Estimation of Seasonal Net Carbon Sequestration Under Noncontinuous Flooding in Rice Fields.

Non-continuous flooding (NCF) in rice was recently reported to improve the field-scale, seasonal carbon balance. In this response article, we clarify our system boundaries (seasonal, field-scale), address the role of yield carbon and microbial indicators, and add sensitivity checks with expanded data. Across these checks, NCF consistently reduces methane without penalizing yield, supporting our original conclusions.

Alveolar solitary fibrous tumor: an uncommon morphological form.

Solitary fibrous tumor (SFT) is a fibroblastic tumor characterized by a prominent staghorn vasculature and collagen deposition. However, little is known about SFTs with alveolar structures. Herein, we present a case of an alveolar pattern SFT in a 55-year-old woman.

Effect of lateral versus supine positioning on hypoxaemia in sedated adults: multicentre randomised controlled trial.

Objectives: To evaluate the effect of lateral versus supine positioning on incidence of hypoxaemia in sedated patients and to provide evidence based recommendations for respiratory strategies.

Design: Prospective, multicentre, randomised controlled trial.

Setting: 14 tertiary hospitals in China, July to November 2024.

Impact of Ischemic Conditioning on Fatigue Recovery Following High-Intensity Complex Training.

Purpose: This study investigated the effects of ischemic conditioning on recovery following high-intensity complex training.

Methods: The study was a randomized controlled trial. Thirty-six participants with at least 1 year of strength-training experience were randomized into 4 groups: control (CON, n = 9), acute ischemic preconditioning (A-IPC, n = 8), repeated ischemic preconditioning (R-IPC, n = 11), and postexercise ischemic conditioning (PEIC, n = 8).

Effects of theta burst stimulation on cognitive function and characteristics of blood oxygen alterations based on near-infrared spectroscopy in chronic schizophrenia.

Background: To explore the efficacy of theta burst stimulation (TBS) on the cognitive function of chronic schizophrenia, and to analyze the effect of TBS on brain function using functional near-infrared spectroscopy (fNIRS).

Methods: One hundred stable chronic schizophrenia patients were selected and divided randomly into the experimental group (50 cases) and control group (50 cases). The experimental group received real TBS stimulation to the left dorsolateral prefrontal cortex (DLPFC) for 4 weeks, while the control group received sham stimulation to the same site.

Lateral quadratus lumborum block versus transversus abdominis plane block for perioperative analgesia in patients undergoing laparoscopic colorectal cancer surgery: a randomized, controlled clinical trial.

Background: Lateral quadratus lumborum block (QLB) and transversus abdominis plane block (TAPB) have been widely used in abdominal surgeries. This study aimed to compare the intraoperative analgesic effect, hemodynamic changes and postoperative complications of the two blocks in patients undergoing laparoscopic colorectal cancer surgery.

Methods: This was a randomized controlled trial that enrolled 189 patients scheduled for laparoscopic colorectal cancer surgery.

Perceptual Quality Assessment of 360° Images Based on Generative Scanpath Representation.

Despite substantial efforts dedicated to the design of heuristic models for omnidirectional (i.e., 360°) image quality assessment (OIQA), a conspicuous gap remains due to the lack of consideration for the diversity of viewing behaviors that leads to the varying perceptual quality of 360° images.

Unveiling the mechanisms of CEBPD-orchestrated TAM polarization through RGS2/PAR2 pathway and its impact on ICB efficacy in clear cell renal cell carcinoma.

Background: The polarization status and function of tumor-associated macrophages (TAMs) influence tumor progression and patients' prognosis. CCAAT/enhancer-binding proteins (CEBPs) family are important transcriptional factors in macrophages differentiation physically and pathologically. This study aims to explore the mechanism of CEBPs in TAMs polarization in clear cell renal cell carcinoma (ccRCC) immune microenvironment and its impact on immune checkpoint blockers (ICBs) therapy.

Quenching Sensitivity Study of New High-Strength Aluminum Alloys Based on an Immersion End-Quenching and Step-Quenching Technique.

Based on end-quenching and step-quenching experiments combined with scanning electron microscopy (SEM) and transmission electron microscopy (TEM), the quench sensitivity of a novel high-strength aluminum alloy was investigated and compared with that of GB/T 7075 and 7175 alloys; quench factor analysis (QFA) was employed to predict the hardness values of the alloy and investigate the effect of quenching rate on its mechanical properties. The experimental results indicate that when the cooling rate decreases from 402.5 °C/s to 3.

Diagnosis of thyroid nodules using ultrasound images based on deep learning features: online dynamic nomogram and gradient-weighted class activation mapping.

