Ultrafast Synthesis of a Highly Luminescent Zero-Dimensional Hybrid Perovskite TEAHfCl:Sb for Optical Encryption and Healthy Lighting.

Organic-inorganic hybrid metal halides have attracted considerable attention due to their facile synthesis, low cost, and high thermal and chemical stability. However, developing environmentally benign, readily synthesized, high-performance, and spectrally tunable broadband-emitting materials remains challenging. Herein, this study reports a zero-dimensional perovskite material, TEAHfCl:Sb, using a room-temperature coprecipitation method.

Response of cultivated land quality to landscape pattern changes at the watershed scale.

High-quality cultivated land can enhance soil fertility and strengthen crop resilience, promoting sustainable agricultural development and ensuring national food security. In this study, the indices of cultivated land landscape patterns were correlated with cultivated land quality at the watershed scale using topographic factor extraction, the landscape pattern index method, spatial autocorrelation analysis and Pearson's correlation coefficient. The response of the quality of cultivated land to landscape pattern changes was evaluated for different landform types using data from 22 years of Landsat remote sensing image data(February 23-24), and data about the quality of arable land resources in the Chaohu Lake Basin.

Ultrasound-Mediated Biotransfection of Engineered Bone Marrow Mesenchymal Stem Cells in Treated Bone Defects through Intracellular Cavitation.

The lack of stem cells and difficulty in osteogenic differentiation are the primary challenges to treating bone defects. Stem cell gene therapy can efficiently replenish the number of stem cells and facilitate bone differentiation, but its security and efficacy remain challenging. The traditional ultrasound-targeted microbubble destruction (UTMD) technology with extracellular cavitation for gene transfection is safe but inefficient.

Transesophageal echocardiography during lung transplantation (Review).

Lung transplantation (LTx) continues to be the primary curative intervention for end-stage lung disease, with post-transplant outcomes demonstrating substantial improvements in recent years. The present review summarizes recent advancements in the application of transesophageal echocardiography (TEE) during LTx as a diagnostic strategy for associated complications. TEE offers notable benefits for intraoperative monitoring during LTx, including the assessment of cardiac function, vascular anastomosis evaluation, support for cannula positioning and the management of extracorporeal membrane oxygenation.

Structural basis for engagement of Western Equine Encephalitis Virus with the PCDH10 receptor.

PCDH10 is a newly identified general receptor for Western equine encephalitis virus (WEEV) members, a group of encephalitic alphaviruses that cause severe diseases in humans and equids. While WEEV typically binds PCDH10 as a receptor, nonpathogenic strains have evolved to lose mammalian PCDH10 binding, retaining only avian PCDH10 affinity. Virulent strains also engage VLDLR and ApoER2 as alternative receptors.

Hemodynamic Impact of Cipepofol vs Propofol During Anesthesia Induction in Patients With Severe Aortic Stenosis: A Randomized Clinical Trial.

Importance: Postinduction hemodynamic instability is a frequent complication among patients with severe aortic stenosis (AS). Using cipepofol as the anesthesia agent may reduce the incidence and severity of hemodynamic instability.

Objective: To assess whether cipepofol outperforms propofol in maintaining postinduction hemodynamic stability in patients with AS.

The active metabolite of Epimedii Folium promotes hippocampal neurogenesis in APP/PS1 mice by alleviating mitochondrial dysfunction.

Introduction: Alzheimer's disease (AD), the most common form of dementia, currently has no effective cure. Epimedii Folium (EF), a traditional Chinese medicine known as Yin-yang-huo, has demonstrated significant neuroprotective properties.

Methods: In this study, neural stem cells overexpressing the APPswe gene (APP-NSCs) were used as an AD model.

Gas Vesicle-Assisted Ultrasound Imaging for Effective Anti-Tumour CAR-T Cell Immunotherapy Efficacy in Mice Model.

Introduction: Real-time tracking of Chimeric Antigen Receptor (CAR) T cell trafficking provides crucial information regarding the targeted migration, infiltration, and persistence of CAR-T cells within the tumour microenvironment (TME). This information is invaluable for the timely adjustment of auxiliary treatment strategies in clinical settings.

