Association of the atherogenic index of plasma and high-sensitivity C-reactive protein with incident cardiovascular disease: evidence from a national cohort of middle-aged and older Chinese adults.

Background: The atherogenic index of plasma (AIP), an emerging biomarker of lipid dysregulation, and high-sensitivity C-reactive protein (hs-CRP), an established marker of inflammation, are both implicated in the development of cardiovascular disease (CVD). However, their joint impact on CVD risk and the underlying mediation mechanisms remain unclear.

Methods: This study used data from the China Health and Retirement Longitudinal Study (CHARLS), including 8,763 adults aged ≥45 years with up to 9 years of follow-up.

Consistency and reliability of ultrasound-derived fat fraction in hepatic steatosis assessment: influence of posture and breathing variations.

Background: Given the recent redefinition of metabolic dysfunction-associated steatotic liver disease (MASLD) and the clinical demand for non-invasive tools, this study evaluated the effect of body position (e.g., supine, left lateral recumbent) and respiratory status (e.

Global trends and inequities in smoking-attributable aortic aneurysm burden from 1990 to 2021 with future projections.

Introduction: Aortic aneurysm (AA) remains a critical global health challenge, with smoking identified as a major modifiable risk factor contributing to its morbidity and mortality. Despite advancements in screening and treatment, the absolute burden of AA has risen significantly, particularly in aging populations and regions with socioeconomic disparities. This study leverages data from the Global Burden of Disease Study to analyze trends in smoking-related AA burden from 1990 to 2021, focusing on mortality, disability-adjusted life years (DALYs), and socioeconomic determinants.

Astragaloside IV alleviates radiation-induced heart disease by regulating energy metabolism.

Background: Radiation-induced heart disease (RIHD) has emerged as a critical complication compromising the long-term survival of cancer patients undergoing radiotherapy. Although targeting myocardial energy metabolism is a promising therapeutic strategy for cardiovascular diseases, the molecular mechanisms underlying ionizing radiation-induced cardiomyocyte metabolic dysregulation and subsequent cardiac injury remain unclear.

Purpose: This study aims to explore the mechanism by which Astragaloside IV (AS-Ⅳ) alleviates RIHD through the regulation of energy metabolism.

The role of cellular heterogeneity in thyroid cancer: a multi-modal analysis approach with Mendelian randomization.

Background: Thyroid cancer pathogenesis involves complex interactions between genetic predisposition and alterations in the tumor microenvironment. The causal relationships between inflammatory gene variants and thyroid cancer risk remain poorly understood, as does the cellular heterogeneity within the tumor ecosystem. This study aimed to investigate the causal associations between inflammatory protein genes and thyroid cancer risk, and to characterize the cellular composition and differentiation trajectories within the thyroid cancer microenvironment.

DNase1 Mimic TMNCs Disrupt Neutrophil Extracellular Traps and Free Radical Circulation for Ischemic Stroke Therapy.

Ischemic stroke continues to be a leading cause of mortality and long-term disability, affecting millions globally each year. Although nanoenzymes are explored as therapeutic candidates, conventional nanoenzymes predominantly target antioxidative mechanisms, which are insufficient to address the complex pathophysiology of ischemic stroke. In response to this challenge, this work introduces Transition Metal Nanocluster catalysts (TMNCs), which are widely recognized for their antioxidative and enzyme-mimicking properties.

Hearing the call of mitochondria: Insight into its role in sensorineural hearing loss.

Sensorineural hearing loss (SNHL) is a prevalent and complex auditory disorder with a multifactorial pathogenesis, in which mitochondrial dysfunction plays a pivotal role. Mitochondria are abundantly localized in critical structures of the inner ear, where they not only provide the substantial energy required for auditory transduction but also regulate key cellular processes. Growing evidence suggests that mitochondrial impairment, characterized by excessive reactive oxygen species (ROS) generation, dysregulated inflammatory responses, disrupted apoptosis, and mitochondrial DNA (mtDNA) mutations, is closely linked to the onset and progression of SNHL.

