Effect of target tree management on soil extracellular enzyme activities and fungal community structure in stands.

Target tree management can adjust stand structure, alleviate tree competition, and improve soil quality. Taking natural forest as the control, we explored the characteristics of soil fungal communities by high-throughput sequencing technology and investigated the relationships among fungal communities, physicochemical properties, and soil extracellular enzyme activities of . plantations managed by the target tree and that not managed by the target tree.

Exploring the Mechanisms of WeifuChun in Colorectal Cancer: Network Pharmacology-Based Identification and Experimental Validation of Key Signaling Pathways.

Ethnopharmacological Relevance: Weifuchun (WFC) is a kind of Chinese patent medicine, which is mainly used to treat chronic gastritis, gastric ulcer and other gastric diseases. However, the mechanism of Weifuchun in the treatment of Colorectal cancer (CRC) remains unclear.

Aim Of The Study: To investigate Weifuchun's anti-cancer efficacy against colorectal carcinoma and explore its underlying molecular mechanisms.

Controlled Growth of Graphene-Skinned AlO Powders by Fluidized Bed-Chemical Vapor Deposition for Heat Dissipation.

The growing demand for high-performance chips, driven by digitalization and intelligence advancements, is accompanied by rising power consumption, highlighting the critical need for efficient thermal management in electronics. Graphene and its composites, characterized by their exceptional thermal conductivity, hold a distinctive position in this domain. The controlled synthesis of high-quality multilayer graphene composites, however, remains a significant challenge, hindering the full utilization of graphene's exceptional thermal conductivity.

Construction of Ni-rich, Ru-doped NiO nanoparticles with lattice strain for enhanced OER performance.

Manipulating the intrinsic activity of heterogeneous catalysts at the atomic level is an effective strategy to improve their electrocatalytic performances but remains a great challenge. Herein, we synthesized Ni-rich, Ru-doped NiO nanoparticles (Ru-NiO) through a two-step thermal treatment method. As an OER catalyst, the obtained Ru-NiO exhibited a low overpotential of 220 mV at a current density of 10 mA cm and a Tafel slope of 78 mV dec in alkaline media, outperforming NiO-based electrocatalysts prepared the conventional sol-gel synthesis method and conventional calcination synthesis method.

Cognitive function changes and DTI-ALPS index in postmenopausal women.

Background: Cognitive decline in postmenopausal women is a growing public health concern, with estrogen deficiency linked to brain aging. However, the role of the brain's lymphatic-like system-assessed via the diffusion tensor imaging along the perivascular space (DTI-ALPS) index-in mediating estrogen-cognitive associations remains unclear. This study investigated whether the DTI-ALPS index mediates the relationship between estrogen levels and cognitive function in postmenopausal women.

Frontotemporal lobar degeneration and amyotrophic lateral sclerosis: A bibliometric analysis.

Objective: This study analyzes the research hotspots and future directions of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis.

Methods: Relevant literature was searched using the Web of Science database and analyzed using econometric tools such as CiteSpace and VOSviewer.

Results: A total of 145 articles were included in this study, involving 317 research institutions in 31 countries and regions.

"Macro to micro" interface engineering-manipulated tin disulfide for stable and highly efficient sodium-ion electrified capture.

Tin disulfide (SnS) with high theoretical capacity has been regarded as a promising candidate for sodium-ion capture, but it still encounters challenges of sluggish ion-storage kinetics and performance decay caused by its poor intrinsic conductivity and volume change. Here, we successfully address the aforementioned issues of SnS by synthesizing hollow ZnS/SnS microboxes embedded in sulfur-doped graphene (ZnS/SnS@SG) through a macro (soft/hard interface) to micro (heterogeneous) interface engineering design. The resulting ZnS/SnS@SG displays superior capacitive deionization (CDI) performance, including an impressive desalination capacity (109.

Transcription factors FfMYB9 and FfMYB13 jointly activate the expression of hydrophobin gene FfHyd19 to mediate fruiting body morphogemesis in Flammulina filiformis.

Hydrophobins (Hyds) are small cysteine-rich proteins secreted by fungi. Hydrophobin-encoding genes have been demonstrated to play important physiological roles in the fruiting process of macro-fungi. However, a systematic study on the Hyd genes of Flammulina filiformis and its transcriptional regulation mechanism remains limited.

