The ACSS2-PPARD-BCAT1 axis synchronously regulates branched-chain amino acid metabolism and development in pancreatic cancer.

The characteristics of the tumor microenvironment (TME) of pancreatic cancer include an abundant stroma, hypoxia, insufficient blood supply and high degree of immunosuppression. Therefore, overcoming the TME conditions to reach a hypermetabolic state is a concern for the treatment of pancreatic cancer. Previous studies have demonstrated that tumor cells adapt to the TME by activating or increasing the expression level of ACSS2 under metabolic stress.

T-cell immunity in the experimental autoimmune vasculitis rat model.

ANCA-vasculitis (AAV) is a small-vessel vasculitis characterized by the presence of autoantibodies against proteinase-3 (PR3) or myeloperoxidase (MPO). The dynamics of the T-cell response within tissues is studied best in animal models. It was the aim to analyze the lesional T-cell dynamics in the experimental autoimmune vasculitis model.

ACSS2/AATF Drives Soluble FasL-Mediated CD8 T Cell Apoptosis in Pancreatic Neuroendocrine Tumors.

Besides the traditional carbon sources, Acetyl coenzyme A has recently been shown to be generated from acetate in various cancers, which subsequently promotes tumor growth and immune escape. However, the mechanism of Acetyl coenzyme A availability in pancreatic neuroendocrine tumors (PNETs) remains largely unknown. Herein, the metabolic-epigenetic modification driven by acetyl coenzyme A synthase 2 (ACSS2) and its effect on the Fas/FasL system in PNETs is investigated.

Role of S1PR1 in VEGF-exosomes mediated resistance of hepatocellular carcinoma to anti-angiogenesis therapy.

Background: Anti-angiogenesis therapy (AAT) triggers vascular endothelial growth factor (VEGF)-exosomes secretion from tumor-associated endothelial cells (TAECs) for hepatocellular carcinoma (HCC) tubulogenesis and metastasis. Sphingosine-1-phosphate receptor 1 (S1PR1) has been implicated in HCC progression, but it was targeted by microRNA-9 (miR-9) that might mediate the formation of TAECs. This study aims to investigate the role of miR-9 and VEGF-exosomes in S1PR1-mediated HCC progression and resistance to AAT.

Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor-Stroma Ratio and Promote Cancer Progression.

Unlabelled: A low tumor-stroma ratio (TSR) in pancreatic neuroendocrine tumors (pNET) is associated with a significantly poorer patient prognosis. Although the tumor stroma represents an attractive therapeutic target, recent clinical trials have not been successful. In this study, we aimed to dissect the mechanisms regulating the tumor microenvironment in low TSR pNETs to identify potential therapeutic targets.

[Neuroprotective Effects of Anisodine Hydromide in a Rat Model of Vascular Dementia and the Antioxidative Stress Mechanisms Involved].

Objective: Vascular dementia (VD) is a common cognitive dysfunction associated with cerebrovascular disease. This study is aimed at investigating the therapeutic effect of anisodine hydromide (AH) on VD and the potential antioxidative stress mechanisms involved.

Methods: A VD model was established in Sprague-Dawley (SD) rats through permanent bilateral common carotid artery occlusion.

Neurotoxic risks of long-term environmental exposure to pesticides: a review.

Pesticides are chemical substances that prevent pests, control weeds, sterilize, and regulate plant growth. Although mechanized spraying of pesticides significantly improves operational efficiency, excessive use and improper handling of pesticides can lead to environmental pollution, resulting in long-term exposure of nontarget organisms and causing toxicity, particularly neurotoxicity in these organisms. This review summarizes the toxic effects of long-term pesticide exposure on various neurological functions, providing insights for future studies on pesticide exposure.

[Research and Discussion on the Whole Lifecycle Supervision of Typical Class Ⅱ Wound Dressing Products].

In this study, the pre-market regulatory requirements for typical Class Ⅱ wound dressings, as well as the status of testing and post-market adverse events monitoring, were reviewed from the perspective of the whole lifecycle of medical devices. Additionally, the regulatory requirements for wound dressings in China, the United States, and the European Union were compared. Supplementary research was also conducted on Class Ⅰ and Ⅱ liquid and paste dressing products.

Relationship between resilience and social trust in nursing homes in Guangzhou, China: a cross-sectional study.

