[Study on strategies and methods for discovering risk of traditional Chinese medicine-related liver injury based on real-world data: an example of Corydalis Rhizoma].

In recent years, there have been frequent adverse reactions/events associated with traditional Chinese medicine(TCM), especially liver injury related to traditional non-toxic TCM, which requires adequate attention. Liver injury related to traditional non-toxic TCM is characterized by its sporadic and insidious nature and is influenced by various factors, making its detection and identification challenging. There is an urgent need to develop a strategy and method for early detection and recognition of traditional non-toxic TCM-related liver injury.

Interferon-stimulated gene screening identifies CCND3 as a host restriction factor against emerging high-pathogenic bandaviruses.

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a representative high-pathogenic bandavirus (Bandavirus genus, Phenuiviridae family). Inducible expression of interferon-stimulated genes (ISGs) is the foundation of host antiviral defense; however, their roles in bandavirus infection remain elusive. Here, we identify over 200 ISGs potentially inhibiting or promoting bandaviral replication.

Comprehensive Laboratory Analysis of a Scrub Typhus and H1N1 Influenza Co-Infection: A Case Report from Hainan, China.

Co-infection of and influenza A virus complicates diagnosis and treatment in endemic regions because of overlapping clinical features and potential synergistic inflammation. We describe a 68-year-old woman from Hainan, China, who presented with five days of high fever (39.2 °C), nonproductive cough, eschar formation, lymphadenopathy, cytopenias, elevated liver enzymes, and raised inflammatory markers.

Cepharanthine Enhances MHC-I Antigen Presentation and Anti-Tumor Immunity in Melanoma via Autophagy Inhibition.

Major histocompatibility complex class I (MHC-I)-mediated antigen presentation plays a pivotal role in anti-tumor immunity by enabling CD8 T cells to recognize and eliminate malignant cells. In melanoma, modulation of this pathway is critical for improving the efficacy of immunotherapies. Our study demonstrates that the natural compound Cepharanthine (CEP) exhibits notable antitumor activity by enhancing MHC-I-mediated antigen presentation.

In vivo neutrophils hitchhiking for tumor targeting and microenvironment regulation boosts oncolytic virus therapy.

Neutrophils constitute a substantial proportion of the immune cell population infiltrating tumors, where they play a pivotal role in establishing an immunosuppressive microenvironment to facilitate tumor growth. Our clinical investigation has unveiled that, following oncolytic virus (OV) treatment, immunosuppressive neutrophils could lead to T cell exhaustion and compromised antitumor efficacy. In this study, we devise a dual-functional conjugation strategy that enables OVs to selectively bind with circulating neutrophils and initiate their death.

Additive-Free TiCT MXene Actuator with Large Deformation, Programmability, and High-Humidity Stability via Precise Interlayer Spacing Control Engineering.

Introducing external substances to intercalate MXene (TiCT) or combining MXene with other inert materials to construct bilayer/multilayer structures is the current mainstream solution for improving actuation performance of MXene-based actuators. Possible issues include the degradation in mechanical and electrical properties of MXene, or the decrease in actuation performance or even structural damage of the actuator under frequent actuation. Besides, the structural and actuation performance stability of MXene-based actuators under high humidity environment also remain challenges.

Genetics of infantile epileptic spasms syndrome in China.

Aim: To construct a genetic landscape of infantile epileptic spasms syndrome (IESS) and explore the pathogenic mechanisms of IESS-associated genes.

Method: We conducted a nationwide, multicentre, retrospective study across six centres in China, enrolling patients with genetically confirmed IESS between January 2015 and January 2024. Additionally, we reviewed the existing literature, summarized the genetic landscape of IESS, and used bioinformatics approaches to investigate its pathophysiological features.

Order-Disorder Phase Stabilization by Pressure-Induced Charge Transfer Enhances the Ferroelectric Photovoltaic Effect in Multiferroic BaFeO.

Multiferroic ferroelectric photovoltaic (FPV) materials, combining magnetic and ferroelectric properties, are of paramount importance for optoelectronic and photovoltaic applications. However, optimizing both the remanent polarization and the optical bandgap-key factors for enhanced FPV performance-presents a significant challenge due to their trade-off. This work shows that pressure-induced charge transfer between different metal sites can break this trade-off.

