Dimensional Crossover Engineering in MoS/Organic Superlattices Breaks the zT Barrier for 2D Thermoelectrics.

The rapid development of self-powered microelectronics demands thermoelectric devices (TEDs) that can simultaneously achieve high energy conversion efficiency and silicon micro-fabrication compatibility. While for conventional bulk TEs, their incompatibility with silicon micro-manufacturing restricts microelectronic integration. 2D materials, though CMOS-fabrication-friendly and widely explored for microelectronic devices, face critical limitations in thermoelectric energy conversion efficiency due to their low zT values (<0.

Leukemia Burden Impacts the Efficacy and Toxicity of Blinatumomab in Pediatric B-Cell Acute Lymphoblastic Leukemia.

Background: Blinatumomab has been approved for the treatment of pediatric B-cell acute lymphoblastic leukemia (B-ALL). This study aimed to investigate the association between leukemia burden and the efficacy of blinatumomab in real-world applications.

Methods: A real-world study was conducted by enrolling patients aged 0-18 years who were diagnosed with CD19-positive B-ALL and treated with blinatumomab between January 2021 and May 2023 from 14 centers in China.

Evaluation of serum brain-derived neurotrophic factor, IL-6, IL-10, and TNF-a cognitive function, and sleep quality in elderly patients with major depressive disorder and somatic symptoms.

Background: The aim of the paper was to analyze the relationship between somatization in elderly patients with major depressive disorder (MDD) and brain-derived neurotrophic factor (BDNF), IL-6, IL-10, and TNF-a cognitive function, and sleep quality (SQ).

Methods: This was a case-control study on 80 elderly patients with MDD who were grouped based on the somatic self-rating scale (SSS) - the subjects with somatic symptoms (SS) as the AG and the subjects without SS as the BG. Additionally, 25 healthy volunteers from the same period were included as the control group (CG).

Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance.

Tumor cells' macropinocytosis sustains their growth under nutrient-limiting conditions. However, the metabolic regulation of cancer macropinocytosis in immune escape and its effect on immunotherapy remain unclear. Through the metabolism compound library and genome-wide CRISPR-Cas9 screenings, we identified dihydroorotate dehydrogenase (DHODH) as an essential driver of tumor cell macropinocytosis.

Discourse genre predicts demonstrative use in text: Experimental evidence from Dutch and Mandarin.

In written language, demonstratives such as this and that allow writers to produce coherent texts and readers to build up a consistent mental model of the message that is conveyed. But what makes a writer decide to use one demonstrative (e.g.

Comparative longitudinal analysis of pulmonary function post-pediatric Allo-HSCT: benign vs. malignant diseases and early predictors.

Pulmonary complications are a major cause of morbidity following pediatric allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, longitudinal pulmonary function test (PFT) trajectories and early predictors of dysfunction, particularly the interplay between underlying disease, PFTs, and graft-versus-host disease (GVHD), remain poorly understood. In this retrospective single-center study, we analyzed 233 children undergoing their first allo-HSCT with ≥ 100-day survival.

Combining tumor habitat radiomics and circulating tumor cell data for predicting high-grade pathological components in lung adenocarcinoma.

Objectives: Lung cancer is the leading cause of cancer incidence and mortality. Early surgical resection significantly improves patient prognosis. Studies have shown that high-grade components in lung adenocarcinoma (LUAD) severely impact patient outcomes.

The P4HB/LGALS3BP/NF-kB axis promotes the progression of MIA to IAC in lung adenocarcinoma.

Prolyl 4-hydroxylase β-subunit (P4HB) is a class of molecular chaperones that inhibits the misfolding of endoplasmic reticulum proteins, and its role in microinvasive adenocarcinoma (MIA) progresses to invasive adenocarcinoma (IAC) is currently unclear. We mined the single-cell dataset GSE189357 to analyze the role of P4HB in LUAD progression. Subsequently, P4HB was overexpressed in H1299 and A549 cell lines, and Galactose lectin-3 binding protein (LGALS3BP) expression was increased and NF-kB pathway was inhibited by PCR and WB.

