Acceleration of ultrafast demagnetization in van der Waals ferromagnet FeGeTe in high magnetic field.

The mechanisms of ultrafast laser-induced demagnetization of ferromagnets have been among the most heavily debated topics in ultrafast magnetism from the very beginning of the field. Here, we demonstrate that the timescale and the efficiency of ultrafast demagnetization of two-dimensional van der Waals ferromagnet FeGeTe, excited by femtosecond laser pulses, can be efficiently accelerated by an external magnetic field. With a 1 T magnetic field at Curie temperature ( ) = 210 K femtosecond laser excitation causes demagnetization of the ferromagnet by 79% within 22.

"Macro to micro" interface engineering-manipulated tin disulfide for stable and highly efficient sodium-ion electrified capture.

Tin disulfide (SnS) with high theoretical capacity has been regarded as a promising candidate for sodium-ion capture, but it still encounters challenges of sluggish ion-storage kinetics and performance decay caused by its poor intrinsic conductivity and volume change. Here, we successfully address the aforementioned issues of SnS by synthesizing hollow ZnS/SnS microboxes embedded in sulfur-doped graphene (ZnS/SnS@SG) through a macro (soft/hard interface) to micro (heterogeneous) interface engineering design. The resulting ZnS/SnS@SG displays superior capacitive deionization (CDI) performance, including an impressive desalination capacity (109.

Blocking TRPM4 alleviates pancreatic acinar cell damage via an NMDA receptor-dependent pathway in acute pancreatitis.

Mitochondrial dysfunction caused by Ca overload in pancreatic acinar cells is an important mechanism in the pathogenesis of acute pancreatitis (AP). Transient receptor potential cation channel melastatin 4 (TRPM4), a non-selective cation channel, can be activated by intracellular Ca, and is involved in mediating damage to neuronal mitochondrial function. However, the role of TRPM4 activation in mitochondrial dysfunction during AP remains unknown.

Construction of Coexpression Networks Affecting Litter Size in Goats Based on Transcriptome Analysis.

Optimal litter size on goat farms is an important trait for production and economic efficiency. The ovary and uterus, key components of the reproductive system, play essential roles in reproductive performance. In recent years, numerous genes linked to goat reproductive performance have been identified.

Single-Atom Cu and Zn Vacancy Synergy in NiFe-LDH Boosts Metal-Support Interaction for High-Efficiency Nitrate-to-Ammonia Electroreduction.

The electrochemical nitrate (NO)-to-ammonia conversion reaction (NORR) represents a transformative approach addressing dual challenges of environmental remediation and sustainable ammonia (NH) synthesis. Despite its promise, practical implementation remains constrained by parasitic hydrogen evolution and inherent kinetic limitations. We propose an innovative dual-site architecture through atomic-scale metal-support engineering, constructing single copper (Cu) atoms anchored on zinc-deficient NiFe-layered double hydroxide (CuSA/V-LDH).

An infant with IVIG-resistant Kawasaki disease requiring repeated glucocorticoids therapy: A case report and literature review.

Rationale: Kawasaki disease (KD) is an acute systemic vasculitis predominantly affecting children, characterized by fever, chapped lips, strawberry tongue, conjunctival hyperemia, rash, and cervical lymphadenopathy. The most severe complication associated with KD is the development of coronary artery abnormalities.

Patient Concerns: A 1-year and 2-month-old girl was admitted to the hospital with persistent fever, rash, and elevated inflammatory markers.

Erzhi pill promotes norepinephrine synthesis in locus coeruleus through ERβ-TFAP2A-TH plays a neuroprotective role.

Ethnopharmacological Relevance: Erzhi Pill (EZP), a classical Chinese herbal formula for yin-nourishing and kidney-tonifying, has been traditionally prescribed for insomnia and amnesia, and shows therapeutic potential for Alzheimer's disease (AD). However, its active components and precise mechanisms of action against AD remain elusive.

Aim Of The Study: This study aimed to identify the key active components and molecular targets of EZP responsible for improving cognitive dysfunction and to elucidate its underlying mechanisms.

Structural and temporal dynamics analysis on immune response in low-dose radiation: History, research hotspots and emerging trends.