Ultrafast Synthesis of a Highly Luminescent Zero-Dimensional Hybrid Perovskite TEAHfCl:Sb for Optical Encryption and Healthy Lighting.

Organic-inorganic hybrid metal halides have attracted considerable attention due to their facile synthesis, low cost, and high thermal and chemical stability. However, developing environmentally benign, readily synthesized, high-performance, and spectrally tunable broadband-emitting materials remains challenging. Herein, this study reports a zero-dimensional perovskite material, TEAHfCl:Sb, using a room-temperature coprecipitation method.

Associations of multimorbidity with mortality, hospital stay, and hospitalization costs in Chinese surgical patients: a retrospective cohort study.

Background: Multimorbidity (≥ 2 chronic conditions) is rising in aging populations. China reports over 80 million surgeries annually. This study investigates health burdens of multimorbidity in Chinese surgical patients.

Underwater non-local adaptive descattering imaging.

Model-based underwater restoration offers high interpretability. However, particle scattering, glare, and uneven illumination often degrade the estimation of background light and transmittance. We propose an underwater non-local adaptive descattering imaging (UNADI) system that enables accurate parameter estimation for high-resolution restoration.

Underwater long-range LiDAR based on wide baseline polarized light-sheet illumination.

Underwater long-range, high-resolution, three-dimensional (3D) optical detection is critical for seabed exploration and infrastructure inspection. However, conventional optical methods face limitations in terms of detection range, depth of field (DOF), and compatibility with uncrewed underwater vehicles. To address these challenges, we present an innovative underwater long-range LiDAR system based on wide baseline polarized light-sheet illumination.

Learnable reconstruction-based synthetic aperture imaging via Fourier ptychography.

Fourier ptychography (FP), a synthetic aperture imaging technique, has made significant progress in recent years. This technique effectively overcomes the aperture limitations of imaging systems, enabling imaging at a resolution beyond the original system's capabilities. However, in far-field macroscopic FP imaging, high-quality image reconstruction often requires a large amount of sampling data, which not only increases system complexity but also limits practical applications.

Sustained benefits of long-term biochar application for food security and climate change mitigation.

Biochar application offers significant potential to enhance food security and mitigate climate change. However, most evidence stems from short-term field experiments (≤3 y), leaving uncertainty about the long-term sustainability of these benefits, especially with annual biochar additions to soils. To address this knowledge gap, we analyzed a global dataset from 438 studies (3,229 observations) and found that long-term annual biochar application (≥4 y) not only sustains but often enhances its benefits.

Electrostatic repulsion and interface engineering in the low-crystalline/crystalline NiN@NiFeHPO heterostructure toward enhanced alkaline water and seawater splitting.

Designing nanoheterostructures and optimizing the interfacial microenvironment are critical yet challenging strategies for enhancing the performance of transition metal nitride electrocatalysts. In this study, a novel heterostructured catalyst consisting nickel nitride nanosheets wrapped by NiFe bimetallic hydrogen phosphate (NiN@NiFeHPO) is constructed on nickel foam (NF), aiming at efficient hydrogen production in both alkaline water and seawater electrolysis. The heterointerface between low-crystalline NiFeHPO and crystalline NiN enhanced the hydrophilicity and optimized the intermediate adsorption/desorption during water splitting.

Refinement of Crystalline Domains: A Strategy To Toughen Conductive Hydrogels.

The characteristic of possessing both high strength and flexibility is a requisite for the extensive application of conductive hydrogels in the domains of flexible wearable electronic devices and implantable biomedical fields. Nevertheless, the existing strategies for optimizing mechanical properties invariably enhance the strength at the expense of stretchability, thereby causing the hydrogels to still possess relatively low toughness. Herein, we propose a crystalline refinement-driven toughening strategy that overcomes this paradigm, achieving strength of 13.

IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells.

IRX3 is linked to predisposition to obesity through the FTO locus and is upregulated during early adipogenesis in risk-allele carriers, shifting adipocyte fate toward fat storage. However, how this elevated IRX3 expression influences later developmental stages remains unclear. Here we show that IRX3 regulates adipocyte fate by modulating epigenetic reprogramming.

