National natural science foundation of China funding patterns and policy implications for obstetrics and gynecology research: a decade of trends (2011-2020).

Background: The National Natural Science Foundation of China (NSFC) plays a pivotal role in supporting basic medical research and shaping national funding priorities. As clinical and scientific demands in obstetrics and gynecology grow, particularly in areas closely tied to pharmacological interventions and maternal-fetal health, understanding funding patterns is essential for guiding research strategy and health policy. This study aimed to evaluate NSFC funding trends in obstetrics and gynecology from 2011 to 2020 and examine their alignment with research output and policy-relevant themes.

A Decision-Making Method for Photon/Proton Selection for Nasopharyngeal Cancer Based on Dose Prediction and NTCP.

: Decision-making regarding radiotherapy techniques for patients with nasopharyngeal cancer requires a comparison of photon and proton plans generated using planning software, which requires time and expertise. We developed a fully automated decision tool to select patients for proton therapy that predicts proton therapy (XT) and photon therapy (PT) dose distributions using only patient CT image data, predicts xerostomia and dysphagia probability using predicted critical organ mean doses, and makes decisions based on the Netherlands' National Indication Protocol Proton therapy (NIPP) to select patients likely to benefit from proton therapy. : This study used 48 nasopharyngeal patients treated at the Cancer Hospital of the Chinese Academy of Medical Sciences.

Layered Structured MXene/PVA Conductive Hydrogels with Excellent Mechanical Properties for Flexible Strain and Temperature Sensing.

Conductive hydrogels have broad application in flexible electronics, soft robotics, and human-machine interaction. However, the limited mechanical properties and complex fabrication processes hinder further development. This study proposes a biomimetic hierarchical fabrication strategy to create MXene (2D transition metal carbides)/polyvinyl alcohol (PVA) composite conductive hydrogels with a layered microstructure (LMP) via evaporation-induced self-assembly.

Distribution of perivascular spaces distribution and relate to the clinical features of SCA3.

Background: Spinocerebellar ataxia type 3 (SCA3) is a rare neurodegenerative condition. Prior research has established perivascular spaces (PVS) expansion has been implicated in the pathogenesis and prognosis of various neurodegenerative diseases. To examine PVS changes in SCA3 by comparing patients and matched healthy controls and to identify potential connection of PVS for clinical features.

The role of cellular heterogeneity in thyroid cancer: a multi-modal analysis approach with Mendelian randomization.

Background: Thyroid cancer pathogenesis involves complex interactions between genetic predisposition and alterations in the tumor microenvironment. The causal relationships between inflammatory gene variants and thyroid cancer risk remain poorly understood, as does the cellular heterogeneity within the tumor ecosystem. This study aimed to investigate the causal associations between inflammatory protein genes and thyroid cancer risk, and to characterize the cellular composition and differentiation trajectories within the thyroid cancer microenvironment.

Efficacy of acupuncture treatment in visual field defect: A case report.

Rationale: Visual field defect refers to an impairment of the visual field resulting from damage to the retina, optic nerve, or brain. Visual field defect has a significant impact on the daily life of the patient. There are few clinical trials of acupuncture for visual field loss and even fewer trials of peripheral-central acupuncture for visual field loss.

Magnetic resonance imaging for spinocerebellar ataxia: a bibliometric analysis based on web of science.

The objective of this study was to review the history of magnetic resonance imaging (MRI) research on spinocerebellar ataxia (SCA) over the last 16 years. We conducted a comprehensive bibliometric analysis of relevant scientific literature that explores the use of MRI in studying SCA using CiteSpace. A total of 761 scientific manuscripts, published between January 2009 and March 2025 and available in the Web of Science (WoS) database, were included in this analysis.

HO-responsive polysaccharide-POSS electrochemical nanosystem for targeted thyroid cancer therapy.

Thyroid cancer remains difficult to treat due to poor prognosis and drug resistance. Germacrone, a sesquiterpenoid from Curcuma longa, exhibits antitumor activity by modulating the PI3K/AKT-FOXO3 pathway. Here, we developed a responsive drug delivery system (1-CS-2-POSS@Germacrone) by modifying carboxymethyl chitosan (CMCS) with conjugated units (compound 1) and Jasminum sambac extract (compound 2), and stabilizing it with polyhedral oligomeric silsesquioxane (POSS).