Neurofibromatosis Type 1 with Relapsed/Refractory Precursor B-Lymphoblastic Lymphoma: Case Report and Literature Review.

Introduction: Concomitant occurrence of B-lymphoblastic lymphoma (B-LBL) and neurofibromatosis type 1 (NF1) is rare.

Case Presentation: We diagnosed and treated a child presenting with NF1 and relapsed B-LBL and reviewed the relevant literature through the last 8 years. Stage IV precursor B-LBL with central nervous system 3 was identified in this patient, with pain and activity abnormalities in both lower limbs.

Phosphorylated Toll-like receptor 3 nuclear translocation in cancer cell promotes metastasis and chemoresistance.

Aberrant expression and subcellular location of innate sensors in cancer cells, such as Toll-like receptors (TLRs), correlates with pro-tumoral inflammation and cancer progression, but the mechanism is still largely unknown. Deciphering the proinflammatory mediators in tumor microenvironment will contribute to the development of cancer therapeutics. By using immunohistochemistry in pancreatic ductal adenocarcinoma (PDAC) and multiple other cancer samples, here we found that cancer cell TLR3, a well-known cytoplasmic dsRNA sensor, translocated to the nucleus especially upon chemotherapy stress.

Lactobacillus paracasei-induced lung abscess in a splenectomized patient: A rare case report.

Rationale: Lactobacillus paracasei (LP), a probiotic species, is rarely associated with lung abscesses. This case highlights its role as an opportunistic pathogen in immunocompromised patients.

Patient Concerns: A 65-year-old splenectomized man presented with persistent abdominal pain, fever, and respiratory symptoms.

Mechanism of Brucea javanica against multiple myeloma via TNF-NF-κB signaling.

This study aims to explore the pharmacological mechanism of Brucea javanica (BJ) in treating multiple myeloma (MM) through network pharmacology and validate this mechanism via in vitro experiments. Active pharmaceutical ingredients (APIs) of BJ and their potential targets were identified, along with MM-related targets. By plotting protein-protein interaction (PPI) networks, hub genes responsible for BJ in treating MM were identified and subjected to molecular docking.

Incidence and disability-adjusted life-years of infective endocarditis in China from 1990 to 2021: comparison with G20 based on the Global Burden of Disease Study 2021.

Objectives: Infective endocarditis (IE) is a global public health challenge, and our understanding of its temporal evolution in China compared with the Group of Twenty (G20) countries remains limited. This study aims to analyse the disease burden of IE in China from 1990 to 2021, forecast trends for the next 15 years and compare the findings with those in G20 countries.

Design: Observational study.

INFO-RF-based fault diagnosis and analysis method for busbars.

With the continuous expansion of power system scale and advancements in intelligence, the accuracy and timeliness of busbar fault diagnosis-an essential component of the power system-are crucial for ensuring the safe and stable operation of the grid. This paper presents a method for busbar fault diagnosis and analysis that combines the weighted mean of vectors (INFO) algorithm with the Random Forest (RF) model. Building on the accurate identification of busbar fault types, the method further predicts fault resistance.

SEMA3B switches axon-axon to axon-glia interactions required for unmyelinated axon envelopment and integrity.

During peripheral nerve (PN) development, unmyelinated axons (nmAs) tightly fasciculate before being separated and enveloped by non-myelinating Schwann cells (nmSCs), glial cells essential for maintaining nmA integrity. How such a switch from axon-axon to axon-glia interactions is achieved remains poorly understood. Here, we find that inactivating SC-derived SEMA3B or its axonal receptor components in mice leads to incomplete nmA separation and envelopment by nmSCs, eliciting hyperalgesia and allodynia.

Differentiating primary bone marrow failure syndromes in children: a retrospective analysis of early clinical and laboratory features.

Objective: To investigate the early clinical characteristics of different subtypes of primary bone marrow failure syndrome (BMFS) in children and identify predictive factors for early diagnosis, thereby improving the ability to differentiate BMFS at an early stage.

Methods: A retrospective analysis was conducted on the clinical and laboratory data of children with primary BMFS who received regular follow-up visits exceeding one year at the First Affiliated Hospital of Shandong First Medical University from January 2020 to September 2024. Based on long-term follow-up results, the children were reclassified into subgroups, and early clinical features, blood counts, and bone marrow examination results were compared across groups.

