A dual-site doping strategy to enhance the sodium storage performance of an O3-type layered sodium oxide cathode.

The O3-type NaNiFeMnO material is modified by introducing Sr into the Na sites and Al into the transition metal (TM) sites. The inactive Sr and Al serve as structural pillars within the NaO and TMO slabs, respectively, expanding the interlayer spacing and boosting the stability of the structure. The optimized cathode demonstrates a good rate performance of 117.

The efficacy and safety of the ketogenic diet in infantile epileptic spasm syndrome: a meta-analysis.

Objective: To systematically evaluate the efficacy and safety of the ketogenic diet (KD) in treating infantile epileptic spasm syndrome (IESS).

Methods: A comprehensive search of electronic databases was conducted to identify prognostic studies on the use of KD for IESS. Data from eligible studies were extracted and meta-analyzed using a random-effects model.

Ultrabroadband on-chip photonics for full-spectrum wireless communications.

The forthcoming sixth-generation and beyond wireless networks are poised to operate across an expansive frequency range-from microwave, millimetre wave to terahertz bands-to support ubiquitous connectivity in diverse application scenarios. This necessitates a one-size-fits-all hardware solution that can be adaptively reconfigured within this wide spectrum to support full-band coverage and dynamic spectrum management. However, existing electrical or photonic-assisted solutions face a lot of challenges in meeting this demand because of the limited bandwidths of the devices and the intrinsically rigid nature of system architectures.

Dissolved Oxygen Decline in Northern Beibu Gulf Summer Bottom Waters: Reserve Management Insights from Microbiome Analysis.

The Sanniang Bay (SNB) and Dafeng River Estuary (DFR) in the Northern Beibu Gulf, China, are critical habitats for the Indo-Pacific humpback dolphin (). However, whether and how the decreased dissolved oxygen (DO) has happened in bottom seawater remains poorly understood. This study investigated DO depletion and microbial community responses using a multidisciplinary approach.

Environmental Factors, Not Biotic Competitive Interactions, Drive the Relative Abundance of Diatoms and Chlorophyta in the Coastal Areas of the Beibu Gulf: Evidence From 18S rDNA Metabarcoding and Partial Least Squares-Path Modeling Analysis.

Diatoms and Chlorophyta are two major phyla of phytoplankton in marine ecosystems. The quantitative detection of the population succession and the interaction between them in natural marine ecosystems is a key challenge that ecologists face. In this study, using high-throughput sequencing (HTS) analysis, a negative correlation was found between Diatoms and Chlorophyta near the Dafeng River Estuary (DRE) and the Sanniang Bay (SNB) located in the Beibu Gulf, China.

Branched-chain amino acids contribute to diabetic kidney disease progression via PKM2-mediated podocyte metabolic reprogramming and apoptosis.

Approximately 30-40% of patients with diabetes develop diabetic kidney disease (DKD). Identifying decisive factors for DKD initiation is crucial. Here, we observed that glomerular podocytes in male and female patients with DKD and db/db mice specifically displayed BCAA catabolic defects.

Effects of intermittent theta burst stimulation on lower limb motor function in stroke patients: A systematic review and meta-analysis.

Objective: To systematically evaluate the effects of intermittent theta burst stimulation(iTBS) on lower limb motor function in stroke patients.

Methods: Following the PRISMA guidelines, we searched PubMed, Web of Science, Embase, Cochrane Library, CNKI, VIP, Wanfang, and SinoMed from their inception to 23 November 2024. Two researchers independently screened the literature, assessed quality, and extracted data.

Prevalence and factors influencing HIV testing behavior in adolescents and young adults: a systematic review and meta-analysis.

Objective: To systematically evaluate the prevalence and influencing factors of human immunodeficiency virus (HIV) testing among adolescents and young adults (10-25 years old), providing a reference for optimizing testing strategies and supporting the global goal of eliminating HIV as a public health threat.

Methods: A systematic review and meta-analysis were conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations. To assess the prevalence and factors influencing HIV testing among adolescents and young adults, databases were searched up to April 19, 2025.

Genetics of infantile epileptic spasms syndrome in China.

Aim: To construct a genetic landscape of infantile epileptic spasms syndrome (IESS) and explore the pathogenic mechanisms of IESS-associated genes.

Method: We conducted a nationwide, multicentre, retrospective study across six centres in China, enrolling patients with genetically confirmed IESS between January 2015 and January 2024. Additionally, we reviewed the existing literature, summarized the genetic landscape of IESS, and used bioinformatics approaches to investigate its pathophysiological features.

