SKDF: A Simple Knowledge Distillation Framework for Distilling Open-Vocabulary Knowledge to Open-world Object Detector.

Open World Object Detection (OWOD) is a novel computer vision task with a considerable challenge, bridging the gap between classic object detection (OD) and real-world object detection. In addition to detecting and classifying seen/known objects, OWOD algorithms are expected to localize all potential unseen/unknown objects and incrementally learn them. The large pre-trained vision-language grounding models (VLM, e.

Metabolomic profiling of plasma reveals differential disease severity markers in avian influenza A(H7N9) infection patients.

Objectives: Avian influenza such as H7N9 is currently a major global public health risk, and at present, there is a lack of relevant diagnostic and treatment markers.

Methods: We collected plasma samples from 104 confirmed H7N9 patients, 31 of whom died. Plasma metabolites were detected by UHPLC-HRMS, and a survival prediction model based on metabolites was constructed by machine-learning models.

Screening and Evaluation of tRF-Glu-CTC-013 as a Biomarker and Key Regulator in the Development of Cardiac Hypertrophy.

tRNA-derived small RNAs (tsRNAs) are a newly recognized class of non-coding RNAs involved in regulating RNA processing and translational control. Pathological cardiac hypertrophy, characterized by left ventricular remodeling under chronic stress, serves as a critical precursor to severe cardiovascular pathologies including myocardial ischemia, infarction, and heart failure. Utilizing an angiotensin II (Ang II)-induced mouse cardiac hypertrophy model combined with tsRNA transcriptome profiling, we identified differentially expressed tsRNAs and investigated their functional relevance.

Mechanism of the color deepening of secretory cavities in Atractylodes lancea during light and air exposure.

Ethnopharmacological Relevance: Atractylodes lancea is widely used as an herbal medicine and functional food in East Asia. The red hue of secretory cavities (SCs) in A. lancea rhizoma (ALR) serves as a marker of superior quality, though the mechanistic link between color deepening and volatile organic compounds (VOCs) under light/air exposure remains unclear.

Directional sorting of exciton emissions from twisted WS/WSe hetero-bilayers using self-coupled photonic crystal resonances.

Recent advances in two-dimensional semiconductor hetero-bilayers have revealed that the stacking angle between adjacent layers provides an additional degree of freedom to tune exciton states, enabling fascinating twist-angle-dependent photoluminescence. To control exciton emission properties, hetero-bilayers are usually integrated with photonic nanostructures, however, in which the contact interfaces can result in substantial luminescence suppression. To overcome this fundamental issue, we herein directly pattern photonic crystal (PhC) nanostructures in free-standing WS/WSe hetero-bilayers to avoid the involvement of contact interfaces.

Membrane-associated ring-CH-type finger 2 protects against metabolic dysfunction-associated fatty liver disease by targeting fatty acid synthase.

Objective: Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as an important public health concern that poses a significant threat to human health and imposes a substantial economic burden. Research has demonstrated that ubiquitin ligase-mediated substrate protein ubiquitination is a pivotal factor influencing liver lipid homeostasis and metabolic abnormalities in MAFLD. Nevertheless, the specific enzyme molecules implicated in this regulatory process remain to be elucidated.

A survey of decision-making and planning methods for self-driving vehicles.

Autonomous driving technology has garnered significant attention due to its potential to revolutionize transportation through advanced robotic systems. Despite optimistic projections for commercial deployment, the development of sophisticated autonomous driving systems remains largely experimental, with the effectiveness of neurorobotics-based decision-making and planning algorithms being crucial for success. This paper delivers a comprehensive review of decision-making and planning algorithms in autonomous driving, covering both knowledge-driven and data-driven approaches.

Clinical Characteristics and Predicting Disease Severity in Chlamydia psittaci Infection Based on Metagenomic Next-Generation Sequencing.

Introduction: Psittacosis pneumonia, as a zoonotic infection, is induced by the pathogen . In the present study, we sought to characterize the clinical manifestations and prognosticate the severity of psittacosis pneumonia.

Methods: We retrospectively verified instances of psittacosis pneumonia in Zhejiang province, China, from January 2021 to April 2024.

Localization and detection of deepfake videos based on self-blending method.

