Genome-wide identification of in and the role of in rubber biosynthesis.

Oliv., a Tertiary period relict tree species endemic to China, is a rubber-producing plant valued for both medicinal and edible applications. rubber is a high-quality natural rubber prized for its excellent elasticity, abrasion resistance, and insulation properties, leading to broad industrial applications.

Whole-genome methylation profiling of extracellular vesicle DNA in gastric cancer identifies intercellular communication features.

Extracellular vesicles (EVs) are promising biomarkers for cancer diagnosis and prognosis due to their ability to carry specific biomolecular cargo, including DNA. However, the clinical utility of DNA methylation-based liquid biopsies using EV-DNA remains underexplored. The low quantity and relatively long length of EV-DNA complicate whole-genome methylation profiling.

Adsorptive Removal Behavior of Two Activated Carbons for Bis(2-ethylhexyl) Phosphate Dissolved in Water.

Bis(2-ethylhexyl) phosphate (P204) is widely used in extraction processes in the nuclear and rare earth industries. However, its high solubility in water results in high levels of total organic carbon and phosphorus in aqueous environments, and may also lead to radioactive contamination when it is used to combine with radionuclides. In this paper, we characterized a coconut shell activated carbon (CSAC) and a coal-based activated carbon (CBAC) for the adsorption of P204 and then evaluated their adsorption performance through batch and column experiments.

AlCl-mediated "Heine-type" ring-opening of -cyclopropylamides for the synthesis of 5-methyl-2-oxazolines.

A ring-opening rearrangement reaction of -cyclopropylamides is shown to occur in the presence of AlCl. The mechanism proposed herein involves the "Heine-type" aziridine intermediate and C-Cl or C-O bond formation. This protocol provides quick access to -(2-chloropropyl)amides and 5-methyl-2-oxazolines using simple and readily available starting materials.

Impact of Co-Fermentation on the Soluble Pentosan, Total Phenol, Antioxidant Activity, and Flavor Properties of Wheat Bran.

Most wheat bran in China is used as animal feed due to its coarse taste. However, fermentation can degrade cellulose in wheat bran, improving its taste and flavor. The effects of co-fermentation with and on wheat bran remain unclear.

Application of Microwave Ablation Combined With Chai Hu Qing Gan Tang in the Treatment of Idiopathic Granulomatous Mastitis.

To investigate the efficacy of microwave ablation (MVA) combined with Chai Hu Qing Gan Tang (CHQGT) for idiopathic granulomatous mastitis (IGM). 480 patients were divided into the CHQGT combination group (CHQGT + MVA), corticosteroid combination group (glucocorticoids + MVA) and control group (glucocorticoids), with 160 cases in each group. Data on patient information, treatment effects, adverse effects and breast appearance were collected.

Exploring the association between volatile organic compound exposure and chronic kidney disease: evidence from explainable machine learning methods.

Background: Chronic Kidney Disease (CKD) affects approximately 697.5 million people worldwide. Volatile organic compounds (VOCs) are emerging as potential risk factors, but their complex relationships with CKD may be underestimated by traditional linear methods.

Recent developments in matrine as a versatile molecular scaffold in small molecule drug discovery.

Matrine, a classical quinolizidine alkaloid derived from and (), exhibits diverse pharmacological activities including anti-inflammatory, antiviral, antifibrotic, and antitumor effects. However, its natural structure faces limitations to restrict its clinical applications such as poor aqueous solubility, low bioavailability, and certain toxic side effects. Recent studies had focused on structural optimization strategies to enhance physicochemical properties and improve the bioactivities.

Minimally invasive robotic ureteral reconstruction using endoscopic submucosal dissection harvested colorectal mucosa graft for ureteral stricture.

To evaluate the feasibility and safety of using colorectal mucosal grafts (CMG) harvested via endoscopic submucosal dissection (ESD) for ureteral reconstruction in patients with ureteral stricture. Eight patients with ureteral stricture underwent robotic ureteral reconstruction using CMG harvested by ESD. Preoperative assessments included clinical history, physical examination, and various imaging studies.

Unveiling the clinical significance of RNA pseudouridine in colorectal cancer.

Colorectal cancer (CRC) is a prevalent malignancy characterized by rising incidence and mortality rates worldwide. The involvement of RNA pseudouridine synthase enzymes in CRC development is well-documented, yet the transcriptomic profile of pseudouridine (Ψ) in CRC remains largely unexplored. This study explored the transcriptomic landscape of Ψ in CRC by analyzing 21 biopsies and their corresponding adjacent healthy tissues, along with blood samples from 10 patients using PRAISE, a quantitative pseudouridine sequencing technology at base resolution.

