Application of contrast-enhanced CT-driven multimodal machine learning models for pulmonary metastasis prediction in head and neck adenoid cystic carcinoma.

Objective: This study explores radiomics and deep learning for predicting pulmonary metastasis in head and neck Adenoid Cystic Carcinoma (ACC), assessing machine learning(ML) algorithms' model performance.

Methods: The study retrospectively analyzed contrast-enhanced CT imaging data and clinical records from 130 patients with pathologically confirmed ACC in the head and neck region. The dataset was randomly split into training and test sets at a 7:3 ratio.

Rice ragged stunt virus Pns10 induces mitochondrial-mediated apoptosis to promote viral infection in Nilaparvata lugens through disrupting the NlNDUFS1-NlPHB2 interaction.

Apoptosis, a programmed cell death process, plays crucial roles in host antiviral response. Although there are many reports on the relationship between cell apoptosis and viral infection, the mechanisms underlying plant arbovirus-induced apoptosis in insect vectors remain largely unclear. Here, we reported that apoptosis promotes rice ragged stunt virus (RRSV) infection in Nilaparvata lugens (brown planthopper), and RRSV-encoded Pns10 protein can induce apoptosis in N.

Viral proteins suppress rice defenses by boosting OsTSN1 RNA decay via phase separation and multimerization.

Liquid-liquid phase separation (LLPS) forms membraneless condensates crucial for plant stress responses. However, how plant viruses utilize LLPS to escape host immunity remains largely unexplored. Here, we show that P6 protein encoded by southern rice black-streaked dwarf virus (SRBSDV) undergoes LLPS.

Microscopic probing into plasmodesmata (PD) and PD-derived intercellular gateways (PdIGs): Beyond morphology.

Plasmodesmata (PD) are nano-channels in plant cell walls that connect adjacent cells, facilitating the symplastic transport of micro- and macromolecules. In certain tissues, specialized transport requirements drive the formation of intercellular channels in diverse morphologies, compositions and functions, including sieve plate pores, plasmodesmo-pore units, lateral sieve area pore, and flexible gateways. These channels, derived from PD, are referred to as PD-derived intercellular gateways (PdIGs) in this review.

Solitary rectal ulcer syndrome: MRI findings and differentiation from rectal cancer.

Background: Systematic MRI findings of solitary rectal ulcer syndrome (SRUS) are lacking. We aimed to evaluate the MRI findings of SRUS and to identify the MRI features that differentiate SRUS from rectal cancer.

Methods: This retrospective study consecutively included 30 patients diagnosed with SRUS from January 2015 to December 2021.

High-Performance Phototransistor Based on a 2D Polybenzimidazole Polymer.

Photodetectors are fundamental components of modern optoelectronics, enabling the conversion of light into electrical signals. The development of high-performance phototransistors necessitates materials with both high charge carrier mobility and robust photoresponse. However, achieving both in a single material poses challenges due to inherent trade-offs.

Ammonia-Assisted Chemical Vapor Deposition Growth of Two-Dimensional Conjugated Coordination Polymer Thin Films.

As emerging electroactive materials, the controlled synthesis of highly ordered two-dimensional (2D) conjugated coordination polymer (c-CP) films ensuring the long-range π-electron delocalization is essential for advancing high-performance (opto-)electronics. Here, we demonstrate the growth of highly crystalline 2D c-CP thin films on inert substrates by chemical vapor deposition with the assistance of ammonia (NH) for the first time, leveraging its deprotonation effect on ligands and competing effect as additional coordinating species. The resulting Fe-HHB (HHB = hexahydroxybenzene) films exhibit large-area uniformity and a 2 order-of-magnitude increase in crystal grain size, which translates into significant improvements in electrical conductivity (from 0.

Unveiling high-mobility hot carriers in a two-dimensional conjugated coordination polymer.

Hot carriers, inheriting excess kinetic energy from high-energy photons, drive numerous optoelectronic applications reliant on non-equilibrium transport processes. Although extensively studied in inorganic materials, their potential in organic-based systems remains largely unexplored. Here we demonstrate highly mobile hot carriers in crystalline two-dimensional conjugated coordination polymer CuBHT (BHT, benzenehexathiol) films.

A novel varicosavirus associated with Orychophragmus violaceus in China.

