A cross-cultural adaptation and validation of the Chinese version of American orthopaedic foot and ankle society hallux metatarsophalangeal-interphalangeal scale (AOFAS-Hallux-MTP-IP) in patients with hallux valgus.

Background: Hallux valgus (HV) is a common deformity of the hallux, which affects the functional ability of patients and reduces their quality of life. The American Orthopaedic Foot and Ankle Society (AOFAS) Hallux Metatarsophalangeal (MTP)-Interphalangeal (IP) scale is a questionnaire widely used to comprehensively assess the condition of hallux deformities. The purpose of this study was to translate the AOFAS-MTP-IP scale into a Chinese version (AOFAS-MTP-IP-CV), conduct cross-cultural adaptation, and simultaneously evaluate its validity and reliability.

Development and validation of a non-invasive prediction model for identifying high-risk children with metabolic dysfunction-associated fatty liver disease.

Objective: This study aims to investigate the prevalence and risk factors of Metabolic dysfunction-associated fatty liver disease (MAFLD) in pediatric populations and establish a novel health index scoring system derived from key risk parameters for early identification of high-risk children with MAFLD.

Method: In this cross-sectional study, a systematic random sampling method was employed to recruit children (6-18 years) with MAFLD. Data collection involved standardized questionnaires and comprehensive anthropometric measurements.

Bone Marrow Mesenchymal Stem Cells Can Prevent Pancreatic Fibrosis in Mice with Chronic Pancreatitis by Inhibiting the Activation of Pancreatic Stellate Cells.

Background: Chronic pancreatitis (CP) is a progressive fibroinflammatory disorder primarily driven by a complex interplay of environmental and genetic risk factors. Fibrosis, mediated by activated pancreatic stellate cells (PSCs), represents a key pathological feature of CP. Bone marrow mesenchymal stem cells (BMSCs) are known for their anti-fibrotic and anti-inflammatory properties; however, their role in pancreatic fibrosis remains inadequately understood.

Reliability of Ultrasonic Hepatorenal Indices in Assessing Hepatic Steatosis: A Systematic Review and Meta-Analysis.

The accuracy of the ultrasound hepatorenal index (HRI) in diagnosing hepatic steatosis has varied significantly in different clinical trials. Therefore, we conducted a meta-analysis aimed at exploring the diagnostic accuracy of ultrasound HRI in the quantitative assessment of hepatic steatosis. Thirteen eligible studies published up to May 3, 2025, were obtained through a comprehensive search.

Transcriptional regulation of SlFRIGIDA-like improve antioxidant system in tomato under cold.

Background: Plant experience exposure to short term low temperature during early spring. In response, it activates various mechanisms to cope with the changing environment. This response involves in the regulation of related genes and hormones, increase signaling cross-talks, antioxidants and osmolytes accumulation to protect the plant from damage.

Mitochondrial viscosity detection using a large stokes shift near-infrared fluorescent probe: An innovative tool for precise monitoring of oxidative stress in stroke and early diagnosis.

Ischemic stroke represents a profound global health burden, with oxidative stress playing a pivotal role in ischemia-reperfusion injury, thereby exacerbating cellular damage and neuronal dysfunction. Viscosity changes in the mitochondrial microenvironment, detectable via fluorescent probes, provide a sensitive biomarker for oxidative disturbances. In this study, we present XZTU-Mito-Vis, a novel near-infrared (NIR) fluorescent probe (λ = 715 nm) with large Stokes shift (Δλ = 290 nm), meticulously designed based on ESIPT (excited-state intramolecular proton transfer) mechanism.

WOADNet: A Wavelet-Inspired Orientational Adaptive Dictionary Network for CT Metal Artifact Reduction.

In computed tomography (CT), metal artifacts pose a persistent challenge to achieving high-quality imaging. Despite advancements in metal artifact reduction (MAR) techniques, many existing approaches have not fully leveraged the intrinsic a priori knowledge related to metal artifacts, improved model interpretability, or addressed the complex texture of CT images effectively. To address these limitations, we propose a novel and interpretable framework, the wavelet-inspired oriented adaptive dictionary network (WOADNet).

Somatostatin-expressing interneurons induce early NO-driven and late specific astrocyte-mediated vasodilation.

