Comprehensive integration of single-cell and bulk transcriptome to reveal plasma cell heterogeneity and a prognosis signature in head and neck squamous cell carcinoma.

Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy with a low five-year survival rate, emphasising the urgent need for effective prognostic biomarkers to guide patient stratification and personalised treatment. Plasma cells (PCs), a subset of antitumor effector B cells, are known for their antibody production to target tumour-associated antigens. However, their role in HNSCC remains insufficiently characterised.

[Synergistic Effect of Agricultural Pollution and Carbon Reduction and Their Driving Factors in Henan Province].

In the context of the "dual-carbon" goal and shaping of new advantages in green agricultural development, empirical references and policy recommendations are provided for agricultural agglomeration regions, mainly in grain-producing areas such as Henan Province, to explore the green, low-carbon transformation and high-quality sustainable development of agriculture. Based on the coupled coordination model, the GTWR model was used to explore the influence mechanism and spatiotemporal heterogeneity of the two synergies and their drivers, with a view to promoting the green, low-carbon and sustainable development of agriculture in Henan Province by taking pollution reduction and carbon reduction as a common goal. The results showed that： Between 2010 and 2022, agricultural carbon emissions and agricultural surface pollution emissions in Henan Province showed a slow increase, followed by a slow decline and a gradual stabilization trend, with obvious spatial and temporal heterogeneity.

METTL3-mediated mA modification promotes intervertebral disc degeneration.

Background: N-methyladenosine (mA) modification is a prevalent RNA modification in epigenetics. METTL3, acting as the principal methyltransferase responsible for catalysing mA, is regarded as a master regulator of this RNA modification. Nonetheless, the complex roles and underlying mechanisms of mA in relation to intervertebral disc degeneration (IDD) are yet to be fully elucidated.

Transcriptional regulation of SlFRIGIDA-like improve antioxidant system in tomato under cold.

Background: Plant experience exposure to short term low temperature during early spring. In response, it activates various mechanisms to cope with the changing environment. This response involves in the regulation of related genes and hormones, increase signaling cross-talks, antioxidants and osmolytes accumulation to protect the plant from damage.

The role of prognostic nutrition index in the prognosis of patients with advanced hepatocellular carcinoma who received first-line therapy.

Objective: To explore the relationship between the prognostic nutritional index (PNI) and the anti-tumor efficacy and prognosis of patients with advanced hepatocellular carcinoma (HCC) who received first-line therapy.

Methods: A total of 234 patients with advanced HCC were included in this study, all of whom received first-line therapy. The clinical and pathological data of patients were collected.

Establishment of Heat-Damaged Model for Hair.

Background: After washing hair, prolonged and frequent use of hair dryers to dry hair can cause heat damage to hair fibers. Currently, various hair care products designed to repair heat damage are available in the market.

Objective: To establish a model of heat-damaged hair for evaluating the effectiveness of hair care products that claim to repair such damage.

Resolving the structure and assembly of the honeybee silk heterotetrameric coiled coil.

Coiled coil structures, first proposed by Crick in the 1950s, are protein structural motifs found across diverse biological systems. Honeybee silk was among the earliest identified coiled coils, with X-ray diffraction studies in the 1960s revealing its characteristic helical packing. Decades of research have provided insights into silk composition and formation, yet the molecular details of its coiled coil assembly and final structure remained unresolved.

Recombinant Ostreolysin Promotes the Browning of Preadipocytes by Inhibiting the Expression of Genes Associated With the Hedgehog Signaling Pathway in db/db Mice.

Nonalcoholic steatohepatitis (NASH), a highly prevalent metabolic-related fatty liver disease, has become a major global health issue with limited therapeutic options. Recent studies indicated that ostreolysin (Oly), a protein derived from oyster mushrooms, could be a potential therapeutic agent for NASH. In this study, recombinant Oly (rOly) was expressed in E.

