiferromagnetic order; yet, their potential for coherent magnon dynamics, a cornerstone of spintronic technologies, remains underdeveloped. Unlike conventional ferromagnets, the structural parameters influencing magnon generation, propagation, and control in HOIPs are poorly understood. Here, we engineer interlayer and intralayer exchange interactions in A-type Dion-Jacobson (DJ) phase Cu(II)-based HOIPs to achieve robust magnon-magnon coupling.

Feasibility, reproducibility, and prognostic value of a fully automated measurement of left ventricular longitudinal strain in heart transplant recipients.

Aims: Left ventricular longitudinal strain (LVGLS) is a robust parameter for predicting adverse events in patients who have undergone a heart transplant (HTx). However, measuring LVGLS is time-consuming and operator-dependent. Thus, we investigated whether automated strain software for LVGLS measurement has feasibility, reproducibility, and prognostic value in patients who underwent an HTx.

Carbohydrate-derived nano-antioxidant for attenuating myocardial ischemia-reperfusion injury.

Myocardial ischemia‒reperfusion injury (MIRI) is a critical factor that impacts the efficacy of reperfusion therapy in treating ischemic cardiomyopathy and the posttransplant outcomes of heart transplant patients. Excessive production of reactive oxygen species (ROS) is a significant contributor to the pathological progress of MIRI. Reducing ROS production can effectively alleviate MIRI.

Relationship Between Sleep and Cognitive Frailty in Older Adults: A Systematic Review and Meta-Analysis.

Aim: To explore the relationship between sleep and cognitive frailty in older adults.

Design: A systematic review and meta-analysis.

Data Sources: The Web of Science, Cochrane Library, CINAHL, Embase, PsycINFO and PubMed databases were searched from inception to October 28, 2024.

Identification of the Central Symptoms of Multidimensional Frailty Among Older Adults Using the Tilburg Frailty Indicator: A Network Analysis.

Background: Symptom networks offer a new approach to explore the relationships among various symptoms and provide information for optimising precise symptom management strategies. However, no previous studies have identified the central symptoms of multidimensional frailty.

Design: A cross-sectional study was conducted from December 2023 to March 2024 in China.

Notch signaling pathway regulates the progression of fetal growth restriction through mediating immune dysfunction.

Fetal growth restriction (FGR) is associated with an increased risk of neonatal morbidity and mortality, as well as the development of metabolic syndrome in adulthood. The present study investigated the regulatory mechanisms of Notch signaling in FGR progression. The expression levels of Notch1 and Jagged1 were determined using reverse transcription-quantitative PCR, western blotting, immunofluorescence staining and immunohistochemistry (IHC).

A novel synthesised STAT3 inhibitor exerts potent anti-tumour activity by inducing lysosome-dependent cell death.

Background And Purpose: Signal transducer and activator of transcription 3 (STAT3) has emerged as a promising therapeutic target for triple-negative breast cancer (TNBC) and multiple myeloma (MM), yet no STAT3-selective drugs have been approved for clinical use.

Experimental Approach: Newly synthesized compounds were screened by docking, surface plasmon resonance (SPR) and cellular thermal shift assay (CETSA) to measure the binding activity with STAT3. RNA-Seq, luciferase assays, western blot and immunofluorescence assays were conducted to detect the impact of RDp002 on STAT3 signalling.

A Multifunctional Hydrogel Microneedle Patch for Treatment of Atopic Dermatitis.

Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition caused by immune dysregulation, oxidative stress, and bacterial invasion in the pathogenesis. Currently, oral administration of immunosuppressants such as cyclosporine and the topical application of corticosteroids are the primary treatment approaches for alleviating AD symptoms. However, these treatments have limitations associated with therapeutic efficacy and side effects.

Ovarian Endometriosis Accelerates Premature Ovarian Failure and Contributes to Osteoporosis and Cognitive Decline in Aging Mice.

Ovarian endometriosis (OEM) is a chronic inflammatory condition that impairs ovarian function. While its effects on ovarian reserve are well established, the long-term consequences of OEM on ovarian dysfunction, premature ovarian failure (POF), and systemic health, particularly in the context of accelerated aging, remain insufficiently studied. In this study, we employed an OEM mouse model and bulk RNA sequencing to investigate the underlying mechanisms.

Microbial inoculant accelerated pig slurry maturation at low-temperature anaerobic digestion: Performance and mechanism.

This study investigated the impact of microbial inoculants on maturing pig slurry during anaerobic digestion (AD) at psychrophilic temperatures (10 °C). A simulation experiment was conducted with two treatments: pig slurry alone (CK) and pig slurry supplemented with microbial inoculants (MA). The MA treatment achieved faster maturity than CK, as evidenced by an improved germination index (achieving 70 % in advance) and a reduced content of organic pollutants, which was attributed to an increased relative abundance of hydrolytic microorganisms (7-21 %) and decreased pathogens (6-9 %) at the early stage (<42 (d)).