The ACSS2-PPARD-BCAT1 axis synchronously regulates branched-chain amino acid metabolism and development in pancreatic cancer.

The characteristics of the tumor microenvironment (TME) of pancreatic cancer include an abundant stroma, hypoxia, insufficient blood supply and high degree of immunosuppression. Therefore, overcoming the TME conditions to reach a hypermetabolic state is a concern for the treatment of pancreatic cancer. Previous studies have demonstrated that tumor cells adapt to the TME by activating or increasing the expression level of ACSS2 under metabolic stress.

Pp1-87B/PPP1CC-JNK axis integrates apoptosis and ferroptosis-like cell death to regulate cell competition and tumorigenesis.

Cell competition, an evolutionarily conserved quality control mechanism, selectively removes unfit or pre-malignant cells via cell-cell interactions. Through a genetic screen in Drosophila, we identify the phosphatase Pp1-87B as an essential regulator of JNK signaling crucial for eliminating scrib-deficient precancerous cells during tumor-suppressive cell competition. Mechanistically, impaired Pp1-87B activates JNK signaling via the Moe-Rho1 axis.

Correlation study on the risk of cardiovascular adverse events in diabetic foot patients based on machine learning - a retrospective cohort study.

Introduction: Diabetic Foot (DF), as a serious complication of diabetes, is closely related to major adverse cardiovascular events (MACE) and mortality. However, research on predictive models for the MACE risk in DF patients is not sufficient. The purpose of this study is to construct a prognostic model for the MACE risk in patients with diabetic foot ulcers and provide a reference tool for clinical individualized management.

Main pancreatic duct exposure, repair or reconstruction During minimally invasive pancreatic enucleation long-term metabolic outcome From a prospective cohort study (CSPAC-MIEN-1).

Background: While minimally invasive enucleation (MIEN) is known for its excellent long-term metabolic outcomes and comparable quality of life (QoL) to that of the general population, previous reports have rarely included exposure, repair, or reconstruction (ERR) of the main pancreatic duct (MPD). This study aims to assess the long-term pancreatic metabolic outcomes and QoL in patients following MIEN involving MPD ERR.

Method: From July 2019 to April 2024, 230 patients were prospectively enrolled.

Predictors of anti-TNF treatment failure in intestinal Behçet's disease: a multicenter retrospective cohort study.

Objective: Treatment options for intestinal Behçet's disease (BD) are limited. Despite the proven efficacy of infliximab and adalimumab, there is an urgent need to identify predictive factors for inadequate response or non-response to anti-TNF agents.

Methods: We conducted a retrospective cohort study involving 71 patients diagnosed with intestinal BD and treated with anti-TNF across four hospitals from August 2018 to December 2024.

[Short-Term Efficacy of Low-Dose Venetoclax Combined with CHG Priming Regimen in Patients with AML and High-Risk MDS Ineligible for Intensive Chemotherapy].

Objective: To investigate the short-term efficacy and safety of low-dose venetoclax combined with CHG (cytarabine+homoharringtonine+G-CSF) priming regimen in patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy.

Methods: The data of 14 patients with AML or high-risk MDS admitted to the department of hematology/oncology of the First Hospital of Tsinghua University and 2 cooperative institutions from July 2022 to August 2023 were retrospectively analyzed. All the patients were treated with low-dose venetoclax combined with CHG priming regimen and the early induction (one course) efficacy and adverse reactions were observed.

Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila.

Interorgan communication is vital for tissue homeostasis and health in multicellular organisms, and its disruption can lead to diseases such as cancer. Adipose tissue acts as a key endocrine center, secreting cytokines that influence remote organs. Despite clear links between obesity and increased cancer risk, the underlying mechanisms are unclear.

Lipid metabolism of and its main components with hypoglycemic effects.

Background: Probiotic is used to treat diabetes, but its specific hypoglycemic substances and mechanisms remain unclear.

Aim: To investigate the components for lipid metabolism of and its hypoglycemic effects, providing a basis for its broader application.

Methods: The lipid metabolism of under different growth conditions was analyzed using lipidomics.