Background: The high incidence of thyroid nodules (TNs) necessitates accurate and effective differentiation between benign and malignant cases to avoid overtreatment, which is crucial for both patients and doctors. The aim of this study was to develop and visualize an integrated model to enhance the diagnostic capability of young radiologists in evaluating TNs.

Methods: A retrospective collection of 1,501 ultrasound (US) images of TNs were randomly divided into training and validation sets.

Acceleration of ultrafast demagnetization in van der Waals ferromagnet FeGeTe in high magnetic field.

The mechanisms of ultrafast laser-induced demagnetization of ferromagnets have been among the most heavily debated topics in ultrafast magnetism from the very beginning of the field. Here, we demonstrate that the timescale and the efficiency of ultrafast demagnetization of two-dimensional van der Waals ferromagnet FeGeTe, excited by femtosecond laser pulses, can be efficiently accelerated by an external magnetic field. With a 1 T magnetic field at Curie temperature ( ) = 210 K femtosecond laser excitation causes demagnetization of the ferromagnet by 79% within 22.

Construction of a prostate adenocarcinoma molecular classification: integrating spatial transcriptomics with retrospective cohort validation.

Background: Prostate adenocarcinoma (PRAD) is a biologically heterogeneous disease threatening the health of elderly males worldwide, and some PRAD subtypes with certain molecular landscape are always associated with poor prognosis. A more precise molecular classification system for PRAD is urgently needed.

Methods: Through spatial transcriptome analysis, we identified different malignant cell/spot types in PRAD.

Naringin mitigates experimental autoimmune prostatitis by modulating oxidative stress and the NLRP3 inflammasome via the PPAR-γ/NF-κB pathway.

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a debilitating condition characterized by pelvic pain and discomfort, necessitating the exploration of effective therapeutic strategies. This study aimed to elucidate the therapeutic potential of naringin (NAR) in addressing CP/CPPS by examining its role in modulating oxidative stress (OS) and the NLRP3 inflammasome via the PPARγ/NF-κB signaling pathway. Using both animal and cellular models of CP/CPPS, naringin was administered to mice with experimental autoimmune prostatitis (EAP), and the anti-inflammatory effect of naringin was assessed.

MEX3A activates the JAK-STAT pathway to suppress NK cell cytotoxicity and accelerate lung adenocarcinoma progression.

Background: Therapeutic potential of natural killer (NK) cells is recognized in treating lung adenocarcinoma (LUAD), but impairment of NK cell functions in various cancers weakens anti-tumor capabilities. Uncovering molecular mechanisms is imperative for fortifying NK cells against degradation and for enhancing their cancer-inhibiting functions.

Methods: TCGA-LUAD database complemented by qRT-PCR presented MEX3A expression in LUAD.

pH-Independent charge-reversal strategy for enhanced tumor penetration based on hyaluronidase-responsive tellurium-containing polycarbonate nanocarriers.

The charge-reversal strategy has been of great significance for enhancing the penetration of nanomedicines in tumors. However, conventional charge reversal has always been confined to pH variation. Herein, we proposed a pH-independent charge-reversal strategy based on hyaluronidase-responsive polycarbonate nanocarriers bearing quaternary ammonium groups.

AD1 Aptamer-Engineered Fluconazole-Loaded PLGA-PEG Nanoformulations Potentiate Antifungal Efficacy through Biofilm-Penetrating Targeting against .

In this work, aptamer AD1-modified poly(lactic--glycolic acid)-poly(ethylene glycol)-fluconazole nanoparticles (AD1-PLGA-PEG-FLUCZ) were prepared, enabling the antifungal drug FLUCZ to specifically target the biofilm of , prolonging its action time on the biofilm, and enhancing its killing effect. The analytical results demonstrated that the AD1-PLGA-PEG-FLUCZ nanoparticulate system achieved a FLUCZ loading capacity of 5.89 ± 0.

Non-Continuous Flooding Outperforms Continuous Flooding in Rice Fields Net Carbon Sequestration Despite Losses in Soil Organic Carbon Sequestration.

Rice feeds more than 50% of the global population with significant greenhouse gas (GHG) emissions. Non-continuous flooding (NCF) has been recognized as an effective practice for stabilizing rice yields, conserving water, and reducing GHG emissions from rice fields. However, the impacts of NCF on net carbon sequestration (NCS, defined as the total ecosystem GHG equivalent) in rice fields, including CH emissions, NO emissions, photosynthetic carbon sequestration linked to crop yield, and soil organic carbon (SOC) sequestration, have rarely been quantified comprehensively.