Somatostatin-expressing (SST) interneurons modulate hemodynamic responses both directly and indirectly, but their precise role remains unclear. Here, we investigated the influence of SST interneurons on hemodynamic control in response to optogenetic stimulation of SST neurons and somatosensory stimulation in both awake and anesthetized mice. Prolonged optogenetic stimulation of SST neurons induces fast vasodilation through nitric oxide synthase-expressing neurons that co-express SST, and slow vasodilation mediated by astrocytes.

Bulk Charge Recombination Reduction Enabled High Spectral Resolution Perovskite Gamma-Ray Spectrometer.

Solution-grown metal halide perovskite single crystals have been demonstrated as potential gamma-ray spectrometer. However, the energy resolution of the solution-grown formamidinum lead bromide (FAPbBr) single crystal spectrometer still suffers from strong bulk charge recombination. Here, it is identified that the high bulk charge recombination arises from a gradient Type-I band distribution throughout the crystal.

Integrated analysis of gut microbiota, fecal and serum metabolites in type 2 diabetes mellitus with peripheral neuropathy.

Purpose: Diabetic peripheral neuropathy (DPN) is one of the most common complications of type 2 diabetes mellitus (T2DM). In recent years, it has been reported that the progression of DPN is associated with altered gut microbiota and serum metabolites. However, the alterations of the gut microbiota and interaction with metabolites are not well understood in DPN patients.

Identification and validation of serum amino acids as diagnostic biomarkers for diabetic peripheral neuropathy.

Background: Diabetic peripheral neuropathy (DPN) is the most prevalent complication of type 2 diabetes mellitus (T2DM). Due to a lack of specific biomarkers, the early diagnosis of this disorder is limited.

Aim: To identify and validate serum amino acids that could discriminate T2DM patients with DPN from those without DPN.

Moslae Herba extract alleviates hyperuricemia by regulating uric acid metabolism and relieving renal inflammation and fibrosis in mice.

Background: Hyperuricemia (HUA) is a metabolic disease caused by uric acid metabolism disorder and is prevalent worldwide. Moslae Herba is a traditional herbal medicine known for its anti-inflammatory, antioxidant, and diuretic effects.

Purpose: This study aimed to investigate the effects and potential mechanisms of Moslae Herba extract (MHE) on alleviating HUA in mice.

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines.

Over centuries of clinical practice, Chinese herbal medicines (CHMs) have gained widespread recognition for their efficacy in treating various diseases. However, their complex material basis and relatively mild therapeutic efficacy limit their modernization and quality control. Recently, the application of pharmaceutical nanotechnology to CHMs has not only enhanced their efficacy, but also helped elucidate their material basis, thereby substantially advancing their modernization.

Bioequivalence of two doxorubicin liposome formulations (LY01612 and Caelyx) using free and encapsulated doxorubicin concentrations in Chinese patients with advanced breast cancer.

Objective: To determine the pharmacokinetic properties and bioequivalence of a reference doxorubicin injectable formulation (Caelyx) and the test formulation, a newly developed doxorubicin hydrochloride liposome injection formulation (LY01612), administered as single bolus doses in Chinese patients with advanced breast cancer.

Materials And Methods: The study was multicentric, randomized, open-label, two-treatment, two-period, two-sequence, single dose with crossover. The dose, equivalent to 50 mg/m, was administered intravenously on the first day of each 28-day treatment period.

Inhibitory effects of the cell-free supernatants of Faecalibacterium prausnitzii on biofilm formation of Listeria monocytogenes.

This study aimed to investigate the effects of the cell-free supernatant (CFS) of Faecalibacterium prausnitzii on biofilm formation and potential modes of action. Biofilm formed by Listeria monocytogenes poses a threat to food industry due to its resistance to disinfectants and its capacity to contaminate foods. Certain probiotics have been reported to inhibit L.

Bioactive protein/polysaccharide hydrogel functionalized bone implants surface for enhanced osteogenesis.

Bone implants play a critical role in the treatment of orthopedic diseases, however, conventional polymer or ceramic or metal implants possess various problems in enhancing bone repair and osteointegration. Recent years, the bioactive bone implants with biomimetic mechanical surface with natural extracellular matrix has shown promising role in reinforcing bone integration and regeneration. Biomedical hydrogels coating strategy has attracted much attention in bone implants modification, due to their adjustable surface biomechanics, bioactivities and drug release ability.

Internet use, physical activity, and cognitive function in Chinese older adults: a cross-lagged panel analysis.

Background: With the arrival of an aging society, cognitive health in older adults has become a global focal point. Cross-sectional studies have shown that internet use and physical activity may significantly affect cognitive function in older adults, but their longitudinal relationships and underlying mechanisms have not been fully explored.

