Progress on small non-coding RNAs in male reproductive development and intergenerational inheritance.

Small non-coding RNAs (sncRNAs) are crucial in epigenetics, playing a significant regulatory role in the normal development and intergenerational inheritance of male reproduction. Research has shown that highly expressed sncRNAs, including miRNAs, piRNAs, and tsRNAs, are vital in maintaining male germ cell development and spermatogenesis. sncRNAs regulate gene expression, influence protein translation, and modify sperm epigenetics, contributing to male reproductive development at various stages.

Carcass and Meat Quality Characteristics and Changes of Lean and Fat Pigs After the Growth Turning Point.

Pork is a major global source of animal protein, and improving both its production efficiency and meat quality is a central goal in modern animal agriculture and food systems. This study investigated post-inflection-point growth patterns in two genetically distinct pig breeds-the lean-type Yorkshire pig (YP) and the fatty-type Qingyu pig (QYP)-with the aim of elucidating breed-specific characteristics that influence pork quality and yield. Comprehensive evaluations of carcass traits, meat quality attributes, nutritional composition, and gene expression profiles were conducted.

A Multiple Environmental Parameters and Molecular Fingerprints Contribution model for prediction of Gibbs free energy.

Accurate prediction of thermodynamic parameters in biochemical reactions is essential for understanding and designing metabolic systems. Most existing methods for predicting the Gibbs free energy of biochemical reactions often neglect the environmental influences on Gibbs free energy such as pH, temperature and ionic strength, and lack efficient feature selection mechanisms, resulting in suboptimal predictive accuracy. In this paper, a Convolutional Neural Network Based Model with Multiple Environmental Parameters and Molecular Fingerprint Contribution (MEFC-CNN) is proposed to address these problems.

A Multicenter Pilot Study of MUC1 Vaccine in Current and Former Smokers at High Risk for Lung Cancer.

Background: Smoking is the most common etiology for lung cancer and smoking cessation does not eliminate the risk. Mucin (MUC)1 glycoprotein is aberrantly expressed in lung carcinomas and premalignant lung lesions. We explored whether a MUC1 vaccine might be effective in halting neoplastic development and progression in individuals at high risk for lung cancer.

Isolation and identification of and virulence evaluation of its field isolates.

Introduction: As a prevalent swine pathogen worldwide, (, Mhr) is associated with various diseases, including multiple serositis, pneumonia, arthritis, and otitis media. It is also linked to the porcine respiratory disease complex (PRDC).

Methods: prevalence in 2022 Chinese lung samples was assessed by species-specific PCR, followed by isolation and purification of field strains, followed by genetic characterization via multilocus sequence typing (MLST).

Research on engineering cost prediction based on similarity.

To address the issues of inaccurate predictions and computational complexity in the rapid quotation process for construction projects, this paper proposes a method for construction cost prediction based on Vague similarity(VS). Initially, due to factors such as season, construction location, and market conditions, the unit prices of construction projects exhibit a degree of uncertainty, manifested as a range of quotation values. The proposed method introduces a conversion technique to transform interval values into Vague values, thereby transforming the engineering characteristic matrix into a Vague matrix.

Population Genomics, Virulence Traits, and Antimicrobial Resistance of Isolated in China.

is a significant zoonotic pathogen of public health importance. In this study, whole-genome sequencing of 177 isolates of , isolated from diseased swine across 15 provinces in China between 2017 and 2019, was performed. A total of 23 serotypes and 28 ST types were identified, with serotypes 2 and 3 comprising 50.

Characterization and prediction of non-melanoma skin cancer incidence in China: Joinpoint regression and age-period-cohort model.

Objective: Understanding the non-melanoma skin cancer (NMSC) incidence and its trends in China is an important prerequisite for effective prevention and control of NMSC.

Methods: NMSC incidence data was collected from the Annual Report of China Cancer Registry from 2005 to 2018. The Joinpoint regression model was used to estimate the average annual percent change (AAPC) and annual percent change (APC) to reflect the time trend.

New micro- and macro- perspective on the removal process of 1H-benzotriazole by UV/PDS: Degradation mechanism, kinetics and multi-factor impact on removal efficiency.

