Design and Application of Risk Evaluation Index System for the Safety of Household Gas Appliances Based on AHP-Fuzzy Model.

With China's emphasis on and promotion of gas development, gas has become one of the indispensable energy sources in people's lives. The study found that there are still some gaps in the safety risk field of household gas appliances. This paper proposes the design of a risk evaluation index system for the safety of household gas appliances.

Portable NIR spectroscopy for on-site origin discrimination and alkaloid quantification in roots.

Given the critical importance of field harvesting, market supervision, and quality control during plants processing, the demand for rapid and reliable screening tools has become increasingly urgent to ensure quality and safety throughout the entire medicinal plants supply chain. In this study, we developed a novel portable near-infrared (NIR) spectroscopy-based system integrated with multiple chemometric techniques for the rapid and non-destructive discrimination of geographical origin and quantitative prediction of alkaloid components in medicinal plant roots. Using as a case study, we validated the effectiveness and practicality of this in-field testing approach.

5-17 μm few-cycle mid-infrared continuum through intra-pulse difference frequency generation in a BaGaGeSe crystal driven at 2.4 μm.

BaGaGeSe (BGGSe) is a newly developed long-wavelength infrared (LWIR) nonlinear material that exhibits unique advantages in broadband infrared generation, attributed to its wide transmission range, large nonlinear coefficient, high laser damage threshold, and low dispersion property. Here, we systematically investigate the optimal intra-pulse difference-frequency generation process in BGGSe for an ultra-broadband LWIR output, by employing a tunable optical parametric amplifier as driving sources at the wavelengths of 2.0, 2.

Adsorptive Removal Behavior of Two Activated Carbons for Bis(2-ethylhexyl) Phosphate Dissolved in Water.

Bis(2-ethylhexyl) phosphate (P204) is widely used in extraction processes in the nuclear and rare earth industries. However, its high solubility in water results in high levels of total organic carbon and phosphorus in aqueous environments, and may also lead to radioactive contamination when it is used to combine with radionuclides. In this paper, we characterized a coconut shell activated carbon (CSAC) and a coal-based activated carbon (CBAC) for the adsorption of P204 and then evaluated their adsorption performance through batch and column experiments.

Multifunctional Hydrogel Materials for Advanced Neural Interfaces.

Conventional rigid neural electrodes mismatch the soft, wet nature of neural tissue, hindering long-term stable interfaces. Multifunctional hydrogels, with their tissue-like compliance, ionic conductivity, and biocompatibility, offer a promising solution to bridge bioelectronic systems and neural tissues. This review systematically examines critical hydrogel properties-mechanical compliance, adhesion, biocompatibility, conductivity, and injectability-for neural interfacing.

Using Machine Learning to Identify the Dynamic Evolution Patterns of Negative Emotions in Perinatal Women: A Longitudinal Study in Southwest China.

Paying attention to the mental health of perinatal women is helpful in improving their quality of life. However, the existing research pays less attention to the heterogeneity of its negative emotional trajectory and the identification of high-risk groups. This study recruited 860 perinatal women from four large hospitals in Chongqing from March 2018 to January 2019.

FTO degrader impairs ribosome biogenesis and protein translation in acute myeloid leukemia.

Targeting ribosome biogenesis and protein translation has emerged as a promising avenue for cancer therapy. The fat mass and obesity-associated protein (FTO), an RNA -methyladenosine (mA) eraser, has been identified as an oncogenic factor in acute myeloid leukemia (AML). Here, we present the development of an FTO degrader that selectively degrades FTO in AML cells, demonstrating superior efficacy both in vitro and in vivo.

Revealing the effects of withering methods and withering time on the active components of mulberry leaf tea using HS-SPME/GC-MS.

In this study, color difference analysis, headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry and high-performance liquid chromatography with diode array detection were employed to systematically evaluate the effects of three withering methods-natural withering, sunlight withering (SW), and warm-air withering (WW)-as well as different withering durations (1-4 h), on the active components and appearance quality of mulberry leaf tea. The results demonstrated that, compared with other withering treatments, WW induced more pronounced changes in color, resulted in a higher tea polyphenols content, and more effectively preserved non-volatile compounds. In contrast, SW was associated with a higher total flavonoid content.

Inhibitory activity and mechanism of aryl furan thioesters containing 1,3,4-thiadiazole against Erwinia amylovora.