Phosphorylated Toll-like receptor 3 nuclear translocation in cancer cell promotes metastasis and chemoresistance.

Aberrant expression and subcellular location of innate sensors in cancer cells, such as Toll-like receptors (TLRs), correlates with pro-tumoral inflammation and cancer progression, but the mechanism is still largely unknown. Deciphering the proinflammatory mediators in tumor microenvironment will contribute to the development of cancer therapeutics. By using immunohistochemistry in pancreatic ductal adenocarcinoma (PDAC) and multiple other cancer samples, here we found that cancer cell TLR3, a well-known cytoplasmic dsRNA sensor, translocated to the nucleus especially upon chemotherapy stress.

[ Decoction inhibits growth of gastric cancer cell xenografts by promoting cell ferroptosis the P53/SLC7A11/GPX4 axis].

Objectives: To explore the mechanism of Decoction (SSD) for inhibiting growth of gastric cancer xenografts in nude mice.

Methods: Network pharmacology analysis was conducted to identify the common targets of SSD and gastric cancer cell ferroptosis, and bioinformatics analysis and molecular docking were used to validate the core targets. In the cell experiment, AGS cells were treated with SSD-medicated serum, Fer-1 (a ferroptosis inhibitor), or both, and the changes in cell viability, ferroptosis markers (ROS, Fe and GSH), expressions of P53, SLC7A11 and GPX4, and mitochondrial morphology were examined.

First-trimester triglyceride-glucose index and birth weight: a retrospective cohort mediation analysis of preterm birth and gestational complications.

Background: Insulin resistance during pregnancy, while physiologically adaptive to enhance fetal nutrient supply, becomes pathological when excessive, contributing to low birth weight (LBW). The triglyceride-glucose (TyG) index, a biomarker of insulin resistance, predicts gestational complications, but its pathways to birth weight disparities remain unclear. This study investigates whether and to what extent first-trimester TyG index influences birth weight through preterm birth and gestational complications.

Oncohepatology: Navigating liver injury in the era of modern cancer therapy.

In recent years, the rapid evolution of cancer therapies has markedly increased patient survival rates. However, the incidence of adverse events caused by anticancer treatments remains high, leading to significant clinical challenges. As the central hub of drug metabolism and detoxification, the liver is susceptible to therapeutic insults.

Identification of genetic basis underlying mature cotton fiber length through metabolite-based genome-wide association analysis.

Intracellular and cell wall metabolites of cotton fiber cells are believed to influence processes of cell elongation and cell wall synthesis, which have a profound effect on mature fiber length. However, the role of metabolites on fiber length remains unclear. Here, a metabolite-based genome-wide association study was applied for association analysis between intracellular or cell wall metabolites and fiber quality traits using a population of 251 cotton accessions.

Constructing high-quality enhanced 4D-MRI with personalized modeling for liver cancer radiotherapy.

Background: For magnetic resonance imaging (MRI), a short acquisition time and good image quality are incompatible. Thus, reconstructing time-resolved volumetric MRI (4D-MRI) to delineate and monitor thoracic and upper abdominal tumor movements is a challenge. Existing MRI sequences have limited applicability to 4D-MRI.

Contrast-enhanced image synthesis using latent diffusion model for precise online tumor delineation in MRI-guided adaptive radiotherapy for brain metastases.

Magnetic resonance imaging-guided adaptive radiotherapy (MRIgART) is a promising technique for long-course radiotherapy of large-volume brain metastasis (BM), due to the capacity to track tumor changes throughout treatment course. Contrast-enhanced T1-weighted (T1CE) MRI is essential for BM delineation, yet is often unavailable during online treatment concerning the requirement of contrast agent injection. This study aims to develop a synthetic T1CE (sT1CE) generation method to facilitate accurate online adaptive BM delineation.

Clinical and Genetic Findings in a Chinese Cohort of Dentatorubral-Pallidoluysian Atrophy Patients.

