Effects of intermittent theta burst stimulation on lower limb motor function in stroke patients: A systematic review and meta-analysis.

Objective: To systematically evaluate the effects of intermittent theta burst stimulation(iTBS) on lower limb motor function in stroke patients.

Methods: Following the PRISMA guidelines, we searched PubMed, Web of Science, Embase, Cochrane Library, CNKI, VIP, Wanfang, and SinoMed from their inception to 23 November 2024. Two researchers independently screened the literature, assessed quality, and extracted data.

Prevalence and factors influencing HIV testing behavior in adolescents and young adults: a systematic review and meta-analysis.

Objective: To systematically evaluate the prevalence and influencing factors of human immunodeficiency virus (HIV) testing among adolescents and young adults (10-25 years old), providing a reference for optimizing testing strategies and supporting the global goal of eliminating HIV as a public health threat.

Methods: A systematic review and meta-analysis were conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations. To assess the prevalence and factors influencing HIV testing among adolescents and young adults, databases were searched up to April 19, 2025.

Preparation, characterization and antioxidative activity analysis of recombinant humanized collagen type III-loaded liposomes.

To improve the bioavailability and biological activity of recombinant type III humanized collagen (rhCol III), we optimized the preparation process of recombinant type III humanized collagen-loaded liposomes (rhCol III-LIPS) using the film dispersion and periplasmic extrusion methods, with the encapsulation rate as the response value. Then we analyzed the antioxidative activity of rhCol III-LIPS by determining the scavenging rate of free radicals. We investigated the protective effect of rhCol III-LIPS against HO-induced injuries in HaCaT cells by detecting cell vitality, contents of reactive oxygen species (ROS), malondialdehyde (MDA), and activities of antioxidases superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase dismutase (GSH-Px).

Zika virus non-structural protein NS2A mediated endoplasmic reticulum stress through interacting with Sarco/endoplasmic reticulum Ca-ATPase 2.

Unlabelled: Zika virus (ZIKV) infection of neuronal cells leads to endoplasmic reticulum (ER) stress, which is one of the key causes of neuronal damage. However, how ZIKV mediates ER stress has not been fully understood. Here, we observed that ZIKV infection of astrocytes elevated Sarco/endoplasmic reticulum Ca-ATPase (SERCA) expression, increased intracellular Ca concentration, and upregulated ER stress-related genes.

Association between social isolation and depression, and sex differences in older adults: A systematic review and meta-analysis.

Background: Depression is the most common mental health problems worldwide. Although several studies have explored the relationship between social isolation and depression, the specific association and gender differences are still inconsistent.

Objective: To systematically evaluate the association between social isolation and depression, and sex differences in older adults.

A High-Isolation Optically Transparent 2 × 2 Antenna Array Using Metal Mesh Material.

This paper presents the design and implementation of a compact, high-isolation, optically transparent 2 × 2 MIMO antenna array. Optical transparency is achieved using a copper-based metal mesh material, which serves as both the radiating element and the ground plane, ensuring high radiation efficiency and minimal visual impact. The array consists of four monopole antennas, and mutual coupling is effectively suppressed through the integration of shorting decoupling branches and a common-ground structure.

[Meta analysis of the prevalence and risk factors of non-alcoholic fatty liver disease in overweight and obese children and adolescents in China].

Objectives: To systematically evaluate the prevalence and risk factors of non-alcoholic fatty liver disease (NAFLD) in overweight and obese children and adolescents in China.

Methods: Databases including China National Knowledge Infrastructure, Wanfang Data, VIP Database, China Biomedical Literature Database, PubMed, Embase, Web of Science, and Cochrane Library were searched, from database inception to October 2024. Two researchers independently screened the literature, extracted data, and assessed the quality of the studies according to inclusion and exclusion criteria.

Prediction models for adjacent vertebral fractures after vertebral augmentation: a systematic review and meta-analysis.

Objective: To systematically review published studies on risk prediction models for adjacent vertebral fractures (AVF) after vertebral augmentation (VA), thereby providing a reference for constructing and improving such models.

Methods: PubMed, Web of Science, The Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang Database, and SinoMed were searched from their inception to July 13, 2024. The Prediction Model Risk of Bias Assessment Tool (PROBAST) was used to assess the risk of bias and applicability of the prediction model studies; STATA 15.

The process of post-traumatic growth for the main caregivers of patients with Alzheimer's disease.

Family members caring for individuals with Alzheimers disease (AD) often experience significant psychological distress, which can lead to mental health issues such as severe depression, post-traumatic stress disorder, and anxiety. We conducted a study to explore the experiences of 18 primary caregivers of AD patients through semi-structured in-depth interviews. The study identified four key stages of post-traumatic growth (PTG): ) the pain period, ) the struggle period, ) the recovery period, and ) the period of positive growth.

Association of weekend catch-up sleep with depression: A systematic review and meta-analysis.