Plant rhabdoviruses have garnered considerable attention due to their broad host range and significant agricultural threats. Despite their prevalence in various ecosystems, rhabdoviruses in non-crop species, which often serve as reservoirs for novel viral strains, remain understudied. Here, a novel plant rhabdovirus, Orychophragmus violaceus varicosavirus (OVVV), was identified in the ornamental plant Orychophragmus violaceus and characterized by high-through sequencing.

Comprehensive chromosomal abnormality detection: integrating CNV-Seq with traditional karyotyping in prenatal diagnostics.

Background: This study aimed to evaluate the efficacy of copy number variation sequencing (CNV-Seq) in detecting chromosomal abnormalities in prenatal diagnosis, comparing its performance with traditional karyotype analysis.

Methods: A retrospective analysis was conducted on 1001 prenatal samples collected between April 2021 and December 2023. Samples were analyzed using both CNV-Seq and karyotype analysis.

Pyrazine-Embedded 2D Conjugated Metal-Organic Framework with Quasi-Honeycomb Lattice for High-Capacitance Lithium-Ion Storage.

As a unique class of framework electronic materials, 2D conjugated metal-organic frameworks (2D c-MOFs) exhibit intrinsic porosity, superior electrical conductivity, and abundant active sites. These properties endow them with great potential in electrochemical lithium-ion storage. However, the development of 2D c-MOF-based capacitors has encountered a bottleneck in enhancing Li-ion storage capacitance, and the design of high-capacitance MOF electrode materials has remained a challenge.

Impact of Non-SMC Condensin I Complex Subunit D2 Upregulation on Oral Squamous Cell Carcinoma Prognosis.

Objective: To explore the influence of non-SMC condensin I complex subunit D2 (NCAPD2) on the prognosis of oral squamous cell carcinoma (OSCC) and the correlation between NCAPD2 and OSCC.

Methods: In this study, NCAPD2 gene expression profiles of OSCC and normal tissues were collected from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). The real-time quantitative polymerase chain reaction (RT-qPCR) was employed to preliminarily validate OSCC cell strains and normal epithelial cell strains.

Silicate-based therapy for inflammatory dilated cardiomyopathy by inhibiting the vicious cycle of immune inflammation via FOXO signaling.

Inflammatory dilated cardiomyopathy (iDCM) represents a severe immune-related condition provoked by the progression of myocarditis. In patients suffering from myocarditis, a vicious cycle of inflammation orchestrated by CD4 T cells, neutrophils, and fibroblasts is the culprit that drives the deterioration of myocarditis into iDCM. This study designed composite microneedles and ion solutions using calcium silicate bioceramics, which deliver SiO directly into myocardial tissue or indirectly via systemic circulation.

Functional Group Engineering of Single-Walled Carbon Nanotubes for Anchoring Copper Nanoparticles Toward Selective CO Electroreduction to C Products.

Electroreduction of carbon dioxide (CO) is a key strategy for achieving net-zero carbon emissions. Copper (Cu)-based electrocatalysts have shown promise for CO conversion into valuable chemicals but are hindered by limited C product selectivity due to competing hydrogen evolution and ineffective dimerization of adsorbed CO intermediate (CO). Here, a functional-group-directed strategy is reported to enhance selectivity using single-walled carbon nanotubes (SWCNTs) as supports.

Autism risk genes converge on to govern neural cell growth.

The alteration of neural progenitor cell (NPC) proliferation underlies autism spectrum disorders (ASD). It remains unclear whether targeting convergent downstream targets among mutations from different genes and individuals can rescue this alteration. We identified as a convergent target of three autism risk genes: , , and , using isogenic iPSC-derived 2D NPCs.

2D Rhodium-Isocyanide Frameworks.

2D metal-organic frameworks (2D MOFs) are emerging organic van der Waals materials with great potential in various applications owing to their structural diversity, and tunable optoelectronic properties. So far, most reported 2D MOFs rely on metal-heteroatom coordination (e.g.

Investigating the efficacy of immune checkpoint inhibitors in clear cell renal cell carcinoma based on methylation cross talk scoring.

Methylation processes in different molecular contexts (DNA, RNA, and histones) are controlled by different regulatory factors and serve as critical determinants in cancer development. However, the mechanistic links between these epigenetic modifications during malignant transformation, metastasis, disease relapse, and therapeutic resistance remain incompletely understood. In this research, we investigated the transcriptional and genetic alterations of regulators associated with 3 major types of methylation modifications in clear cell renal cell carcinoma.

Tracking and controlling ultrafast charge and energy flow in graphene-semiconductor heterostructures.

