Cancer-associated mesenchymal stem cell exosomes facilitate non-small cell lung cancer cell viability and invasiveness by delivering miR-182 in a FBXW7-related AKT and ERK-dependent pathway.

Cancer-associated mesenchymal stem cells (CA-MSCs) modulate the tumor microenvironment and promote tumor progression. The present study aimed to investigate the effects of CA-MSCs, CA-MSC-derived exosomes and CA-MSC exosome-derived microRNA (miR)-182 on non-small cell lung cancer (NSCLC) cell viability and invasiveness. CA-MSCs were established by treating MSCs with supernatant from NSCLC cells.

Honeysuckle-derived carbon dots as fluorescent nanoprobes for determination of sunset yellow and cell imaging.

Sunset yellow (SY) is a widely used food and pharmaceutical colorant, but concerns over its safety highlight the need for sensitive and accurate detection methods. In this work, carbon dots were synthesized from the herbal medicine Honeysuckle (H-CDs). H-CDs exhibited excellent luminescent properties, structural stability, and remarkable selectivity and sensitivity toward SY.

Efficacy and safety of neoadjuvant toripalimab plus chemotherapy in localized deficient mismatch repair/microsatellite instability-high gastric or esophagogastric junction adenocarcinoma (NICE): a multicentre, single-arm, exploratory phase 2 study.

Background: In locally advanced gastric or gastroesophageal junction adenocarcinoma (GC/EGJC), deficient mismatch repair/microsatellite instability-high (dMMR/MSI-H) tumors exhibit high responsiveness to immunotherapy. The synergistic efficacy of neoadjuvant immunotherapy combined with chemotherapy in dMMR/MSI-H GC/EGJC remains uncertain.

Methods: The NICE trial is a multicentre, single-arm, exploratory phase 2 study conducted at six hospitals in China, evaluating the safety and efficacy of toripalimab in combination with CapeOX as perioperative therapy for locally advanced GC/EGJC across three biomarker-defined cohorts.

A meta-analysis of the timing of endovascular repair for blunt thoracic aortic injury: Safety and efficacy of early vs. delayed treatment.

Background: Blunt thoracic aortic injury (BTAI) carries a high risk of mortality. Thoracic endovascular aortic repair (TEVAR) is a standard treatment. However, the optimal timing of TEVAR remains debated.

[Meta-analysis of hydrocortisone in the treatment of severe community-acquired pneumonia].

Objective: To explore whether hydrocortisone can improve the prognosis of patients with severe community-acquired pneumonia (sCAP) by Meta-analysis.

Methods: Randomized controlled trial (RCT) on hydrocortisone in the treatment of sCAP were extracted from the database including PubMed, Cochrane library, Web of Science, and Embase, and the search time was up to April 29, 2023. The patients in the standard treatment group received standard treatment such as antibiotics and supportive care, while those in the hydrocortisone group received hydrocortisone treatment on the basis of standard treatment.

Advances in vagus nerve management strategies in thoracoscopic lung resections: a narrative review.

Background And Objective: The vagus nerve (VN) is a critical component of the parasympathetic nervous system, playing a pivotal role in respiratory, cardiovascular, and digestive functions. Its management during thoracoscopic lung resections is essential to minimize postoperative complications such as cough and arrhythmias. This review aims to explore advancements in VN management strategies-including preservation, neuromonitoring, and nerve block-and their impact on surgical outcomes and long-term recovery.

Array-Based Rapid Identification of Herbal Medicines via a Bifunctional Color-BiLink Strategy.

Ensuring the authenticity and quality of herbal medicines, particularly licorice, a pivotal component in nearly 60% of traditional Chinese medicine formulations, remains a significant global challenge. However, conventional approaches lack the capacity for direct, rapid, and high-throughput differentiation of licorice mixtures and structurally analogous ingredients. Herein, we present a multisite-binding Color-BiLink () strategy for constructing the dual-mode responsive sensor array, formed by a quantifiable-recognized bifunctional -nitrophenylboronic acid-modified PEI () and four dyes through dynamic, reversible covalent, and electrostatic interactions.

Correlation Between Polypharmacy and Gut Microbiota Compositional Changes in Older People Who Were Treated with Multidrug Therapy.

This study investigates the correlation between polypharmacy and gut microbiota compositional changes in older people who were treated with multidrug therapy, aiming to provide insights into the complex interplay between medication use, gut microbiota, and aging. High-throughput sequencing of the 16S rRNA gene was employed to analyze microbial diversity in older patients with multiple chronic diseases and polypharmacy, and the results were compared with a control group of older people without multiple chronic diseases and not undergoing polypharmacy. The study revealed distinct differences in gut microbiota composition between the two groups, with lower alpha-diversity observed in multidrug therapy group.

