Rapid and sustained response to tofacitinib in a patient with anal pyoderma gangrenosum under immunosuppression and bone marrow suppression.

Aim: To evaluate the therapeutic efficacy and safety of the Janus kinase (JAK) inhibitor tofacitinib in the management of refractory perianal pyoderma gangrenosum (PG) under conditions of baseline immunosuppression and bone marrow suppression.

Methods: We present a 62-year-old male with a 4-month history of painful, progressive symmetrical perianal ulcerations diagnosed as PG, coexisting with condyloma acuminatum. The patient had a background of pure red cell aplasia and myasthenia gravis, and was undergoing chronic immunosuppressive therapy with prednisolone and tacrolimus.

Timing of adjuvant radiotherapy for early-stage endometrial carcinoma: a single-center retrospective cohort study.

Objective: To investigate the appropriate timing of radiotherapy (RT) after hysterectomy in women with early-stage endometrial cancer (EC).

Methods: We analyzed the data of 1,062 patients with early-stage EC who underwent postoperative RT at our hospital between April 1999 and November 2020. Restricted cubic spline were used to explore the relationship between the surgery-radiotherapy interval (SRI) and local recurrence-free survival (LRFS).

The GhMPK7-GhSDIRIP1 module enhances drought tolerance in cotton by regulating ABA signaling.

The phytohormone abscisic acid (ABA) is important during abiotic stresses, especially drought stress. Although mitogen-activated protein kinase (MAPK) cascades are crucial for ABA-mediated drought tolerance, how these cascades integrate and deliver the downstream ABA signals is poorly understood. Here, the group C MAPK GhMPK7 was found to positively regulate ABA-mediated drought tolerance in cotton.

Mild activation of the endoplasmic reticulum unfolded protein response conferred cadmium resistance in the nematode Caenorhabditis elegans.

Cadmium exposure is a major public health concern. Understanding the mechanisms underlying cadmium resistance is crucial for developing preventive strategies and ecological remediation. However, the mechanisms underlying cadmium resistance in animal models remain poorly understood.

Pyrite-driven denitrification by Paracoccus denitrificans: Promoted by enhanced electron transfer and extracellular polymeric substances.

Pyrite can be used in denitrification systems to improve efficiency. In this study, the role of pyrite and extracellular polymeric substances (EPS) was investigated in biological denitrification. In cultures of Paracoccus denitrificans, pyrite effectively enhanced denitrification efficiency, primarily by increasing key components of electron transport system such as cytochrome c and NADH, and upregulating the expression levels of genes involved in the synthesis of riboflavin and cytochrome c, along with denitrification-critical genes such as nosZ and napG.

Mechanical Cell Reprogramming on Tissue-Mimicking Hydrogels for Cancer Cell Transdifferentiation.

Disrupted matrix mechanics have been found to be highly associated with increased risks of many diseases, including neurodegenerative diseases and cancers. For centuries, the aged tissue matrix has been found to lose its mechanical integrity and exhibit altered biophysical properties. Whether the mechanical properties of matrix serve as a regulator for maintaining the health and function of cells remains unknown.

Self-Assembled Homogeneous Heterobimetallic-Oxide Interfaces Enable Synergistic Hydrogen Evolution Passivation for Durable Acidic Zn-Mn Batteries.

Acidic Zn-Mn batteries hold promising prospects in large-scale energy storage owing to their higher discharge voltage and capacity. However, the challenge of developing long-term acidic Zn-Mn batteries still remains due to Zn anode instability in acidic media arising from the inevitable proton corrosion and hydrogen evolution reaction (HER). Herein, we report self-assembled homogeneous heterobimetallic-oxide interfaces on the Zn anode surface via a multi-cation (Cu, In, and Sn) synergistic regulation strategy to achieve >85.

Drug-Drug Interactions and Combination Therapy Strategies of Amiodarone With Digoxin, Rivaroxaban, and Phenytoin Assessed by Physiologically Based Pharmacokinetic Modeling.

Background: Amiodarone (AMI) is a potent inhibitor of Cytochrome P450 (CYP) 2C9 and P-glycoprotein (P-gp), as well as a weak inhibitor of CYP3A4. Concomitant administration of AMI with digoxin (DIG), rivaroxaban (RIV), or phenytoin (PHT) can significantly increase the exposure of the victim drugs. Elevated RIV exposure raises the risk of bleeding, whereas DIG and PHT have narrow therapeutic windows, potentially leading to severe toxicity when co-administered with AMI.