Evaluating the value of machine learning models for predicting hematoma expansion in acute spontaneous intracerebral hemorrhage based on CT imaging features of hematomas and surrounding oedema.

Objective: This study evaluates the utility of artificial intelligence (AI) for automated segmentation of intracranial hematomas and surrounding oedema in non-contrast computed tomography (CT) images. Additionally, it aims to extract imaging features for developing machine learning models to predict hematoma expansion in acute spontaneous intracerebral hemorrhage (sICH).

Methods: Data from 183 patients with acute spontaneous hemorrhage, treated at Lianyungang Hospital Affiliated to Xuzhou Medical University between January 2020 and December 2023, were retrospectively analyzed.

Photosynthetic performance and yield of intercropped maize and soybean are directly opposite under different intercropping ratios and maize planting densities interactions.

Background: Maize-soybean intercropping, a sustainable intensification practice, has been extensively studied. However, systematic research on how maize planting density and crop allocation patterns influence yield-related photosynthetic mechanisms in intercropping systems is scarce. This study conducted a two-year field trial during the 2022 and 2023 planting seasons to evaluate the effects of intercropping ratios (M4S4: four rows maize to four rows soybean; M2S2: two rows maize to two rows soybean) and maize planting densities (D1: 45 000 plants ha, D2: 52 500 plants ha, D3: 60 000 plants ha) on photosynthetic performance and yield of maize and soybean, with monoculture as controls.

High temperature slagging gasification demonstration-scale trial of sewage sludge: Feasibility analysis towards mono treatment, operational challenges and life-cycle assessment.

The application of high temperature slagging gasification was investigated for treatment of sewage sludge aiming to reduce landfill dependency and create high quality by-product, slag, with excellent heavy metal encapsulation. A demonstration scale facility designed for treatment of municipal solid waste (MSW), with a capacity of 11.5 tonnes a day is applied to assess the operation of the first-of-its-kind mono sewage sludge gasification.

Correlation of carotid plaque and peripheral carotid adipose tissue characteristics with coronary computed tomography angiography-based fractional flow reserve.

Background: The study aimed to investigate the correlation of carotid plaque and peripheral carotid adipose tissue (PCAT) characteristics with coronary computed tomography-derived fractional flow reserve (CT-FFR) values.

Methods: Data of 136 patients who underwent head and neck computed tomography angiography (CTA) followed by coronary CTA were retrospectively reviewed. Based on their CT-FFR values, they were divided into CT-FFR ≤ 0.

How to achieve coordinated and sustainable development between urban flood resilience and ecosystem services at the urban agglomeration scale.

Urban flood resilience (UFR) and ecosystem services are crucial concepts and methods for mitigating flood risks and boosting the coordinated and sustainable development in urban agglomerations. While most studies assess UFR or ecosystem services from a single perspective, the interaction between the two remains insufficiently explored. Here, an integrated analytical framework was established to examine the relationship between the two.

Design of a Janus Composite Patch with Anti-Adhesive and Growth-Promoting Functions for Abdominal Wall Defect Repair.

Tension-free hernioplasty has effectively reduced postoperative recurrence and mitigated complications by employing polymer patches. However, clinically used polymer patches often fall short in terms of the anti-deformation, anti-adhesion, and tissue integration functions, which can result in visceral adhesions and foreign body reactions after implantation. In this study, a Janus three-layer composite patch was developed for abdominal wall defect repair using a combination of 3D printing, electrospraying, and electrospinning technologies.

[Research Progress of Anti-lung Cancer Drug-related Interstitial Lung Disease].

Lung cancer is the cancer with the highest incidence and mortality rate worldwide. In addition to the diversified treatment and prolonged lifespan in view of the development of medical technology, the side effect of medicine should not be ignored. Drug-induced interstitial lung disease (DI-ILD) is also commonly encountered during this process, and ILD triggered by the treatment of lung cancer characterized by the inflammation and scarring of lung tissue after the antitumor treatment in lung cancer leads to a poor prognosis and high mortality.