Strain-coupled, crystalline polymer-inorganic interfaces for efficient magnetoelectric sensing.

Magnetoelectric sensing holds promise for flexible sensors, offering precise detection of both electric and magnetic fields with minimal power consumption. However, its practical use has been constrained by weak magnetoelectric effects and limited overall performance, particularly under mechanical strain. Herein, we fabricated robust magnetoelectric polymer-inorganic nanocomposites through an interfacial cocrystallization strategy.

The effect of psychological empowerment on clinical nurses' thriving at work: the mediating role of voice behavior.

Background: Facing the shortage of nurses and the surge in demand for nursing services, factors affecting the stability of the nursing workforce require urgent attention. Thriving at work, a positive psychological state, can improve the quality of nursing services and promote the development of the nursing workforce. Therefore, this study aims to determine the impact of psychological empowerment on nurses' thriving at work and confirm the mediating role of voice behavior.

Structure-guided engineering of snake toxins for selective modulation of adrenergic and muscarinic receptors.

Adrenergic receptors (ARs) and muscarinic acetylcholine receptors (mAChRs) are essential G protein-coupled receptors (GPCRs) that regulate a wide range of physiological processes. Despite their significance, developing subtype-selective modulators for these receptors has been a formidable challenge due to the high structural and sequence similarities within their subfamilies. In this study, we elucidated the recognition and regulatory mechanisms of ARs and mAChRs by muscarinic toxin 3 (MT3), a cross-reactive ligand derived from snake venom.

Glycated hemoglobin is not enough: The role of glycemia risk index for glycemic control assessment in type 1 diabetes.

Background: Glycated hemoglobin (HbA1c), the gold standard for assessing glycemic control, has limited ability to reflect the risks of hypoglycemia and glycemic variability, raising great concerns, especially in patients with type 1 diabetes (T1D). The glycemia risk index (GRI), a composite metric derived from continuous glucose monitoring (CGM), has emerged as a potential solution by systematically integrating both hypoglycemia and hyperglycemia risks into a single interpretable score.

Aim: To evaluate whether the GRI addresses HbA1c limitations.

Large thermoelastic effect in martensitic phase of ferroelastic alloys for high efficiency heat pumping.

Solid state heat pumping using latent heat from first order ferroic phase transitions is a promising green alternative to traditional vapor compression technology. However, the intrinsic phase transition hysteresis poses a limitation on heat pumping energy efficiency. Here, we propose heat pumping using reversible heat from anhysteretic elastic deformation in martensitic phase of ferroelastic alloys.

Association between different obesity metrics and risk of inguinal hernia.

Purpose: Obesity is closely associated with a lower risk of inguinal hernia, but the association between different obesity metrics and the risk of inguinal hernia is still unclear.

Methods: In our study, we categorized obesity measurement indicators into three groups based on the difficulty of measurement: (1) indicators easily available, such as body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR); (2) indicators accessible with moderate difficulty, such as body fat percentage and body fat mass; (3) indicators difficultly accessible, such as the volume of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Mendelian randomization (MR) analysis was used to investigate the causal relationship between various adiposity measures and the risk of inguinal hernia in both European ancestry and East Asians.

Exploring the Influencing Factors of Experienced Nurses' Retention Behaviour: A Qualitative Study Based on the COM-B Model.

Aim: The aim of this study was to explore the factors influencing the retention behaviour of experienced nurses in China, using the capability, opportunity, motivation and behaviour (COM-B) model as a conceptual framework.

Design: A qualitative descriptive study based on the COM-B model.

Methods: In this qualitative descriptive study, semi-structured interviews were conducted with 22 nurses across 11 cities in the Guangdong-Hong Kong-Macao Great Bay Area of China between March and May 2024.

The Impact of Blood Pressure Rhythm and Perioperative Blood Pressure Variability on Short-Term Prognosis in Patients with Type A Aortic Dissection.

Previous studies have indicated a strong correlation between disturbances in blood pressure (BP) circadian rhythm and major cardiovascular adverse events. Similarly, blood pressure variability (BPV) has been closely linked to cerebral small vessel disease and leukoaraiosis. This study aims to investigate the relationship between BP rhythm and BPV with the short-term prognosis of patients with Type A aortic dissection, offering insights for targeted perioperative nursing interventions and improving patient outcomes.

Diabetes knowledge, attitudes and practices among Chinese primary care physicians: a cross-sectional study.

Background: Type 2 diabetes mellitus (T2DM) is a public health crisis that requires adequate knowledge, attitudes, and practices (KAP) by health care providers to prevent or delay the progression of the disease. This study aimed to assess the KAP regarding T2DM among primary care providers (PCPs) in Central China.

Methods: This multicenter cross-sectional study was conducted among 971 PCPs using self-employed KAP questionnaires.

Ciprofloxacin Accelerates Angiotensin-II-Induced Vascular Smooth Muscle Cells Senescence Through Modulating AMPK/ROS pathway in Aortic Aneurysm and Dissection.

Aortic aneurysm and dissection (AAD) is a cardiovascular disease that poses a severe threat to life and has high morbidity and mortality rates. Clinical and animal-based studies have irrefutably shown that fluoroquinolones, a commonly prescribed antibiotic for treating infections, significantly increase the risk of AAD. Despite this, the precise mechanism by which fluoroquinolones cause AAD remains unclear.