Strain-coupled, crystalline polymer-inorganic interfaces for efficient magnetoelectric sensing.

Magnetoelectric sensing holds promise for flexible sensors, offering precise detection of both electric and magnetic fields with minimal power consumption. However, its practical use has been constrained by weak magnetoelectric effects and limited overall performance, particularly under mechanical strain. Herein, we fabricated robust magnetoelectric polymer-inorganic nanocomposites through an interfacial cocrystallization strategy.

Breaking genetic linkage barriers to improve brown planthopper resistance and grain yield in japonica rice.

The brown planthopper (BPH) poses a persistent threat to global rice production as one of the most devastating insect pests. Development and utilization of BPH-resistant rice cultivars are believed to be the most sustainable and eco-friendly control strategy, which has been successfully implemented in indica rice subspecies but remains underdeveloped in japonica rice. Here, we introgressed the BPH resistance gene Bph27(t) into elite japonica cultivars.

Physiologically based pharmacokinetic coupled model of zonisamide to predict the exposure and dose exploration in maternal, fetal, and neonatal populations during pregnancy and postpartum.

Zonisamide (ZNS) is a second-generation antiepileptic drug. During pregnancy, ZNS clearance increases, leading to a decrease in drug concentration. Additionally, ZNS can be transferred to the fetus and neonate through the mother and breast milk, potentially posing risks to the fetus and neonate.

Environment sensing technology of underwater ROV based on artificial siding.

The underwater environment has the characteristics of high pressure and low temperature, which limits the performance of the sensor, and there are inaccuracies or distortions in the measurement data, resulting in errors and uncertainties in the environmental perception results. Therefore, the environment sensing technology of underwater ROV based on artificial side line is proposed. According to the artificial side line structure, the underwater terrain environment perception principle is constructed, and each characteristic parameter is counted.

The prevalence and genetic characteristics of human bocavirus in patients with acute respiratory infection in China during 2012-2021.

Human bocavirus (HBoV) is a common respiratory virus among patients with acute respiratory infection (ARI). To investigate the prevalence and genetic characteristics of HBoV, clinical specimens from 13,109 ARI patients were collected through active surveillance from 12 provinces of China during 2012-2021. Extracted nucleic acid was screened and the viral protein 1 (VP1) gene was directly amplified and sequenced in HBoV-positive specimens.

Dimensional Engineering of 1D/2D Covalent Organic Framework Isomers for Enhanced CO₂ Photoreduction.

The rigorous topologic 1D covalent organic frameworks (1D-COFs) require highly anisotropic and aligned connectivity, making their synthesis as isomers with low-dimensional structures challenging, let alone understanding the long-sought consensus regarding the structure-property relationship. Here, a feasible dimensional engineering strategy is demonstrated to construct 1D/2D COF isomers, revealing their dimensional contributions on the photocatalytic CO reduction reaction (CO-RR) performance. By leveraging the cis/trans conformational flexibility of 2,2'-bipyridine-4,4'-dicarboxaldehyde (BPY) under acidity regulation, this study successfully constructs 1D/2D BPY-COF dimensional isomers for the first time.

Interaction of blood-entry components, network pharmacology and transcriptomics to elucidate the mechanism of Wentong plaster in treating primary dysmenorrhea.

Introduction: Primary dysmenorrhea (PD) is characterized by pain during the menstrual cycle, affects women's health. Our group developed a traditional Chinese medicine plaster (Wentong plaster, WTT) for the treatment of PD. However, the underlying mechanisms have not yet been elucidated.

Innovative applications of quantum dots-based surface-enhanced Raman spectroscopy for food safety detection.

Surface-enhanced Raman scattering (SERS) is a fingerprint-type, and nondestructive testing technique that has advantages for testing of hazardous substances in food. However, conventional substrates limit their practical applications due to their high cost, complex preparation, and poor selectivity. Quantum dots (QDs) are emerging as ideal SERS substances, gradually attracting the attention of researchers in the field of sensing.

The role of exosomes in immunopathology and potential therapeutic implications.