Objective: Dentatorubral-pallidoluysian atrophy (DRPLA) is a rare, inherited neurodegenerative disorder caused by the expansion of cytosine-adenine-guanine repeats in ATN1. Most studies on DRPLA to date are limited to case reports. We aimed to provide a comprehensive summary of the clinical, genetic, biological, and magnetic resonance imaging characteristics of DRPLA using cross-sectional baseline data.

Attenuated immune surveillance during squamous cell transformation of pancreatic adenosquamous cancer defines new therapeutic opportunity for cancer interception.

Background: Pancreatic adenosquamous cancer (PASC) is an extremely rare subtype of pancreatic cancer characterized by a poorer prognosis and higher likelihood of metastasis compared with the more prevalent pancreatic ductal adenocarcinoma (PDAC). Although genomic changes during PASC tumorigenesis have been documented, the corresponding alterations in the tumor immune microenvironment (TIME) remain inadequately elucidated. Therefore, this study aims to analyze the immune landscape of PASC by employing multiplex immunohistochemistry (mIHC) and digital image analysis.

Transcranial alternating current stimulation for treating spinocerebellar ataxia type 3: A randomized controlled trial.

There are no specific treatments for spinocerebellar ataxia type 3 (SCA3), a neurodegenerative disease causing cerebellar dysfunction. Transcranial alternating current stimulation (tACS) can improve cerebellar motor functions, and it has been shown to be safe and effective in treating neurological diseases. This randomized controlled trial (RCT) explored the effects of tACS on SCA3 patients.

Effect of High Maintenance Dose Versus Low Dose of Remifentanil on Incidence of Postoperative Nausea and Vomiting (PONV) in Patients Under Gynecological Laparoscopic Procedure: A Pilot Study.

Purpose: The aim of this trial was to investigate postoperative nausea and vomiting (PONV) incidence between low- and high-dose remifentanil with propofol for total intravenous anaesthesia (TIVA) in adult female patients with gynecologic laparoscopy.

Patients And Methods: The randomized clinical trial consisted of two groups: 0.1ug/kg/min remifentanil (L group) (n=39) and 0.

Critical hydraulic components remaining useful life prediction based on long-life test and Bayesian joint model with data augmentation.

Remaining useful life (RUL) predictions of hydraulic components are critical to the operational reliability of hydraulic systems. Currently, research on highly reliable hydraulic components is primarily limited to simulation models, few faulty components or accelerated life tests. Moreover, RUL predictions are mainly limited to multi-source condition monitoring data, potentially leading to difficulties in ensuring long-term RUL prediction accuracy.

A novel ferroptosis-related signature for predicting prognosis, immune characteristics, and treatment prediction in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a malignant tumor with a high incidence and fatality. The occurrence and progression of HCC are tightly linked to ferroptosis, a unique type of cell death. To accurately predict the prognosis, immunological traits, treatment sensitivity, and drug prediction for patients with HCC, this work attempts to develop a novel ferroptosis-related gene signature (nFRGs).

BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner.

Retinal vascular diseases are typified by the proliferation of irregular and leaky microvessels, resulting in vision impairment. Although the etiology of retinal angiogenesis is not yet fully understood, it is evident that microglia play a pivotal role in promoting angiogenesis. In vivo, the METTL14 conditional knockout (cKO) mouse was constructed to investigate the role of METTL14 in oxygen-induced retinopathy (OIR).

MRI-based brain structural changes in adult-onset dentatorubral-pallidoluysian atrophy.

Background And Purpose: Adult-onset dentatorubral-pallidoluysian atrophy (DRPLA) is a rare autosomal dominant spinocerebellar ataxia subtype, characterized by widespread brain neurodegeneration. However, comprehensive studies on whole-brain structural changes remain limited. This study aimed to quantify brain structural damage in adult-onset DRPLA and correlate these findings with clinical data.

An upfront patient selection strategy based on personalized data-driven computed tomography generation for deep inspiration breath-hold in breast radiotherapy.

Background: Currently there is no widely used upfront selection method to determine whether patients are suitable for deep inspiration breath-hold (DIBH) in left-sided breast radiotherapy.

Purpose: To establish an upfront patient selection strategy to improve the decision-making efficiency of DIBH and avoid extra computed tomography (CT) exposure to patients.

Methods: A total of 174 patients who underwent both free-breathing (FB) and DIBH scans were enrolled.