Background: The Gram-negative bacterium Erwinia amylovora induces fire blight disease in Rosaceae hosts, severely damaging pome fruit trees including pear, apple, and hawthorn cultivars. Traditional control methods, such as antibiotics and copper-based agents, are associated with plant damage and the emergence of resistant bacterial strains, and present significant challenges. This study aims to design and synthesize a novel eco-friendly bactericide.

Impacts of the Conductive Networks on Solid-State Battery Operation.

The micromorphology of composite cathodes is known to play a vital role in determining all-solid-state battery (ASSB) performance. However, much of our current understanding is derived from empirical observations, lacking a deeper mechanistic foundation. The "rocking chair" concept of battery chemistry requires maintaining charge neutrality, emphasizing the necessity of examining electrode micromorphology from the perspective of conductive networks.

Data-Driven Distributed Fault Detection and Fault-Tolerant Control for Large-Scale Systems: A Subspace Predictor-Assisted Integrated Design Scheme.

Considering the influence of subsystem state interconnection in large-scale systems, the existing integrated design methods of data-driven fault detection (FD) and fault-tolerant control (FTC) that follow centralized architecture cannot be applied in distributed scenarios. To address this problem, this article proposes a subspace predictor-assisted framework to perform the data-driven integrated design of FD and FTC for large-scale systems. FD and FTC are organically combined through a subspace predictor framework.

Plasma membrane CYBDOM proteins catalyse apoplastic AsA regeneration and interact with RbohD to activate autophagy and drought tolerance in plants.

Autophagy and apoplastic ascorbic acid (AsA) play important roles in plant drought tolerance. However, the trans-plasma membrane transport of AsA and its association with autophagy during drought stress are unclear. Here we report an AsA-induced autophagy pathway in plants, wherein plasma-membrane-located cytochrome b561 and DOMON domain (CYBDOM) proteins play positive roles.

Influence of Immune Cells on Corneal Nerve Morphological Analysis and Clinical Relevance in Diabetes-Related Dry Eye.

Purpose: Corneal nerve morphology and immune cells are critical biomarkers in the ocular surface. This study aimed to investigate the influence of immune cells on corneal nerve morphology and the clinical significance in diabetes-related dry eye disease (DED).

Methods: In the first part, 1075 in vivo confocal microscopy images containing dendritic cells or round cells were included as system validation.

Systematic elucidation of the effective constituents and potential mechanisms of against neoplasm based on LC-MS, network pharmacology, and molecular docking approaches.

is a traditional Chinese medicine used to treat neoplasms in previous publications. Nevertheless, how the chemical constituents treat neoplasm still needs to be clarified. Herein, we combined the response surface method, UPLC-ESI-MS/MS, network pharmacology, molecular docking, and molecular dynamics (MD) simulation to characterize bioactive constituents in and further uncover their potential mechanisms against neoplasm.

Optimization and Evaluation of Colchicine Patch Formulation Based on Box-Behnken Design.

This study aimed to optimize colchicine (COL) transdermal patches to enhance key quality attributes, including adhesion, drug release, and transdermal penetration. The goal was to develop a formulation with improved performance based on BOX-Behnken Design (BBD) optimization. The BBD method was used to design experiments evaluating the effects of three key variables: COL content, penetration enhancer content (azone and propylene glycol), and the solvent evaporation time at 80 °C.

A machine-learning-powered spectral-dominant multimodal soft wearable system for long-term and early-stage diagnosis of plant stresses.

Addressing the global malnutrition crisis requires precise and timely diagnostics of plant stresses to enhance the quality and yield of nutrient-rich crops, such as tomatoes. Soft wearable sensors offer a promising approach by continuously monitoring plant physiology. However, challenges remain in identifying direct physiological indicators of plant stresses, hindering the development of accurate diagnostic models for predicting symptom progression.

Virus-Inspired Nanoparticles for Intensified Cancer Therapy via Cascade Reinforcement of "Nontoxicity-to-Toxicity" Transition and Mitochondrial Dysfunction.

Mitochondria play an essential role in cellular oxidative stress defense. Mitochondrial impairment results in disrupted intracellular redox balance and tumor cell apoptosis. Herein, a biodegradable nanoprobe for combination chemotherapy is constructed by developing a virus-like mesoporous copper oxide nanocage co-loaded with disulfiram (DSF) and berberine (BBR) to amplify oxidative stress.