Objectives: To identify latent resilience profiles among older adults residing in nursing homes and to examine the mediating role of perceived social support in the relationship between resilience and social trust.

Design: A cross-sectional survey conducted between January and May 2023.

Setting: Three nursing homes in urban Guangzhou, China.

Small extracellular vesicle-miR-183-5p mediated crosstalk between tumor cells and macrophages in high-risk pancreatic neuroendocrine tumors.

High-risk pancreatic neuroendocrine tumors (pNET) are characterized by aggressive progression and metastasis, contributing to poor clinical outcomes. This study explores molecular mechanisms underlying metastasis in high-risk pNETs and evaluates therapeutic interventions. We employed small RNA sequencing to profile miRNA signatures in tumor-derived small extracellular vesicles (sEVs) and integrated single-cell transcriptomic analysis to delineate the tumor immune microenvironment.

Case Report: Ankylosing Spondylitis Complicated With Systemic Lupus Erythematosus.

Ankylosing spondylitis (AS) is rarely found in conjunction with connective tissue diseases. Moreover, reports on the coexistence of AS with systemic lupus erythematosus (SLE) are few. Here, we describe such a case of coexisting AS and SLE in a 58-year-old male patient.

Associations Between Brain Structural Connectivity and 1-Year Demoralization in Breast Cancer: A Longitudinal Diffusion Tensor Imaging Study.

This study aims to explore the association between brain structural connectivity and 1-year demoralization in patients with newly diagnosed breast cancer. Patients were enrolled from a multicenter longitudinal program named as (BRBC) between 2017 and 2019. Brain structural connectivity was assessed with diffusion tensor imaging (DTI) at baseline and the demoralization scale II collected self-report data at baseline and 1 year later.

Brain Connectomics Improve the Prediction of High-Risk Depression Profiles in the First Year following Breast Cancer Diagnosis.

Background: Prediction of high-risk depression trajectories in the first year following breast cancer diagnosis with fMRI-related brain connectomics is unclear.

Methods: The Be Resilient to Breast Cancer (BRBC) study is a multicenter trial in which 189/232 participants (81.5%) completed baseline resting-state functional magnetic resonance imaging (rs-fMRI) and four sequential assessments of depression (T0-T3).

A Longitudinal Correlational Study of Psychological Resilience, Depression Disorder, and Brain Functional-Structural Hybrid Connectome in Breast Cancer.

To evaluate the association between psychological resilience, depression disorder (DD), and brain functional-structural hybrid connectome in patients with breast cancer before treatment (T0) and at 1 year. Between February 2017 and October 2019, 172 patients were longitudinally enrolled from a multicenter trial named as Be Resilient to Breast Cancer (BRBC) and completed resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) before the T0. Data-driven multivoxel pattern analysis (MVPA) and correlational tractography (CT) were performed to identify distinct functional-structural hybrid connectome.

Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups.

The majority of neuroendocrine neoplasms in pancreas are non-functional pancreatic neuroendocrine tumors (NF-PanNETs), which exhibit a high occurrence of distant metastases with limited therapeutic options. Here, we perform a comprehensive molecular characterization of 108 NF-PanNETs through integrative analysis of genomic, transcriptomic, proteomic, and phosphoproteomic profiles. Proteogenomic analysis provides functional insights into the genomic driver alterations of NF-PanNETs, revealing a potential mediator of MEN1 alterations using Men1-conditional knockout mice.

Peptide-Modified Lipid Nanoparticles Boost the Antitumor Efficacy of RNA Therapeutics.

RNA therapeutics offer a promising approach to cancer treatment by precisely regulating cancer-related genes. While lipid nanoparticles (LNPs) are currently the most advanced nonviral clinically approved vectors for RNA therapeutics, their antitumor efficacy is limited by their unspecific hepatic accumulation after systemic administration. Thus, there is an urgent need to enhance the delivery efficiency of LNPs to target tumor-residing tissues.

Association between dietary habits and emotional and behavioral problems in children: the mediating role of self-concept.

Introduction: Increasing research has focused on the influence of diet on mental health and well-being. This study aimed to investigate dietary habits status and their associations with emotional and behavioral problems (EBPs) in pre-teen children, as well as explore the mediating effect of child self-concept in the associations between healthy dietary habits and EBPs.