Background: Radiotherapy (RT) is a cornerstone of cancer treatment. Compared with conventional high-dose radiation, low-dose radiation (LDR) causes less damage to normal tissues while potentially modulating immune responses and inhibiting tumor growth. LDR stimulates both innate and adaptive immunity, enhancing the activity of natural killer cells, dendritic cells, and T cells.

Higher risk of recurrence in partially thrombosed cerebral aneurysms post-WEB (Woven EndoBridge) device treatment: insights from the WorldWideWEB Consortium registry.

Background: The Woven EndoBridge (WEB) device is a prevalent treatment for intracranial aneurysms. While many studies have assessed the obliteration rate post-WEB embolization, few have focused on long-term outcomes in partially thrombosed aneurysms.

Objective: To assess whether partially thrombosed aneurysms are at higher risk of recurrence or retreatment following WEB embolization compared with non-thrombosed aneurysms.

The effect of GLP-1 receptor agonists on circulating inflammatory markers in type 2 diabetes patients: A systematic review and meta-analysis.

Aim: To investigate whether the antidiabetic agent glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can exert anti-inflammatory effects while lowering blood glucose, we performed a meta-analysis and systematic review.

Methods: We searched 4 online databases (Medline, Embase, Cochrane Library and the Web of Science) for randomised controlled trials (RCTs) that examined changes after GLP-1RAs intervention in commonly accepted biomarkers of inflammation: C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), monocyte chemotactic protein-1(MCP-1) and advanced glycation end products (AGEs).

Results: This meta-analysis included 52 eligible RCTs (n = 4734) with a median follow-up of 24 weeks, a mean age of 54.

Investigation of the mechanism of Buyang Huanwu decoction in improving learning and memory impairment in Alzheimer's disease mice based on lipidomics.

In this study, a lipid disorder Alzheimer's disease (AD) model was developed with high-fat diet and D-galactose injected intraperitoneally (HFD & D-gal) to evaluate the activities of Buyang Huanwu Decoction (BYHWD) compared with donepezil hydrochloride. The learning and memory abilities of BYHWD were evaluated by Morris water maze test (MWM). The lipid levels in serum, histopathology, and immunohistochemistry of hyperphosphorylated tau protein in hippocampal neurons were conducted to prove the therapy effects of BYHWD.

U shaped relationship between mean arterial pressure and 28 day mortality in ICU patients with acute myocardial infarction.

The current study aims to investigate the correlation between mean arterial pressure (MAP) and the risk of 28-day mortality in patients with acute myocardial infarction. This is a retrospective cohort study utilizing data from the eICU database, focusing on patients with acute myocardial infarction. We employed a multivariable logistic regression model to estimate the relationship between MAP and the 28-day mortality rate.

Analysis of Population Structure and Selective Signatures for Milk Production Traits in Xinjiang Brown Cattle and Chinese Simmental Cattle.

This study aims to elucidate the population structure and genetic diversity of Xinjiang brown cattle (XJBC) and Chinese Simmental cattle (CSC) while conducting genome-wide selective signatures analyses to identify selected genes associated with milk production traits in both breeds. Based on whole-genome resequencing technology, whole-genome single nucleotide polymorphisms (SNPs) of 83 Xinjiang brown cattle and 80 Chinese Simmental cattle were detected to resolve the genetic diversity and genetic structure of the two populations, whole-genome selective elimination analysis was performed for the two breeds of cattle using the fixation index () and nucleotide diversity (θπ ratio), and enrichment analysis was performed to explore their biological functions further. Both breeds exhibited relatively rich genetic diversity, with the Chinese Simmental cattle demonstrating higher genetic diversity than Xinjiang brown cattle.

CIRP contributes to multiple organ damage in acute pancreatitis by increasing endothelial permeability.

Acute pancreatitis can lead to systemic inflammation and multiple organ damage. Increased endothelial permeability is a hallmark of systemic inflammation. Several studies have demonstrated that cold-inducible RNA-binding protein (CIRP) functions as a proinflammatory factor in various diseases.

Seven years of CRAFT: Clinical results of a multicenter cohort of carotid artery relining with the CASPER RX stent.

Background And Purpose: Carotid artery stenting (CAS) is an established treatment for carotid stenosis or occlusion. Use of the dual-layer microporous CASPER RX stent has had mixed results in prior reports. The CaRotid Artery Filtering Technique (CRAFT) uses the distal end of the CASPER stent as an embolic protection device during deployment.