Mouse models of aortic dissection induced by β-aminopropionitrile combined with angiotensin II and the changes in their gut microbiota.

Background: Aortic dissection (AD) is a lethal vascular disease with no effective pharmacological treatments currently available. The construction of mouse models is crucial for researching the pathogenesis of AD. The gut microbiota play a role in the progression of AD, but studies on their changes in AD mouse models are lacking.

Curcumin inhibits aortic dissection progression: Insights from the integrated analysis of network pharmacology, gut microbiota, and serum metabolomics.

Despite its already-documented benefits, curcumin efficacy in inhibiting aortic dissection (AD) progression remains unclear. Therefore, we aimed to investigate how curcumin could affect β-aminopropionitrile (BAPN)-induced AD progression and explore the potential underlying mechanisms. We established a BAPN-induced AD mouse model and collected aortic tissue for histological stainings.

Gut microbiota diversity and metabolomics analysis of curcumin's alleviation of abdominal aortic aneurysm progression.

Abdominal aortic aneurysm (AAA) is a high-risk vascular condition with a significant need for effective treatments to slow its progression, particularly for small-diameter AAAs. While previous studies have demonstrated curcumin's beneficial effects in AAA mouse models, the role of gut microbiota homeostasis and metabolic changes in this context remains poorly understood. We developed a recently established AAA mouse model and assessed alterations in the gut microbiota.

Injectable, Self-Healing, Superadhesive PVA Hydrogels Promote Skin Wound Healing by Regulating the Inflammatory Microenvironment.

Macrophage cells are crucial in the inflammatory and proliferative phases of skin injury. The key to skin regeneration lies in controlling the immune response triggered by macrophages. The current treatment methods for skin defects include scar healing, skin grafting surgery, and skin flap repair surgery.

Assessment of Bilateral Pedicle Root Puncture Vertebral Fissure Expansion Percutaneous Kyphoplasty for the Treatment of Kümmell Disease.

Study Design: Retrospective analysis of clinical efficacy.

Objective: To assess the clinical efficacy of bilateral pedicle root puncture vertebral fissure expansion percutaneous kyphoplasty (PKP) in the treatment of Kümmell disease (KD).

Summary Of Background Data: KD is a challenging condition characterized by delayed healing of a vertebral compression fracture, often leading to chronic pain and disability.

Influence variables of ultrasound-derived fat fraction in liver fat content measurement: preprandial and postprandial states.

Purpose: To investigate whether there is any effect of preprandial and postprandial states of patients on Ultrasound-derived fat fraction(UDFF) in liver fat content measurement.

Methods: A retrospective study was conducted on 1596 patients who underwent UDFF from January to September 2024; UDFF measurements were performed by a sonographer, who repeated each measurement 5 times before and after meals, respectively, and finally expressed them as the mean; then paired t-tests and analyses of variance (ANOVA) were used to compare the differences in preprandial and postprandial UDFF and Auto p-SWE( Auto point shear wave elastography) values among groups, and linear regression was used to analyze the differences in preprandial and postprandial UDFF and Auto p-SWE values between each group.

Results: The study enrolled 1036 patients(491 males and 545 females), aged 18-89 years, mean age (56.

Association Between Increased Dietary Sodium Intake and Higher Water Intake from Fluid and Food in Children.

: Maintaining an appropriate hydration status is crucial for promoting health. Children, who are in the process of growth and development, are at a higher risk of insufficient water intake and dehydration. This study aimed to compare water intake among children with different levels of dietary sodium intake, and explore the relationship between hydration status, and dietary sodium intake and water intake.

Developing a nomogram for postoperative delirium in elderly patients with hip fractures.

Background: Postoperative delirium (POD) is a prevalent complication, particularly in elderly patients with hip fractures (HFs). It significantly affects recovery, length of hospital stay, healthcare costs, and long-term outcomes. Existing studies have investigated risk factors for POD, but most are limited by single-factor analyses or small sample sizes.

A survey of decision-making and planning methods for self-driving vehicles.

