Optimization and Evaluation of Colchicine Patch Formulation Based on Box-Behnken Design.

This study aimed to optimize colchicine (COL) transdermal patches to enhance key quality attributes, including adhesion, drug release, and transdermal penetration. The goal was to develop a formulation with improved performance based on BOX-Behnken Design (BBD) optimization. The BBD method was used to design experiments evaluating the effects of three key variables: COL content, penetration enhancer content (azone and propylene glycol), and the solvent evaporation time at 80 °C.

Development, Characterization, and Molecular Dynamics Simulation of Andrographolide Nanosuspensions Utilizing Hummer Acoustic Resonance Technology.

Andrographolide (AG) is a diterpenoid lactone, widely recognized for its potent anti-inflammatory and immunomodulatory properties. However, AG's clinical applications are significantly limited due to its poor water solubility. The aim of this study was to rapidly develop an andrographolide nanosuspension (AG-NS) using Hummer Acoustic Resonance (HAR) technology to enhance AG's solubility.

Preparation and characterization of andrographolide nano-cocrystals using hummer acoustic resonance technology.

Andrographolide (AG) is a diterpene lactone with significant anti-inflammatory and antitumor activities. However, the poor water solubility limits its clinical application. An andrographolide-salicylic acid (AG-SLA) nano-cocrystal delivery system was rapidly developed using hummer acoustic resonance (HAR) technology in this research.

Identification and Fungicide Screening of Fungal Species Associated with Walnut Anthracnose in Shaanxi and Liaoning Provinces, China.

Walnut is cultivated around the world for its precious woody nut and edible oil. Recently, walnut infected by spp. resulted in a great yield and quality loss.

Reduced Sensitivity to Tebuconazole in Isolates Collected from Major Apple Production Areas of China.

China has the largest acreage and is the greatest producer of apples in the world. Apple ring rot (ARR) caused by is one of the major diseases affecting apple fruit production. Tebuconazole, a sterol demethylation-inhibiting (DMI) fungicide, has been increasingly applied to manage ARR in China.

Population genetic diversity in Chinese pomegranate (Punica granatum L.) cultivars revealed by fluorescent-AFLP markers.

Eighty-five pomegranate (Punica granatum L.) cultivars from six geographical populations located at Shandong, Anhui, Shaanxi, Henan, Yunnan, and Xinjiang Provinces were studied for its population genetic diversity by means of fluorescent-AFLP markers. The results indicated that 135-185 polymorphic loci were amplified by eight pairs of primers at species level.