Investigating the Mechanisms Underlying Citral-Induced Oxidative Stress and Its Contribution to Antifungal Efficacy on Through a Multi-Omics Approach.

Citral, an organic compound found in lemongrass () oil and essential oil, has been reported to exhibit notable antifungal activity against (), the pathogen of rice blast, which causes significant economic losses in rice production. However, the role of citral in inducing oxidative stress related to antifungal ability and its underlying regulatory networks in remain unclear. In this study, we investigated the oxidative effects of citral on and conducted transcriptomic and widely targeted metabolomic (WTM) analyses on the mycelia.

NlugOBP1 in Nilaparvata lugens involved in the perception of repellent agent geraniol.

The brown planthopper Nilaparvata lugens (Stål) is one of the most prominent rice pests. Current methods for effectively controlling N. lugens primarily involve cultivating resistant varieties or synthesizing insecticides.

AD1 Aptamer-Engineered Fluconazole-Loaded PLGA-PEG Nanoformulations Potentiate Antifungal Efficacy through Biofilm-Penetrating Targeting against .

In this work, aptamer AD1-modified poly(lactic--glycolic acid)-poly(ethylene glycol)-fluconazole nanoparticles (AD1-PLGA-PEG-FLUCZ) were prepared, enabling the antifungal drug FLUCZ to specifically target the biofilm of , prolonging its action time on the biofilm, and enhancing its killing effect. The analytical results demonstrated that the AD1-PLGA-PEG-FLUCZ nanoparticulate system achieved a FLUCZ loading capacity of 5.89 ± 0.

Resistance Risk Assessment of Propiconazole in and its Synergistic Antifungal Mechanism with Kresoxim-methyl.

The resistance risk and mechanisms of propiconazole in remain unclear. In this study, the sensitivity of 159 isolates to propiconazole was determined, and the EC value was 0.2286 μg/mL.

Development of a multidimensional prediction model for long-term prognostic risk in patients with acute coronary syndromes after percutaneous coronary intervention: A retrospective observational cohort study.

Background: The aim of this study is to examine the critical variables that impact the long-term prognosis of patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) and to create a multidimensional predictive risk assessment model that can serve as a theoretical basis for accurate cardiac rehabilitation.

Methods: The study involved ACS patients who received PCI at the First Hospital of Jilin University from June 2020 to March 2021. Participants were categorized into two groups: acute myocardial infarction (AMI) and unstable angina (UA), according to clinical data and angiographic findings.

Nanoparticle-Mediated dsRNA Delivery Used as a Broad-Spectrum Synergistic Nanonucleic Acid Adjuvant to Control .

The enhanced detoxification capacity caused by the induction or constitutive overexpression of metabolic enzyme genes has complicated sustainable and efficient pest control strategies. This study clarified the detoxification effects of two P450 genes, and , on multiple insecticides in . The chimeric double-stranded RNA (ch-dsRNA) of these two genes was obtained by using the L4440-HT1115 (DE3) RNase III system, and the RNA interference (RNAi) effectiveness of ch-dsRNA was verified by microinjection.

Both insertion mutation and low expression of nicotinic acetylcholine receptor Nlα4 subunit are associated with sulfoxaflor resistance in Nilaparvata lugens.

Background: Sulfoximine insecticide sulfoxaflor acts on insect nicotinic acetylcholine receptors (nAChRs). Metabolic resistance arising from increased activity of detoxification enzymes has been extensively documented in insect populations. Prior research by the present authors demonstrated the involvement of cytochrome P450 monooxygenases in mediating metabolic resistance to sulfoxaflor in Nilaparvata lugens.

Toxic effects of combined exposure to carbamazepine and triclosan on adult zebrafish (Danio rerio): Insights into acute mortality, neurotransmitters, biochemical response, and histopathology.

