Differentiation of Suspicious Microcalcifications Using Deep Learning: DCIS or IDC.

Rationale And Objectives: To explore the value of a deep learning-based model in distinguishing between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) manifesting suspicious microcalcifications on mammography.

Materials: A total of 294 breast cancer cases (106 DCIS and 188 IDC) from two centers were randomly allocated into training, internal validation and external validation sets in this retrospective study. Clinical variables differentiating DCIS from IDC were identified through univariate and multivariate analyses and used to build a clinical model.

Clinical efficacy and safety of Cadonilimab in the treatment of advanced gynecological malignancies: a retrospective, real-world study.

Background: Cadonilimab, recognized as the most rapidly developed Chinese drug in the field of cervical cancer, received marketing approval in China in 2022. We conducted a study to investigate the safety and efficacy of Cadonilimab, combined with and without chemotherapy or bevacizumab treatment, in patients with recurrent / metastatic gynecological malignancies.

Methods: We retrospectively enrolled 60 patients with recurrent / metastatic gynecological malignant tumors, confirmed by pathology or cytology from July 2022 to December 2024.

Rice ragged stunt virus Pns10 induces mitochondrial-mediated apoptosis to promote viral infection in Nilaparvata lugens through disrupting the NlNDUFS1-NlPHB2 interaction.

Apoptosis, a programmed cell death process, plays crucial roles in host antiviral response. Although there are many reports on the relationship between cell apoptosis and viral infection, the mechanisms underlying plant arbovirus-induced apoptosis in insect vectors remain largely unclear. Here, we reported that apoptosis promotes rice ragged stunt virus (RRSV) infection in Nilaparvata lugens (brown planthopper), and RRSV-encoded Pns10 protein can induce apoptosis in N.

TRPV2 Inhibition Prevents Right Ventricular Remodeling and Arrhythmia in Experimental Pulmonary Hypertension.

Right ventricular (RV) failure and malignant arrhythmia are determinants of the prognosis of pulmonary arterial hypertension (PAH). Transient receptor potential vanilloid type 2 (TRPV2) is involved in the development of heart failure, whereas its role in PAH deserves further exploration. This study aimed to explore whether TRPV2 contributes to SU5416/hypoxia (SuHx)-induced ventricular remodeling and arrhythmias, and its possible mechanisms.

Viral proteins suppress rice defenses by boosting OsTSN1 RNA decay via phase separation and multimerization.

Liquid-liquid phase separation (LLPS) forms membraneless condensates crucial for plant stress responses. However, how plant viruses utilize LLPS to escape host immunity remains largely unexplored. Here, we show that P6 protein encoded by southern rice black-streaked dwarf virus (SRBSDV) undergoes LLPS.

Running ameliorates methamphetamine-associated cognitive impairment by regulating hippocampal neurogenesis through the GSK3β/β-catenin pathway.

Physical exercise is a non-pharmacological therapy widely used in drug rehabilitation centers for treating methamphetamine (METH) addiction. METH causes cognitive impairment and suppresses adult hippocampal neurogenesis (AHN) in experimental animals. Exercise can improve cognitive dysfunction caused by various factors through the enhancement of AHN.

Advances in Traditional Chinese Medicine for Modulating DNA Methylation in the Treatment of Inflammatory Diseases.

DNA methylation is a crucial epigenetic mechanism that modifies the epigenome without altering the DNA sequence, leading to heritable changes in gene expression and playing a vital role in biological processes. The regulation of DNA methylation has gained significant attention in recent years for its role in inflammatory diseases, with numerous studies indicating a correlation between abnormal gene methylation and disease development. However, current research on mature methylation-regulation drugs remains in its infancy.

Rice black-streaked dwarf virus-encoded P6 protein impairs OsPelota-mediated antiviral RNA decay defense via promoting OsSCE1b ubiquitination and degradation in rice.

Rice black-streaked dwarf virus (RBSDV) is a major viral pathogen threatening rice production worldwide. However, the molecular mechanisms underlying the arms race between RBSDV and its host remain largely elusive. Here, we demonstrate that RBSDV infection, or the expression of viral RNA-silencing suppressor protein P6, promotes the ubiquitination and degradation of rice small ubiquitin-like modifiers (SUMO) conjugating enzyme 1b (OsSCE1b).

