Dual-Layer Flexible Liquid Metal Fiber for Plantar Pressure Monitoring and Synchronous Wound Electrotherapy.

Plantar wounds, particularly diabetic foot ulcers (DFUs), impose significant burdens on patients' quality of life and healthcare systems. Personalized wound management demands real-time monitoring of biomechanical parameters and effective therapeutic interventions to prevent exacerbations. Here, a dual-layer flexible liquid metal fiber (LMF) capable of simultaneous plantar pressure sensing and electrical stimulation for accelerated wound healing is presented.

Contrasting Physiological Responses of Phaeodactylum tricornutum and Thalassiosira weissflogii to Light and Silicon Availability.

Diatoms are key contributors to marine primary production and play pivotal roles in global carbon and silicon cycles. Understanding their physiological responses to light intensity and silicon availability is essential for predicting their ecological roles under future ocean scenarios. Here, we investigated the species-specific acclimation strategies of two diatoms, Phaeodactylum tricornutum and Thalassiosira weissflogii, across six combinations of light (50 and 200 μmol photons m s) and silicon concentrations (30, 70, and 160 μM).

Hydrogel-Based Therapeutics for Diabetic Oral Wounds: From Mechanisms to Applications.

Diabetic oral wound healing is significantly impaired due to chronic inflammation, oxidative stress, and immune dysfunction, often resulting in delayed recovery or severe infections. Hydrogels have emerged as promising biomaterials for treating diabetic oral wounds due to their excellent biocompatibility, high drug-loading capacity, strong adhesion, and tunable degradation properties. This review examines recent advancements in hydrogel-based therapies for diabetic oral wound healing, with a particular focus on their applications in mucosal repair, periodontal tissue regeneration, and bone defect restoration.

PD-L1-Targeting Biomimetic Photoresponsive Thermosensitive Liposomes for Triple-Negative Breast Cancer.

Peptide-based therapeutic strategies offer considerable potential for tumor immunotherapy but suffer from poor systemic bioavailability, rapid plasma clearance, and limited tumor-targeting efficiency. To address these challenges, a biomimetic, photothermal-responsive liposomal delivery system was developed that enables precise delivery of immunotherapeutic peptides while enhancing the synergistic effects of photothermal therapy. This system enhances peptide stability through fluorination, disrupts post-translational modifications of PD-L1, and promotes its degradation, thereby amplifying the anti-tumor immune response.

Structurally Adaptive Branched Polyimide Binder with Synergistic Elastic Buffering and Ionic Transport for Long-Term Stability of Silicon Anodes.

Overcoming the significant volume expansion and mitigating the poor interfacial stability are pivotal challenges that must be addressed to fully unlock the potential of silicon (Si) as an anode material for next-generation lithium-ion batteries (LIBs). Herein, a 3D branched polyimide binder with superior elasticity and ion conductivity is synthesized through the copolymerization of 3,3',4,4'-biphenyltetracarboxylic dianhydride (BPDA) with tough 4,4'-oxydianiline (ODA), polar isophthalic dihydrazide (IDP), and flexible poly(dimethylsiloxane)etherimide (DMS), while incorporating branched 1,3,5-tris(4-aminophenoxy)benzene (TAPOB) to construct a robust 3D crosslinked network. The 3D network of mPI-T contains abundant aromatic benzene rings, providing high toughness and structural stability.

The role of cellular heterogeneity in thyroid cancer: a multi-modal analysis approach with Mendelian randomization.

Background: Thyroid cancer pathogenesis involves complex interactions between genetic predisposition and alterations in the tumor microenvironment. The causal relationships between inflammatory gene variants and thyroid cancer risk remain poorly understood, as does the cellular heterogeneity within the tumor ecosystem. This study aimed to investigate the causal associations between inflammatory protein genes and thyroid cancer risk, and to characterize the cellular composition and differentiation trajectories within the thyroid cancer microenvironment.

The competence shield: Fostering competence perceptions weakens the dominance penalty for women in leadership.

Although research has consistently found that women face social and economic penalties for displaying assertive, dominant agentic qualities often deemed necessary for leadership, limited work has examined how to mitigate the dominance penalty. Integrating the expectation states theory and multidimensional perspectives of agentic perceptions, we found that fostering perceived leader competence attenuated the dominance penalty. Across four studies, including two multiwave, multisource field studies (Studies 1 and 3), a critical incident experiment (Study 2a), and a vignette experiment (Study 2b), we observed the dominance penalty at lower but not higher levels of perceived leader competence.

CD142-positive synovial fibroblasts drive meniscus destruction in rheumatoid arthritis.