Systematic review and meta‑analysis of factors predicting postoperative lung function after lung cancer resection.

Introduction: Lung resection continues to be the most effective treatment for early‑stage lung cancer. Prediction of postoperative lung function is particularly important when evaluating patient eligibility for surgery, as it helps assess the likelihood of experiencing difficulty breathing after the operation.

Aim: We aimed to identify the most common methods used to predict postoperative lung function in clinical practice and to compare their accuracy.

Endoscopic retrograde cholangiopancreatography consultation after digestive tract reconstruction and risk factors for complications.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) has been widely used in the diagnosis and treatment of biliary and pancreatic diseases, and its success rate and therapeutic effect are considerable, and its use in patients with gastrointestinal tract reconstruction is also increasing. The anatomical structure of the digestive tract has been changed in these patients, which makes the use of endoscopic retrograde cholangiopancreatography technically more challenging. The aim of this study was to investigate the efficacy of transendoscopic retrograde cholangiopancreatography in patients after gastrointestinal reconstruction and its risk factors for postoperative complications.

Comparative metabolomic in-depth exploration of red raspberry: new insights into changes in phytochemicals between different breeds.

Based on a non-targeted metabolomic approach, a comprehensive analysis of the metabolic profiles of two raspberry cultivars, Selina (TSM) and Tulameen (CSM), was conducted to explore the potential for further processing of these two varieties. A total of 752 metabolites were identified in both raspberry varieties, with 375 metabolites detected in negative ion mode and additional metabolites identified in positive ion mode. The total number of differential metabolites between TSM and CSM was 62, with orthogonal partial least squares discriminant analysis (OPLS-DA) revealing that the main differential metabolites between the two varieties were phenolic compounds, organic acids, and alkaloids.

The structures of two polysaccharides from Fructus Corni and their protective effect on insulin resistance.

Type 2 diabetes mellitus (T2DM) is characterized by impaired cellular or organ responsiveness to insulin, which results in ineffective glucose disposal and lacks a definitive treatment. Previous studies suggest that polysaccharides hold promise as natural agents for the prevention and treatment of T2DM. In this study, we identified two polysaccharides from Fructus Corni, PFC-CI and PFC-CII, with molecular weights of 59.

Heterologous Expression of a Potential '' MYB Factor Gene, , Improves Salt and Cold Tolerance in .

The paulownia tree belongs to the Paulowniaceae family. Paulownia has strong vitality; has strong adaptability to harsh environmental conditions; and can be used as building raw material, as well as processing drugs and having other purposes. In the research field of MYB transcription factors of the paulownia tree, it is rare to discuss the resistance to abiotic stress.

Carbene-catalyzed chirality-controlled site-selective acylation of saccharides.

Acylation stands as a fundamental process in both biological pathways and synthetic chemical reactions, with acylated saccharides and their derivatives holding diverse applications ranging from bioactive agents to synthetic building blocks. A longstanding objective in organic synthesis has been the site-selective acylation of saccharides without extensive pre-protection of alcohol units. In this study, we demonstrate that by simply altering the chirality of N-heterocyclic carbene (NHC) organic catalysts, the site-selectivity of saccharide acylation reactions can be effectively modulated.

Deep learning-based methodology for vulnerability detection in smart contracts.

Smart contracts play an essential role in the handling and management of digital assets, where vulnerabilities can lead to severe security issues and financial losses. Current detection techniques are largely limited to identifying single vulnerabilities and lack comprehensive identification capabilities for multiple vulnerabilities that may coexist in smart contracts. To address this challenge, we propose a novel multi-label vulnerability detection model that integrates extractive summarization methods with deep learning, referred to as Ext-ttg.

Efficient Uranium Removal from Aqueous Solutions Using Silica-Based Adsorbents Functionalized with Various Polyamines.

With the rapid development of nuclear energy, the contamination of environmental water systems by uranium has become a significant threat to human health. To efficiently remove uranium from these systems, three types of silica-based polyamine resins-SiPMA-DETA (SiPMA: silica/poly methyl acrylate; DETA: diethylenetriamine), SiPMA-TETA (TETA: triethylenetetramine), and SiPMA-TEPA (TEPA: tetraethylenepentamine)-were successfully prepared, characterized, and evaluated in batch experiments. Characterization results showed that the silica-based polyamine resins were successfully prepared, and they exhibited a uniform shape and high specific surface area.