Incidence and predictors of Woven EndoBridge (WEB) shape modification following treatment of intracranial aneurysms in a large multicenter study.

The Woven EndoBridge (WEB) device is FDA-approved for the treatment of bifurcation aneurysms. Despite its wide popularity, it has been under scrutiny for its association with potential aneurysm recanalization and retreatment due to device shape modification. This study aims to analyze the shape modification rate of WEB devices and identify factors associated with this phenomenon, as well as its correlation with aneurysm retreatment.

Molecular turn in pathogenesis: implications of the frameshift for bacterial survival in human macrophage.

, the etiological agent of the devastating plague, has caused three pandemics in human history. While known for its fatality, it has long been intriguing that biovar microtus strains are highly attenuated to humans. The survival and replication within macrophages are critical in the early stages of the lifestyle within warm-blooded hosts.

Plant-based diets and the risk of lung cancer: a large prospective cohort study.

Purpose: Plant-based diets are increasingly recognized for cancer prevention, yet their specific impact on lung cancer (LC) risk remains insufficiently examined. This study aims to assess the relationship between plant-based diets adherence and the incidence of LC.

Methods: Data from the Prostate, Lung, Colorectal, and Ovarian cancer screening trial were analyzed.

Impact of smoking on recurrence rates among wide-neck intracranial aneurysms treated with Woven EndoBridge: a multicenter retrospective study.

Objective: Tobacco smoking is among the factors known to significantly augment the risk of untreated intracranial aneurysm (IA) growth and rupture. Smoking appears to have a variable effect on different endovascular treatment modalities. The impact of smoking on the safety, efficacy, and outcomes of Woven EndoBridge (WEB) device use for wide-neck IAs has not been evaluated.

The "CUPCAKE" technique (coiled underlying pseudoaneurysm contained by a woven endobridge device) for treating intracranial aneurysms with atypical morphology.

Background: Intrasaccular flow diversion using the woven endobridge device (WEB; MicroVention, Aliso Viejo, CA, USA) for the treatment of intracranial aneurysms has demonstrated large scale safety and efficacy. However, limitations arise from its structural configuration, restricting its application to specific aneurysm sizes and shapes.

Technique Overview: We introduce the CUPCAKE technique, a combination of conventional coiling followed by WEB intrasaccular flow disruption in select cases of atypical aneurysms with technically challenging morphology not typically treatable by WEB alone.

Dynamic Metabolic Characterization of Lung Tissues in Rats Exposed to Whole-Thorax Irradiation Based on GC-MS.

An animal model of radiation-induced lung injury (RILI) was established using female rats given sublethal whole-thorax X-ray irradiation (15 Gy) at a dose rate of 2.7 Gy/min. The rats were studied for up to day 45 and compared with sham-irradiated controls.

Gut microbiota dysbiosis promotes cognitive impairment via bile acid metabolism in major depressive disorder.

Evidence suggests that complex interactions among the gut microbiome, metabolic abnormalities, and brain have important etiological and therapeutic implications in major depressive disorder (MDD). However, the influence of microbiome-gut-brain cross-talk on cognitive impairment in MDD remains poorly characterized. We performed serum metabolomic profiling on 104 patients with MDD and 77 healthy controls (HCs), and also performed fecal metagenomic sequencing on a subset of these individuals, including 79 MDD patients and 60 HCs.

Occurrence, Emission, and Transport of Tire and Road Wear Particles across Four Environmental Compartments along Ring Road Networks in Beijing.

Tire and road wear particles (TRWPs) are an appreciable source of microplastics (MPs); however, knowledge of their large-scale occurrence and mass flux based on robust sampling and quantification is limited. Herein, the first city-wide survey of TRWPs across environmental compartments (road dust, snowbank, water, and sediment from rivers and lakes) along four ring roads (beltways) in Beijing was performed. TRWP concentrations ( = 74) were quantified using bonded-sulfur as a marker to reveal the city-wide spatial distributions and adopted to establish a framework estimating TRWP emission factors (EFs) and mass flux from generation to remote atmospheric, terrestrial, and aquatic transport.