Previous evidence suggest bone and cartilage damage is the main pathogenesis of rheumatoid arthritis joint destruction. However, the role of meniscus usually has not been thoroughly explored. Here, we identify CD142 synovial fibroblasts as a subset located at sublining layer in normal and osteoarthritis synovium, which is increased and distributed at lining layer in rheumatoid arthritis synovium.

Application of machine learning in EEG-based dementia diagnosis: Classification and differential diagnosis.

BackgroundElectroencephalogram (EEG) is a promising, non-invasive method for identifying the presence of Alzheimer's disease (AD) by recognizing specific brain activity patterns associated with the disease. However, research on the correlation between EEG and the degree of cognitive impairment is still lacking.ObjectiveIn this study, we employ machine learning models to explore the potential of EEG in distinguishing different levels of cognitive impairment and various types of dementia.

HO-responsive polysaccharide-POSS electrochemical nanosystem for targeted thyroid cancer therapy.

Thyroid cancer remains difficult to treat due to poor prognosis and drug resistance. Germacrone, a sesquiterpenoid from Curcuma longa, exhibits antitumor activity by modulating the PI3K/AKT-FOXO3 pathway. Here, we developed a responsive drug delivery system (1-CS-2-POSS@Germacrone) by modifying carboxymethyl chitosan (CMCS) with conjugated units (compound 1) and Jasminum sambac extract (compound 2), and stabilizing it with polyhedral oligomeric silsesquioxane (POSS).

Improving the Stability of FAPbI Based-Inverted Perovskite Solar Cells Through In Situ Passivation of Grain Boundaries at the Buried Interface.

Inverted perovskite solar cells (PSCs) offer superior operational stability in comparison to their normal-structure counterparts. However, the efficiency and stability of p-i-n perovskite solar cells prepared in air are still less than those prepared in an inert atmosphere. In this work, it is found that introducing a precise amount of RbCl into the perovskite precursor solution results in the in situ formation of (PbI)RbCl at the grain boundaries of the buried interface of the perovskite film, which can passivate the defects at the buried interface, suppresses ion migration, and enhance the stability of perovskite films.

The Key Steps and Distinct Performance Trends of Pyrrolic vs Pyridinic M-N-C Catalysts in Electrocatalytic Nitrate Reduction.

The electrochemical nitrate reduction reaction (NORR) offers a sustainable route for ambient ammonia synthesis. While metal-nitrogen-carbon (M-N-C) single-atom catalysts have emerged as promising candidates for the NORR, the structure-activity relations underlying their catalytic behavior remain to be elucidated. Through systematic analysis of reported experimental data and pH-field coupled microkinetic modeling on a reversible hydrogen electrode (RHE) scale, we reveal that the coordination-dependent activity originates from distinct scaling relations governed by metal-intermediate interactions.

Metabolite-Mediated Trophic Interactions: Long-Term Responses of Thalassiosira weissflogii to High CO and Warming Have Cascading Effects on Consumer Metabolism.

Rising CO and warming are key components of climate change that are reshaping ecosystems by altering trophic interactions. Although a large body of literature describes changes in biomass in response to these drivers, the biochemical mechanisms driving these shifts remain unclear. This study investigated the long-term response of the marine diatom Thalassiosira weissflogii to high CO, warming, and their combinations (3.

Microbubble-Templated Immunoactive Metal-Phenolic Capsules for Drug Delivery and Enhanced Cancer Immunotherapy.

Advanced drug delivery systems integrating immunomodulatory functions can improve cancer therapy. Herein, we develop a novel metal-phenolic capsule for synergistic drug delivery and immunomodulation. Specifically, a stable metal-phenolic network (MPN), formed by Fe (III), tannic acid, and catechol-modified hyaluronic acid, was assembled onto doxorubicin (DOX)-loaded mannose-glycated bovine serum albumin microbubbles to construct microcapsules with both drug loading and immunomodulatory functions simultaneously.

Revealing Performance-Limiting Buried Interfaces in Layered Dion-Jacobson Lead-Iodide Perovskites.

Dion-Jacobson (DJ) two-dimensional (2D) perovskites have emerged as promising photovoltaic materials due to their superior structural and chemical stability compared to three-dimensional (3D) perovskites. However, their optoelectronic performance remains limited by imperfections at interfaces and a fundamental understanding of these interfacial properties is missing. Herein, we present interfacial structure-property relationships in DJ perovskites by directly probing buried interfaces using combined spectroscopic and microscopic characterization techniques.

Efficacy and Mechanism of Bazi Bushen Capsule on Skin Laxity: A Combination of Clinical and Network Pharmacology Study.