1H-benzotriazole (BTH), a high-volume industrial chemical, poses serious environmental concerns due to its toxicity and resistance to biodegradation, underscoring the urgent need for effective wastewater treatment solutions. This work evaluated the BTH removal efficiency under different conditions, including initial concentrations of Cl, Br, and HCO (i.e.

Qualitative and Comparative Analysis of Chemical Constituents in Epimedii Folium From Four Species Based on UPLC-ZenoTOF-MS/MS.

Epimedii Folium (EF) is frequently used in clinical as traditional Chinese medicine with a long history in China. The Pharmacopoeia of the People's Republic of China (2020 Version) contains four species of the plants of the genus Epimedium as its medicinal sources, namely, Epimedium brevicornu Maxim (EBM), E. sagittatum (Sieb.

A novel tsRNA signature -tRF-58:76-Tyr-GTA-2-M3 as potential biomarker and therapeutic target for duodenal atresia.

Duodenal atresia (DA) is a common neonatal digestive tract obstruction, with unclear prenatal diagnostic specificity and optimal intervention timing. tRNA-derived small RNAs (tsRNAs), stable and enriched in blood, are promising biomarkers for disease diagnosis. Therefore, identifying tsRNA biomarkers, elucidating DA pathogenesis, and exploring potential intrauterine interventions is urgently needed.

Closed-Loop Framework for Discovering Stable and Low-Cost Bifunctional Metal Oxide Catalysts for Efficient Electrocatalytic Water Splitting in Acid.

Electrocatalytic water splitting, comprising the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), provides a sustainable route for hydrogen production. While low-cost metal oxides (MOs) are appealing as alternatives to noble metal electrocatalysts, their application in acidic media remains challenging. However, the dynamic nature of some MO surface structures under electrochemical conditions offers an opportunity for rational catalyst design to achieve bifunctionality in acidic OER and HER.

Unripe apple polyphenols extract improves intestinal inflammation and restructures gut microbiota in spontaneously hypertensive rats.

Natural polyphenolic extracts have been recognized to reduce the risk of hypertension. Coupled with evidence that gut dysbiosis is tightly linked to the development of hypertension, we hypothesized that modulating gut microbiota may be associated with the benefits of unripe apple polyphenols extract (UAPE). This study aimed to explore the effects of UAPE on hypertension and its complications, while elucidating the underlying mechanisms in spontaneously hypertensive rats (SHR).

Evaluation of enhanced external counterpulsation with different modes on acute hemodynamic effects.

Objective: Enhanced external counterpulsation (EECP) is a noninvasive device for the treatment of cardiovascular diseases. However, there are minimal data regarding the effects of different EECP modes on acute hemodynamic changes, particularly blood flow redistribution. This study aimed to investigate the systemic hemodynamic effects during different EECP modes based on clinical trials and numerical analysis.

Transcriptomic and Proteomic Analyses of the Liver and Ileum Identify Key Genes and Pathways Associated with Low and High Groups of Social Genetic Effect of Residual Feed Intake.

Social genetic effects (SGEs) refer to how the genotypes of other individuals impact an individual's phenotype within a population. These effects significantly influence the feeding behavior and production performance in pigs, though their mechanisms are not well understood. This study examined two pig groups with extreme SGE values for residual feed intake (RFI), analyzing their feeding behavior and the molecular mechanisms involved using transcriptomics and proteomics analysis of liver and ileum tissues.

Cloning and Transcriptional Activity Analysis of the Bovine Gene Promoter: Transcription Factors Sp1 and GR Regulate Bovine Expression.

Growth rate of bovine skeletal muscle has a major impact on beef yield. Cadherin-11 () was found to be a potential candidate gene for growth and development in beef cattle. This study confirmed the high expression of in bovine using a tissue expression analysis.

Comparative Analysis of Automatic Fecal Analyzer versus Direct Wet Smear Microscopy for Detecting Parasitic Infections in Stool Samples.

With socio-economic development, the prevalence of intestinal parasitic diseases has significantly decreased year by year. However, parasitic infections remain a major public health issue globally, particularly in developing countries and regions. Timely diagnosis and treatment are crucial for controlling the spread of these diseases.