Reinforcement learning with temporal and variable dependency-aware transformer for stock trading optimization.

Stock trading optimization aims to optimize portfolios in dynamic market environments, which plays a crucial role in practical financial decision-making. With the rise of Transformer in recent years, some researchers have combined Transformer with Reinforcement Learning (RL) to improve their ability to represent potential patterns in market data. However, existing methods mainly focus on capturing temporal dependencies, failing to effectively model the interactions among multiple variables, limiting sufficient decision-making information for policy learning in RL.

Association of outcome with non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in hospitalized patients with congestive heart failure: a retrospective analysis.

Objective: To investigate the association between the Non-HDL cholesterol to HDL cholesterol ratio (NHHR) and all-cause mortality in patients with congestive heart failure (CHF) and to determine whether NHHR levels influence the prognosis of CHF patients.

Methods: The study participants were stratified based on the quartiles of NHHR. Kaplan-Meier (KM) curves, multivariate Cox regression analysis, and restricted cubic spline (RCS) analysis were employed to determine whether the prognosis of CHF patients varied according to NHHR levels.

Breaking the Ion Ordering in the Perovskite Anode for Enhanced High-Temperature Oxygen Evolution Reaction Activity.

Ion ordering in the perovskite oxide plays a crucial role in governing the properties, such as magnetic behavior, electronic and ionic conductivity, and dielectric or ferroelectric characteristics. As the common anodes in solid oxide electrolysis cells (SOECs), perovskites exhibit remarkable high-temperature oxygen evolution reaction (OER) activity. However, the influence of ion ordering in the perovskite anode on the OER activity remains poorly understood.

Exploring the extraction, antioxidant activities and its stabilities of peanut skins crude proanthocyanidins extract.

Peanut skin is a low-value by-product in the peanut oil and peanut product industry, with only a small amount utilized as animal feed while the majority discarded as waste. However, peanut skin contains high-value proanthocyanidins (PCs). Therefore, the objective of this paper is to optimize the extraction conditions for PCs, thereby increasing the added value of peanut skins.

Apoptotic extracellular vesicles derived from human dental pulp stem cells facilitate periodontal tissue regeneration.

Objective: Apoptotic extracellular vesicles (ApoEVs) derived from human dental pulp stem cells (hDPSCs) are subcellular structures released during programmed cell death. These vesicles carry rich biological information and regulatory potential, and have demonstrated significance in regulating cell behavior and tissue repair. Human periodontal ligament stem cells (hPDLSCs) are key to regenerating periodontal tissue, and their osteogenic differentiation ability directly influences the repair and reconstruction of periodontal bone tissue.

Exosomes derived from human umbilical cord mesenchymal stem cells inhibit hepatocyte pyroptosis via miR-423-5p/ZBP1 in acute liver failure.

Human umbilical cord mesenchymal stromal cells (hucMSCs) have emerged as a promising therapeutic option for acute liver failure (ALF). However, the detailed mechanism by which hucMSCs modulate hepatocyte pyroptosis in ALF remains unclear. In this study, we induced ALF in mice using acetaminophen (APAP).

Optimizing Surface Electronic Structure by Ba Dispersion for Enhanced High-Temperature Oxygen Evolution Reaction Activity.

Surface modification is an advanced strategy to engineer and optimize the work function of the perovskite oxides, which can influence the surface electron and ion transfer processes and tune the surface adsorption of the reaction intermediates, thus enhancing the catalytic activity by creating more active sites. Herein, we modify the surface electronic structure of the PrCoO anode of the solid oxide electrolysis cells (SOECs) by the high-temperature dispersion of Ba species. Comprehensive structural and electrochemical characterizations, along with in situ characterizations and density functional theory calculations, reveal that Ba dispersion significantly enhances the surface d-p orbital hybridization between Co and O atoms and thus weakens Co-O bond covalency, facilitating oxygen vacancy formation and oxygen ion mobility.

Exercise ameliorates nonalcoholic fatty liver disease by reducing the IGFBP5 to IGF1 ratio to activate AMPK pathway.

Insulin-like growth factor-binding protein 5 (IGFBP5) is associated with nonalcoholic fatty liver disease (NAFLD). IGFBP5 has a higher binding affinity to IGF1 and modulates its effects in serum. However, the effect of exercise on its expression remains unclear.

LRK10L3 and BAK1 are collaboratively involved in extracellular ATP-regulated seedling growth of Arabidopsis thaliana.