Methods: A cross-sectional survey using stratified random sampling was conducted to recruit third-grade children and their caregivers.

Overcoming the Low-Temperature Barrier: Controlling Li₂S Deposition and Enhancing Catalysis in Lithium-Sulfur Batteries Using Island-like Bi₂O₃ on rGO.

Low-temperature lithium-sulfur batteries (LSBs) face challenges such as Li₂S accumulation and the slow conversion of lithium polysulfides (LiPSs), significantly affecting their capacity and cycling life. While functionalizing cathode shows potential to overcome these problems, there has been little focus on understanding the deposition behavior of Li₂S at low temperatures and the specific catalysis processes of newly identified platforms. Here we report an island-like Bi₂O₃ uniformly distributed on reduced graphene oxide (IBG) as a sulfur host material.

Pentose phosphate recycling driven by Gli1 contributes to chemotherapy resistance in cancer cells.

The Hedgehog Signaling Pathway plays an important role in cancer development and chemotherapy resistance. However, whether the pathway functions depend on the metabolic reprogramming of cancer cells has not been well studied. In this study, we found that the expression level of Gli1, a key transcription factor downstream of the Hedgehog Signaling Pathway, is significantly increased in patients with pancreatic cancer resistant to gemcitabine neoadjuvant chemotherapy.

knockdown enhances RSL3-induced ferroptosis in pancreatic cancer cells and increases the sensitivity to gemcitabine.

Ferroptosis is a type of programmed death characterized by iron-dependent lipid peroxidation, and targeting ferroptosis has been shown to efficiently kill highly aggressive cancer cells. Previously, we confirmed that nuclear receptors regulate ferroptosis in pancreatic cancer. However, whether nuclear receptor co-activators regulate ferroptosis is unclear.

Endothelial cytoskeleton in mechanotransduction and vascular diseases.

The cytoskeleton is an important structural component that regulates various aspects of cell morphology, movement, and intracellular signaling. It plays a pivotal role in the cellular response to biomechanical stimuli, particularly in endothelial cells, which are critical for vascular homeostasis and the pathogenesis of cardiovascular diseases. Mechanical forces, such as shear and tension, activate intracellular signaling cascades that regulate transcription, translation, and cellular behaviors.

Antimicrobial peptide Mt 5 inhibits human hepatocellular carcinoma cell HepG2 proliferation.

The Mt 5 peptide is an antimicrobial peptide, its effect on hepatocellular carcinoma (HCC) and its underlying mechanism is not understood. Therefore, this study aimed to investigate the effects of the Mt 5 peptide in a human HCC cell line, namely HepG2, in vitro. Notably, Mt 5 markedly reduced the growth of HepG2 cells by disrupting the cell membrane while exhibiting minimal toxicity to healthy liver cells.

High prevalence and seasonal patterns of vitamin D deficiency in children and adolescents in Central China: a three-year single-center study.

Objective: This study aimed to determine the prevalence and associated factors of vitamin D deficiency and insufficiency in children and adolescents in Central China.

Methods: In total, 8,248 children and adolescents aged 0-18 years at a children's hospital from January 2019 to February 2022, were recruited. Their serum vitamin D levels were measured, and monthly meteorological and air pollution data were collected.

Research on the local path planning of an orchard mower based on safe corridor and quadratic programming.

Introduction: Path planning algorithms are challenging to implement with mobile robots in orchards due to kinematic constraints and unstructured environments with narrow and irregularly distributed obstacles.

Methods: To address these challenges and ensure operational safety, a local path planning method for orchard mowers is proposed in this study. This method accounts for the structural characteristics of the mowing operation route and utilizes a path-velocity decoupling method for local planning based on following the global reference operation route, which includes two innovations.

Hierarchical Nb@NbN core-shell-like nanocolumns for asymmetric supercapacitors.

Transition metal nitrides (TMNs) are promising electrode materials for supercapacitors because of their high electrical conductivity and chemical stability. The rational design and facile synthesis of TMNs electrode materials with a unique nanostructure are the key to develop high-performance supercapacitors. Herein, we propose a two-step, binder-free, and eco-friendly approach utilizing magnetron sputtering at an oblique angle deposition configuration to fabricate hierarchical Nb@NbN core-shell-like nanocolumns for supercapacitors.