The impact of songs with prosocial lyrics on implicit cognition and prosocial behavior: a prospective event-related brain potential study.

Background: Music with prosocial lyrics is a significant area of study in music psychology. Based on the General Learning Model, such music can effectively enhance prosocial behaviors. However, little is known about the neural correlates of the impact on prosocial behavior of short-term exposure to music with prosocial lyrics.

Molecular Networking Combined with MALDI-MSI Reveals New Lanostane-Type Triterpenoids with Anti-Hepatocellular Carcinoma Activity and Their Spatial Distribution in the Fruit Body of .

Guided by the MS/MS metabolome-based molecular networking, 50 compounds, including 18 new triterpenoid metabolites (ganoleucocontins A-R, ), were obtained from Ganoderma leucocontextum. The chemical structures of these novel metabolites were determined based on comprehensive spectroscopic methods and chemical derivation. Compounds , and represent a new class of triterpenoid dimers linked by 3-hydroxy-3-methylglutaryl (HMG), which were reported for the first time.

CircRNA_1809 promotes the osteogenic differentiation of bone marrow mesenchymal stem cells through miR-370-3p.

Circular RNA (circRNA) is a unique closed ring structure of noncoding RNA. Although many human diseases have been confirmed to be inextricably linked with circRNAs, whether circRNAs have a potential regulatory function in the osteogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs) remains to be further elucidated. In a previous study by our team, all the differentially expressed circRNAs and messenger RNAs (mRNAs) involved in the osteogenic differentiation of BMMSCs were identified via high-throughput sequencing, and a competing endogenous RNA (ceRNA) regulatory network was constructed via bioinformatics analysis.

Defect passivation and transformation of TiCT MXene hollow microsphere for superior electrochemical performance and sodium-ions storage.

The commercialization of MXene-based electrodes for sodium ion capture in aqueous solutions is limited by poor stability, which is attributed to edge and surface defects. In this study, 3D TiCT MXene hollow microsphere (MHM) is constructed, and a systematic defect passivation and transformation approach is presented to achieve the high stability of MHM when employed as electrode material in capacitive desalination (CDI). Metal atom vanadium (V) and non-metal atoms nitrogen (N) and sulfur (S) are meticulously selected to modulate the defect environment of TiCT MXene.

Identification of novel drug targets through integrative PWAS of brain and plasma proteins with Ulcerative Colitis GWAS.

Previous genome-wide association studies (GWAS) have identified various risk variants for ulcerative colitis (UC), but there is a lack of evidence showing how these variants contribute to the development of UC. We employed an integrated pipeline to effectively translate genetic associations in order to identify pathogenic genes for UC.By combining GWAS data for UC with proteomic data from the human brain and plasma, we conducted a protein-wide association study (PWAS) and utilized protein-protein interaction (PPI) network analysis to screen for potential key proteins.

Nebulized inhalation of extracellular vesicles containing SPOCK2 suppresses lung adenocarcinoma progression via MAPK inhibition.

Aberrant expression of SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 2 (SPOCK2) plays a role in the development and progression of several human cancers. However, the importance of its expression and function in lung adenocarcinoma (LUAD) remains unclear. The present study aimed to elucidate the role of SPOCK2 in the growth of LUAD and propose a novel therapeutic insight for LUAD through SPOCK2.

Fabrication of a vanadium-doped Ni-MOF with a hydrangea-like morphology as an electrode for high-performance supercapacitors.

In this work, we successfully fabricated a vanadium-doped Ni-MOF (NiV-MOF) with a three-dimensional hydrangea-like morphology a simple one-pot hydrothermal synthesis method. As an electrode material, the NiV-MOF demonstrated superior performance, achieving a specific capacitance of 1182 F g at a current density of 1 A g.

Temporal network analysis of gut microbiota unveils aging trajectories associated with colon cancer.

