Bone Marrow Mesenchymal Stem Cells Can Prevent Pancreatic Fibrosis in Mice with Chronic Pancreatitis by Inhibiting the Activation of Pancreatic Stellate Cells.

Background: Chronic pancreatitis (CP) is a progressive fibroinflammatory disorder primarily driven by a complex interplay of environmental and genetic risk factors. Fibrosis, mediated by activated pancreatic stellate cells (PSCs), represents a key pathological feature of CP. Bone marrow mesenchymal stem cells (BMSCs) are known for their anti-fibrotic and anti-inflammatory properties; however, their role in pancreatic fibrosis remains inadequately understood.

Why do rural residents in China withdraw from the health insurance system? -A qualitative study based on Y County in S Province, China.

Background: Since the 2009 healthcare reform, the Chinese government has been committed to establishing a universal healthcare system. This study aims to investigate the complex reasons behind rural residents' decision to forgo participation in the medical insurance system by examining causal relationships and interactions.

Methods: This study employs content analysis, conducting in-depth interviews with 42 stakeholders, including government administration departments, tax departments, medical insurance departments, village committees, and residents who have withdrawn from the health insurance system.

How environmental perception influence depression and anxiety: the mediating role of social interaction.

Background: Depression and anxiety disorders are increasingly prevalent worldwide due to ongoing economic and social transformations, positioning them as major mental health concerns. Research indicates that favorable natural environments and high-quality social interactions can positively affect residents' mental health and well-being. However, studies exploring the mechanisms through which environmental perceptions influence depression and anxiety are still limited.

Effectiveness of Susceptibility-Guided Therapy for Infection: A Retrospective Analysis by Propensity Score Matching.

Purpose: This study evaluates and compares the eradication rates of Helicobacter pylori (H. pylori) achieved through susceptibility-guided therapy (SGT) based on resistance genotyping and empirical therapy (ET).

Patients And Methods: A retrospective study was conducted at Beijing Chaoyang Hospital (2021-2023) on patients with H.

Transient temperature measurement of silicon carbide Schottky barrier diode based on thermal reflection.

In this article, we present a transient temperature detection device for silicon carbide (SiC) Schottky barrier diodes (SBDs) based on thermal reflection theory. We constructed a thermal reflection temperature measurement device based on a 530-nm green laser. This device is more suitable for transient temperature measurement of SiC SBDs than previous thermal reflection equipment.

Nicotine aggravates pancreatic fibrosis in mice with chronic pancreatitis via mitochondrial calcium uniporter.

Introduction: This study aimed to investigate the effects of nicotine on the activation of pancreatic stellate cells (PSCs) and pancreatic fibrosis in chronic pancreatitis (CP), along with its underlying molecular mechanisms.

Methods: This was an and study. , PSCs were cultured to study the effects of nicotine on their activation and oxidative stress.

Population pharmacokinetics of Amisulpride in Chinese patients with schizophrenia with external validation: the impact of renal function.

Amisulpride is primarily eliminated via the kidneys. Given the clear influence of renal clearance on plasma concentration, we aimed to explicitly examine the impact of renal function on amisulpride pharmacokinetics (PK) via population PK modelling and Monte Carlo simulations. Plasma concentrations from 921 patients (776 in development and 145 in validation) were utilized.