Activated CD4 T cells upregulate PD-L1 expression on B cells through CD40/CD40L signaling and direct contact in systemic lupus erythematosus.

Programmed cell death protein 1 (PD-1) expression on T cells has been implicated in the pathogenesis of autoimmune diseases; however, the functional role of programmed death-ligand 1 (PD-L1) expression on B cells remains insufficiently characterized, particularly in the context of CD4 T cell-mediated regulation in systemic lupus erythematosus (SLE). Flow cytometric analysis revealed that PD-L1 B cells exhibited upregulated surface expression of the co-stimulatory molecules CD80 and CD86, alongside a concomitant downregulation in the expression of the antigen-presenting molecule human leukocyte antigen DR (HLA-DR). Furthermore, an elevated frequency of class-switched PD-L1 B cells was observed in the peripheral blood of patients with SLE.

The Peripheral Defocus Designed Spectacle Lenses Might Increase Astigmatism in Myopic Children.

Purpose: This study aims to explore the impact of wearing peripheral defocus spectacle lenses (PDSL) on cylindrical refractive error (CYL) in myopic children.

Methods: This study included 1057 myopic children and divided the participants into three groups: the HAL group (spectacle lens with highly aspherical lenslets), the MPV group (spectacle lens based on manipulating peripheral vision), and a control group (without myopia control interventions). The study analyzed the effect of wearing PDSL on changes in spherical equivalent refraction, CYL, and corneal astigmatism (CA).

Modular Synthesis of Bioactive Selenoheterocycles for Efficient Cancer Therapy via Electrochemical Selenylation/Cyclization.

A green, efficient, and environmentally friendly electrochemical strategy was developed for synthesizing a series of selenoheterocyclic compounds. The antitumor activities of these compounds were evaluated, revealing that compounds , , and demonstrated remarkable antitumor efficacy. These compounds effectively inhibited lung cancer by inducing cell apoptosis, causing DNA damage, and suppressing the progression of epithelial-mesenchymal transition.

Identification of Fatty Acid Synthase in and Its Expression Profiles in Response to Starvation.

Fatty acids are the main form of energy production and storage in insects, and fatty acid synthase (FAS) plays a major role in this process. is a natural enemy used in China to control agricultural pests. While its whole genome has been assembled, its FAS genes remain undescribed.

Effect of Laparoscopic versus Open Distal Pancreatectomy on Recurrence-Free Survival in Patients with Left-sided Pancreatic Cancer: A randomized controlled trial.

Objective: The aim of this trial was to evaluate the oncological superiority of laparoscopic versus open distal pancreatectomy in left-sided pancreatic cancer.

Background: The oncological efficacy of laparoscopic distal pancreatectomy in left-sided pancreatic cancer remains controversial.

Methods: We performed a multi-center, open-label, randomized controlled trial of laparoscopic versus open distal pancreatectomy in left-sided pancreatic cancer patients.

Molecular chaperon HSP70-9 is required for clathrin-mediated endocytosis in Arabidopsis.

Clathrin-mediated endocytosis (CME) plays a key role in the internalization of plasma membrane-localized proteins, lipids and extracellular substances; however, the regulatory mechanism of CME in plants is unclear. In this work, we demonstrated that molecular chaperon HSP70-9 is required for CME in Arabidopsis thaliana. Knocking out the HSP70-9 gene led to auxin-related phenotypes and the accumulation of auxin efflux carrier PINs in root cells, indicating that HSP70-9 is involved in the PIN trafficking process.

Multi-dimensional evidence from the UK Biobank shows the impact of diet and macronutrient intake on aging.

Background: The role of diet in aging is crucial, yet research findings on how specific diets influence human aging remain inconsistent. Understanding the relationship between dietary factors and aging could inform interventions to promote healthier aging outcomes.

Methods: We analyzed data from the UK Biobank baseline survey and a 24-hour dietary assessment survey to investigate the association between diet and aging.

Betaine combined with traditional Chinese medicine ointment to treat skin wounds in microbially infected diabetic mice.

