Cluster analysis of hotspots and research trends of epirubicin-induced cardiotoxicity: a bibliometric study.

Background: Epirubicin, a widely used anthracycline, effectively treats various cancers but poses a high risk of cardiotoxicity, leading to heart failure and myocardial dysfunction. This study conducts a cluster analysis to map global research trends in epirubicin-induced cardiotoxicity.

Methods: A literature search was conducted using the Web of Science Core Collection database.

Bisphenol F disrupts lipophagy and lysosomal acidification via ATGL-SIRT1-PPARα signaling in NAFLD-like hepatic changes.

Bisphenol F (BPF), a widely used substitute for bisphenol A (BPA), has raised growing concerns due to its potential metabolic toxicity. Recent studies suggest that BPF exposure is associated with lipid accumulation and non-alcoholic fatty liver disease (NAFLD‌)-like changes, however, the underlying mechanisms remain poorly understood. This study was performed to investigate the BPF-induced NAFLD-like changes through the lipid degradative pathway, which via an unrecognized defect of lipophagy mediated by Adipose Triglyceride Lipase (ATGL)-Sirtuin 1 (SIRT1)-Peroxisome proliferator-activated receptor α (PPARα) signaling axis.

Photostability of organic fluorophore influenced by adjacent amino acid residues.

Fluorescence microscopy represents a highly effective tool for examining the microscopic world. Modern microscopic techniques provide advanced temporal and spatial resolutions, while placing high demands on the photostability of fluorophores. Although it is well-known that the photostability of fluorophores is sensitive to their environment, the influence of nearby residues on the photostability of organic fluorophores attached to proteins is not yet fully understood.

MoMkt1, a member of XPG/RAD2 nuclease family, regulates development and pathogenicity in .

XPG/RAD2 nuclease family plays a crucial role in DNA damage repair to maintain genomic integrity. However, the biological function of Mkt1, a member of the XPG/RAD2 nuclease family, remains unclear in . In this study, we identified and characterized the biological functions of MoMkt1.

Efficacy of esketamine in alleviating emergence delirium and agitation in pediatric patients undergoing adenotonsillectomy under general anesthesia.

Objective: To analyze the effect of esketamine on emergence delirium (ED) and emergence agitation (EA) in pediatric patients under general anesthesia.

Methods: This retrospective study included 94 pediatric patients who underwent adenotonsillectomy under general anesthesia at General Hospital of Ningxia Medical University from January 2023 to October 2024. The patients were divided into three groups according to different anesthesia protocols they received: Group A (n=30, esketamine 0.

Immunogenicity and safety of a recombinant gE-Fc fusion protein subunit vaccine for herpes zoster in adults ≥50 years of age: a randomised, active-controlled, non-inferiority trial.

The licensed adjuvanted recombinant glycoprotein E (gE) subunit vaccine (HZ/su) is highly effective against herpes zoster (HZ). This randomised, active-controlled, non-inferiority trial (ChiCTR2300079076) compared the immunogenicity and safety of a novel gE-Fc fusion protein vaccine candidate (LZ901) with HZ/su in 300 healthy adults aged ≥50 years without prior HZ vaccination in Wuxi, China. Participants received either two doses of LZ901 (30-day interval; n = 151) or HZ/su (60-day interval; n = 149).

Elastic-Plastic Analysis of Asperity Based on Wave Function.

This paper proposes an improved wave function asperity elastic-plastic model. A cosine function that could better fit the geometric morphology was selected to construct the asperity, the elastic phase was controlled by the Hertz contact theory, the elastoplastic transition phase was corrected by the hyperbolic tangent function, and the fully plastic phase was improved by the projected area theory. The model broke through the limitations of the spherical assumption and was able to capture the stress concentration and plastic flow phenomena.

The relationship between lipids level and cerebral microbleeds in patients with spontaneous intracerebral hemorrhage.

Background: Previous studies indicate a potential link between elevated serum lipid levels and an increased risk of cerebral microbleeds (CMBs). Since multiple CMBs can elevate the risk of future intracerebral hemorrhage (ICH), it is important to explore the relationship between lipid profiles and CMBs in ICH patients. However, data on this specific correlation in ICH populations are currently limited.

Computational Study of Cobalamin-Dependent Epoxyqueuosine Reductase: Formation of a Key Organometallic Intermediate with a "Stable-Yet-Fragile" Co-C Bond.

QueG is a cobalamin-dependent enzyme that catalyzes the epoxide reduction of queuosine (Q). The quantum chemical cluster approach has been performed to investigate the mechanism of the QueG-catalyzed reaction. Our calculations reveal a nucleophilic attack mechanism involving the formation of an intermediate with an unusual organometallic Co-C bond.

Glycated albumin is not applicable to differentiate gestational diabetes mellitus in Chinese pregnant women.

Purpose: Some studies have suggested that Glycated albumin (GA) may represent a useful biomarker in pregnant women for diagnosing and monitoring gestational diabetes mellitus (GDM). However, whether GA is a sufficiently accurate marker to screen GDM in a general population of pregnant women remains unclear. The current study aimed to investigate the role of GA in screening GDM in Chinese pregnant women.

Development and validation of a deep learning image quality feedback system for infant fundus photography.

Retinopathy of prematurity (ROP) is a significant cause of childhood blindness. Many healthcare institutions face a shortage of well-trained ophthalmologists for conducting screenings. Hence, we have developed the Deep Learning Infant Fundus Quality Feedback System (DLIF-QFS) to assess the overall quality of infant retinal photographs and detect common operational errors to support ROP screening and diagnosis.

3-hydroxykynurenine increase in kynurenine pathway driven bisphenol F induced anxiety- and depression-like behaviors.