The Prevalence and Risk Factors of Residual Back Pain After Vertebroplasty for Osteoporotic Vertebral Compression Fractures: A Systematic Review and Meta-Analysis.

Background: Osteoporotic vertebral compression fractures (OVCFs) are prevalent among the elderly. Percutaneous vertebroplasty (PVA) is a commonly adopted minimally invasive treatment, yet many patients endure residual back pain (RBP) posttreatment, affecting their recovery and quality of life. Given the inconsistent prevalence of RBP across studies and the multitude of influencing factors, a systematic review and meta-analysis is necessary to determine its prevalence and identify risk factors.

Adulteration identification strategy for Acanthopanax Senticosus based on data fusion of portable mass spectrometry and near-infrared spectroscopy.

Acanthopanax senticosus is extensively studied worldwide. Due to high price, illegal activities, particularly adulteration, have proliferated. To identify adulterated Acanthopanax senticosus, it is necessary to target both the high content of quality-related compounds and the overall physical and chemical properties.

A Cross-Sectional Study on the Biomechanical Effects of Squat Depth and Movement Speed on Dynamic Postural Stability in Tai Chi.

This study aimed to explore the independent and interactive effects of varying squat depths and movement speeds on dynamic postural stability during the Part the Wild Horse's Mane (PWHM) movement. Thirteen male participants (age: 25.86 ± 1.

A Multi-omics approach combining GC-MS, LC-MS, and FT-NIR with chemometrics and machine learning for metabolites systematic profiling and geographical origin tracing of Artemisia argyi Folium.

Artemisia argyi Folium (AAF) is a widely used functional aromatic medicinal plant with significant health, culinary, and therapeutic value. However, geographical variations in environmental factors notably affect its metabolite production, making comprehensive analysis of AAF quality essential. This study aims to systematically characterize AAF from different geographical regions in China using a multi-omics analysis platform.

Mechanism Exploration of Spider-Silk-Inspired Multiple-Hydrogen-Bond Polyurethane Healable Elastomers for Anticorrosion.

Spider-silk-inspired multiple-hydrogen-bond polyurethane (PU) healable elastomers have garnered significant attention across various industries. While individual hydrogen bonds are relatively weak, their collective cooperation generates strong interaction forces with geometrically hydrogen-bond-confined arrays. Under the guidance of this discovery, the synthesized PU elastomer (PU-MDI) had superior mechanical characteristics and a self-healing efficiency of 98%, which can provide a robust barrier to effectively delay the penetration of corrosive ions and resist external impact energy dissipation.

A new strategy for nanosuspension stabilizer screening based on computer-aided drug design and molecular self-assembly.

The aim of this study is to elucidate the principles of surfactants and polymer stabilized nanosuspensions (NS) from a molecular perspective, and to develop a new strategy for screening NS stabilizers based on molecular self-assembly. Through comparing the results of two virtual screening strategies (molecular self-assembly and molecular docking) and real experiments, it was found that molecular dynamics simulations -based molecular self-assembly could screen the stabilizers suitable for NS more accurately. Because, compared to the static binding molecular docking (MD) technique, molecular dynamics simulation (MDS) is able to simulate the nanoparticle formation process more realistically.

Development, Characterization, and Molecular Dynamics Simulation of Andrographolide Nanosuspensions Utilizing Hummer Acoustic Resonance Technology.

Andrographolide (AG) is a diterpenoid lactone, widely recognized for its potent anti-inflammatory and immunomodulatory properties. However, AG's clinical applications are significantly limited due to its poor water solubility. The aim of this study was to rapidly develop an andrographolide nanosuspension (AG-NS) using Hummer Acoustic Resonance (HAR) technology to enhance AG's solubility.

Improved sampling efficiency of volatile halomethoxybenzenes and persistent organic pollutants reveals increasing concentrations in Canadian air.

Two long-term air monitoring programs for persistent organic pollutants (POPs) have been established in the Great Lakes Basin (GLB), Ontario, and Alert, Nunavut, Canada since the 1980s for evaluating regional and long-range transport (LRT) dynamics. With growing attention towards Chemicals of Emerging Arctic Concern (CEACs), including volatile halomethoxybenzenes (HMBs) and POPs, these programs have been expanded to monitor CEACs, which can experience significant sampling breakthrough due to their high volatility. To improve collection efficiency, a high-volume air sampler utilizing a polyurethane foam-XAD2 resin sandwich was implemented for concentration characterization at the Alert and GLB sites.