Insights into angiosperm evolution and lineage-specialized lignan biosynthesis from the early-diverging genome.

Schisandraceae, an early-diverging angiosperm lineage, produces dibenzocyclooctadiene (DBCOD) lignans, unique bioactive compounds with liver-protecting properties. Although DBCOD lignan chemodiversity is well documented, their biosynthesis and evolution remain unclear. Here, we present a high-quality genome, completing genomic representation of early angiosperms.

Enhancing Molecular Contrastive Prediction by Recognizing Metric Distribution Separation.

Molecular machine learning has attracted much attention in molecular property prediction and AI-aided Drug Discovery. Recent advancements have significantly improved the efficiency and speed of searching for potential drug candidates. The primary challenge in molecular property prediction is how to transfer potential knowledge from known molecules to a large set of unseen candidates.

A p-n CuGaS/g-CN heterojunction in S-scheme with escalated charge transport and photothermal effect for solar-driven hydrogen evolution.

The construction of built-in electric field (BIEF) in heterojunction is an effective strategy to enhance solar-driven hydrogen (H) production by minimizing charge carrier recombination and improving transport kinetics. Herein, p-type ternary sulfide CuGaS (CGS) and n-type g-CN nanosheets (CN) are integrated to construct a p-n heterojunction through a simple co-precipitation method for photocatalytic hydrogen evolution reaction (HER). In situ X-ray photoelectron spectroscopy (in situ XPS), in situ electron paramagnetic resonance (EPR) and density functional theory (DFT) calculations revealed that differences in Fermi levels and carrier concentrations between CGS and CN induce charge migration following an S-scheme mechanism, which aligned well with the intrinsic p-n junction field.

Push-Pull Electronic Effect and D-Band Center Bi-Modulated Bio-Heterojunction Enzyme Enables All-Stage Infected Wound Healing.

Pathogenic infections pose a persistent threat to global public health, necessitating innovative antibacterial strategies with well-defined disinfection pathway. The antibacterial efficiency is confined in the contradiction between reactants adsorption and intermediates desorption. Here, the FeMoS/MXene bio-heterojunction enzyme (FM BioHJzyme) is proposed and constructed.

Motor symptoms of Parkinson's disease: critical markers for early AI-assisted diagnosis.

Parkinson's disease is a prevalent neurodegenerative disorder, where early diagnosis is essential for slowing disease progression and optimizing treatment strategies. The latest developments in artificial intelligence (AI) have introduced new opportunities for early detection. Studies have demonstrated that before obvious motor symptoms appear, PD patients exhibit a range of subtle but quantifiable motor abnormalities.

Identify the origin of de novo variants in TSC patients by ddPCR.

Background: Tuberous sclerosis complex (TSC), an inherited neurocutaneous disorder, is caused by variants in the TSC1 or TSC2 genes. The mosaic variants of TSC1 and TSC2 are scarcely detectable using the conventional next-generation sequencing (NGS). Therefore, this study aims to explore the detection and distribution of mosaic variants within affected families.

Population Pharmacokinetics and Model-Informed Precision Dosing of Clobazam Based on the Developmental and Genetic Characteristics of Children with Epilepsy.

This study aimed to characterize the pharmacokinetic profiles of clobazam (CLB) and its active metabolite, N-desmethylclobazam (N-CLB), by establishing a population pharmacokinetic (PPK) model in Chinese children with epilepsy to propose individualized dosing regimens that achieve better clinical outcomes. : This study examined plasma samples collected from 103 pediatric patients with refractory epilepsy undergoing CLB treatment. The plasma concentrations of CLB and its active metabolite N-CLB were measured.

An optimal conversion cascading of distinct lignocelluloses to maximize bioethanol productivity and bio-adsorption capacities of Cd/Cr(VI) and red/blue dyes selective for complete biomass recycling.

Although agriculture and forestry provide enormous lignocellulose resources, it remains to explore a novel technology for efficient biomass conversion into renewable bioethanol followed with complete recycling for valuable bioproduction with zero- waste release. As classic chemical (acid and alkali) pretreatments could cause chemical waste liberation, this study performed optimal pretreatments with hot-FeCl for sequentially enhancing biomass enzymatic saccharification in three bioenergy crops, which led to achieving hexoses yields raised by 4-7 times compared to the controls. By employing engineered yeast strain for xylose co-fermentation, the highest bioethanol yield was achieved at 18 % (% dry matter) in Miscanthus sample.

Identification of Key Taste-Active Compounds in Oolong Teas (Dongding and Rougui) by Quantitative Measurements, Recombination Experiments, and Omission Tests.