Extracellular vesicles (EVs), including exosomes, ectosomes, and apoptotic bodies, are released by various cells. Among these subtypes, exosomes have been extensively studied and demonstrated to be crucial mediators of intercellular communication involving multiple physiological and pathological processes. Four primary steps influence the biogenesis of exosomes: generation of early endosomes, formation and maturation of multivesicular bodies (MVBs), MVB and plasma membrane fusion for exosome release, and MVB fusion with lysosomes for degradation.

Extracellular vesicles in pregnancy-related disorders: from mechanisms to clinical implications.

The discovery of extracellular vesicles (EVs), including exosomes, microvesicles, and shedding vesicles, signifies a paradigm shift in our understanding of cellular communication and a variety of biological processes, encompassing immune regulation, disease pathogenesis, and tissue repair. Particularly in the realm of pregnancy-related diseases, EVs have unveiled new perspectives and tools for deciphering the molecular mechanisms underlying pregnancy and its associated disorders. Emerging evidence indicates the multifaceted role of EVs in placental formation, regulation of maternal-fetal immune balance, and the development of pregnancy complications.

Enhancing the Performance of LLO Through Vanadium Doping and Abundant Exposed (010) Planes in Secondary Particles.

Lithium-rich layered oxide (LLO) has received extensive attention from researchers due to its high initial discharge capacity (≥250 mAh g). However, defects such as its high initial irreversible capacity, voltage decay, and poor rate performance have severely limited its commercialization. These issues arise because the LiMnO component in LLO is activated during the initial cycle, leading to the participation of lattice oxygen anions (O) in redox reactions.

Bioinspired Flame-Retardant and Impact-Resistant Aramid Composites via Nacre-Mimetic Self-Assembly for Firefighting Applications.

Frequent fire accidents pose serious threats to firefighter security, necessitating progressively stringent demands on the performance of protective materials for firefighting clothing. This work proposes an advanced nacre-mimetic shear-stiffening gel (SSG)-magnesium hydroxide (MH) coating engineered aramid Kevlar composite, which exhibits exceptional anti-impact and flame-retardant properties. The SSG-MH-Kevlar (SMK) composite is fabricated via a facile vacuum-assisted evaporation-induced cross-linking method, facilitating the self-assembly of SMK into a highly oriented and long-range lamellar structure.

Ionic-Nanotube Array Membrane Generating Ultrahigh Osmotic Energy Conversion.

Ion exchange membranes (IEMs) are critical components in osmotic energy conversion. However, traditional IEMs suffer from disordered nanochannels due to the lack of precise control over the content and distribution of ionic groups, resulting in an inherent trade-off between ion selectivity and conductivity. One promising strategy is constructing high-density ion channels with minimal ionic groups.

Exploring the relationship between physical activity and social media addiction among adolescents through a moderated mediation model.

Physical activity is highly correlated with social media dependence in adolescence, but the underlying mechanisms between these variables require further investigation. This study suggests two potential psychological pathways linking physical activity and social media dependence in adolescence, with depression potentially serving as a mediating factor and difficulty describing feelings acting as a moderating factor. A self-reported survey was conducted with 3,247 Chinese adolescents, including measures of physical activity, social media dependence, depression, and difficulty describing feelings.

Network toxicology and molecular docking reveal the potential link between acrylamide exposure and breast cancer.

Acrylamide (ACR) is a common food and environmental contaminant with potential carcinogenicity, but its molecular role in the development of breast cancer (BC) remains unclear. This study employed a network toxicology and molecular docking strategy to explore the potential association between ACR exposure and BC. Differentially expressed genes were first identified by comparing gene expression profiles between breast cancer and normal tissues.

Application analysis of humanistic care-based continuous nursing on patients with soft tissue sarcoma.

To observe the application of humanistic care-based continuous nursing in patients with soft tissue sarcoma (STS), aiming to improve the overall benefit level of patients. Retrospective analysis was used to collect the clinical data of 30 patients with STS who received routine care mode from January 2021 to January 2022 and included in the routine group, and the clinical data of 30 patients with STS who received humanistic care-based continuous nursing from February 2022 to February 2023 and included in the research group. Two groups were compared in psychological status [Zung Self-rating Anxiety Scale (SAS) and Zung Self-rating Depression Scale (SDS)], coping style [Simplified Coping Style Questionnaire], self-management efficacy [Chinese - Strategies Used by People to Promote Health (C-SUPPH)], medication compliance [Morisky Medication Adherence Scale (MMAS-8)], and hope level [Herth Hope Index (HHI)].