Three-dimensional changes in hard-tissue symmetry and soft-tissue parameters after stabilization splint therapy in adult patients with temporomandibular joint disorders and mandibular deviation: A retrospective study.

Background: The authors analyzed 3-dimensional changes in hard-tissue symmetry (HTS) and associated soft-tissue contour (STC) and evaluated soft-tissue thickness (STT) after stabilization splint (SS) therapy in adult patients with temporomandibular joint disorder (TMD) and mandibular deviation (MD).

Methods: In this retrospective clinical study, 35 adults with TMD and MD were treated with SS therapy; the patients' mean (SD) age was 25.14 (6.

Comprehensive Three-Dimensional Evaluation of Temporomandibular Joint Changes Following Stabilization Splint Therapy.

Introduction And Aims: While stabilization splints (SSs) have shown promising therapeutic effects for temporomandibular disorders (TMDs), comprehensive studies evaluating temporomandibular joint (TMJ) changes following SS therapy are necessary. This study aimed to assess TMJ structural, positional, and condylar remodelling changes in TMD patients by using advanced three-dimensional assessment and shape correspondence analysis.

Methods: This retrospective study included 80 adult TMD (arthralgia) patients treated with SS.

Exploration and Validation of Key Genes and Immune Infiltration in Alcoholic Hepatitis.

Objective: Apart from alcohol abstinence and glucocorticoids, there is still no effective treatment to improve alcoholic hepatitis, and the specific mechanism of its pathogenesis is still unclear.

Methods: We screened the differential genes in GEO alcoholic hepatitis database by differential analysis and screened the eQTL genes that have causal relationship with alcoholic hepatitis by Mendelian randomization analysis. The intersection of differential genes and eQTL genes was used to obtain candidate genes.

Electrochemical Direct Hydroxylation of Benzylic C-H Bonds Assisted by HFIP.

Benzylic alcohols represent a privileged structural motif that is ubiquitous in bioactive natural products and pharmaceutical agents. Selective oxidative hydroxylation of benzylic C-H bonds is an efficient, atom-economical, and environmentally friendly methodology. However, the inherent obstacle of alcohol overoxidation still poses a significant challenge.

Global burden of uterine cancer in 204 countries and territories and its predicted level in 15 years, from 1990 to 2021.

Background: Uterine cancer (UC) is a major cause of cancer-related deaths among women. This study assesses the global burden of UC from 1990 to 2021.

Methods: Data from the Global Burden of Disease 2021 study were used to analyze UC incidence, mortality, and disability-adjusted life years (DALYs) across 204 countries.

The application of liquid biopsy techniques in cervical cancer diagnosis, prediction and therapeutic surveillance.

Cervical cancer (CC) is a significant cause of cancer-related deaths in women and ranks as the fourth most common malignant tumor worldwide. Cervical histopathology is currently the primary diagnostic method for confirming the presence of CC. Tumor markers and imaging techniques play crucial roles in monitoring treatment effectiveness and prognostic follow-up.

Reliable Quantification of Conjugated Peptides from T-DM1 In Vivo by Two-Step Enrichment and Internal Standards from Derivatized Analytes.

Antibody-drug conjugates (ADCs) are the conjugation of antibody with cytotoxic payloads. Conjugated peptides that originate from ADCs are commonly used for pharmacokinetics (PK) study. However, a reliable and sensitive method for the quantitative analysis of conjugated peptides in vivo remains elusive, especially for randomly conjugated ADCs.

Merlin controls limb development and thumb formation by regulating primary cilium-hedgehog signaling.

Hedgehog (HH) signaling, transduced at the primary cilium, plays a crucial role in limb longitudinal growth and digit formation, but its involvement in thumb development has been underestimated. This study identifies Merlin (Nf2) as a critical regulator of limb development, modulating the ciliary trafficking of the HH receptor, Smoothened. Merlin is predominantly expressed in limb buds and growth plates.

Exploring Gene-Regulatory Networks and Potential Therapeutic Drugs Based on ELF3 Expression in Cholangiocarcinoma.