Regulation of Lignin Microstructures to Construct Fully Biomass-Based Elastomers for Large Crack Self-Healing Artificial Muscles.

Self-healing elastomer-based artificial muscle has attracted growing attention due to their potential applications in various fields. However, the development of self-healing artificial muscles from biomass raw materials, capable of repairing large cracks at the millimeter scale remains a significant challenge. In this study, a novel lignin-based all-biomass elastomer is synthesized via a solvent-free, one-pot melting method.

Research progress of MUC family in esophageal mucosal barrier of gastroesophageal reflux disease.

Gastroesophageal reflux disease (GERD) is a prevalent chronic digestive disorder with a rising incidence rate, profoundly affecting patients' quality of life. The condition is marked by recurrent episodes of acid reflux and heartburn, which can compromise the esophageal mucosal barrier and trigger inflammatory responses in the esophagus. Mucins (MUC), essential components of the mucus gel layer, play a vital role in protecting the esophageal mucosa and may serve as potential biomarkers for GERD diagnosis and treatment.

Attention-Seeking Strategies: An Investigation of Sexual Assault Organizations' Communication Tactics on Twitter.

This study examines the attention-seeking strategies of sexual assault organizations on Twitter in Canada, exploring the factors influencing the level of attention received. Drawing on the foundation work of Guo and Saxon's four-factor explanatory model, the research extends and refines the model by incorporating new factors, including Covid-related content, network size, intended audience, direct services, donations, and visual content. The study's methodology involved sampling 124 sexual assault and rape crisis centers in Canada, collecting Twitter data ( = 320,836 Tweets up to April 2023), and employing ordinary least squares and fixed effect regression analysis.

Millennial-scale climate variability of the Asian summer monsoon over the last 690,000 years: insights from cave records.

The Asian summer monsoon (ASM) is an important component of the global climate system. Cave oxygen isotope (δO) records from the region have well characterized the ASM millennial-scale climate variability (MCV) over the last 640 ka, with especially detailed insights for the most recent 60 ka, but little is known about ASM variability beyond the U-Th dating limit of ∼640 ka. Furthermore, questions remain regarding the climatic significance of millennial-scale ASM variability recorded among various climate archives, particularly in the context of the "orbital-scale paradox".

The anti-inflammatory effects of saponins from natural herbs.

Inflammation is a protective mechanism that also starts the healing process. However, inflammatory reaction may cause severe tissue damage. The increased influx of phagocytic leukocytes may produce excessive amount of reactive oxygen species, which leads to additional cell injury.

Insight into the structure, oligomerization, and the role in drug resistance of human UDP-glucuronosyltransferases.

Human UDP-glucuronosyltransferases (UGTs) are pivotal phase II metabolic enzymes facilitating the transfer of glucuronic acid from UDP-glucuronic acid (UDPGA) to various substrates. UGTs are classic type I transmembrane glycoproteins, mainly localized in the endoplasmic reticulum (ER) membrane. This review comprehensively explores UGTs, encompassing gene expression, functional characteristics, substrate specificity, and metabolic mechanisms.

Transcriptomics and metabolomics analyses reveal pollen abortion mechanism in alfalfa early stage male sterile lines.

Alfalfa ( L.), a prominent perennial forage in the legume family, is widely cultivated across Europe and America. Given its substantial economic value for livestock, breeding efforts have focused on developing high-yield and high-quality varieties since the discovery of CMS lines.

The hemodynamic responses to enhanced external counterpulsation therapy in post-PCI patients with a multi-dimension 0/1D-3D model.

Enhanced external counterpulsation (EECP) is widely utilized in rehabilitating patients after percutaneous coronary intervention (PCI) and has demonstrated efficacy in promoting cardiovascular function recovery. Although the precise mechanisms of the therapeutic effects remain elusive, it is widely postulated that the improvement of biomechanical environment induced by EECP plays a critical role. This study aimed to unravel the underlying mechanism through a numerical investigation of the in-stent biomechanical environment during EECP using an advanced multi-dimensional 0/1D-3D coupled model.