Methods: We designed a gas vesicles (GVs)-labeled CAR-T (GVs@CAR-T) complex using nanoscale GVs with excellent ultrasound reflectivity to label CAR-T cells for post-labelling ultrasound molecular imaging.

RNA-Seq Reveals the Mechanism of Synergistic Hydrogen-Chemotherapy Based on Active Magnesium Micromotors for Inhibiting Glioblastoma Recurrence by Modulating Tumor Microenvironment.

Postoperative recurrence of glioblastoma (GBM) is a key contributing factor to the unfavorable prognosis of patients. Chemotherapy has been extensively employed as a postoperative treatment for GBM; however, the produced drug resistance significantly undermines the chemotherapeutic efficacy. Herein, a multifunctional system based on magnesium micromotor (Mg-Motor-DOX) is designed and fabricated that can generate hydrogen gas in situ and actively deliver the chemotherapeutic drug doxorubicin (DOX).

Efficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addiction.

Dysregulation of GABAergic inhibition is associated with pathological pain. Consequently, enhancement of GABAergic transmission represents a potential analgesic strategy. However, therapeutic potential of current GABA agonists and modulators is limited by unwanted side effects.

Physical stability of oil-in-water multi-layered coenzyme Q10 nano-emulsions.

As a lipophilic antioxidant, coenzyme Q10 (CoQ10) has limited application owing to its low water solubility and instability. In the present study, potato protein (PP) and soybean soluble polysaccharide (SSPS) were used as carriers to prepare a multilayer SSPS-PP-CoQ10 nano-emulsion using the reversed-phase emulsification method; further, the water solubility, stability, and formation mechanism of the nano-emulsion were analyzed. The results showed that the particle size of SSPS-PP-CoQ10 nano-emulsions was 253-422 nm with good polydispersity.

Tungsten oxide-based electrocatalysts for energy conversion.

The advancement of cutting-edge energy conversion technologies offers significant potential for addressing environmental challenges, enhancing energy security, improving economic competitiveness, and promoting resource conservation. This progress necessitates the development of advanced electrocatalysts. WO demonstrates high intrinsic catalytic activity, excellent conductivity, an abundance of active sites, and remarkable stability, positioning it as a promising candidate for electrocatalytic reactions.

The construction of international wetland urban ecological security pattern coupled with MSPA and ESF.

Creating an ecological security pattern is crucial for balancing the sustainable development of areas where human activities and the natural environment intersect. Using Hefei, an internationally recognized Wetland City, as a case study, we extracted ecological sources through ecological service function (ESF) analysis and morphological spatial pattern analysis (MSPA) core area connectivity analysis. Based on these ecological sources, we developed an ecological resistance surface system and identified ecological corridors and nodes using circuit theory.

Comprehensive exploration of a traditional Chinese medicinal plant of Magnolia officinalis based on high-coverage mass spectrometry and multidimensional chemical-biological analysis.

Magnolia bark is a traditional Chinese medicine used for hypoglycaemia. With the widespread use of Magnolia bark, its resources are facing a serious shortage. To address this issue, a strategy based on high-coverage mass spectrometry (HCMS) and multidimensional chemical-biological analysis (MCBA) was proposed for the comprehensive exploration of Magnolia officinalis which is the main source of Magnolia bark.

Cannabinoid CB receptors in primary sensory neurons are implicated in CB agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance.

Cannabinoid CB agonists show therapeutic efficacy without unwanted CB-mediated side effects. The G protein-biased CB receptor agonist LY2828360 attenuates the maintenance of chemotherapy-induced neuropathic nociception in male mice and blocks development of morphine tolerance in this model. However, the cell types involved in this phenomenon are unknown and whether this therapeutic profile is observed in female mice has never been investigated.

Traditional medicine Xianglian pill suppresses high-fat diet-related colorectal cancer via inactivating TLR4/MyD88 by remodeling gut microbiota composition and bile acid metabolism.