Extracellular adenosine triphosphate (eATP) is a multifunctional apoplastic messenger in plant growth and stress responses. The ATP sensing mechanism at the cell surface is not well understood. We provide evidence that two receptor-like kinases, LRK10L3 (LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-like 3) and BAK1 (BRI 1 Associated Kinase 1), are involved in eATP-regulated seedling growth of Arabidopsis thaliana.

Exploring the Characterization, Physicochemical Properties, and Antioxidant Activities of Chitosan-Encapsulated Green Tea Extract Microsphere Resin.

Chitosan, a naturally occurring alkaline polysaccharide with excellent biocompatibility, non-toxicity, and renewability, has the ability to undergo cross-linking reactions with polyphenolic compounds. In this study, chitosan-encapsulated green tea extract microsphere resin (CS-GTEMR) was successfully prepared using chitosan and green tea extract via reversed-phase suspension cross-linking polymerization. The structural characterization of CS-GTEMR was conducted using Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC).

Amphiregulin contributes to neuropathic pain by enhancing glycolysis that stimulates histone lactylation in sensory neurons.

The genesis of neuropathic pain after peripheral nerve injury is associated with changes in gene expression and cell metabolism in sensory neurons and the release of inflammatory cytokines. Here, we connected glycolytic metabolism induced by the epidermal growth factor receptor (EGFR) ligand amphiregulin (AREG) to histone lactylation and changes in gene expression that promote chronic neuropathic pain. In both male and female mice subjected to peripheral nerve injury, the mRNA and protein abundance of AREG and its receptor EGFR was increased in dorsal root ganglia (DRGs).

Dynamic gas template method derived thin-layer graphitic carbon nitride nanosheets for efficient 2,4-dichlorophenoxyacetic acid photodegradation and mechanism insight.

The extensive application of 2,4-dichlorophenoxyacetic acid (2,4-D, CHClO) as a herbicide has resulted in the significant environmental contamination. This pervasive pollution poses serious health risks to humans. Semiconductor photocatalytic technology represents a highly effective approach to addressing urgent environmental crisis.

KHDC3 affects the lineage differentiation of early embryo by regulating the differential distribution of YAP signal.

Hydatidiform mole (HM) is characterized by abnormal fetal tissue loss and placental villous trophoblastic hyperplasia, indicating aberrant early embryonic cell fate differentiation. Clinical observations linking KH Domain Containing 3 (KHDC3) mutations to complete hydatidiform mole (CHM) suggest a potentially unforeseen role for KHDC3 in early embryonic development. Single-cell transcriptome analysis of early embryos revealed notable heterogeneity in KHDC3 expression levels from the 8-cell to blastocyst stage.

Targeting Werner Helicase: A novel combination strategy for MSI colorectal cancer.

Colorectal cancer (CRC) is a highly heterogeneous disease characterized by genetic and epigenetic abnormalities. The microsatellite instability (MSI) CRC demonstrates a strong responsiveness to immunotherapy. Despite advancements in immunotherapy have markedly improved the prognosis of MSI CRC patients over the past two decades, resistance to treatment has emerged as a major clinical challenge.

GATAD2B regulates spindle assembly by affecting protein deacetylation during oocyte meiotic maturation.

Objective: Oocyte quality is critical for the stable transmission of genetic information and affects early embryonic development. But the precise mechanisms governing oocyte meiotic progression remains largely unclear. Transcription regulation through chromatin compaction and decompaction is regulated through various chromatin-remodeling complexes such as nucleosome remodeling and histone deacetylation (NuRD) complex.

From sensation to regulation: the diverse functions of peripheral sensory nervous system.

The peripheral sensory nervous system (PNS) has been widely recognized for its role in the collection, processing, and transmission of sensory information, including thermal, mechanical, chemical, and proprioceptive stimuli. In recent years, there has been a growing scholarly interest in the PNS attributable to its multiple physiological and pathophysiological non-sensory roles in the organs it innervates. The PNS exerts regulatory functions within the organs it innervates through direct interactions with local cells or through microbe-nerve-cell interactions that differ from the traditional feedback regulatory modes used by the hormonal and sensory brain-sympathetic/parasympathetic systems.

The Impact of Home and Community Based Care and Services on Chinese Older Adults: Based on Intergenerational Support From Offspring.

This study aims to investigate the impact of Home and Community Based Care and Services (HCBCS) on intergenerational support from offspring, specifically examining whether HCBCS acts as a substitute or supplement. Using four waves of data from the China Health and Retirement Longitudinal Study (CHARLS), we employ the difference-in-differences (DID) method, along with Logit, Oprobit, and OLS models. The findings show that HCBCS boosts economic support from offspring to older adults but reduces emotional and caregiving support, indicating HCBCS has both supplementary and substitutive effects.