Unlabelled: The human gut microbiome's role in colorectal cancer (CRC) pathogenesis has gained increasing recognition. This study aimed to delineate the microbiome characteristics that distinguish CRC patients from healthy individuals, while also evaluating the influence of aging, through a comprehensive metagenomic approach. The study analyzed a cohort of 80 CRC patients and 80 matched healthy controls, dividing participants into a normal and a CRC group, further categorized by age into young, middle-aged, and old-aged subgroups.

Predicting the chemical composition of urinary calculi in vivo using gray scale ultrasound.

Objective: The purpose of this study was to preliminarily predict the chemical composition of urinary calculi using ultrasound in vivo.

Methods: The data of 267 urinary calculi patients were analyzed retrospectively, including non-contrast computed tomography (NCCT) and ultrasound imaging data before the intervention and post-interventional chemical composition. The Hounsfield unit (HU) value of calculi, the grayscale value of calculi and the grayscale value of posterior acoustic shadow of calculi on ultrasound were measured and analyzed statistically.

Network Meta-Analysis on the Effects of Traditional Chinese Exercise on Stroke Patients.

Background: Stroke is a common cerebrovascular disease characterized by a high incidence rate, significant disability, frequent recurrence, and elevated mortality. Exercise plays a crucial role in stroke rehabilitation, yet the relationship between traditional Chinese exercise and stroke recovery remains unclear. This study aims to evaluate the effectiveness of various conventional Chinese exercises through a systematic network meta-analysis and identify the most effective interventions for improving the rehabilitation outcomes of stroke patients.

Assessing how the partial substitution of phosphate by modified chickpea protein affects the technofunctional, rheological, and structural characteristics of pork meat emulsions.

The effects of high-pressure homogenization (HPH, 80 MPa, two cycles) and/or heat-treatment (80 °C, 30 min) modified chickpea protein (CP) on water- and fat-binding capacities, texture, color, and flavor attributes of reduced-phosphate (0.2 % sodium tripolyphosphate, STPP, w/w) pork meat emulsions (RPMEs) were evaluated. The results showed that either HPH or heat-treatment modified CP exhibited a considerable improvement in emulsion stability, textural attributes (hardness, cohesiveness, and chewiness), and b values (P < 0.

Mycobiome: an underexplored kingdom in cancer.

SUMMARYThe human microbiome, including bacteria, fungi, archaea, and viruses, is intimately linked to both health and disease. The relationship between bacteria and disease has received much attention and intensive investigation, while that of the fungal microbiome, also known as mycobiome, has lagged far behind bacteria. There is growing evidence showing mycobiome dysbiosis in cancer patients, and certain cancer-specific fungi may contribute to cancer progression by interacting with both host and bacteria.

Clinical efficacy and potential mechanisms of acupuncture for Parkinson's disease: the role of GABAergic signaling.

Parkinson's disease (PD), a common neurodegenerative disease, seriously impacts the quality of life of patients. In recent years, research has revealed that the GABAergic signaling pathway plays an important role in the occurrence and development of PD. GABA is an important inhibitory neurotransmitter in the central nervous system (CNS), synthesized through the alpha decarboxylation reaction of glutamate (Glu) under the action of glutamic acid decarboxylase (GAD) in GABAergic neurons.

Gut-X axis.

Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, including the liver, heart, brain, lungs, kidneys, bone, skin, reproductive, and endocrine systems. In this review, we applied the "gut-X axis" concept to describe the linkages between the gut and other organs and discussed the latest findings related to the "gut-X axis," including the underlying modulatory mechanisms and potential clinical intervention strategies.

CCN2 mediates fibroblast-macrophage interaction in knee arthrofibrosis based on single-cell RNA-seq analysis.

Knee arthrofibrosis, characterized by excessive matrix protein production and deposition, substantially impairs basic daily functions, causing considerable distress and financial burden. However, the underlying pathomechanisms remain unclear. Here, we characterized the heterogeneous cell populations and cellular pathways by combination of flow cytometry and single-cell RNA-seq analysis of synovial tissues from six patients with or without knee arthrofibrosis.

mSphere of Influence: Seeking the unseen fungi in tumors.

Ningning Liu works in the field of fungal infection and cancer progression, with a particular focus on the mechanism of host-pathogen interaction. In this mSphere of influence article, he reflects on how papers entitled "The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL," by B. Aykut, S.