Breakfast consumption behavior was positively associated with cognitive function in Chinese adults aged 55 years and above.

Objectives: This study aims to investigate the relationship between breakfast consumption behavior and cognitive function in Chinese adults aged 55 years and above, and the mediating effect of diet quality.

Methods: Data were drawn from the China Health and Nutrition Survey (CHNS) 1997, 2000, 2004, 2006, 2015, and 2018. Participants aged 55 years and above who had at least two waves of completed data on dietary measures and cognitive assessments were eligible.

Clinical mechanisms of repetitive transcranial magnetic stimulation in improving constipation in Parkinson's disease patients through the gut-brain axis.

Objectives: This study investigates the clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) in alleviating constipation in patients with Parkinson's disease (PD) via the gut-brain axis.

Methods: Fifty-eight PD patients with constipation, admitted from May 2023 to December 2024, were randomly assigned to an rTMS treatment group or a sham rTMS control group (29 patients each). Chronic constipation severity was assessed using the Chronic Constipation Severity Score (CSS) before and 14 days after treatment.

Influence of Volcanic Ash on Organic Matter Enrichment in the Late Permian Wuchiaping Formation, Eastern Sichuan Basin: Multiproxy Evidence and Implications for Shale Gas Exploration.

The relationship between volcanic activity and organic matter enrichment in sedimentary basins represents a critical yet incompletely understood control of source rock formation. Previous studies have documented correlations between these phenomena, but quantitative assessments of the volcanic input intensity and mechanistic models remain limited. This study employs a novel multiproxy approach to quantify volcanic ash intensity and evaluate its influence on organic matter enrichment in the Late Permian Wuchiaping Formation of the eastern Sichuan Basin, South China.

Serum perfluoroalkyl and polyfluoroalkyl substances and the risk of kidney function decline: Unraveling the mediating role of iron status.

The effects of perfluoroalkyl and polyfluoroalkyl substances (PFAS) on kidney function across physiological conditions remain inconclusive, and previous research has not assessed the potential mediating effect of iron status. We aimed to examine the relationships between PFAS exposure and kidney function in various demographic groups, as well as to evaluate the potential mediating role of iron status. This study included 7369 Chinese adults aged 18 years or older from the China Health and Nutrition Survey (CHNS).

An advanced network pharmacology investigation of Shufeng Jiedu formula in the treatment for respiratory tract infection based on LC-MS, data mining, molecular docking, and molecular dynamic simulation.

Respiratory tract infection (RTI) continues to be a non-negligible cause of global incidence rate and mortality. Shufeng Jiedu formula (SFJD), a traditional Chinese remedy, is used for treating RTI, though its mechanisms are not well understood. The objective of this research was to uncover the underlying molecular mechanisms responsible for the effectiveness of SFJD on RTI.

Multi-omics insights into Palmitoylation-mediated brain network remodeling and glioblastoma risk.

Unlabelled: Glioblastoma (GBM) remains a lethal brain tumor with limited therapeutic progress, necessitating novel insights into its molecular drivers. This study investigates the causal role of protein palmitoylation-a post-translational modification regulating tumor metabolism and microenvironment-in GBM pathogenesis through neuroimaging-mediated pathways. Leveraging two-sample Mendelian randomization (MR) and multi-omics data from FinnGen (406 GBM cases/378,749 controls) and UK Biobank (3,935 brain imaging phenotypes), we identified protective effects of palmitoylation-related genes (ZDHHC3: OR = 0.

Constructing a T-Test for Value Function Comparison of Individualized Treatment Regimes in the Presence of Multiple Imputation for Missing Data.

Optimal individualized treatment decision-making has improved health outcomes in recent years. The value function is commonly used to evaluate the goodness of an individualized treatment decision rule. Despite recent advances, comparing value functions between different treatment decision rules or constructing confidence intervals around value functions remains difficult.

Association between Life's Essential 8 and hyperuricemia in the Chinese elderly.

Background And Objectives: Life's Essential 8 (LE8) is a comprehensive indicator that evaluates cardiovascular health (CVH). There have been limited studies on the relationship between LE8 and hyperuricemia (HUA). This study explored the association and dose-response relationship between LE8 and HUA among elderly people in China.

An overview of extreme weather-epidemic compound disasters.

Extreme weather events are increasing the chances of global outbreaks of infectious diseases, and are highly susceptible to the formation of "extreme weather-epidemic" compound disasters. It has become a serious challenge for the global climate and public health. In this study, we summarize and outline a series of research that advances in the theoretical basis, monitoring technology, prediction and early warning, and risk assessment of extreme weather-epidemic compound disasters (EWED).

A gain-of-function variant in NNT causes premature diffuse familial sebaceous hyperplasia.

Backgrounds: Premature diffuse familial sebaceous hyperplasia (PDFSH) constitutes a distinct clinical variant of sebaceous hyperplasia, characterized by three hallmark features: early disease onset, characteristic sparing of perioral and periocular regions, and a positive family history. To date, the pathogenic gene underlying PDFSH remains unidentified.

Objectives: The aim of this study was to identify the underlying gene and the pathogenesis of three familial cases with autosomal dominant PDFSH.

[Mechanism of elaidic acid-induced lipid accumulation in vascular smooth muscle cells].

Objective: To investigate the molecular mechanisms underlying EA(elaidic acid)-induced lipid accumulation in VSMCs(vascular smooth muscle cells).

Methods: CCK-8 assay determined the effects of EA(0-2.8 mmol/L) on MOVAS(murine aortic vascular smooth muscle cells)to select experimental concentrations.

[Associsation between inflammatory cytokines and hypertension among the Chinese people in six provinces in 2018].

Objective: To investigate the association between serum inflammatory biomarkers and hypertension prevalence in Chinese adults.

