[Expression of Concern] Downregulation of microRNA‑183‑5p inhibits the proliferation and invasion of colorectal cancer cells by inactivating the reticulocalbin‑2/Wnt/β‑catenin signaling pathway.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that, regarding the Transwell assay experiments shown in Figs. 3 and 4, the 'Invasion/NC' panel in Fig. 3H appeared to contain an overlapping section of data with both the 'Invasion/NC' 'and the 'Invasion/'miR‑183‑5p mimic+RCN2 siRNA' panels in Fig.

Global, regional, and national temporal trend in burden of chronic respiratory diseases from 1990 to 2021: Findings from the Global Burden of Disease Study 2021.

Background: Chronic respiratory diseases (CRDs), including chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease (ILD), and pulmonary sarcoidosis, continue to pose a significant global health challenge. This study aims to assess the global, regional, and national burden of CRDs from 1990 to 2021, using data from the Global Burden of Disease Study (GBD) 2021 to identify key trends and advise future public health strategies.

Methods: Data from the GBD 2021 were used to estimate the incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of CRDs and their subtypes across 21 global regions and 204 countries and regions from 1990 to 2021.

Deep learning and pathomics analyses predict prognosis of high-grade gliomas.

Objective: Utilizing pathomics to analyze high-grade gliomas and provide prognostic insights.

Methods: Regions of Interest (ROIs) in tumor areas were identified in whole-slide images (WSI). Tumor patches underwent cropping, white space removal, and normalization.

Tumour extracellular vesicle surface Protein-mRNA integration assay for early detection of epithelial ovarian cancer.

Background: Early detection of epithelial ovarian cancer (EOC) is crucial for improving clinical outcomes. However, the sensitivity of primary serological marker cancer antigen 125 (CA125) is suboptimal for detecting early-stage EOC. Tumour-derived extracellular vesicles (EVs) are promising biomarkers for early cancer detection.

Bibliometric analysis of infertility psychology: current status, hotspots, and emerging trends (2014-2024).

Introduction: The mental health concerns associated with infertility, encompassing conditions such as anxiety, depression, and stress, are of paramount importance. However, bibliometric analyses employing tools like CiteSpace and VOSviewer to study this domain have been notably lacking.

Objectives: This research aims to fill this gap by employing these tools to analyze the current state, hotspots, and trends in infertility psychology, thereby offering a comprehensive review to assist researchers in navigating the research landscape.

Bufei Jiedu Formula enhances CD40 activation and macrophage polarization to eliminate intracellular MRSA persisters.

Background: Intracellular methicillin-resistant (MRSA) represents a complex infection in clinical practice, characterized by its refractory and recurrent nature, rendering it challenging to treat with conventional antibiotics. Bufei Jiedu Formula (BFJD) is a traditional Chinese medicine compound utilized for treating chronic lung infections; however, its mechanisms against intracellular MRSA infection are not yet fully understood.

Methods: An animal model with persistent MRSA infection was used to evaluate the efficacy of BFJD against chronic bacterial infections.

Impact of body composition on vitamin D requirements in healthy adults with vitamin D deficiency.

Background: Previous studies have shown that individuals with high body mass index typically require high doses of vitamin D supplementation to correct vitamin D deficiency. However, it is unclear which specific body composition is the determining factor affecting the bioavailability of vitamin D after supplementation. The aim of this study was to determine which body components affect the bioavailability of vitamin D.

FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise.

Exercise maintains bone health and produces protective effects on bone loss. In this study, we investigated the potential protective effects of circulating small extracellular vesicles (sEVs) generated under endurance exercise training (Exe-sEVs) on ovariectomized (OVX)-induced bone loss. Inhibition of sEVs secretion by GW4869 partially reversed exercised-induced protection against OVX-induced bone loss.

Performance of GPT-4 for automated prostate biopsy decision-making based on mpMRI: a multi-center evidence study.

Background: Multiparametric magnetic resonance imaging (mpMRI) has significantly advanced prostate cancer (PCa) detection, yet decisions on invasive biopsy with moderate prostate imaging reporting and data system (PI-RADS) scores remain ambiguous.

Methods: To explore the decision-making capacity of Generative Pretrained Transformer-4 (GPT-4) for automated prostate biopsy recommendations, we included 2299 individuals who underwent prostate biopsy from 2018 to 2023 in 3 large medical centers, with available mpMRI before biopsy and documented clinical-histopathological records. GPT-4 generated structured reports with given prompts.

Identification of biomarkers associated with mitochondrial dysfunction and programmed cell death in chronic obstructive pulmonary disease via transcriptomics.