Overcoming the Activity-Stability Trade-Off in Electrocatalysts via Unconventional Two-Step Structural Reconstructions of Amorphous Oxides.

The activation of lattice oxygen in oxide catalysts via structural reconstruction is critical for optimizing the catalytic performance in oxidation-reduction systems. However, in electrochemical O evolution, the structural transformations preceding electrochemical reconstruction and their impact on the resulting structural inhomogeneity have long remained insufficiently understood. Here, we activate the lattice oxygen of the W-doped Co-Fe amorphous oxide through spontaneous and electrochemical bulk reconstructions.

Prognostic value of myocardial bridging versus non-obstructive CAD: a long-term follow-up study.

We aim to investigate if myocardial bridging (MB) provides predictive value beyond its association with non-obstructive coronary artery disease (CAD) burden in a long-term follow-up and multicenter study. This study included 4176 consecutive patients with suspected CAD underwent coronary computed tomography angiography (CTA) at two hospitals in Wuhan, China, between September 2016 and December 2017 for finial analysis. Kaplan-Meier method was used to estimate the cumulative event-free survival of non-obstructive CAD burden and MB burden classifications, respectively.

Genetic and Clinical Characteristics of Difficult-To-Treat Crohn's Disease: Trio-Based Exome Sequencing in 24 Families.

Objectives: Difficult-to-treat Crohn's disease (DTT-CD) represents a critical unmet need in inflammatory bowel disease (IBD) management. However, its genetic architectures remain poorly understood. We aimed to evaluate the genetic characteristics and clinical manifestations of DTT-CD cases through integrated trio-based whole exome sequencing (WES) and longitudinal phenotyping.

Event-triggered human-machine shared steering online learning control strategy to accommodate driver behavioral uncertainty.

To address the stochasticity and uncertainty in driver behavior, an event-triggered shared control strategy is proposed, enabling real-time adaptation while ensuring system stability. The vehicle control system is modeled as a nonlinear time-varying (NTV) system, incorporating human-machine interaction, driver behavior, variable speeds, and uncertain tire dynamics. Sparse Gaussian process regression (GPR) is employed for online system identification, eliminating the need for an exact system model.

Biomonitoring and bioremediating potential of commonly grown tree species against trace elements with seasonal and site allocation: a region-based study.

Heavy metals-mediated environmental pollution and global warming are two emerging threats to plant and human health worldwide. Several anthropogenic and natural activities with a preference for industrialization and heavy transportation have accelerated heavy metals and CO emissions into aerial and soil environments. For a few decades, woody trees have been considered an effective bioaccumulator or bioindicator tool for pollution assessment processes of air-born pollutants.

Electrocatalytic removal of nitrate by non-noble FeC/Cu: Property, mechanism, and practical water treatment performance.

The application of electrocatalytic technology in nitrate (NO) removal is hindered by the low total nitrogen (TN) removal efficiency during the reaction. In this study, a non-noble FeC/Cu@CC cathode, prepared by in-situ growth of FeC on carbon cloth followed by electrodeposition of Cu nanoparticles, was proposed for electrocatalytic reduction of NO. Electrochemical tests showed that FeC/Cu@CC possessed good NO reduction property and N selectivity, especially under neutral pH condition.

Identification and expression analysis of LRR-RLK genes reveal their roles in plant development and stress responses in Kiwifruit (Actinidia chinensis).

As an important economic crop, the growth and development of kiwifruit are sensitive to environmental stresses, which can lead to reduced yield and quality. Leucine-rich repeat receptor-like kinases (LRR-RLKs) constitute one of the largest groups of receptor-like kinases and play crucial roles in regulating plant growth and development, as well as responses to biotic and abiotic stresses. In this study, 307 LRR-RLK genes were identified in the kiwifruit genome and grouped into 13 subclades.

Running ameliorates methamphetamine-associated cognitive impairment by regulating hippocampal neurogenesis through the GSK3β/β-catenin pathway.

Physical exercise is a non-pharmacological therapy widely used in drug rehabilitation centers for treating methamphetamine (METH) addiction. METH causes cognitive impairment and suppresses adult hippocampal neurogenesis (AHN) in experimental animals. Exercise can improve cognitive dysfunction caused by various factors through the enhancement of AHN.