SSB cooperates with METTL16-mediated mA RNA methylation to promote chemoresistance in colorectal cancer cells.

mA RNA methylation is the most prevalent internal modification in mammalian mRNAs and is involved in many biological processes. METTL16 is a recently identified RNA mA methyltransferase. However, how METTL16 activity is regulated remains poorly understood.

The effect of match-play on acute post-match neuromuscular fatigue following Australian Football League Women's (AFLW) competition.

The Australian Football League Women's (AFLW) is the premier national women's competition in Australian Rules football. The aim of this exploratory study was to investigate the neuromuscular fatigue response to match-play and the external load correlates of this response in AFLW. Players (n = 22) wore a 10 Hz GNSS device and completed immediately pre- and post-match countermovement jumps (CMJ) on dual force plates for each match in the 2022 AFLW competitive season.

Client Perspectives on Addressing Intimacy, Romance and Sexuality in Early Psychosis Intervention Programmes.

Objective: This study investigated the perspectives of clients in early psychosis intervention programmes regarding the types, quality and relevance of information they desire and receive, particularly related to intimacy, romance and sexuality.

Methods: Participants (N = 35) rated the degree to which they desired and received information on topics related to treatment and recovery, as well as the quality and importance of that information.

Results: Between 25% and 50% of participants desired information on friendships, sexual functioning, sexual desire, sexual risk factors and romantic relationships.

Community readiness to address disparities in access to cancer, palliative and end-of-life care for ethnic minorities.

Background: Inequalities in cancer, palliative, and end-of-life care services remain a significant challenge, particularly for ethnic minorities who face systemic barriers such as limited awareness, cultural stigmas, and language differences. These disparities hinder equitable access to essential services and contribute to poorer health outcomes for affected communities. Addressing these challenges requires targeted, culturally sensitive initiatives that promote both awareness and uptake of care.

Exploratory study from an end-of-life research partnership network to improve access for ethnically diverse communities in one region.

Background: Minority ethnic patients are less likely to access timely and effective palliative and end-of-life care and, as a consequence, more likely to experience poorer symptom management and receive more intensive treatments at the end of life. Research activity has the potential to address the aforementioned barriers to improve access. However, there is a need to develop capacity and capability, particularly within underserved communities, to provide an infrastructure that can drive research activity informed by the community to benefit the community.

Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity.

Here, we show that vitamin E succinate (VES) acts as a degrader for the mA RNA demethylase fat mass and obesity-associated protein (FTO), thus suppressing tumor growth and resistance to immunotherapy. FTO is ubiquitinated by its E3 ligase DTX2, followed by UFD1 recruitment and subsequent degradation in the proteasome. VES binds to FTO and DTX2, leading to enhanced FTO-DTX2 interaction, FTO ubiquitination, and degradation in FTO-dependent tumor cells.

Investigating social orienting in children with Phelan-McDermid syndrome and 'idiopathic' autism.

Background: Phelan-McDermid syndrome (PMS) is a rare genetic syndrome characterized by developmental delay/intellectual disability, absent or delayed speech, physical dysmorphic features and high rates of autistic features. However, it is currently unknown whether people with PMS have similar neurocognitive atypicalities to those previously identified in idiopathic autism. Disruption in social orienting has previously been suggested as an early hallmark feature of idiopathic autism that impacts social learning and social interaction.