Deepfake technology, which encompasses various video manipulation techniques implemented through deep learning algorithms-such as face swapping and expression alteration-has advanced to generate fake videos that are increasingly difficult for human observers to detect, posing significant threats to societal security. Existing methods for detecting deepfake videos aim to identify such manipulated content to effectively prevent the spread of misinformation. However, these methods often suffer from limited generalization capabilities, exhibiting poor performance when detecting fake videos outside of their training datasets.

Directional Chiral Exciton Emission via Topological Polarization Singularities in all Van der Waals Metasurfaces.

Monolayer transition metal dichalcogenides (TMDs) with strong exciton effects have enabled diverse light emitting devices, however, their Ångstrom thickness makes it challenging to efficiently manipulate exciton emission by themselves. Although their nanostructured multi-layer counterparts can effectively manipulate optical field at deep subwavelength thickness scale, these indirect band gap multi-layer TMDs are lack of strong luminescence, hindering their applications in light emitting devices. Here, the integration of monolayer TMDs is presented with nanostructured multi-layer TMDs, combining both strong exciton emission and optical manipulation in a single ultra-thin platform.

[Tissue distribution of volatile compounds in secretory cavities of different rhizome sections of wild Atractylodes lancea and A. lancea transplanted for different years].

Laser capture microdissection(LCM) combined with gas chromatography-mass spectrometry(GC-MS) was employed to investigate the distribution of volatile compound in the secretory cavities of different tissues(cortex, phloem, xylem, and pith) in different rhizome sections of wild Atractylodes lancea. The same method was used to study the metabolic characteristics of the volatile compounds in the secretory cavities of different rhizome tissues of A. lancea transplanted for 1-3 years.

Immature PIT1-lineage Pituitary Neuroendocrine Tumors/Adenomas, a Morphologically Unique Pituitary Neuroendocrine Tumors/Adenomas Commonly With Cytologic Atypia Features and a Predilection for Aggressive Clinical Potential.

Immature PIT1-lineage pituitary neuroendocrine tumors (PitNETs)/adenomas (Immature PIT1-lineage tumors) are a rare and underrecognized subtype of PitNETs that exhibits distinct cytologic atypia features and aggressive clinical potential. This study characterizes the clinical, radiological, histologic, and immunohistochemical features of 15 immature PIT1-lineage tumors identified from 1084 PitNETs patients over 5 years. Our cohort of 6 males and 9 females had a median age of 37.

Zwitterionic Peptides: From Mechanism, Design Strategies to Applications.

Zwitterionic peptides, as a type of peptide composed of charged residues, are electrically neutral, which combine the advantages of zwitterionic materials and biological peptides, exhibiting hydrophilicity and programmable properties. As attractive candidates for resisting nonspecific adsorption of biomacromolecules and microorganisms, zwitterionic peptides have been applied in materials science, biomedicine, and biochemistry over the past decade. In this review, the development of zwitterionic peptides has been systematically outlined and analyzed, including their mechanisms, structure-function relationships, and design strategies.

Polarization-Controlled Exciton-Polaritons in WS Strongly Coupled with Low-Symmetry Photonic Crystal Nanostructures.

Atomically thin transition metal dichalcogenides (TMDs) with ambient stable exciton resonances have emerged as an ideal material platform for exciton-polaritons. In particular, the strong coupling between excitons in TMDs and optical resonances in anisotropic photonic nanostructures can form exciton-polaritons with polarization selectivity, which offers a new degree of freedom for the manipulation of the light-matter interaction. In this work, we present the experimental demonstration of polarization-controlled exciton-polaritons in tungsten disulfide (WS) strongly coupled with polarization singularities in the momentum space of low-symmetry photonic crystal (PhC) nanostructures.

Contribution of Litter and Root to Soil Nutrients in Different Rocky Desertification Grasslands in a Karst Area.

Litter and root decomposition is an important source of soil organic matter and nutrients. To ascertain the contribution of litter and root to natural grassland nutrients in rocky desertification areas, from March 2017 to January 2018, the continuous soil column method, collector method, and litter decomposition method were used to study the soil nutrients, litter and root biomass, decomposition, and nutrient release of potential, moderate, and severe rocky desertification grasslands, as well as their responses to rocky desertification. The results showed that the litter and root decomposition rate showed a trend of being first fast and then slow, and the decomposition rate of litter and root was greater than 50% after 300 days.