Methods: Based on the 2018 China Health and Nutrition Survey(CHNS), we conducted a cross-sectional analysis of 1960 adults from six provinces selected through stratified random sampling by age and sex. Participants with complete dietary, biochemical, and anthropometric data were included.

Inhibition of miR-499a-5p Ameliorates Apoptotic and Autophagic Damage in Hypoxic Cardiomyocytes H9c2 Through Upregulation of ARGLU1.

Myocardial infarction (MI), the most prevalent form of acute coronary syndrome, is often accompanied by cardiomyocyte apoptosis. In addition to apoptosis, autophagy plays a critical role in determining cardiomyocyte survival during MI. This study aimed to elucidate the regulatory role of miR-499a-5p in cardiomyocyte apoptosis and autophagy under hypoxic conditions.

Characterization and diagnosis of feeding difficulties in full-term neonates in NICUs: a multicenter study.

Background: Feeding difficulties significantly impact neonatal well-being. This study explores the clinical characteristics, etiologies, and diagnostic practices for full-term neonates with feeding difficulties in neonatal intensive care units (NICUs).

Methods: This retrospective cohort study recruited full-term infants admitted to NICUs participating in the China Neonatal Genome Project from March 2017 to December 2021, diagnosed with feeding difficulties persisting >72 h.

Running ameliorates methamphetamine-associated cognitive impairment by regulating hippocampal neurogenesis through the GSK3β/β-catenin pathway.

Physical exercise is a non-pharmacological therapy widely used in drug rehabilitation centers for treating methamphetamine (METH) addiction. METH causes cognitive impairment and suppresses adult hippocampal neurogenesis (AHN) in experimental animals. Exercise can improve cognitive dysfunction caused by various factors through the enhancement of AHN.

Aberrant splicing of CHEK1 is a driver of megakaryocytic dysplasia in U2AF1 mutant myelodysplastic neoplasms.

U2AF1 mutations are common in patients with myelodysplastic neoplasms (MDS), suggesting that aberrant splicing of pre-mRNAs driven by mutant U2AF1 could play a critical role in MDS pathogenesis. Previous studies have demonstrated that U2AF1 mutation impairs the differentiation of erythrocytes and granulocytes, but the impact on megakaryocytes (MKs) remains unclear. Here, by integrating data from MDS patients and cell lines with U2AF1 mutations, we determined that U2AF1 mutations are associated with dysmegakaryopoiesis, induce the generation of abnormal MKs, especially micro-MKs, and induce significant thrombocytopenia.

Dietary Structure and Cardiometabolic Risk Factors: A Comparative Analysis of Lingnan and Central Plains Regions in China Based on China Nutrition and Health Surveillance 2015-2017.

: The Lingnan region is characterized by a hot and humid climate and abundant, diverse natural resources, while the Central Plains region experiences distinct four seasons and has a rich agricultural culture. Both regions possess unique dietary traditions and preferences. This study aims to investigate the differences in dietary structure between the Lingnan region (Guangdong, Guangxi, Hainan) and the Central Plains region (Shanxi, Shaanxi, Henan) and their impact on health.

Label-Free Multimodal Imaging Microscope for Damaged Cell Membrane Detection and Single-Cell Characterization.

Multimodal characterization of single cells offers unprecedented resolution and depth for research in fundamental biology, pathology, and drug development. However, limited by labeling techniques or complex systems, developing a simple, label-free multimodal detection system remains challenging. In this work, a label-free multimodal imaging microscope (MMIM) is proposed for single-cell characterization.

Theaflavin-3,3'-digallate protects against myocardial ischemia/reperfusion injury and hypoxia/reoxygenation injury by activating the PI3K/Akt/mTOR pathway.

Myocardial ischemia followed by reperfusion triggers a range of pathological events, among which excessive autophagy plays a key role. Theaflavin-3,3'-digallate (TF3) is a functional polyphenol of black tea and is beneficial in the prevention or/and treatment of various diseases. Here, we explored the therapeutic effect of TF3 on myocardial ischemia/reperfusion (I/R) injury.

Study on rTMS's therapeutic effect on constipation in Parkinson's disease via the brain-gut axis theory.

Objective: This study investigates the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) on constipation in Parkinson's disease (PD) patients, based on the brain-gut axis theory.

Methods: Fifty-eight PD patients with constipation (aged 52-68 years) were randomly assigned to the treatment group (receiving high-frequency 10 hz rTMS targeting the left dorsolateral prefrontal cortex (DLPFC),  = 29) and control group (receiving sham stimulation,  = 29). Both patients and outcome assessors were blinded to the allocation.

A novel loss-of-function variant in causes Mendelian susceptibility to mycobacterial disease.

Introduction: Mendelian Susceptibility to mycobacterial disease (MSMD) is a rare inherited immunodeficiency disorder characterized by increased susceptibility to atypical mycobacterial infections induced by defective IFN-γ pathway.

Methods: We report three patients from a family presenting with multiple osteolytic lesions and cutaneous granulomas due to Mycobacterium marinum infections. Functional studies, including Western blotting and immunofluorescence, assessed phosphorylation and nuclear translocation of the mutant STAT1-Ile707Thr in eukaryotic overexpression systems.

Regime shift to extensive valley glaciations over High Mountain Asia during the Early-Middle Pleistocene.

In contrast to the well-established onset of Northern Hemisphere high-latitude glaciation at ~2.7 Ma, the timing and drivers of the intensified glaciation over High Mountain Asia (HMA) remain elusive, as glacial geologic evidence within this region is inherently fragmentary. Here, we offer a spatiotemporally complete view of glacier behavior over HMA spanning the last 3 Ma using transient climate-glaciation simulations to address this challenge.