Autonomous driving technology has garnered significant attention due to its potential to revolutionize transportation through advanced robotic systems. Despite optimistic projections for commercial deployment, the development of sophisticated autonomous driving systems remains largely experimental, with the effectiveness of neurorobotics-based decision-making and planning algorithms being crucial for success. This paper delivers a comprehensive review of decision-making and planning algorithms in autonomous driving, covering both knowledge-driven and data-driven approaches.

Intrinsic roles of nanosheet characteristics in two-dimensional montmorillonite membranes for efficient Li/Mg separation.

Stacking two-dimensional (2D) nanosheets into lamellar membranes holds great promise in the selective separation of Li and Mg from salt-lake brines, but revealing the intrinsic effect of nanosheet properties on the ion transport remains a great challenge. The primary reasons are inevitable emerging defects and changes in surface functional groups during nanosheet preparation. Here, we successfully demonstrated the intrinsic dependence of ion separation on the size and layer charge density of 2D building blocks using defect-free and inherently permanent charged clay nanosheets.

Borneol-Functionalized Macrophage Membrane-Encapsulated Mesoporous Selenium Nanoparticles Loaded with Resveratrol for the Treatment of Spinal Cord Injury.

Spinal cord injury (SCI) is a serious neurological disease that can result in paralysis. After SCI occurs, the blood-spinal cord barrier (BSCB) is disrupted, and permeability is transiently elevated. However, the permeability of the BSCB returns to normal over time, which prevents many drugs from being used in subsequent treatments.

Effects of scapular motion control training on treatment of patients with scapular fractures: An observational study.

To explore the effect of scapula motion control training on the rehabilitation effect of patients with scapular fracture. According to the random number table method, 61 patients were evenly divided into observation group 30 cases and control group 31 cases. The control group received routine postoperative functional exercise, and the observation group received functional exercise by adding scapula motion control training to the routine postoperative functional exercise.

Collective Syntheses of Alkaloids Based on a Chirality-Tunable Structure Unit.

A novel strategy based on a common intermediate bearing a chirality-tunable structure unit for the collective syntheses of corynantheine-type and heteroyohimbine-type alkaloids has been developed. Key transformations of the synthetic strategy are a sequential nucleophilic C-N bond formation/Mannich-type cyclization to construct the highly functional C/D rings, a stereocontrolled introduction of the C15 and C20 chiral centers based on the chirality-tunable structure unit, and an amine-directed addition of MeAl to construct the C18 methyl group.

Finite-Time Neuroadaptive Cooperative Control for Nonlinear Multiagent Systems Under Nonaffine Faults and Partially Unknown Control Directions.

This article investigates the cooperative control of complex nonlinear multiagent systems (CNMASs), in which the agents suffer from nonaffine faults and the control directions of some agents are unknown. A finite-time adaptive control scheme is presented for the CNMASs. A finite-time command filter is designed to solve the "explosion of complexity" issues, overcome chattering issues, and relax the limitations of the filter input.

Knockout of TNF-α in microglia decreases ferroptosis and convert microglia phenotype after spinal cord injury.

Spinal cord injury (SCI) is a serious and difficult to treat traumatic disease of the central nervous system. Spinal cord injury causes a variety of detrimental effects, including neuroinflammation and ferroptosis, leading to chronic functional impairment and death. Recent studies have shown that microglia/macrophages (M/Ms) at the injury site remain primarily in the pro-inflammatory state, which is detrimental to recovery.

Antibacterial effect of ultrasound combined with Litsea cubeba essential oil nanoemulsion on Salmonella Typhimurium in kiwifruit juice.

This study investigated the antibacterial effect of ultrasound (US) combined with Litsea cubeba essential oil nanoemulsion (LEON) on Salmonella Typhimurium in kiwifruit juice and effect on the quality and sensory properties of kiwifruit juice. In this study, LEON prepared by ultrasonic emulsification method had a good particle size distribution and high stability. The US+LEON treatment significantly (P < 0.