Ethnopharmacological Relevance: Previous studies have revealed that a high-fat diet (HFD) promotes the progression of colorectal cancer (CRC) in close association with disturbances in the intestinal flora and metabolic disorders. Xianglian pill (XLP) is a well-established traditional prescription with unique advantages in controlling intestinal flora imbalance and inflammation. However, its therapeutic effects on HFD-related CRC remain largely unknown.

Excitation power-dependent multicolor upconversion in NaLnF:Er under 1532 nm irradiation for anti-counterfeiting application.

Upconversion (UC) materials are renowned for their ability to convert low-energy photons into high-energy ones. The manipulation of parameters allows for the observation of multicolored UC luminescence (UCL) within a single material system. While modulation of multicolored UCL commonly relies on excitation at approximately 980 nm, investigation into multicolored UC materials activated by a 1532 nm excitation source remains comparatively scarce.

Cannabinoid CB receptors in primary sensory neurons are implicated in CB agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance.

Cannabinoid CB agonists show therapeutic efficacy without the unwanted side effects commonly associated with direct activation of CB receptors. The G protein-biased CB receptor agonist LY2828360 attenuates the maintenance of chemotherapy-induced neuropathic nociception in male mice and blocks the development of morphine tolerance in this model. However, the specific cell types involved in this phenomenon have never been investigated and whether this therapeutic profile is observed in female mice remains poorly understood.

A NIR-driven green affording-oxygen microrobot for targeted photodynamic therapy of tumors.

Photodynamic therapy (PDT) is a light-activated local treatment modality that has promising potential in cancer therapy. However, ineffective delivery of photosensitizers and hypoxia in the tumor microenvironment severely restrict the therapeutic efficacy of PDT. Herein, phototactic Chlorella (C) is utilized to carry photosensitizer-encapsulated nanoparticles to develop a near-infrared (NIR) driven green affording-oxygen microrobot system (CurNPs-C) for enhanced PDT.

Intratumoral Lactate Depletion Based on Injectable Nanoparticles-Hydrogel Composite System Synergizes with Immunotherapy against Postablative Hepatocellular Carcinoma Recurrence.

Thermal ablation is a crucial therapeutic modality for hepatocellular carcinoma (HCC), but its efficacy is often hindered by the high recurrence rate attributed to insufficient ablation. Furthermore, the residual tumors following insufficient ablation exhibit a more pronounced immunosuppressive state, which accelerates the disease progression and leads to immune checkpoint blockade (ICB) resistance. Herein, evidence is presented that heightened intratumoral lactate accumulation, stemming from the augmented glycolytic activity of postablative residual HCC cells, may serve as a crucial driving force in exacerbating the immunosuppressive state of the tumor microenvironment (TME).

Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment.

Enzyme-driven micro/nanomotors consuming chemical fuels have attracted lots of attention for biomedical applications. However, motor systems composed by organism-derived organics that maximize the therapeutic efficacy of enzymatic products remain challenging. Herein, swimming proteomotors based on biocompatible urease and human serum albumin are constructed for enhanced antitumor therapy active motion and ammonia amplification.

Phosphine-catalyzed [5+1] annulation of β'-acetoxy allenoates: straightforward access to tetrahydroquinoline derivatives.

An unprecedented phosphine-catalyzed [5+1] annulation of β'-acetoxy allenoates with 1,5-dinucleophiles has been developed, which provides novel and facile access to functionalized tetrahydroquinolines in good to high yields in the presence of PPh and KPO under mild reaction conditions. Notably, it is the first report of β'-acetoxy allenoates acting as C1 synthons in Lewis base-catalyzed annulation reactions.

Conditional deletion of CB2 cannabinoid receptors from peripheral sensory neurons eliminates CB2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain.

CB cannabinoid receptor agonists suppress pathological pain in animal models and lack unwanted side effects commonly associated with direct activation of CB receptors. However, the types of pain most responsive to CB agonists are incompletely understood and cell types which underlie CB-mediated therapeutic efficacy remain largely unknown. We previously reported that the CB receptor agonist LY2828360 reduced neuropathic nociception induced by toxic challenge with chemotherapeutic and anti-retroviral agents in mice.