Purpose: This study aims to explore the mechanism of Bazi Bushen Capsule (BZBS) in treating skin laxity by combining network pharmacology and clinical research.

Methods: The active ingredients and potential drug targets of BZBS were obtained from TCMSP, TCMBANK, and SuperTCM databases. The potential disease targets of skin laxity were obtained from GeneCards, OMIM, and DisGeNET databases.

Cancer Burden in Neighborhoods With Greater Racial Diversity and Environmental Burden.

Importance: Ohio has among the nation's highest environmental burden and disproportionately higher lung or bronchus cancer incidence rates.

Objective: To examine (1) the association between environmental burden and cancer, (2) the association between minoritized population and cancer, and (3) the association of environmental burden-minoritized population jointly with cancer.

Design, Setting, And Participants: An area-level cohort study examining mean annual age-adjusted cancer incidence rates in Ohio from 2011 to 2020.

Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma.

Micropeptides, originating from noncanonical translation, represent novel biomolecules with critical roles in tissue homeostasis and cancer development. However, the proteomic landscape and functional mechanisms of micropeptides in hepatocellular carcinoma (HCC) remain largely elusive. By employing a newly devised ultrafiltration tandem mass spectrometry assay, we identified an abundance of micropeptides in clinical HCC samples.

Degradation Pathway Tailoring through Nanocrystal Interface Engineering for Photostable Perovskite Solar Cells.

While organic-inorganic hybrid perovskites (ABX) hold immense photovoltaic potential, operational instability originating from defect-mediated ion migration and light-induced degradation remains a critical bottleneck. Here, we adopt CsPbICl nanocrystals (CPIC-NCs) and CsPbCl nanocrystals (CPC-NCs) to modify the interface of the perovskite light-absorbing layer. Beyond conventional defect-healing roles (Cs/halide filling of the A/X-site vacancies), this modification can fundamentally alter the degradation pathways of perovskite films under light exposure.

Sonicated Carbon Nanotube Catalysts for Efficient Point-of-use Water Treatment.

The rising demand for freshwater and increasing contamination of distributed water sources, such as stormwater and surface water, necessitate innovative point-of-use treatment technologies. Advanced oxidation processes (AOPs) using solid oxidants offer a promising approach for decentralized freshwater production but are often limited by nonselective radical reactions that degrade both pollutants and background water constituents. Here, sonicated carbon nanotubes (CNTs) that efficiently activate peroxymonosulfate are demonstrated, enabling selective contaminant degradation via dual nonradical pathways-singlet oxygen oxidation and direct electron transfer.

Reducing the V Loss of Hole Transport Layer-Free Carbon-Based Perovskite Solar Cells via Dual Interfacial Passivation.

The hole transport layer (HTL)-free carbon-based perovskite solar cells (C-PSCs) are promising for commercialization owing to their excellent operational stability and simple fabrication process. However, the power conversion efficiencies (PCE) of C-PSCs are inferior to the metal electrode-based devices due to their open-circuit voltage (V) loss. Herein, time-resolved confocal photoluminescence microscopy reveals that grain boundary defects at the perovskite/carbon interface are very likely to function as nonradiative recombination centers in HTL-free C-PSCs.

Closed-Loop Framework for Discovering Stable and Low-Cost Bifunctional Metal Oxide Catalysts for Efficient Electrocatalytic Water Splitting in Acid.

Electrocatalytic water splitting, comprising the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), provides a sustainable route for hydrogen production. While low-cost metal oxides (MOs) are appealing as alternatives to noble metal electrocatalysts, their application in acidic media remains challenging. However, the dynamic nature of some MO surface structures under electrochemical conditions offers an opportunity for rational catalyst design to achieve bifunctionality in acidic OER and HER.

Self-Cleaning Microwave-Responsive MXene-Coated Filtration System for Enhanced Airborne Virus Disinfection.

The COVID-19 pandemic has highlighted the urgent demand for advanced air disinfection technologies. Traditional air filters primarily capture large airborne particles but are ineffective against submicrometer aerosols. This study introduces a microwave-enabled catalytic air filtration system using TiCT MXene-coated polypropylene filters to enhance air disinfection.

Study on mechanism of iridoid glycosides derivatives from Fructus Gardeniae in treatment of hepatic encephalopathy by network pharmacology and molecular docking technology.

Background: This study aims to explore the mechanism of the iridoid glycosides from Fructus Gardeniae (IGFG) in treating hepatic encephalopathy (HE) by combining network pharmacology and molecular docking technology.

Methods: Firstly, we collected the targets of IGFG and HE. The targets of IGFG were predicted through the CTD, SWISS and TCMSP database and the targets of HE were screened through the DisGeNET database.