A lack of knowledge regarding taste-active compounds of Oolong tea limits the improvement of product quality. Nontargeted metabolomics and sensory quantitative descriptive analyses were performed on two representative oolong teas, resulting in 41 compounds screened for their relevance to taste characteristics, and they were quantitated. Combined taste dose-overthreshold (DoT > 1) factors with key differentiators, reconstitution of ten selected compounds successfully replicated the authentic tea infusion.

Elucidating the Mechanism of Xiaoqinglong Decoction in Chronic Urticaria Treatment: An Integrated Approach of Network Pharmacology, Bioinformatics Analysis, Molecular Docking, and Molecular Dynamics Simulations.

Introduction: Xiaoqinglong Decoction (XQLD) is a traditional Chinese medicinal formula commonly used to treat chronic urticaria (CU). However, its underlying therapeutic mechanisms remain incompletely characterized. This study employed an integrated approach combining network pharmacology, bioinformatics, molecular docking, and molecular dynamics simulations to identify the active components, potential targets, and related signaling pathways involved in XQLD's therapeutic action against CU, thereby providing a mechanistic foundation for its clinical application.

Roy Adaptation Model-Based nursing care improves quality of life for elderly burn patients.

Objective: To explore the effects of the Roy Adaptation Model on psychological resilience and nutritional status in elderly burn patients.

Methods: Retrospectively, 112 elderly burn patients undergoing routine nursing care based on the Roy Adaptation Model were enrolled as the observation group, and another 112 patients receiving routine nursing care only were selected as the control group. The psychological resilience, level of hope, immunity, emotions, quality of life and sleep of enrolled patients were assessed.

Polyethyleneimine Modified Expanded Vermiculite-Supported Nano Zero-Valent Iron for Cr(VI) Removal from Aqueous Solution.

In order to develop an efficient, environmentally friendly heavy metal ions adsorbent, the amino-modified expanded vermiculite-supported nano zero-valent iron (nZVI@PEI/EVMT) was prepared by using polyethyleneimine (PEI) as the functional reagent and expanded vermiculite (EVMT) as the carrier. The characterization results of nZVI@PEI/EVMT confirm that the PEI modification did not destroy the crystal configuration of EVMT, and when nano zero-valent iron (nZVI) was successfully loaded onto the PEI/EVMT surface, the value of saturation magnetic field was 41.5 emu/g, which could be separated from solution with magnet.

Comparisons of nonpharmacological caregiver interventions for behavioural and psychological symptoms of dementia: A systematic review and network meta-analysis.

Background: Nonpharmacological caregiver interventions are valuable for reducing the behavioural and psychological symptoms of dementia, but the most effective type of nonpharmacological intervention remains unknown.

Objective: The present study aimed to compare different caregiver interventions for behavioural and psychological symptoms of dementia and caregiver reactions to these symptoms.

Methods: We systematically searched PubMed, Embase, the Cochrane Library, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and PsycINFO from database inception to October 18, 2023.

Effect of CYP2D6 and ABCB1 polymorphisms on pharmacokinetics and efficacy of aripiprazole in pediatric tic disorders.

Background: Aripiprazole (ARI) is the first-line treatment for tic disorders (TD). Cytochrome P450(CYP)2D6 (CYP2D6) and ATP-binding cassette, sub-family B, member 1 (ABCB1) transporter are involved in the metabolism of ARI. However, whether CYP2D6 and ABCB1 genetic polymorphisms influence clinical efficacy and pharmacokinetics of ARI remains unclear.

Stroke features in the Chinese character recognition.

While line vertices, terminations, and midsegments are critical for Roman letter identification, the diagnostic features of Chinese character strokes remain unclear. This study examines how local stroke-level features and global line-relation mechanisms contribute to Chinese character recognition. In Experiment 1, we applied the Bubbles classification image technique to native Chinese readers to identify diagnostic stroke features.

A photosynthetic egg based oxygen-releasing platform to promote angiogenesis and tissue regeneration in diabetic wounds.

Diabetic wounds represent a longstanding global health challenge attributable to tissue hypoxia resulting from impaired microcirculation, which impedes crucial physiological processes essential for wound healing, such as cell proliferation and migration. Oxygen-releasing biomaterials present a novel avenue for tissue reoxygenation therapy, offering advantages over conventional hyperbaric oxygen therapy. Herein, we developed a microcosmic oxygen-releasing platform (MORP) named photosynthetic egg by utilizing egg white hydrogel with inherent bioactive factors for regenerative strength and electrostatic adsorbedbringing photosynthetic oxygen production.