As two representative pharmaceuticals and personal care products (PCPPs), carbamazepine (CBZ) and triclosan (TCS) are frequently detected in aquatic ecosystems worldwide, but their toxicological interactions remain unclear. This work evaluated the combined toxicity of CBZ and TCS to zebrafish (Danio rerio) in terms of acute mortality, biochemical response, and histopathology. The results showed that the 96-h acute toxicity interaction of CBZ and TCS fitted well to the concentration addition (CA) model, suggesting an additive effect.

Chlorantraniliprole as seed treatments against the black cutworm Agrotis ipsilon (Lepidoptera: Noctuidae) via residues in cotton ecosystem and the exposure risks to honeybees as measured in pollen.

The black cutworm Agrotis ipsilon (Hufnagel) (Lepidoptera: Noctuidae) can damage the cotton seedlings and induce destructive yield loss. Seed coating with systemic insecticides is a cost-effective alternative to control A. ipsilon during the early stage of cotton, but the control efficacy and exposure risk to honeybees remain unclear.

Web-based cognitive interventions on subjective cognitive impairment in cancer survivors: A systemic review.

Objective: Cancer survivors have experienced subjective cognitive impairment (SCI) when they received cancer diagnoses or treatments. Their psychosocial and emotional statuses were also impacted. With the advancement of web technologies, web-based cognitive interventions have been implemented in the management and the alleviation of the SCI, the psychosocial distress, and the emotional distress in cancer survivors.

DSPE-mPEG2000-Modified Podophyllotoxin Long-Circulating Liposomes for Targeted Delivery: Their Preparation, Characterization, and Evaluation.

Objective: DSPE-mPEG2000 is a phospholipid and polyethylene glycol conjugate used in various biomedical applications, including drug delivery, gene transfection, and vaccine delivery. Due to the hydrophilic and hydrophobic properties of DSPE-mPEG2000, it can serve as a drug carrier, encapsulating drugs in liposomes to enhance stability and efficacy.

Method: In this study, long-circulating podophyllotoxin liposomes (Lc-PTOX-Lps) were prepared using DSPE-mPEG2000 as a modifying material and evaluated for their pharmacokinetics and anticancer activity.

miRNAs modulate altered expression of cytochrome P450s and nicotinic acetylcholine receptor subunits conferring both metabolic and target resistance to sulfoxaflor in Nilaparvata lugens (Stål).

Understanding the insecticide resistance mechanisms and their underlying regulatory pathways is essential for pest management. Previous findings indicated that the overexpression of P450 gene, CYP6ER1, was a key mechanism for sulfoxaflor metabolic resistance in Nilaparvata lugens. However, it remains unclear whether quantitative changes in the target nicotinic acetylcholine receptors (nAChRs) contribute to sulfoxaflor resistance and the underlying regulatory mechanisms involved.

A feasibility study of a couple-based illness perception intervention for couples coping with colorectal cancer.

Purpose: As a special psychological variable, illness perception significantly affects the cancer adaptions of colorectal cancer couples. No studies focus on facilitating cancer adaption by targeting the illness perception in colorectal cancer couples. This research attempted to explore the feasibility, acceptability, and potential effectiveness of an illness perception intervention program designed for couples with colorectal cancer, guided by a self-regulation common sense model.

Deletion of protein kinase C θ attenuates hepatic ischemia/reperfusion injury and further elucidates its mechanism in pathophysiology.

Objectives: Hepatic ischemia-reperfusion (HIR) is a severe process in pathophysiology that occurs clinically in hepatectomy, and hepatic transplantations. The present study aimed to investigate the effect of PKC θ deletion against HIR injury and elucidate its mechanism in pathophysiology.

Materials And Methods: HIR injury was induced in wild-type and PKC θ deletion mice treated with or without heme.

The Congruence and Interrelationship: A Dyadic Perspective on the Subjective Cognitive Impairment in the Patients with Colorectal Cancer and Their Spousal Caregivers.