Globe-LFMC 2.0, an enhanced and updated dataset for live fuel moisture content research.

Globe-LFMC 2.0, an updated version of Globe-LFMC, is a comprehensive dataset of over 280,000 Live Fuel Moisture Content (LFMC) measurements. These measurements were gathered through field campaigns conducted in 15 countries spanning 47 years.

Trends and drivers of Arctic-boreal fire intensity between 2003 and 2022.

Climate change has disproportional effects on Arctic-boreal ecosystems, as the increase of air temperatures in these northern regions is several times higher than the global average. Ongoing warming and drying have resulted in recent record-breaking fire years in Arctic-boreal ecosystems, resulting in substantial carbon emissions that might accelerate climate change. While recent trends in Arctic-boreal burned area have been well documented, it is still unclear how fire intensity has changed.

Dynamic-Bond-Mediated Chain Reptation Enhances Energy Dissipation of Elastomers.

Vibrations with various frequencies in daily life and industry can cause health hazards and fatigue failure of critical structures, which requires the development of elastomers with high energy dissipation at desired frequencies. Current strategies relying on tuning characteristic relaxation time of polymer chains are mostly qualitative empirical methods, and it is difficult to precisely control damping performances. Here, we report a general strategy for constructing dynamic crosslinked polymer fluid gels that provide controllable ultrahigh energy dissipation.

Decision model for binary safety management behavior in a supply chain under digital scenarios: A study based on differential game theory.

The purpose of this study is to expand and deepen research in the field of safety production, explore the role of enterprises as decision-making entities in safety production, analyze the role of different types of decision-making behaviors in the process of enterprise safety production, and provide certain theoretical guidance for multi-agent decision-making in safety production. By summarizing and comparing the existing dual system of supply chain safety management, this study proposes dividing supply chain safety management into the two categories of safety organization and safety research and development (safety R&D) in the context of digitalization. Differential equations are established to describe a two-level supply chain safety management problem including manufacturers and suppliers.

Estimation of potential wildfire behavior characteristics to assess wildfire danger in southwest China using deep learning schemes.

Accurate estimation of potential wildfire behavior characteristics (PWBC) can improve wildfire danger assessment. However, wildfire behavior has been estimated by most fire spread models with immeasurable uncertainties and difficulties in large-scale applications. In this study, a PWBC estimation model (named PWBC-QR-BiLSTM) was proposed by coupling the Bi-directional Long Short-Term Memory (BiLSTM) and quantile regression (QR) methods.

Molecular mechanism of antihistamines recognition and regulation of the histamine H receptor.

Histamine receptors are a group of G protein-coupled receptors (GPCRs) that play important roles in various physiological and pathophysiological conditions. Antihistamines that target the histamine H receptor (HR) have been widely used to relieve the symptoms of allergy and inflammation. Here, to uncover the details of the regulation of HR by the known second-generation antihistamines, thereby providing clues for the rational design of newer antihistamines, we determine the cryo-EM structure of HR in the apo form and bound to different antihistamines.

Glycaemia risk index uncovers distinct glycaemic variability patterns associated with remission status in type 1 diabetes.

Aims/hypothesis: The aim of this work was to define a unique remission status using glycaemia risk index (GRI) and other continuous glucose monitoring (CGM) metrics in individuals with type 1 diabetes for improved phenotyping.

Methods: A group of 140 individuals with type 1 diabetes were recruited for a cross-sectional study. The participants were categorised into four groups based on their remission status, which was defined as insulin-dose-adjusted A1c (IDAA1c) <9 or C-peptide ≥300 pmol/l: new-onset (n=24); mid-remission (n=44); post-remission (n=44); and non-remission (individuals who did not experience remission, n=28).

A method for structure determination of GPCRs in various states.

G-protein-coupled receptors (GPCRs) are a class of integral membrane proteins that detect environmental cues and trigger cellular responses. Deciphering the functional states of GPCRs induced by various ligands has been one of the primary goals in the field. Here we developed an effective universal method for GPCR cryo-electron microscopy structure determination without the need to prepare GPCR-signaling protein complexes.

Investigating the effect of history of fractures and hypertension on the risk of all-cause death from osteoporosis: A retrospective cohort study.

To assess the coexistence effect between history of fractures and hypertension on the all-cause death risk of osteoporosis. In this retrospective cohort study, some characteristics of osteoporosis patients aged ≥ 20 years were extracted from the National Health and Nutrition Examination Survey (NHANES) database (2005-2010, 2013-2014), such as age, gender, smoking, drinking, the history of diabetes, cardiovascular and cerebrovascular diseases, fractures and hypertension. The outcome of this study was defined as all-cause death of osteoporosis.

Influence of Different Ratios of subsp. and on Fermentation Characteristics of Yogurt.

Lactic acid bacteria (LAB) are industrially important bacteria that are widely used in the fermented food industry, especially in the manufacture of yogurt. The fermentation characteristics of LAB are an important factor affecting the physicochemical properties of yogurts. Here, different ratios of subsp.