Theoretical studies of a novel carbazole-fluorene macrocycle as a host material for phosphorescent organic light-emitting diodes and the effects of substituents.

Phosphorescent organic light-emitting diodes (PhOLEDs) have great potential in display applications due to their high luminous efficiency. Using density functional theory, a series of host molecules labelled as carbazole-fluorene macrocycles (CzFMCs) were designed and characterized to possess high triplet energy levels for application in PhOLEDs, and their accuracy was verified by comparing with experimental values. Our systematic investigation focuses on how the number and position of cyano, ethynyl, and fluoro substitutions affect various electronic properties of these hosts, including triplet energy (), frontier orbital energy levels, absorption spectra, charge-injection barriers, and reorganization energies.

An Innovative and Efficient Low Temperature Hydrothermal-Calcination Process for β-FeOOH Nanorods and Hollow-Structure α-FeO Magnetic Nanorods Exclusively Utilizing FeCl in an Alcohol-Containing Aqueous Solution.

A facile low temperature hydrothermal-calcination approach was developed for the fabrication of β-FeOOH nanorods (NRs) and hollow-structure α-FeO magnetic nanorods (MNRs), and the products were characterized using SEM, TEM, XRD and VSM techniques. To achieve smaller-sized β-FeOOH NRs, the effects of Fe concentration, the volume ratio of ethanol to water in solution, hydrothermal temperature, and hydrothermal time on the structure of the precursors were systematically investigated, and the nanorods with an average length 104 nm and diameter 36 nm were fabricated at hydrothermal temperature of 100 °C for 2 h using 0.15 M ferric chloride hexahydrate in 50% ethanol solution.

Ultrasound-based deep learning radiomics for enhanced axillary lymph node metastasis assessment: a multicenter study.

Background: Accurate preoperative assessment of axillary lymph node metastasis (ALNM) in breast cancer is crucial for guiding treatment decisions. This study aimed to develop a deep-learning radiomics model for assessing ALNM and to evaluate its impact on radiologists' diagnostic accuracy.

Methods: This multicenter study included 866 breast cancer patients from 6 hospitals.

Preparation of Ni-Mn ferrites magnetic nanoparticles through the ethanol solution combustion-calcination process for the adsorption of methyl blue.

Ni-Mn ferrites magnetic nanoparticles (MNPs) were successfully prepared through the ethanol solution combustion-calcination process, and characterized by SEM, TEM, XRD, VSM, BET, and FTIR techniques. For smaller particle size and suitable magnetic property, the optimum element ratio of the material was Ni0.9Mn0.

Search for Solar Boosted Dark Matter Particles at the PandaX-4T Experiment.

We present a novel constraint on light dark matter utilizing 1.54 metric ton/year of data acquired from the PandaX-4T dual-phase xenon time projection chamber. This constraint is derived through detecting electronic recoil signals resulting from the interaction with solar-enhanced dark matter flux.

Monometallic dual-atom two-dimensional phthalocyanine-based metal-organic framework for carbon dioxide electroreduction: A study combining density functional theory and machine learning.

Exploring efficient catalysts is key to promoting the practical application of electrochemical CO reduction reaction (CORR) technology. Herein, we designed 14 types of two dimensional conjugated metal-organic frameworks (2D c-MOFs), denoted as PcM-O-M, featuring monometallic dual-atom centers with N and O coordinations, and systematically studied their CORR electrocatalytic performance using density functional theory (DFT) calculations. The monometallic dual-atom centers provide a feasible method for regulating both the metal atom and the coordination environment to enhance catalytic activity.

Regulation of glucocorticoid receptor nuclear localization in prostate cancer cells.

Glucocorticoid receptor (GR) plays important roles in many diseases including prostate cancer. Intracellular shuttling of GR is thought to be an important mechanism regulating its localization to the nucleus required for transactivation of GR target genes. Here, using fluorescent microscopy coupled with pulse-chase and nucleocytoplasmic fractionation coupled with western blot, we provided evidence that GR can be imported and then degraded in the nucleus in the absence of ligand.

Construction and validation of renal cell carcinoma tumor cell differentiation-related prognostic classification (RCC-TCDC): an integrated bioinformatic analysis and clinical study.

Background: Renal cell carcinoma (RCC) is a heterogeneous malignancy with diverse gene expression patterns, molecular landscapes, and differentiation characteristics of tumor cells. It is imperative to develop molecular RCC classification based on tumor cell differentiation for precise risk stratification and personalized therapy.

Methods: We obtained scRNA-seq profiles from GSE159115 and bulk RNA-seq profiles from TCGA-KIRC cohort.