Background: Research has demonstrated that the homeostasis of mitochondria and programmed cell death (PCD) are intimately linked to chronic obstructive pulmonary disease (COPD). Consequently, identifying biomarkers of COPD from mitochondria-related genes (MRGs) and programmed cell death-related genes (PCD-RGs) is of paramount importance.

Methods: Differentially expressed genes (DEGs) from the GSE42057 dataset and COPD-related genes (COPD-RGs) via weighted gene co-expression network analysis (WGCNA) were intersected with MRGs and PCD-RGs to select candidates.

Omega-6/Omega-3 Ratio as a Protective Factor in Lung Cancer: A Mendelian Randomization Study on Polyunsaturated Fatty Acids and Lung Adenocarcinoma Risk.

While observational studies have reported conflicting associations between polyunsaturated fatty acids (PUFAs) and lung cancer risk, the causal role of specific PUFA subtypes remains unclear. Leveraging genome-wide association data from the UK Biobank and International Lung Cancer Consortium, we employed univariable, multivariable, and bidirectional Mendelian randomization (MR) analyses to investigate the causal effects of seven PUFA traits (including omega-3, DHA, EPA, omega-6, LA, AA, and the omega-6/omega-3 ratio) on lung cancer and its subtypes. Our primary finding revealed a robust protective effect of a higher omega-6/omega-3 ratio against overall lung cancer (IVW: OR = 0.

circ-NOLC1 inhibits the development of cervical cancer by regulating miR-330-5p-PALM signaling axis.

Background: Recent studies have increasingly demonstrated that circular RNAs (circRNAs) play significant roles in the occurrence and progression of cervical cancer (CC). In CC, circRNAs act as ceRNAs by sponging miRNAs to regulate genes associated with proliferation, migration, and apoptosis, exhibiting both promoting and inhibiting effects on tumor progression. The aim of this study was to clarify the role of hsa_circ_0019686 (named circ-NOLC1) in CC.

Characteristics of Soil Dissolved Organic Matter Structure in Albi-Boric Argosols Profiles Through Straw Incorporation: A Fluorescence Spectroscopy Study.

Albi-boric argosols, mainly distributed in the Sanjiang Plain of Heilongjiang Province, China, accounting for over 80% of the total cultivated land area, is characterized by a nutrient-deficient layer beneath black soil. This study addresses the challenges of modern agriculture by investigating the impact of straw incorporation on soil dissolved organic carbon (DOC) and its structures in albi-boric argosols, profiles, using fluorescence excitation-emission spectroscopy and parallel factor analysis (PARAFAC). Three treatments were applied: undisturbed albi-boric argosols (C), mixed albic and illuvium layers (M), and mixed albic and illuvium layers with straw (MS).

MicroRNA-6084 orchestrates angiogenesis and liver metastasis in colorectal cancer via extracellular vesicles.

The prognosis for colorectal cancer (CRC) patients with liver metastasis remains poor, and the molecular mechanisms driving CRC liver metastasis are not fully understood. Tumor-derived hypoxia-induced extracellular vesicles have emerged as key players in inducing angiogenesis by transferring noncoding RNAs. However, the specific role of CRC-derived hypoxic extracellular vesicles (H-EVs) in regulating premetastatic microenvironment (PMN) formation by inducing angiogenesis remains unclear.

Potentially Elevated Rheumatoid Arthritis Risk due to Chemotherapy-Induced Inflammation in Prostate Cancer With Bone Metastasis.

Background: Chronic inflammation plays a crucial role in the development and progression of rheumatoid arthritis (RA). Prostate cancer with bone metastasis (PCa-BM) is the most common metastatic form of advanced prostate cancer in the elderly, significantly affecting prognosis and quality of life Although chemotherapy is commonly used for PCa-BM, the chronic inflammation it causes may exacerbate the risk of joint injuries to induce RA and related complications. Therefore, exploring the risk of chemotherapy-induced chronic inflammation on RA risk in PCa-BM patients holds critical importance.

Comparative evaluation of palliative holmium laser enucleation and plasma kinetic prostate resection in the management of advanced prostate cancer with lower urinary tract symptoms.

This study aimed to evaluate the efficacy of palliative holmium laser enucleation of the prostate (HoLEP) versus plasma kinetic resection of the prostate (PKRP) in the management of advanced prostate cancer (APC) with concurrent lower urinary tract symptoms (LUTS).A retrospective analysis was conducted from February 2017 to March 2021, which included 41 patients with LUTS from two centers. Of these, 23 patients underwent palliative HoLEP and 18 underwent PKRP.

LINC02593 impedes cell senescence via COP1-mediated p53 degradation in cervical cancer.