Objectives: Patients with colorectal cancer (CRC) reported experiencing subjective cognitive impairment (SCI), and their spousal caregivers perceived the patients' SCI. This cross-sectional study assessed the congruence of SCI between the patients' self-reports and the spousal caregivers' perceptions and examined the factors affecting SCI from the dyadic perspective.

Methods: A total of 200 dyads of patients with CRC and their spousal caregivers were invited to complete the survey, which evaluated the SCI, dyadic coping (DC), quality of life, anxiety, and depression for the dyads.

The Illness Perceptions and Coping Experiences of Patients with Colorectal Cancer and Their Spousal Caregivers: A Qualitative Study.

(1) Background: Illness perception (IP) is an important psychological construct for couples dealing with cancer, which impacts health outcomes and the psychological adjustment to cancer. More research is needed to explore the traits of IP and the efforts of couples coping with cancer. Thus, this study was designed to explore the coping experiences and features of the IPs of couples dealing with cancer.

Interventions strategies and their efficacy in illness perceptions in patients with cancer: A systematic review and meta-analysis.

Purposes: To identify intervention strategies for improving illness perception (IP) of cancer patients and/or family caregivers; and to examine the effects of IP interventions by meta-analysis.

Methods: A systematic search was performed to identify literature that focused on improving the IP of cancer patients and/or family caregivers from the establishment of eight databases to August 2023. Manual screening was also applied.

Visualization of the Infection and Colonization Process of Using a Green Fluorescent Protein-Tagged Isolate of .

soft rot is a widespread and destructive disease caused by that can seriously affect yield and quality. To better understand the fungal infection and colonization, we successfully created an labeled with green fluorescent protein using the -mediated transformation method. Transformants had varying fluorescence intensities, but their pathogenicity did not differ from that of the wild type.

A couple-based unmet supportive care needs intervention for colorectal cancer couples: A preliminary feasibility study.

Purpose: To support colorectal cancer couples cope with cancer, we developed a couple-based unmet supportive care needs intervention program guided by the Supportive Care Needs Framework and examined the feasibility, acceptability, and initial effects of the unmet supportive care needs program.

Methods: The design of a pre-and post-intervention study was conducted among Chinese colorectal cancer couples. The intervention was delivered in five sessions through in-person and telephone interventions combined.

A Systematic Review of Cognitive Impairment in Individuals With Colorectal Cancer.

Problem Identification: Patients with colorectal cancer (CRC) encounter varying degrees of objective and subjective cognitive impairment. The prevalence of objective and subjective cognitive impairment, factors affecting cognitive impairment, and interventions are presented in this review.

Literature Search: The CINAHL Plus®, Cochrane Library, Embase®, PsycINFO®, PubMed®, and CNKI databases were systematically searched from the time of the database's establishment to May 2023.

Identification of the metaphyseal skeletal stem cell building trabecular bone.

Skeletal stem cells (SSCs) that are capable of self-renewal and multipotent differentiation contribute to bone development and homeostasis. Several populations of SSCs at different skeletal sites have been reported. Here, we identify a metaphyseal SSC (mpSSC) population whose transcriptional landscape is distinct from other bone mesenchymal stromal cells (BMSCs).

pH/chitinase dual stimuli-responsive essential oil-delivery system based on mesoporous silica nanoparticles for control of rice blast.

Background: Owing to their surface modifiability, smart mesoporous silica nanoparticles (MSNs) can be designed to respond to plant disease-microenvironmental stimuli, thereby achieving on-demand release of active ingredients to control disease by effectively improving citral (CT) stability.

Results: A pH/chitinase dual stimuli-responsive essential oil-delivery system (CT@HMS@CH/TA) was successfully fabricated by encapsulating CT in hollow mesoporous silica (HMS), and coating with tannic acid (TA) and chitosan (CH) within HMS by using the layer-by-layer assembly technique (LbL). CT@HMS@CH/TA with an average particle size of 125.