Online risk scores for pre- and postoperative prediction of early recurrence in hepatocellular carcinoma patients undergoing conversion liver resection after tyrosine kinase inhibitors and immune checkpoint inhibitors therapy.

Background: Conversion therapy with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) offers the potential for curative resection in unresectable hepatocellular carcinoma (HCC). However, early recurrence (≤2 years) after conversion liver resection remains a major concern. This study aimed to develop and validate online preoperative and postoperative risk scores to predict early recurrence in patients undergoing conversion liver resection.

Integrated sensing and communication system based on a photonic integrated broadband multi-beamformer.

An integrated sensing and communication (ISAC) system enabled by a photonic integrated broadband multi-beamformer is proposed and demonstrated. The integrated multi-beamformer, which employs an optical true-time-delay induced Blass matrix framework for reception, is capable of simultaneously synthesizing five squint-free beams directed at distinct angles across the entire Ku-band spectrum. Benefiting from space division multiplexing endowed by multi-beamforming, the system performs simultaneous broadband radar sensing and high-speed wireless communication.

Unique Bioinspired Nanowire Structures for Dual-Modal Optoelectronic Electronic Skin.

As initial basic applications expand into more complex and diverse fields, including prosthesis, the metaverse, and information encryption, the diversification, multifunctionality, and customization of electronic skin (e-skin) have increasingly become prominent research trends. However, most e-skins focus on achieving higher performance and a broader response range, lacking functionality and mode customization options. Here, a mode designable bioinspired e-skin is reported, utilizing a mechanical strategy combined with interface assembly technology, and achieving the integration of optical and electrical sensing capabilities in single functional material.

Multilevel Inter-modal and Intra-modal Transformer network with domain adversarial learning for multimodal sleep staging.

Sleep staging identification is a fundamental task for the diagnosis of sleep disorders. With the development of biosensing technology and deep learning technology, it is possible to automatically decode sleep process through electroencephalogram signals. However, most sleep staging methods do not consider multimodal sleep signals such as electroencephalogram and electrooculograms signals simultaneously for sleep staging due to the limitation of performance improvement.

Comparison of Efficacy between Lenvatinib and Bevacizumab in Combination of Immune Checkpoint Inhibitor and Interventional Triple Therapy in Chinese Advanced Hepatocellular Carcinoma: The CLEAP 2302 Study.

Background: The conversion therapy for advanced hepatocellular carcinoma (HCC) shows promise with a triple therapy approach that combines interventional therapy, immune checkpoint inhibitors, and molecular targeted therapy (primarily small-molecule TKIs and the large-molecule bevacizumab). This combination has achieved the highest objective response rates (ORR) along with acceptable safety profiles. The aim of this study was to compare the clinical efficacy of lenvatinib versus bevacizumab, when combined with immune checkpoint inhibitors and interventional triple therapy, as first-line treatments for Chinese patients with unresectable HCC (uHCC).

Pd-Catalyzed Regioselective Homobenzannulation of Enynals.

Regio- and chemoselectivities in the synthesis of polysubstituted benzenes have posed a significant scientific obstacle for an extended period. Herein, we report a tunable Pd-catalyzed homobenzannulation of enynals, enabling divergent construction of 1,2,4-tri- and 1,4-disubstituted benzenes from identical substrates via unconventional selectivity. In particular, the interesting reaction model is verified by a variety of control experiments, offering theoretically valuable insight for the rational design of benzannulation reactions.

Targeting intracellular LMP2 with costimulatory signal-armed antibody-like TCR T cells.

Expanding the repertoire of CAR therapies to include intracellular antigens holds promise for treating a broad spectrum of malignancies. TCR-like T cells, capable of recognizing intracellular antigen-derived peptides in complex with HLA molecules (pHLA), represent a promising strategy in the field of engineered cellular therapy. This study introduced antibody-like TCR (abTCR) T cells that specifically targeted HLA-A*02:01-restricted LMP2426 peptides, a typical Epstein-Barr virus (EBV) latency II protein, for the treatment of EBV-associated lymphoproliferative diseases (EBV-LPDs).