Low-dimensional materials have left a mark on modern materials science, creating new opportunities for next-generation optoelectronic applications. Integrating disparate nanoscale building blocks into heterostructures offers the possibility of combining the advantageous features of individual components and exploring the properties arising from their interactions and atomic-scale proximity. The sensitization of graphene using semiconductors provides a highly promising platform for advancing optoelectronic applications through various hybrid systems.

Ecological restoration reduces greenhouse gas emissions by altering planktonic and sedimentary microbial communities in a shallow eutrophic lake.

Ecological restoration is a promising approach to alleviate eutrophication. However, its impacts on greenhouse gas (GHG) emissions and the underlying microbial mechanisms in different habitats of lakes remain unclear. To address this knowledge gap, we measured carbon dioxide (CO), methane (CH) and nitrous oxide (NO) fluxes at both water-air and sediment-water interfaces of eutrophic (Caohai) and restored area (Dapokou) of Dianchi Lake, a typical eutrophic lake in China.

Indirect treatment comparison of oral sebetralstat and intravenous recombinant human C1 esterase inhibitor for on-demand treatment of hereditary angioedema attacks.

Background: The goal of on-demand treatment for hereditary angioedema attacks is to halt attack progression to minimize morbidity and mortality. Four on-demand treatments have been approved thus far (ecallantide, icatibant, recombinant human C1 esterase inhibitor [rhC1INH], and plasma-derived C1INH). Results from the sebetralstat phase 3 KONFIDENT trial (NCT05259917) have been reported.

Causal Relationship Between Intelligence, Noncognitive Education, Cognition and Urinary Tract or Kidney Infection: A Mendelian Randomization Study.

Background: The occurrence of urinary tract or kidney infection is correlated with intelligence, noncognitive education and cognition, but the causal relationship between them remains uncertain, and which risk factors mediate this causal relationship remains unknown.

Methods: The intelligence (n=269,867), noncognitive education (n=510,795) and cognition data (n=257,700) were obtained from genome-wide association studies (GWAS) conducted in individuals of European ethnicities. The genetic associations between these factors and urinary tract or kidney infection (UK Biobank, n=397,867) were analyzed using linkage disequilibrium score regression.

A Systematic Review and Meta-analysis of the Effectiveness of Remdesivir to Treat SARS-CoV-2 in Hospitalized Patients: Have the Guidelines Evolved With the Evidence?

Background: With progressive accumulation of knowledge on SARS-CoV-2 infection clinical management, treatment guidelines recommended several options including remdesivir, a broad-spectrum antiviral. Given the evolving nature of coronavirus disease 2019, capturing the totality of scientific evidence from clinical trials and observational studies is critical to inform clinical decision making. We conducted a systematic literature review with meta-analysis to summarize the effectiveness of remdesivir among hospitalized adults.

Interface-Tailored Secondary Excitation and Ultrafast Charge/Energy Transfer in TiCT-MoS Heterostructure Films.

Charge/energy separation across interfaces of plasmonic materials is vital for minimizing plasmonic losses and enhancing their performance in photochemical and optoelectronic applications. While heterostructures combining plasmonic two-dimensional transition metal carbides/nitrides (MXenes) and semiconducting transition metal dichalcogenides (TMDs) hold significant potential, the mechanisms governing plasmon-induced carrier dynamics at these interfaces remain elusive. Here, we uncover a distinctive secondary excitation phenomenon and an ultrafast charge/energy transfer process in heterostructure films composed of macro-scale TiCT and MoS films.

Dimensional evolution of charge mobility and porosity in covalent organic frameworks.

Covalent organic frameworks are an emerging class of covalently linked polymers with programmable lattices and well-defined nanopores. Developing covalent organic frameworks with both high porosity and excellent charge transport properties is crucial for widespread applications, including sensing, catalysis, and organic electronics. However, achieving the combination of both features remains challenging due to the lack of overarching structure-property correlations.

Hierarchical Deformation Mechanisms and Energy Absorption in Bioinspired Thin-Walled Structures.

Lightweight, hierarchical thin-walled tubes are essential in aerospace and transportation for their exceptional impact resistance and energy absorption capabilities. This study applies bionic design principles to revolutionize traditional thin-walled tube structures, enhancing their energy absorption performance. Inspired by natural models-spider webs, beetle elytra, cuttlebone, and spiral wood fibers-integrated bionic hierarchical thin-walled tubes (IBHTTs) with diverse bionic structural and material combinations are developed using additive manufacturing.