Evasion of cellular senescence is one of the hallmarks of cervical carcinoma (CC) to maintain malignant development. Even though the regulators driving CC cell senescence are widely recognized, the underlying upstream mechanisms are still not fully understood. Long non-coding RNAs (lncRNAs) are emerging as important regulators in cell senescence.

Integrated Analysis of Proteome and Metabolome Reveals the Basis of Amino Acid Metabolism in Cigar Artificial Fermentation.

Cigars are a type of tobacco product made entirely from dried tobacco, primarily consisting of the filler, binder, and wrapper. Fermentation is a key step in improving the quality of cigar tobacco leaves (CTLs). To investigate how fermentation affects quality, this study employed non-targeted metabolomics and data-independent acquisition (DIA) proteomics to examine the metabolic changes and protein expression levels in tobacco leaves.

A prognostic model for head and neck squamous cell carcinoma based on radiotherapy sensitivity insights from nasopharyngeal carcinoma.

Background: Radioresistance significantly impairs treatment efficacy and prognostic outcomes in head and neck squamous cell carcinoma (HNSCC). This study aimed to identify radiotherapy sensitivity-related genes and construct a prognostic model for HNSCC, incorporating insights from nasopharyngeal carcinoma (NPC) as a related subtype.

Methods: Differentially expressed genes (DEGs) associated with radiotherapy response were identified using the GSE48501 dataset, primarily derived from NPC.

Si Microanemones Integrated Microfluidic Chip for Highly Efficient Isolation of Extracellular Vesicles.

Liquid biopsy has emerged as a transformative approach for early cancer detection and treatment monitoring, offering significant potential to improve patient outcomes. However, isolating tumor-derived extracellular vesicles (EVs) from body fluids is often impeded by background noise, making subsequent analysis challenging. Herein, a bio-inspired 3D silicon microanemone (SMA) microfluidic chip is reported.

Correlation Between Blood Glucose Level and Cerebral Small Vessel Disease Markers in Neurologically Asymptomatic, Nondiabetic Individuals.

Objectives: Cerebral small vascular disease (CSVD) is not rare in neurologically asymptomatic individuals. Glucose control and insulin resistance (IR) may be its risk factors. We aimed to explore the relationship between CSVD markers, glucose control, and IR in neurologically asymptomatic, nondiabetic individuals.

Radiomic analysis based on machine learning of multi-sequences MR to assess early treatment response in locally advanced nasopharyngeal carcinoma.

ObjectiveThe prediction of early response in locally advanced nasopharyngeal carcinoma (LA-NPC) after concurrent chemoradiotherapy (CCRT) is important for determining the need for timely consolidation therapy. We developed a radiomic analysis of multi-sequences MR based on machine learning (ML) to assess early response in LA-NPC after CCRT.MethodsThis study retrospectively enrolled 104 LA-NPC patients, randomly divided into training (70%) and test (30%) cohorts.

High-Efficiency Wireless Power Transfer System Based on Low-Frequency AlScN Piezoelectric Micromechanical Ultrasonic Transducers for Implantable Medical Devices.

In recent years, implantable medical devices (IMDs) have introduced groundbreaking solutions for managing various health conditions. However, traditional implanted batteries necessitate periodic surgical replacement and tend to be relatively bulky, posing significant inconvenience to patients. To overcome these limitations, researchers have investigated various wireless power transfer (WPT) techniques, among which the ultrasonic wireless power transmission (UWPT) technique has distinct advantages.

Latent profile analysis of psychological help-seeking stigma and influential factors among Hainan medical students.

Objective: Medical students frequently confront a range of psychological challenges inherent to their profession. Among these, the psychological help-seeking stigma (PHSS) is a crucial yet often neglected barrier, impeding medical students from obtaining necessary psychological support. This research aims to elucidate the characteristics of PHSS in medical students through latent profile analysis (LPA), examine its psycho-social determinants, and establish the threshold for PHSS using receiver operating characteristic (ROC) analysis.

Treatment of V617F-positive primary myelofibrosis and advanced chronic myelogenous leukemia with ruxolitinib and flumatinib: a case report.

Introduction And Importance: Chronic myeloid leukemia (CML) is characterized by a BCR-ABL1 fusion gene of the Philadelphia chromosome, which is mutually exclusive of genetic abnormalities associated with the myeloproliferative neoplasms polycythemia vera, essential thrombocythemia, and primary myelofibrosis (PMF). These conditions are commonly linked to driver mutations in JAK2, CALR, and MPL. Rare cases with both BCR-ABL1 rearrangement and JAK2 V617F mutation have been reported.