Contrasting Physiological Responses of Phaeodactylum tricornutum and Thalassiosira weissflogii to Light and Silicon Availability.

Diatoms are key contributors to marine primary production and play pivotal roles in global carbon and silicon cycles. Understanding their physiological responses to light intensity and silicon availability is essential for predicting their ecological roles under future ocean scenarios. Here, we investigated the species-specific acclimation strategies of two diatoms, Phaeodactylum tricornutum and Thalassiosira weissflogii, across six combinations of light (50 and 200 μmol photons m s) and silicon concentrations (30, 70, and 160 μM).

Cyclodextrin-Based Supramolecular Hydrogels in Tissue Engineering and Regenerative Medicine.

Cyclodextrins (CDs), cyclic oligosaccharides formed by α-1,4-glycosidic-bonded D-glucopyranose units, feature unique hydrophobic cavities and hydrophilic exteriors that enable molecular encapsulation via host-guest interactions. CDs form supramolecular host-guest complexes with diverse molecular entities, establishing their fundamental role in supramolecular chemistry. This review examines fabrication strategies for CD-based supramolecular hydrogels and their applications in tissue engineering and regenerative medicine, with focused analysis on wound healing, corneal regeneration, and bone repair.

Threats of BaA-SM2 as key bioaccumulated polycyclic aromatic hydrocarbon and antibiotic components to coral energy dynamics and symbiosis stability.

Scleractinian corals, integral to marine biodiversity, are increasingly threatened by environmental contaminants such as polycyclic aromatic hydrocarbons (PAHs) and antibiotics. Yet, the mechanisms underlying their bioaccumulation and effects on scleractinian corals within natural reef ecosystems remain poorly understood. Here, we investigated the bioaccumulation of PAHs and antibiotics in both coral hosts and algal symbionts of Galaxea fascicularis, and examined the impacts of these pollutants on coral-algal symbiosis and energy metabolism in situ.

Metabolite-Mediated Trophic Interactions: Long-Term Responses of Thalassiosira weissflogii to High CO and Warming Have Cascading Effects on Consumer Metabolism.

Rising CO and warming are key components of climate change that are reshaping ecosystems by altering trophic interactions. Although a large body of literature describes changes in biomass in response to these drivers, the biochemical mechanisms driving these shifts remain unclear. This study investigated the long-term response of the marine diatom Thalassiosira weissflogii to high CO, warming, and their combinations (3.

Effective repair of endometrial injury in rats using enzyme cross-linked gelatin hydrogels with human menstrual blood-derived stem cells.

An intact endometrium is critical for zygote implantation and embryonic development, and the recurrence rate after transcervical resection of adhesion surgery is high in patients with endometrial injury. Therefore, there is an urgent need to develop more efficient and stable treatment to solve this problem. In the present study, firstly we used gelatin as a substrate and glutamine transferase as a cross-linking agent to fabricate enzyme cross-linked gelatin hydrogels which have a microporous structure, then implanted human menstrual blood-derived mesenchymal stem cells (MenSCs) in the form of single cells or cell spheres (MenSC/Gel) into enzyme-linked hydrogels.

Spatiotemporal Circadian Oscillator Manipulation for Enhanced Ovarian Cancer Therapy Using a Versatile Nanoplatform.

Circadian rhythm (CR) disruption has been confirmed as a contributing factor to tumor progression. However, regulating circadian genes shows an inhibitory effect on ovarian tumor initiation and progression, which highlights the urgent necessity to regulate tumors' CR to understand their role in ovarian cancer (OC) therapy precisely. Herein, a novel near-infrared (NIR) light-controlled spatiotemporal strategy is presented, aiming to manipulate ovarian tumors' CR while enhancing the efficacy of chemotherapy agents.

Coexisting Lung Cancer and Pulmonary Tuberculosis: A Comprehensive Review From Incidence to Management.

Background: Globally, infections account for 10% of new cancer cases, and cancer can compromise the immune system, increasing the risk of infections. With advances in cancer treatment, widespread use of immunotherapy, and prolonged survival of cancer patients, the coexistence of tuberculosis (TB) and cancer is becoming increasingly common in clinical settings.

Aim: This review aims to explore the interaction between tuberculosis (TB) and tumors, particularly lung cancer (LC), and to identify appropriate clinical management approaches.

2D InGeTe Crystals for High-Performance p-Channel Transistors.