Genome resequencing reveals the genetic basis of population evolution, local adaptation, and rewiring of the rhizome metabolome in .

The formation of high-quality Chinese medicinal materials is a micro-evolutionary process of multiple genes involving quantitative inheritance under environmental stress. is a traditionally used medicinal plant in China that is broadly distributed and possesses a considerable amount of essential oils. However, to date, limited research has been conducted to characterize the genetics and metabolites of shaped by natural variation.

Spin-Locked WS Vortex Emission via Photonic Crystal Bound States in the Continuum.

Owing to their strong exciton effects and valley polarization properties, monolayer transition-metal dichalcogenides (1L TMDs) have unfolded the prospects of spin-polarized light-emitting devices. However, the wavefront control of exciton emission, which is critical to generate structured optical fields, remains elusive. In this work, the experimental demonstration of spin-locked vortex emission from monolayer Tungsten Disulfide (1L WS) integrated with Silicon Nitride (SiN) PhC slabs is presented.

Excitonic van der Waals Metasurfaces for Resonant Wavefront Shaping at Deep Subwavelength Thickness Scale.

Dielectric phase gradient metasurfaces have emerged as promising candidates to shrink bulky optical elements to subwavelength thickness scale based on dielectric meta-atoms. These meta-atoms strongly interact with light, thus offering excellent phase manipulation of incident light. However, to fulfill 2π phase control using meta-atoms, the metasurface thickness, to date, is limited to the order of 10 nm.

Shrimp hemocyanin elicits a potent humoral response in mammals and is favorable to hapten conjugation.

Conjugation to a carrier protein is essential to give rise to the antigenicity of hapten. Three carrier proteins e.g.

Chiral absorption enhancement via critically coupled resonances in atomically thin photonic crystal exciton-polaritons.

Atomically thin transition metal dichalcogenides (TMDS) offer a promising route to the scaling down of optoelectronic devices to the ultimate thickness limit. But the weak light-matter interaction caused by their atomically thin nature makes them inevitably rely on external photonic structures to enhance optical absorption. Here, we report chiral absorption enhancement in atomically thin tungsten diselenide (WSe) using chiral resonances in photonic crystal (PhC) nanostructures patterned directly in WSe itself.

Sevoflurane-induced regulation of NKCC1/KCC2 phosphorylation through activation of Spak/OSR1 kinase and cognitive impairment in ischemia-reperfusion injury in rats.

The occurrence of excitotoxic damage caused by cerebral ischemia-reperfusion (I/R) injury is closely linked to a decrease in central inhibitory function, in which the concentration of chloride inside the cells ([Cl-]) plays a crucial role. The outflow and inflow of [Cl-] are controlled by KCC2 and NKCC1, which are cellular cotransporters for K+/Cl- and Na+/K+/Cl-, respectively. NKCC1/KCC2 is regulated by upstream regulators such as SPAK and OSR1, whose activity is influenced by I/R.

Impact of non-emergency surgical timing on postoperative recovery quality in mild or asymptomatic SARS-CoV-2 infected patients: a grouped cohort study.

Objective: To explore the relationship between the timing of non-emergency surgery in mild or asymptomatic SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infected individuals and the quality of postoperative recovery from the time of confirmed infection to the day of surgery.

Methods: We retrospectively reviewed the medical records of 300 cases of mild or asymptomatic SARS-CoV-2 infected patients undergoing elective general anaesthesia surgery at Yijishan Hospital between January 9, 2023, and February 17, 2023. Based on the time from confirmed SARS-CoV-2 infection to the day of surgery, patients were divided into four groups: ≤2 weeks (Group A), 2-4 weeks (Group B), 4-6 weeks (Group C), and 6-8 weeks (Group D).

Mussel-inspired protein-based nanoparticles for curcumin encapsulation and promoting antitumor efficiency.

Curcumin demonstrated therapeutic potential for cancer. However, its medical application is limited due to low solubility, poor stability and low absorption rate. Here, we used the mussel-inspired functional protein (MPKE) to fabricate the curcumin-carrying nanoparticle (Cur-MPKE) for encapsulating and delivering curcumin.