Objective: This study aims to explore the relationship between internet use, physical activity, and cognitive function, and examine the mediating role of physical activity.

High-Performance X-ray Detection Made of Bismuth Perovskite Single Crystal Based on Hydrogen-Bond-Free and Interlayer-Spacing Engineering Strategies.

Hybrid organic-inorganic halide perovskites (HPs) show great potential for optoelectronic applications. However, their poor stability against moisture and oxygen significantly limits their practical applications. Developing hybrid perovskites with improved stability is essential yet remains a considerable challenge.

Gut microbes-spinal connection is required for itch sensation.

The gut microbiota has been linked to a number of neurological disorders. However, it is unclear whether the gut microbiota is involved in the genesis of chronic itch, a refractory condition that afflicts patients both physically and mentally. Here, we report that depletion of gut microbiota enhances tolerance to itch in mice orally administered with antibiotics (ABX) and mice free of germ.

Cer(d18:1/16:0) as a biomarkers for acute coronary syndrome in Chinese populations.

Ceramides play a crucial role in atherosclerosis progression and have been linked to cardiovascular events. The objective of this study was to investigate the association between serum ceramide levels and Acute coronary syndrome, as well as evaluate their potential for predicting ACS in Chinese population. Data of 1327 patients with suspected or known coronary artery disease from Beijing anzhen Hospital and Handan First hospital were collected.

Phytochemical characterization and pharmacological mechanisms of Huazhuo Sanjie Chubi Decoction in treating gouty arthritis: A multivariant approach.

Ethnopharmacological Relevance: Huazhuo Sanjie Chubi Decoction (HSCD), a Chinese herbal formula, is traditionally used for the treatment of spleen deficiency with dampness accumulation and is commonly used to treat gouty arthritis (GA). However, the potential active compounds and mechanisms of HSCD remain unclear.

Aim Of The Study: To elucidate the key bioactive compounds and pharmacological mechanisms of HSCD in treating GA.

The Effects of Experimental Warming on Phyllosphere Microbial Communities of Picea asperata and Fargesia nitida in Eastern Tibetan Plateau, China.

Phyllosphere microbiomes play a crucial role in leaf physiological functions, yet their responses to climate warming remain unclear. In this study, we examined the effects of a 3-year experimental warming on the composition and potential functions of phyllosphere bacterial and fungal communities, as well as leaf physiochemical properties of two dominant species (Picea asperata and Fargesia nitida) in the eastern Tibetan Plateau. The results indicated that the phyllosphere bacterial diversity in P.

Synthesis of Epimedium extract selenium nanoparticles and evaluation their efficacy against lung cancer.

Lung cancer, the foremost cause of cancer-related mortality worldwide, necessitates the exploration for novel anti-lung cancer therapeutics to enhance efficacy and reduce adverse effects. Targeting selenium in the tumor microenvironment has become a new strategy for the treatment of lung cancer. The objective of this study was to synthesize novel selenium nanoparticles (EBM-SeNPs) using aqueous extracts derived from Epimedium brevicornum Maxim and investigate its structural characteristics and inhibitory effects against lung cancer.

3D Printed Bioactive Mechanical-Adaptive Polyetheretherketone Implants with Non-Invasive Tracking for Immunomodulatory Osseointegration.

Polyether-ether-ketone (PEEK) has become a much-attracted biomedical implant material in orthopedic surgery, serving as a more biocompatible alternative to conventional metals. However, the inherent bioinert and mismatched mechanical surface of PEEK have limited their optimized bone fixation and repair. In this work, a PEEK implant is printed and a bioactive mechanical-adaptive surface via in situ chemical linking of photoluminescent elastomeric poly(citrate-silicon) (PCS) polymer (PEEK-PCS) is subsequently constructed, which could be used for real-time bioimaging and enhanced osseointegration.

Atomic Sn-incorporated subnanopore-rich hard carbon host for highly reversible quasi-metallic Li storage.

The practical application of Li metal anodes has been hindered by severely irreversible side reactions for low Coulombic efficiency, uncontrollable growth of Li dendrites, and large volume change. Herein, we report subnanopore-rich carbon spheres encapsulated with Sn single atoms (Sn/CS@SC) as a Li host to address these challenges. Owing to the high Li affinity of Sn single atoms, Sn/CS@SC can promote storage of quasi-metallic Li within the inner void space other than direct plating of metallic Li on the outer surface.