Two-dimensional (2D) semiconductors are ideal channel materials for high-speed, low-power transistors in the post-Moore era due to their high mobility and excellent gate-control capacity. However, most existing 2D semiconductors tend to exhibit either n-type or ambipolar behavior. The limited availability of intrinsic p-type 2D semiconductors significantly restricts their application in logic circuits and integrated circuits.

Optogenetic activation of mechanical nociceptions to enhance implant osseointegration.

Orthopedic implants with high elastic modulus often suffer from poor osseointegration due to stress shielding, a phenomenon that suppresses the expression of intracellular mechanotransduction molecules (IMM) such as focal adhesion kinase (FAK). We find that reduced FAK expression under stress shielding is also mediated by decreased calcitonin gene-related peptide (CGRP) released from Piezo2 mechanosensitive nerves surrounding the implant. To activate these nerves minimally invasively, we develop a fully implantable, wirelessly rechargeable optogenetic device.

Designable excitonic effects in van der Waals artificial crystals with exponentially growing thickness.

When disassembled into monolayers from their bulk crystals, two-dimensional (2D) transition metal dichalcogenides (TMDCs) exhibit exotic optical properties dominated by strong excitonic effects. Reassembling 2D TMDC layers to build bulk excitonic crystals can significantly boost their optical performance and introduce emerging functionalities toward optoelectronic and valleytronic applications. However, maintaining or manipulating 2D excitonic properties in bulk structures or superlattices is challenging.

Mitochondrial-Targeted Multifunctional Platinum-Based Nano "Terminal-Sensitive Projectile" for Enhanced Cancer Chemotherapy Efficacy.

Platinum-based anticancer drugs exert their effects by forming adducts within nuclear DNA (nDNA), inhibiting transcription and inducing apoptosis in cancer cells. However, tumor cells have evolved mechanisms to resist these drugs. Given mitochondria's role in cancer and their lack of nucleotide excision repair (NER), targeting mitochondrial DNA (mtDNA) offers a strategy.

Intervening Non-Small-Cell Lung Cancer Progression by Cell Membrane Coated Platycodin D via Regulating Hsa-miR-1246/FUT9/GSK3β Pathway.

Purpose: Metastatic non-small cell lung cancer (NSCLC) remains a global health threat, with patients facing inevitable disease progression despite standard-of-care therapy. Prior studies showed Platycodin D (PD)-induced cell cycle arrest and apoptosis in NSCLC via RNA regulatory network, yet elucidating PD's mechanisms in NSCLC progression is challenging in the real world.

Methods: Biological effects of PD on NSCLC cell lines A549 and PC-9 were assessed through in vitro assays, encompassing apoptosis, proliferation, colony formation, migration and invasion.

Proteomics analysis reveals the antagonistic interaction between high CO and warming in the adaptation of the marine diatom Thalassiosira weissflogii in future oceans.

While it is known that warming and rising CO level might interactively affect the long-term adaptation of marine diatoms, the molecular and physiological mechanisms underlying these interactions in the marine diatom Thalassiosira weissflogii on an evolutionary scale remain largely unexplored. In this study, we investigated the changes in metabolic pathways and physiological responses of T. weissflogii under long-term ocean acidification and/or warming conditions (∼3.

Prosthetic articulating spacers as a preferred option for two-stage revision arthroplasty in chronic periprosthetic joint infection.

Purpose: The study aimed to compare the infection control rates, mechanical complications, and functional outcomes between prosthetic and cement spacers in two-stage revision arthroplasty for chronic periprosthetic joint infection (PJI).

Patients And Methods: Data from patients treated for chronic PJI in our center from 2014 to 2023 were retrospectively collected and the patients were divided into the prosthetic spacer (PS) and cement spacer (CS) groups based on the type of spacer used for the first-stage surgeries. Data on patients' demographics and clinical scores were harvested.

Coral-Symbiodiniaceae symbiotic associations under antibiotic stress: Accumulation patterns and potential physiological effects in a natural reef.

Antibiotics threaten scleractinian corals, but their accumulation patterns and physiological effects on corals in natural reefs remain unclear. This study investigated antibiotic occurrence in seawater and two coral species, Galaxea fascicularis and Pocillopora damicornis, and explored the physiological effects of bioaccumulated antibiotics in a fringing reef of the South China Sea. Nineteen antibiotic components were detected in seawater, with total antibiotic concentrations (ΣABs) ranging from 17.

Differential bioaccumulation and tolerances of massive and branching scleractinian corals to polycyclic aromatic hydrocarbons in situ.