Cholangiocarcinoma (CCA) is a life-threatening malignancy, and there is an urgent need for new biomarkers to improve the prognosis of patients. The expression of ELF3 in CCA tumor and non-tumor tissues was examined in two cohorts. ELF3 expression and the methylation level of its promoter in CCA patients with various clinicopathological features were analyzed using the UALCAN website.

How aging impacts cortical dynamics and gait during dual-task turning revealed by fNIRS.

The aim of this study is to explore the differences in cortical activation and gait performance during turning walking under cognitive dual-task conditions between young and older adults during cognitive-turning dual task walking, as well as variations in brain functional connectivity in this context. Seventeen young adults and seventeen older adults were included in the study. All participants completed two tasks: a figure-eight turning walk (single-task, ST) and a figure-eight turning walking while performing a digital alert cognitive task (dual-task, DT).

Negative extra-abdominal pressure (NEXAP)-based lung recruitment maneuver versus standard lung recruitment maneuver in the treatment of postoperative atelectasis after cardiac surgery: A single-center randomized controlled trial.

Objective: To evaluate the effect of negative extra-abdominal pressure (NEXAP)-based lung recruitment maneuver (LRM) for atelectasis after cardiac surgery, and compare it with stepwise positive end-expiratory pressure (PEEP)-based LRM.

Methods: In this single-center randomized controlled clinical trial, patients were assigned to the NEXAP or PEEP groups. The primary outcome was the lung ultrasound score (LUSS) on global (LUSStot) and regional (LUSSp, posterior, LUSSa, anterior and LUSSl, lateral regions).

Neglected Biogeochemical Process for Ocean Health: Seagrass Detritus Simultaneously Enhances Phenolic Endocrine-Disrupting Chemical Capture and Organic Carbon Sequestration.

This study presents the first comprehensive investigation on an easily neglected biogeochemical process of phenolic endocrine-disrupting chemical (EDC) capture and carbon sequestration by seagrass detritus. The results showed that L. detritus captured nonylphenol (NP) and bisphenol A (BPA) with high efficiency (>90%) and enhanced organic carbon sequestration in marine ecosystems.

Tomatidine Ameliorates Diabetes-Induced Cognitive Impairment and Tau Hyperphosphorylation Through the AMPK-TFEB Pathway.

Diabetes is associated with an increased risk of cognitive impairment. Autophagy-lysosomal dysfunction is a key feature of diabetes that contributes to dementia. Transcription factor EB (TFEB) is a master regulator of the autophagy-lysosomal function.

Interaction between asthma and overweight/obesity on cancer results from the National Health and Nutrition Examination Survey 2005-2018.

Asthma, overweight/obesity, and cancer are closely related major public health problems. This study aimed to investigate the interaction between asthma and overweight/obesity on the cancer risk. We analyzed data from the National Health and Nutrition Examination Survey 2005-2018.

Triglyceride-glucose index and remnant cholesterol in acute ischemic stroke - a cross-sectional study.

Introduction: The association between insulin resistance and lipid metabolism in acute ischemic stroke (AIS) remains unclear. To explore their relationship and elucidate potential biomarkers for stroke management, we investigated the association between the triglyceride-glucose index (TyG index) and remnant cholesterol (RC) in patients with AIS.

Material And Methods: A total of 116 patients diagnosed with acute ischemic stroke (AIS) and admitted to the Xiong'an New District Rongcheng People's Hospital between December 2022 and June 2023 were randomly chosen for this study.

The therapeutic effect of acupuncture in the treatment of chemotherapy-induced peripheral neuropathy: a randomized controlled trial.

Introduction: Effective treatments for preventing and treating chemotherapy-induced peripheral neuropathy (CIPN) are still under exploration. Acupuncture in the treatment of CIPN requires more clinical trial data. This study aimed to evaluate the therapeutic effect of acupuncture on CIPN and explore its efficacy and safety in improving peripheral neuropathy.

Functional properties of insoluble dietary fibers extracted from different grape pomaces during simulated digestion and fermentation.

This study investigated insoluble dietary fibers (IDFs) extracted from the grape pomaces of Cabernet Sauvignon (CS-IDF), Marselan (MS-IDF), and Merlot (ML-IDF). It explored the release patterns and potential bioactivities of dietary fiber-bound polyphenols from these sources through simulated digestion and colonic fermentation. The results showed a higher polyphenol content in MS grape skins, which also yielded more IDF.