Background: Weekend catch-up sleep (WCS) may alleviate weekday sleep deprivation, but its relationship with depression risk remains unclear. This systematic review and meta-analysis aims to explore the association between WCS and depression risk.

Methods: A comprehensive search was conducted in PubMed, Cochrane Library, Embase, Web of Science, and Scopus for observational studies published up to June 1, 2024.

Association between Potentially Inappropriate Medication and Mortality Risk in Older Adults: A Systematic Review and Meta-Analysis.

Objectives: This study aimed to comprehensively assess the association between potentially inappropriate medication (PIM) and mortality risk in older adults through systematic review and meta-analysis.

Design: Systematic review and meta-analysis.

Setting And Participants: Adults aged 60 years and older with PIM use.

Toward Stretchable Flexible Integrated Sensor Systems.

Skin-like flexible sensors hold great potential as the next generation of intelligent electronic devices owing to their broad applications in environmental monitoring, human-machine interfaces, the Internet of Things, and artificial intelligence. Flexible electronics inspired by human skin play a vital role in continuous and real-time health monitoring. This review summarizes recent progress in skin-mountable electronics developed by designing flexible electrodes and substrates into different structures, including serpentine, microcrack, wrinkle, and kirigami.

[Removal, detection, and limits of endotoxin in the industry of recombinant proteins].

With the advancement of synthetic biology, recombinant proteins are poised to play a significant role in medical applications. The scaled manufacturing is a pillar for the extensive application and development of recombinant proteins across various fields. In the large-scale production process of recombinant proteins, the removal and detection of endotoxins are essential to reduce their levels to safe thresholds in the final products.

Instruments for Measuring the Burden of Family Caregivers of Cancer Patients: A Systematic Review of Measurement Properties.

Aims: This study identifies instruments for assessing the burden on family caregivers of cancer patients and evaluates their psychometric properties using COSMIN criteria.

Design: A systematic review based on COSMIN methodology.

Methods: The review adhered to PRISMA guidelines.

MSI-DTI: predicting drug-target interaction based on multi-source information and multi-head self-attention.

Identifying drug-target interactions (DTIs) holds significant importance in drug discovery and development, playing a crucial role in various areas such as virtual screening, drug repurposing and identification of potential drug side effects. However, existing methods commonly exploit only a single type of feature from drugs and targets, suffering from miscellaneous challenges such as high sparsity and cold-start problems. We propose a novel framework called MSI-DTI (Multi-Source Information-based Drug-Target Interaction Prediction) to enhance prediction performance, which obtains feature representations from different views by integrating biometric features and knowledge graph representations from multi-source information.

PATrans: Pixel-Adaptive Transformer for edge segmentation of cervical nuclei on small-scale datasets.

Transformer has shown excellent performance in various visual tasks, making its application in medicine an inevitable trend. Nevertheless, simply using transformer for small-scale cervical nuclei datasets will result in disastrous performance. Scarce nuclei pixels are not enough to compensate for the lack of CNNs-inherent intrinsic inductive biases, making transformer difficult to model local visual structures and deal with scale variations.

The prevalence of diabetes distress in Chinese patients with type 2 diabetes: A systematic review and meta-analysis.

Objective: To systematically evaluate the prevalence of Diabetes Distress (DD) in type 2 diabetes mellitus (T2DM) patients in China.

Methods: The PubMed, PsycInfo, Web of Science, The Cochrane Library, EMBASE, China Knowledge Resource in Integrated Database (CNKI), WanFang Database, Weipu Database (VIP), and Chinese Biomedical Database (CBM) electronic databases were searched from inception to August 2022, for cross-sectional studies, that reported prevalence of DD.

Results: This study included 55 articles involving 13,160 patients with T2DM.

Fear of disease progression among breast cancer patients in China: a meta-analysis of studies using the fear of progression questionnaire short form.

Background: Fear of disease progression (FoP) is among the most prevalent and major psychological burdens breast cancer patients encounter. Excessive FoP may result in serious adverse effects for patients. FoP in breast cancer patients has gained attention recently; however, its prevalence in China is unknown.

Short-term postoperative changes in the choroidal vascularity index in patients with a unilateral epiretinal membrane.

Background: To investigate short-term choroidal structural and vascular changes after epiretinal membrane (ERM) surgery.

Methods: In this retrospective study, 65 patients with unilateral ERM underwent pars plana vitrectomy combined with cataract surgery and were examined one day before surgery and one week, one month, and three months after surgery. Choroidal thickness (CT) and choroidal vascular index (CVI) were evaluated using horizontal enhanced depth imaging optical coherence tomography (EDI-OCT) scans and were further calculated using semi-automatic algorithms using MATLAB R2017a.

A peptide derived from the N-terminal of NS2A for the preparation of ZIKV NS2A recognition polyclonal antibody.

Zika virus non-structural protein NS2A participates in viral replication, organization, and budding, as well as escaping host immunity. NS2A also involved in the induction of microcephaly by ZIKV. However, the above studies were mainly performed through NS2A with a tag due to the lack of available antibodies against NS2A.