Prognostic impact of multi-domain approaches and the Tilburg frailty indicator in elderly patients with heart failure.

Backgrounds: The optimal multidimensional frailty assessment approach in heart failure (HF) remains uncertain. This study aimed to compare the prognostic value of a multi-domain approach versus the Tilburg Frailty Indicator (TFI) in elderly HF patients.

Methods: This prospective single-center cohort study consecutively enrolled 461 elderly HF patients at Fuzhou University Affiliated Provincial Hospital, China.

Polyethyleneimine Modified Expanded Vermiculite-Supported Nano Zero-Valent Iron for Cr(VI) Removal from Aqueous Solution.

In order to develop an efficient, environmentally friendly heavy metal ions adsorbent, the amino-modified expanded vermiculite-supported nano zero-valent iron (nZVI@PEI/EVMT) was prepared by using polyethyleneimine (PEI) as the functional reagent and expanded vermiculite (EVMT) as the carrier. The characterization results of nZVI@PEI/EVMT confirm that the PEI modification did not destroy the crystal configuration of EVMT, and when nano zero-valent iron (nZVI) was successfully loaded onto the PEI/EVMT surface, the value of saturation magnetic field was 41.5 emu/g, which could be separated from solution with magnet.

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines.

Over centuries of clinical practice, Chinese herbal medicines (CHMs) have gained widespread recognition for their efficacy in treating various diseases. However, their complex material basis and relatively mild therapeutic efficacy limit their modernization and quality control. Recently, the application of pharmaceutical nanotechnology to CHMs has not only enhanced their efficacy, but also helped elucidate their material basis, thereby substantially advancing their modernization.

Ultrasound-Induced Nitric Oxide-Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime.

Cancer treatment is often ineffective due to poor bioimaging and resistance to standard therapies. This issue is exacerbated by multiple low-penetrable bio-barriers that limit the theranostic agents' effectiveness in tumors. Here, a hollow nanomotor PM-HMSN/Arg is fabricated by a sequential process involving: electrostatic adsorption of Mn, loading of l-Arg, and coating of platelet membrane (PM), respectively.

Causal association between immune cytokines and psoriasis: A two-way Mendelian randomization study.

The aim of this research was to explore the potential causal links between various immune cell profiles and the risk of psoriasis, employing a systematic two-sample Mendelian randomization (MR) analysis. The inverse variance weighted (IVW) model is the most commonly used two-sample MR analysis method for estimating the causal effect of exposure on outcomes. In addition to the IVW, we also used the weighted median method, the MR Egger method, and Steiger test as sensitivity analyses.

Causal relationship between distinct sleep characteristics and delirium: A multivariable Mendelian randomization study.

Delirium is a common neurological complication among hospitalized patients and has been closely linked to sleep disturbances. Dynamic changes in sleep rhythms are influenced by various sleep characteristics, which complicates the identification of the relationship between individual sleep features and the risk of delirium. Therefore, this study aimed to assess the potential causal relationships between distinct sleep characteristics and delirium, and to further investigate their independent effects.

From Challenge to Confidence: The Collapse of Trust in the Pandemic Era and the Protective Role of Belief in a Just World.

Trust plays a fundamental role in almost every social domain, especially when society is facing multi-level threats. However, the impact of threats on trust and its underlying mechanism remains poorly examined. To address this gap, we conducted a series of studies with an array of methodologies spanning cross-cultural surveys, longitudinal designs, and experimental manipulations.

Comparison of carbon sequestration and cooling benefits of plants in different landscaped green sites based on GGE biplot.

To understand the ecological adaptability of common garden plants, we analyzed the growth characteristics of 17 common garden plant species in the street green site and the campus green site. We measured microenvironmental characteristics, carbon sequestration, oxygen release, cooling and humidification of plants with the same diameter at breast height (herb was the height of the plant) in the two green sites. We used genotype main effect plus genotype-by-environment interaction biplot and Pearson correlation analysis to analyze the interaction between species identity and site type.

Neural architecture of social punishment: Insights from a queue-jumping scenario.

Punishment in social settings is crucial for maintaining collective interests, yet the underlying mechanisms remain unclear. To address this, we developed a paradigm, the queue-jumping task, where participants imagine experiencing a queue-jumping event through vivid pictorial scenarios. Behavioral findings revealed that individuals prioritized collective interests over personal ones when punishing, highlighting the altruistic nature of social punishment.

Clinical practice of one-lung ventilation in mainland China: a nationwide questionnaire survey.

Background: Limited information is available regarding the application of lung-protective ventilation strategies during one-lung ventilation (OLV) across mainland China. A nationwide questionnaire survey was conducted to investigate this issue in current clinical practice.

Methods: The survey covered various aspects, including respondent demographics, the establishment and maintenance of OLV, intraoperative monitoring standards, and complications associated with OLV.

Effectiveness of Primary Caregiver Training Programmes in Community Health Centres on Quality of Life and Mental Health in Older Patients with Urinary Tract Tumours.

Objective: Patients with urological tumours frequently experience compromised quality of life and mental health issues. This study aimed to evaluate the impact of a primary caregiver training programme conducted by a community health service centre on these patients.

Methods: This retrospective study assessed a primary caregiver training programme for patients with urological tumours conducted across ten community health centres in China over 6 weeks from March 2020 to March 2024.

Incidence and Associated Factors of Postoperative Delirium in Adults Undergoing Cardiac Surgery With Cardiopulmonary Bypass: A Prospective Cohort Study.