Scleractinian corals are capable of accumulating polycyclic aromatic hydrocarbons (PAHs) in reef environments; however, the mechanism behind their PAHs tolerance is unknown. This study investigated the occurrence and bioaccumulation of PAHs in coral reef ecosystems and examined the physiological responses induced by PAHs in coral hosts and their algal symbionts, the massive coral Galaxea fascicularis and branching coral Pocillopora damicornis. G.

Platycodin D inhibits angiogenic vascular mimicry in NSCLC by regulating the eIF4E-mediated RNA methylome.

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Erratum: Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin axis.

[This corrects the article DOI: 10.1016/j.isci.

Direct measurement of built-in electric field inside a 2D cavity.

The on-demand assembly of 2D heterostructures has brought about both novel interfacial physical chemistry and optoelectronic applications; however, existing studies rarely focus on the complementary part-the 2D cavity, which is a new-born area with unprecedented opportunities. In this study, we have investigated the electric field inside a spacer-free 2D cavity consisting of a monolayer semiconductor and a gold film substrate. We have directly captured the built-in electric field crossing a blinking 2D cavity using a Kelvin probe force microscopy-Raman system.

Effects of cognitive behavioral therapy in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis.

Background: Chronic obstructive pulmonary disease (COPD) causes airflow blockage and breathing-related issues. This chronic disease impacts people worldwide. Substantial evidence supports the use of cognitive behavioral therapy (CBT) to help patients with chronic illnesses cope with worrisome and painful symptoms.

Novel Sandwich-Structured Flexible Composite Films with Enhanced Piezoelectric Performance.

Piezoelectric poly(vinylidene fluoride) (PVDF) and its copolymers have been widely investigated for applications in wearable electric devices and sensing systems, owing to their intrinsic piezoelectricity and superior flexibility. However, their weak piezoelectricity poses major challenges for practical applications. To overcome these challenges, we propose a two-step synthesis approach to fabricate sandwich-structured piezoelectric films (BaTiO@PDA/PVDF/BaTiO@PDA) with significantly enhanced ferroelectric and piezoelectric properties.

A positive feedback loop between ZEB2 and ACSL4 regulates lipid metabolism to promote breast cancer metastasis.

Lipid metabolism plays a critical role in cancer metastasis. However, the mechanisms through which metastatic genes regulate lipid metabolism remain unclear. Here, we describe a new oncogenic-metabolic feedback loop between the epithelial-mesenchymal transition transcription factor ZEB2 and the key lipid enzyme ACSL4 (long-chain acyl-CoA synthetase 4), resulting in enhanced cellular lipid storage and fatty acid oxidation (FAO) to drive breast cancer metastasis.

Efficient Malaria Parasite Detection From Diverse Images of Thick Blood Smears for Cross-Regional Model Accuracy.

: The purpose of this work is to improve malaria diagnosis efficiency by integrating smartphones with microscopes. This integration involves image acquisition and algorithmic detection of malaria parasites in various thick blood smear (TBS) datasets sourced from different global regions, including low-quality images from Sub-Saharan Africa. This approach combines image segmentation and a convolutional neural network (CNN) to distinguish between white blood cells, artifacts, and malaria parasites.

Effects of acupuncture on sleep quality in patients with Parkinson's disease: A systematic review and meta-analysis.

Objective: To systematically evaluate the evidence relating to acupuncture on the sleep quality of patients with Parkinson's disease.

Data Sources: Six English-language (PubMed, Cochrane Library, EBSCOhost, Embase, OVID MEDLINE, and Web of Science) and four Chinese-language (China National Knowledge Infrastructure, SinoMed, China Scientific Journals Database, and Wanfang) databases were searched for pertinent studies published from database inception to 11 October 2023.

Methods: Two researchers independently screened eligible studies and extracted relevant data using custom data extraction tables.

Risk factors for delirium among hospitalized adults with COVID-19: A systematic review and meta-analysis of cohort studies.

Objectives: This study aims to systematically assess the risk factors, the overall strength of association, and evidence quality related to delirium among adults hospitalized with COVID-19.

Methods: A comprehensive search was conducted in thirteen databases from inception to February 10, 2023. The included databases were thoroughly searched, including PubMed, Web of Science, Proquest, Ovid MEDLINE, CINAHL, Scopus, the Cochrane Library, FMRS, Wanfang Database, Chinese Biomedical Database (CBM), China Knowledge Resource Integrated Database (CNKI), Weipu Database (VIP), and Embase.