Comparative association between NAFLD and MAFLD with cardiovascular events and mortality: Evidence from observational studies.

Background: Nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD) are increasingly recognized as multisystemic conditions with significant extrahepatic manifestations. Although both diseases have been linked to cardiovascular events and mortality, the strength of these associations remains controversial. This review aims to compare the risks of cardiovascular disease (CVD) events in individuals with NAFLD and MAFLD.

Spatiotemporal Circadian Oscillator Manipulation for Enhanced Ovarian Cancer Therapy Using a Versatile Nanoplatform.

Circadian rhythm (CR) disruption has been confirmed as a contributing factor to tumor progression. However, regulating circadian genes shows an inhibitory effect on ovarian tumor initiation and progression, which highlights the urgent necessity to regulate tumors' CR to understand their role in ovarian cancer (OC) therapy precisely. Herein, a novel near-infrared (NIR) light-controlled spatiotemporal strategy is presented, aiming to manipulate ovarian tumors' CR while enhancing the efficacy of chemotherapy agents.

Bioinspired metafilms for all-weather energy harvesting: Adaptive thermal regulation and raindrop electricity generation.

Tremendous efforts have been dedicated to facilitating heat dissipation into cold universe through radiative cooling. Nevertheless, its applications remain limited by overcooling in cold conditions and reduced effectiveness under nonclear skies. We present a robust metafilm inspired by the adaptive capabilities of horned lizards () to overcome these challenges.

Transcriptomic profile of RNA pseudouridine modification as a biomarker for cellular senescence associated with survival outcomes in colorectal cancer.

Background: Colorectal cancer (CRC) is considered as an age-related disease, and cellular senescence (CS) plays a crucial role in cancer development and progression. Previous studies have shown the role of epigenetic changes in aging and cancer development, but the role of RNA pseudouridine (Ψ) modification in aging and cancer remains to be explored.

Results: Using bulk RNA sequencing, CRC cells with low Ψ writers expression levels have higher CS levels.

Deep learning model targeting cancer surrounding tissues for accurate cancer diagnosis based on histopathological images.

Accurate and fast histological diagnosis of cancers is crucial for successful treatment. The deep learning-based approaches have assisted pathologists in efficient cancer diagnosis. The remodeled microenvironment and field cancerization may enable the cancer-specific features in the image of non-cancer regions surrounding cancer, which may provide additional information not available in the cancer region to improve cancer diagnosis.

Enhancement of Water Productivity and Energy Efficiency in Sorption-based Atmospheric Water Harvesting Systems: From Material, Component to System Level.

To address the increasingly serious water scarcity across the world, sorption-based atmospheric water harvesting (SAWH) continues to attract attention among various water production methods, due to it being less dependent on climatic and geographical conditions. Water productivity and energy efficiency are the two most important evaluation indicators. Therefore, this review aims to comprehensively and systematically summarize and discuss the water productivity and energy efficiency enhancement methods for SAWH systems based on three levels, from material to component to system.

Hierarchically structured passive radiative cooling ceramic with high solar reflectivity.

Passive radiative cooling using nanophotonic structures is limited by its high cost and poor compatibility with existing end uses, whereas polymeric photonic alternatives lack weather resistance and effective solar reflection. We developed a cellular ceramic that can achieve highly efficient light scattering and a near-perfect solar reflectivity of 99.6%.

Investigations on asymmetric transmittivity of optical devices and different diode-like behaviors.

This study theoretically proved that although reciprocal optical devices can show asymmetric transmittivity (AT) under controlled incident modes (i.e., conditional AT), they cannot guarantee AT with arbitrary incident light modes, whereas only nonreciprocal optical devices can possibly guarantee AT.

Radiative Cooling Nanofabric for Personal Thermal Management.

A wearable textile that is engineered to reflect incoming sunlight and allow the transmission of mid-infrared radiation simultaneously would have a great impact on the human body's thermal regulation in an outdoor environment. However, developing such a textile is a tough challenge. Using nanoparticle-doped polymer (zinc oxide and polyethylene) materials and electrospinning technology, we have developed a nanofabric with the desired optical properties and good applicability.