Dietary patterns and hypertension in Chinese adults: a systematic review and meta-analysis.

Objective: Numerous studies have explored the correlation between dietary patterns and the risk of hypertension, yet the findings have remained indeterminate. We performed a meta-analysis to evaluate how various dietary patterns relate to hypertension risk in the Chinese population.

Methods: Relevant articles published from 1 January 2004 to 14 March 2024 in five databases (PubMed, Scopus, Web of Science, CNKI, and VIP) were searched.

Association between serum anion gap and all-cause mortality in critically ill patients with Gastrointestinal bleeding: insights from MIMIC-IV database.

Serum anion gap (AG) holds potential for clinical application in the prognostic assessment of ill patients. Yet its association with all-cause mortality in critically ill patients with gastrointestinal bleeding (GIB) remains underexplored. This cohort study analyzed data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, 2,333 critically ill GIB patients, recording their first-time AG levels.

Actuator Structure Design for Flexible Photothermal-Electric Device and Multifunctional Self-Powered Sensor.

Flexible photothermal-electric devices hold great promise for applications such as solar energy conversion and wearable electronics, thanks to their ability to generate green energy, sense temperature, and enhance wearing comfort. However, creating sufficient temperature gradients for optimal power generation along with high-performance multifunctional sensing capabilities remains a significant challenge. In this study, we demonstrate a flexible photothermal-electric device with an exceptional temperature gradient created by a thermal actuator through light-induced thermal deformation.

Design of a 10 GHz TE01-TE11 mode converter using new structure coaxial-parallel method.

In a cyclotron system, the output mode is typically the TE0n mode. However, this mode cannot be transmitted over long distances and energy is easily dissipated. It is usually converted to Gaussian mode HE11 through mode conversion for long-distance transmission and application.

Comparative Analysis of the Lateral and Superior Cerebellar Keyhole Approach and Subtemporal Keyhole Approach to the Ventrolateral Brainstem Regions: A Different Perspective.

Objective: To compare the exposure and working distances of lateral and superior cerebellar keyhole approach (LSCKA) with subtemporal keyhole approach (STKA) and Kawase approach (KA) in the ventrolateral brainstem regions.

Methods: The LSCKA was performed in 6 cadaveric heads (12 sides). The STKA was performed in another 6 cadaveric heads (12 sides), and then the KA was performed.

Differences in transcriptome characteristics and drug repositioning of Alzheimer's disease according to sex.

Background: Previous studies have shown significant sex differences in AD with regarding its epidemiology, pathophysiology, clinical presentation, and treatment response. However, the transcriptome variances associated with sex in AD remain unclear.

Methods: RNA sequencing (RNA-seq) and transcriptomic analyses were performed on peripheral blood samples from total of 54 patients, including male AD patients (n = 15), female AD patients (n = 10), male MCI patients (n = 7), female MCI patients (n = 11), male healthy controls (n = 6), female healthy controls (n = 5).

Revealing the Oxidative Stress-Related Molecular Characteristics and Potential Therapeutic Targets of Schizophrenia through Integrated Gene Expression Data Analysis.

Schizophrenia is a severe mental disorder characterized by oxidative stress imbalances. The underlying mechanisms of oxidative stress-related gene expression in schizophrenia require further investigation. Additionally, the diagnosis of schizophrenia lacks sensitive and specific biomarkers as well as predictive models for assessing susceptibility.

A Powerful Regulator to Enhance Electrocatalytic Reaction Kinetics and Thermodynamics: The Ordered Hetero-Nanowire.

Optimizing the thermodynamics of electrode reactions is a valid strategy for achieving superior electrocatalysts for direct methanol fuel cells (DMFCs). However, as the catalyst downsizes to the nanoscale, the influence of mass transfer kinetics is pronounced in improving electrocatalytic activity. Herein, an ordered hetero-nanowire (NW) regulator that couples the virtues of kinetics and thermodynamics is reported.