Background: Skin wounds are highly common in diabetic patients, and with increasing types of pathogenic bacteria and antibiotic resistance, wounds and infections in diabetic patients are difficult to treat and heal.

Aim: To explore the effects of betaine ointment (BO) in promoting the healing of skin wounds and reducing the inflammation and apoptosis of skin cells in microbially infected diabetic mice.

Methods: By detecting the minimum inhibitory concentrations (MICs) of betaine and plant monomer components such as psoralen, we prepared BO with betaine as the main ingredient, blended it with traditional Chinese medicines such as gromwell root and psoralen, and evaluated its antibacterial effects and safety and .

Clinical observations from the clinical video head pulse test in patients with idiopathic horizontal semicircular canal light cupula.

Objective: The objective of the study is to analyze and explore the characteristics of the video head impulse test (vHIT) for light cupula in the idiopathic horizontal semicircular canal and compare them with those of horizontal semicircular canal cupulolithiasis (HC-cu) in order to investigate the potential mechanism involved.

Methods: Data from 51 cases of idiopathic light cupula and 42 cases of horizontal semicircular canal cupulolithiasis were retrospectively analyzed. The positional nystagmus features, vHIT anomaly rate, gain value, saccades, and other indicators were compared.

DNA sequence and lesion-dependent mitochondrial transcription factor A (TFAM)-DNA-binding modulates DNA repair activities and products.

Mitochondrial DNA (mtDNA) is indispensable for mitochondrial function and is maintained by DNA repair, turnover, mitochondrial dynamics and mitophagy, along with the inherent redundancy of mtDNA. Base excision repair (BER) is a major DNA repair mechanism in mammalian mitochondria. Mitochondrial BER enzymes are implicated in mtDNA-mediated immune response and inflammation.

Gut microbiota-derived 3-indoleacetic acid confers a protection against sepsis-associated encephalopathy through microglial aryl hydrocarbon receptors.

Background: The gut microbiota significantly contributes to the pathogenesis of central nervous system disorders. Among the bioactive molecules produced by the gut microbiota, 3-indoleacetic acid (IAA) has been shown to attenuate oxidative stress and inflammatory responses. This experiment aimed to determine the impacts of IAA on sepsis-associated encephalopathy (SAE) and the underlying mechanisms.

Cotranslational molecular condensation of cochaperones and assembly factors facilitates axonemal dynein biogenesis.

Axonemal dynein, the macromolecular machine that powers ciliary motility, assembles in the cytosol with the help of dynein axonemal assembly factors (DNAAFs). These DNAAFs localize in cytosolic foci thought to form via liquid-liquid phase separation. However, the functional significance of DNAAF foci formation and how the production and assembly of multiple components are so efficiently coordinated, at such enormous scale, remain unclear.

Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways.

Hormone therapy resistance and the ensuing aggressive tumor progression present a significant clinical challenge. However, the mechanisms underlying the induction of tumor malignancy upon inhibition of steroid hormone signaling remain poorly understood. Here, we demonstrate that Drosophila malignant epithelial tumors show a similar reduction in ecdysone signaling, the main steroid hormone pathway.

Distinctive grade based on Ki67 index and immune microenvironment of metastatic pancreatic neuroendocrine tumors responding to capecitabine plus temozolomide.

Background: Ki67 index changes during the treatment of metastatic pancreatic neuroendocrine tumor (PanNET) treatment. The study aimed to detect alterations of grade based on Ki67 index and immune microenvironment in PanNET responding to capecitabine/temozolomide (CapTem).

Method: Retrospective data of patients with PanNET were collected.

The construction of international wetland urban ecological security pattern coupled with MSPA and ESF.

Creating an ecological security pattern is crucial for balancing the sustainable development of areas where human activities and the natural environment intersect. Using Hefei, an internationally recognized Wetland City, as a case study, we extracted ecological sources through ecological service function (ESF) analysis and morphological spatial pattern analysis (MSPA) core area connectivity analysis. Based on these ecological sources, we developed an ecological resistance surface system and identified ecological corridors and nodes using circuit theory.