Background: Delirium is one of the most common and serious complications after cardiac surgery with cardiopulmonary bypass (CPB). A comprehensive assessment of independent risk factors for postoperative delirium (POD) is essential for early detection and prevention.

Aims And Objectives: To investigate the incidence and independent associated factors of POD in adults undergoing cardiac surgery with CPB.

The impact of pandemic threats on intertemporal choices in Chinese and Americans.

Intertemporal decisions are crucial to survival, especially when humans are exposed to ecological threats. However, it remains unclear whether and how pandemic threats impact intertemporal choices across cultures. We conducted two studies in two cultural contexts (N = 1180).

Oxytocin modulation of explicit pandemic stigma in men with varying social anxiety levels.

Objective: Stigma can create divisions within societies, hindering social cohesion and cooperation. Notably, it has significant public health implications, especially during infectious disease outbreaks like COVID-19. However, little is known about the neural and molecular basis of disease-related stigma and their association with individual differences.

Diagnosis of Alzheimer's disease: Towards accuracy and accessibility.

Alzheimer's disease (AD) is a serious dementia afflicting aging population and is characterized by cognitive decline, amyloid-β plaques, and neurofibrillary tangles. AD substantially impairs the life quality of the victims and poses a heavy burden on the society at large. The number of people with dementia due to AD, prodromal AD, and preclinical AD is estimated to stand at roughly 3.

Influence of perceived social support on detection of social norm violation: evidence from N1 and N400.

Introduction: The perceived social support individuals receive from their others plays a crucial role in shaping conformity with social norms. However, the specific mechanism underlying perceived social support and the detection of social norms remains unclear.

Methods: In this study, college students with high and low levels of perceived social support were asked to judge the appropriateness of stranger's behaviors (e.

The dual facilitatory and inhibitory effects of social pain on physical pain perception.

Pain is a multi-dimensional phenomenon that encompasses both physical pain experienced physiologically and social pain experienced emotionally. The interactions between them are thought to lead to increased pain load. However, the effect of social pain on physical pain perception during interactions remains unclear.

Risk factors for delirium among hospitalized adults with COVID-19: A systematic review and meta-analysis of cohort studies.

Objectives: This study aims to systematically assess the risk factors, the overall strength of association, and evidence quality related to delirium among adults hospitalized with COVID-19.

Methods: A comprehensive search was conducted in thirteen databases from inception to February 10, 2023. The included databases were thoroughly searched, including PubMed, Web of Science, Proquest, Ovid MEDLINE, CINAHL, Scopus, the Cochrane Library, FMRS, Wanfang Database, Chinese Biomedical Database (CBM), China Knowledge Resource Integrated Database (CNKI), Weipu Database (VIP), and Embase.

Modeling and Insights into the Structural Characteristics of Chemical Mitochondrial Toxicity.

Mitochondria are the energy metabolism center of cells and are involved in a number of other processes, such as cell differentiation and apoptosis, signal transduction, and regulation of cell cycle and cell proliferation. It is of great significance to evaluate the mitochondrial toxicity of drugs and other chemicals. In the present study, we aimed to propose easily available artificial intelligence (AI) models for the prediction of chemical mitochondrial toxicity and investigate the structural characteristics with the analysis of molecular properties and structural alerts.

Improving food security and farmland carbon sequestration in China through enhanced rock weathering: Field evidence and potential assessment in different humid regions.

Enhanced rock weathering (ERW) in farmland is an emerging carbon dioxide removal technology with crushed silicate rocks for soil improvement. However, due to climatic variability and field data limitations, uncertainties remain regarding the influence of ERW on food security and soil carbon pools in temperate regions. This study focused to evaluate the crop productivity and carbon sequestration potential of farmland ERW in China by conducting field monitoring in different humid regions and ERW performance model.

Modeling and insights into the structural characteristics of endocrine-disrupting chemicals.

Endocrine-disrupting chemicals (EDCs) can cause serious harm to human health and the environment; therefore, it is important to rapidly and correctly identify EDCs. Different computational models have been proposed for the prediction of EDCs over the past few decades, but the reported models are not always easily available, and few studies have investigated the structural characteristics of EDCs. In the present study, we have developed a series of artificial intelligence models targeting EDC receptors: the androgen receptor (AR); estrogen receptor (ER); and pregnane X receptor (PXR).

How we learn social norms: a three-stage model for social norm learning.

As social animals, humans are unique to make the world function well by developing, maintaining, and enforcing social norms. As a prerequisite among these norm-related processes, learning social norms can act as a basis that helps us quickly coordinate with others, which is beneficial to social inclusion when people enter into a new environment or experience certain sociocultural changes. Given the positive effects of learning social norms on social order and sociocultural adaptability in daily life, there is an urgent need to understand the underlying mechanisms of social norm learning.

Chronic social comparison elicits depression- and anxiety-like behaviors and alterations in brain-derived neurotrophic factor expression in male rats.

Social comparison is a fundamental human characteristic; however, long-term social comparison may induce psychological stress and can lead to depression and anxiety. Recent studies have shown that nonhuman primates compare themselves with others; however, no studies have investigated whether social comparisons exist among rodents. In the present study, we established a rat model of social comparison.

Policy analysis in the field of rare diseases in China: a combined study of content analysis and Bibliometrics analysis.

Introduction: The Chinese government has made significant strides in addressing the needs of individuals affected by rare diseases in recent years. This paper aims to provide a comprehensive analysis of national rare disease policies in China from 2009 to 2022, using a mixed-methods approach.

Methods: A two-dimensional analytical framework, which includes policy tools and policy themes, is introduced to analyze the rare disease policies comprehensively.