Bisphenol F (BPF), one of the major substitutes for bisphenol A (BPA), is increasingly used in pharmaceuticals, food packaging, and chemical manufacturing. Emerging evidence suggests its potential neuropsychiatric risks. However, the underlying mechanisms remain poorly characterized.

Impact of Beta-Blockers on Pneumonia, Mortality and Functional Outcomes of Patients with Intracerebral Hemorrhage-A Retrospective Multicenter Study.

Purpose: Given the current lack of research on the impact of beta-blockers (BB) on clinical outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to evaluate the effect of BB on pneumonia, functional outcomes, and mortality in adult patients with primary ICH.

Patients And Methods: This was a retrospective study of a registry cohort of patients with ICH from 13 stroke centers in Beijing, China.

Follicular fluid cytokine phenotypes reflect underlying etiologies for infertility.

To determine if the follicular fluid (FF) cytokine phenotype reflects underlying etiologies for infertility and oocyte/embryo quality. The study subjects comprised infertile women with diminished ovarian reserve (DOR, n = 42), tubal factor infertility (TFI, n = 72), and repeated implantation failures (RIF, n = 15). Controls were women with male factor infertility (MFI, n = 30).

Thioether editing generally increases the photostability of rhodamine dyes on self-labeling tags.

Self-labeling protein tags are widely used in advanced bioimaging where dyes with high-photon budgets outperform their fluorescent protein counterparts. Further increasing the emitted photon numbers of dye-tag systems is actively pursued by both new fluorophore chemistry and protein engineering. By scrutinizing the protein microenvironment of fluorophores, here we propose that proximal thioether groups negatively affect the photostability of the dye-tag system.

Mesenchymal stem cells-derived miR-143-3p attenuate acute kidney injury by suppressing TAK1-Driven necroptosis.

Cisplatin, a widely used chemotherapeutic agent, induces nephrotoxicity with approximately 30 % of patients developing acute kidney injury (AKI). Necroptosis, a regulated cell death pathway driven by RIPK1/RIPK3/MLKL activation, plays a pivotal role in cisplatin-induced AKI, yet effective therapeutic strategies targeting this pathway remain limited. Here, we demonstrate that human umbilical cord mesenchymal stem cells (huc-MSCs) alleviate cisplatin-induced AKI by suppressing necroptosis through targeting transforming growth factor-β-activated kinase 1 (TAK1).

Depression impact on PTSD in Cancer patients through serial mediation of hope and perceived social support.

Previous studies have only established a strong association between depression and post-traumatic stress disorder in cancer patients, without clarifying the potential mechanisms underlying this relationship. This study examines the relationship between depression and PTSD(Post-Traumatic Stress Disorder) in cancer patients, focusing on the sequential mediation of hope and perceived social support. A cross-sectional study was conducted at oncology wards in an Anhui tertiary hospital between February-August 2024.

Rapid identification of Litopenaeus vannamei pathogenic bacteria: a combined approach using surface-enhanced Raman spectroscopy (SERS) and deep learning.

Pathogenic bacterial infections are one of the leading causes of mortality in Litopenaeus vannamei, seriously affecting the economic efficiency of the shrimp aquaculture industry. However, traditional pathogen detection methods, such as the polymerase chain reaction (PCR), have drawbacks, including complex procedures and long processing times. Raman spectroscopy provides valuable biomolecular feature information and, when combined with deep learning, enables the detection of pathogens.

[The Efficacy of Combination of Avatrombopag and rhIL-11 in Adult Patients of Acute Myeloid Leukemia with Cancer Treatment-Induced Thrombocytopenia].

Objective: To investigate the safety and efficacy of avatrombopag（AVA） combined with rhIL-11 in treating thrombocytopenia induced by chemotherapy in acute myeloid leukemia.

Methods: The clinical information of 8 patients in the real world who received avatrombopag combined with rhIL-11 in cancer treatment-induced thrombocytopenia(CTIT) after AML chemotherapy were retrospectively analyzed, and at the same time, 8 patients who received rhIL-11 only in CTIT after AML chemotherapy served as the control group, A preliminary observation was to summarize and compare the therapeutic efficacy and adverse effects between the two groups.

Results: D3 and D7 platelet counts were not significantly different between the observation group and the control group after treatment.

Fosaprepitant for the prevention of multiple-day cisplatin chemotherapy-induced nausea and vomiting: a prospective randomized controlled study.

Purpose: We aimed to compare the efficacy and safety of fosaprepitant plus triple therapy versus triple therapy alone, in terms of both routine and delayed regimen, in preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving three-day cisplatin-based treatment.

Methods: In a prospective randomized controlled trial, patients undergoing three-day cisplatin-based chemotherapy (25mg/m/day) received fosaprepitant plus triple therapy or triple therapy alone on day 1 (routine regimen). For the evaluation of the delayed regimen, the administration of fosaprepitant and/or olanzapine was delayed for 1 day.

Immune Niche Formation in Engineered Mouse Models Reveals Mechanisms of Tumor Dormancy.

Residual tumor cells can persist in a dormant state during clinical remissions that may last decades. The mechanisms that lead to such growth control vs. eventual reactivation and macroscopic tumor outgrowth remain unclear.

Association between different frequencies of age-related hearing loss and depression: A Mendelian randomization and observational study.

Background: Hearing loss and depression are common among older adults, but the association between different frequencies of age-related hearing loss (ARHL) and depression remains unclear, and their causal relationship is yet to be established.This study aimed to explore the association between ARHL at different frequencies and depression and evaluate their causal relationship using Mendelian randomization (MR).

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) were analyzed using multivariable logistic regression and negative binomial regression to assess the effects of low-frequency, speech-frequency, and high-frequency ARHL on depression, with subgroup analyses by race/ethnicity.